BR112021012401A2 - Acetil-transferases inovadoras - Google Patents

Acetil-transferases inovadoras

Info

Publication number
BR112021012401A2
BR112021012401A2 BR112021012401A BR112021012401A BR112021012401A2 BR 112021012401 A2 BR112021012401 A2 BR 112021012401A2 BR 112021012401 A BR112021012401 A BR 112021012401A BR 112021012401 A BR112021012401 A BR 112021012401A BR 112021012401 A2 BR112021012401 A2 BR 112021012401A2
Authority
BR
Brazil
Prior art keywords
innovative
acetyltransferases
retinol
production
process including
Prior art date
Application number
BR112021012401A
Other languages
English (en)
Inventor
Anna Symbor-Nagrabska
Jenna Mcmahon
Louis Houston Peter
Marcel De Jong René
René Verwaal
Kanubhai Vyas Valmik
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BR112021012401A2 publication Critical patent/BR112021012401A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01084—Alcohol O-acetyltransferase (2.3.1.84)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

acetil-transferases inovadoras. a presente invenção se refere à produção de acetato de retinila gerado por meio da conversão enzimática de retinol, sendo que o dito processo inclui o uso de enzimas modificadas com atividade aprimorada.
BR112021012401A 2018-12-31 2019-12-30 Acetil-transferases inovadoras BR112021012401A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH16162018 2018-12-31
PCT/EP2019/087183 WO2020141168A1 (en) 2018-12-31 2019-12-30 Novel acetyl-transferases

Publications (1)

Publication Number Publication Date
BR112021012401A2 true BR112021012401A2 (pt) 2021-12-14

Family

ID=69061387

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021012401A BR112021012401A2 (pt) 2018-12-31 2019-12-30 Acetil-transferases inovadoras

Country Status (7)

Country Link
US (1) US20220064607A1 (pt)
EP (1) EP3906305A1 (pt)
JP (1) JP2022515041A (pt)
CN (1) CN113227365A (pt)
BR (1) BR112021012401A2 (pt)
EA (1) EA202191822A1 (pt)
WO (1) WO2020141168A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
WO2022023173A1 (en) 2020-07-27 2022-02-03 Dsm Ip Assets B.V. Reduction of fatty acid retinyl ester formation
US20230407344A1 (en) 2020-10-30 2023-12-21 Dsm Ip Assets B.V. Fermentative production of isoprenoids
US20240018564A1 (en) 2020-10-30 2024-01-18 Dsm Ip Assets B.V. In situ two-phase extraction system
CN112522331B (zh) * 2020-12-09 2024-03-22 上海克琴科技有限公司 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法
JP2024517415A (ja) * 2021-04-16 2024-04-22 カプラ バイオサイエンシーズ インコーポレイテッド バイオフィルムバイオリアクタにおける遺伝子操作された炭化水素分解性生物を使用するイソプレノイド合成の方法
WO2023275212A1 (en) 2021-07-01 2023-01-05 Dsm Ip Assets B.V. Sustainable production of retinyl fatty esters
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
WO2023067030A1 (en) 2021-10-19 2023-04-27 Dsm Ip Assets B.V. Retinoid production
WO2023214072A2 (en) 2022-05-05 2023-11-09 Dsm Ip Assets B.V. Novel process

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3379344B2 (ja) * 1996-07-24 2003-02-24 トヨタ自動車株式会社 ファルネシル二リン酸合成酵素
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
TWI328612B (en) * 2002-07-25 2010-08-11 Dsm Ip Assets Bv Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
EP2371967B1 (en) 2005-03-18 2015-06-03 DSM IP Assets B.V. Production of carotenoids in oleaginous yeast and fungi
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
US20120149886A1 (en) 2008-04-10 2012-06-14 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
KR101392159B1 (ko) * 2011-07-29 2014-05-12 경상대학교산학협력단 미생물로부터 레티노이드를 생산하는 방법
EP2831238B1 (en) 2012-03-27 2018-01-03 DSM IP Assets B.V. Cloning method
KR20150022889A (ko) * 2012-05-29 2015-03-04 리젠츠 오브 더 유니버시티 오브 미네소타 생합성 경로, 재조합 세포 및 방법
EP2935571B1 (en) * 2012-12-20 2018-03-07 DSM IP Assets B.V. Acetyl transferases and their use for producing carotenoids
WO2014195377A2 (en) 2013-06-05 2014-12-11 Dsm Ip Assets B.V. Polypeptides with permease activity
KR20140147982A (ko) * 2013-06-20 2014-12-31 경상대학교산학협력단 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법
WO2016110512A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a yeast host cell
WO2016172282A1 (en) 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Microbial production of terpenoids
US11207393B2 (en) * 2015-10-16 2021-12-28 President And Fellows Of Harvard College Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
BR112020005774A2 (pt) 2017-09-25 2020-09-24 Dsm Ip Assets B.V. biossíntese de retinoides
WO2019058001A1 (en) * 2017-09-25 2019-03-28 Dsm Ip Assets B.V. PRODUCTION OF RETINYL ESTERS

Also Published As

Publication number Publication date
CN113227365A (zh) 2021-08-06
JP2022515041A (ja) 2022-02-17
EP3906305A1 (en) 2021-11-10
US20220064607A1 (en) 2022-03-03
WO2020141168A1 (en) 2020-07-09
EA202191822A1 (ru) 2021-11-16

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