CY1126145T1 - Κατασκευασματα αντισωματων για flt3 και cd3 - Google Patents

Κατασκευασματα αντισωματων για flt3 και cd3

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Publication number
CY1126145T1
CY1126145T1 CY20231100234T CY231100234T CY1126145T1 CY 1126145 T1 CY1126145 T1 CY 1126145T1 CY 20231100234 T CY20231100234 T CY 20231100234T CY 231100234 T CY231100234 T CY 231100234T CY 1126145 T1 CY1126145 T1 CY 1126145T1
Authority
CY
Cyprus
Prior art keywords
antibody construct
flt3
polynucleotide
disclosure
binds
Prior art date
Application number
CY20231100234T
Other languages
English (en)
Inventor
Tobias Raum
Jochen PENDZIALEK
Claudia Bluemel
Franziska BOTT
Christoph DAHLHOFF
Patrick Hoffmann
Elisabeth NAHRWOLD
Markus Muenz
Johannes BROZY
Peter Kufer
Matthias Friedrich
Benno Rattel
Pamela BOGNER
Andreas Wolf
Cornelius Pompe
Original Assignee
Amgen Research (Munich) Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Research (Munich) Gmbh filed Critical Amgen Research (Munich) Gmbh
Publication of CY1126145T1 publication Critical patent/CY1126145T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Abstract

Η παρούσα αποκάλυψη αναφέρεται σε ένα κατασκεύασμα διειδικού αντισώματος που περιλαμβάνει μια πρώτη επικράτεια δέσμευσης που συνδέεται με ανθρώπινο FLT3 στην επιφάνεια ενός κυττάρου στόχου και μια δεύτερη επικράτεια δέσμευσης που συνδέεται με ανθρώπινο CD3 στην επιφάνεια ενός Τ κυττάρου. Επιπλέον, η αποκάλυψη παρέχει ένα πολυνουκλεοτίδιο που κωδικοποιεί το κατασκεύασμα αντισώματος, έναν φορέα που περιλαμβάνει το εν λόγω πολυνουκλεοτίδιο και κύτταρο ξενιστή μετασχηματισμένο ή επιμολυσμένο με το εν λόγω πολυνουκλεοτίδιο ή φορέα. Περαιτέρω η αποκάλυψη παρέχει μια διαδικασία για την παραγωγή του κατασκευάσματος αντισώματος της αποκάλυψης, μια ιατρική χρήση του εν λόγω κατασκευάσματος αντισώματος και ένα κιτ που περιλαμβάνει το εν λόγω κατασκεύασμα αντισώματος.
CY20231100234T 2015-07-31 2023-05-18 Κατασκευασματα αντισωματων για flt3 και cd3 CY1126145T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562199944P 2015-07-31 2015-07-31
US201662290861P 2016-02-03 2016-02-03
PCT/EP2016/068319 WO2017021362A1 (en) 2015-07-31 2016-08-01 Antibody constructs for flt3 and cd3

Publications (1)

Publication Number Publication Date
CY1126145T1 true CY1126145T1 (el) 2023-11-15

Family

ID=56800254

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20231100234T CY1126145T1 (el) 2015-07-31 2023-05-18 Κατασκευασματα αντισωματων για flt3 και cd3

Country Status (36)

Country Link
US (2) US11447567B2 (el)
EP (2) EP4219562A3 (el)
JP (2) JP7011574B2 (el)
KR (1) KR20180030852A (el)
CN (2) CN109476735B (el)
AU (1) AU2016302580B2 (el)
BR (1) BR112018001042A2 (el)
CA (1) CA2991607A1 (el)
CL (3) CL2018000269A1 (el)
CO (1) CO2018000882A2 (el)
CR (1) CR20180067A (el)
CY (1) CY1126145T1 (el)
DK (1) DK3328891T3 (el)
EA (1) EA201890337A8 (el)
ES (1) ES2943147T3 (el)
FI (1) FI3328891T3 (el)
HK (1) HK1248251A1 (el)
HR (1) HRP20230401T1 (el)
HU (1) HUE061579T2 (el)
IL (2) IL289894B2 (el)
JO (1) JO3792B1 (el)
LT (1) LT3328891T (el)
MD (1) MD3328891T2 (el)
MX (1) MX2018001159A (el)
MY (1) MY193235A (el)
PE (1) PE20181082A1 (el)
PH (1) PH12018500157A1 (el)
PL (1) PL3328891T3 (el)
PT (1) PT3328891T (el)
RS (1) RS64184B1 (el)
SG (1) SG10202000793XA (el)
SI (1) SI3328891T1 (el)
TN (1) TN2017000550A1 (el)
TW (1) TWI829617B (el)
UA (1) UA125717C2 (el)
WO (1) WO2017021362A1 (el)

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