BR112021012401A2 - Acetil-transferases inovadoras - Google Patents

Acetil-transferases inovadoras

Info

Publication number
BR112021012401A2
BR112021012401A2 BR112021012401A BR112021012401A BR112021012401A2 BR 112021012401 A2 BR112021012401 A2 BR 112021012401A2 BR 112021012401 A BR112021012401 A BR 112021012401A BR 112021012401 A BR112021012401 A BR 112021012401A BR 112021012401 A2 BR112021012401 A2 BR 112021012401A2
Authority
BR
Brazil
Prior art keywords
innovative
acetyltransferases
retinol
production
process including
Prior art date
Application number
BR112021012401A
Other languages
English (en)
Inventor
Anna Symbor-Nagrabska
Jenna Mcmahon
Louis Houston Peter
Marcel De Jong René
René Verwaal
Kanubhai Vyas Valmik
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BR112021012401A2 publication Critical patent/BR112021012401A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01084—Alcohol O-acetyltransferase (2.3.1.84)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

acetil-transferases inovadoras. a presente invenção se refere à produção de acetato de retinila gerado por meio da conversão enzimática de retinol, sendo que o dito processo inclui o uso de enzimas modificadas com atividade aprimorada.
BR112021012401A 2018-12-31 2019-12-30 Acetil-transferases inovadoras BR112021012401A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH16162018 2018-12-31
PCT/EP2019/087183 WO2020141168A1 (en) 2018-12-31 2019-12-30 Novel acetyl-transferases

Publications (1)

Publication Number Publication Date
BR112021012401A2 true BR112021012401A2 (pt) 2021-12-14

Family

ID=69061387

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021012401A BR112021012401A2 (pt) 2018-12-31 2019-12-30 Acetil-transferases inovadoras

Country Status (7)

Country Link
US (1) US20220064607A1 (pt)
EP (1) EP3906305A1 (pt)
JP (1) JP2022515041A (pt)
CN (1) CN113227365A (pt)
BR (1) BR112021012401A2 (pt)
EA (1) EA202191822A1 (pt)
WO (1) WO2020141168A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4189079A1 (en) 2020-07-27 2023-06-07 DSM IP Assets B.V. Reduction of fatty acid retinyl ester formation
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
EP4237574A1 (en) 2020-10-30 2023-09-06 DSM IP Assets B.V. In situ two-phase extraction system
EP4237570A1 (en) 2020-10-30 2023-09-06 DSM IP Assets B.V. Fermentative production of isoprenoids
CN112522331B (zh) * 2020-12-09 2024-03-22 上海克琴科技有限公司 一种生物酶催化的羟基频哪酮视黄酸酯的合成方法
BR112023020933A2 (pt) * 2021-04-16 2023-12-12 Capra Biosciences Inc Organismo geneticamente modificado, gene de retinol desidrogenase (rdh12), vetor de expressão, célula hospedeira, retinol desidrogenase 12 (rdh12), biofilme, biorreator e reator de biofilme, e método para produzir um isoprenoide em um biorreator de biofilme
WO2023275212A1 (en) 2021-07-01 2023-01-05 Dsm Ip Assets B.V. Sustainable production of retinyl fatty esters
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
WO2023067030A1 (en) 2021-10-19 2023-04-27 Dsm Ip Assets B.V. Retinoid production
WO2023214072A2 (en) 2022-05-05 2023-11-09 Dsm Ip Assets B.V. Novel process

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3379344B2 (ja) * 1996-07-24 2003-02-24 トヨタ自動車株式会社 ファルネシル二リン酸合成酵素
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
TWI328612B (en) * 2002-07-25 2010-08-11 Dsm Ip Assets Bv Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12
KR101482081B1 (ko) 2005-03-18 2015-01-13 마이크로비아 인크. 유질 효모와 진균 내에서 카로티노이드의 생산
EP2078092A2 (en) 2006-09-28 2009-07-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
WO2009126890A2 (en) 2008-04-10 2009-10-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
WO2012125027A1 (en) 2011-03-14 2012-09-20 Dsm Ip Assets B.V. Yeast strains that ferment uronic acids
US9644217B2 (en) * 2011-07-29 2017-05-09 Industry-Academic Cooperation Foundation Gyeongsang National University Method for producing retinoid from microorganism
US9738890B2 (en) 2012-03-27 2017-08-22 Dsm Ip Assets B.V. Cloning method
US10006064B2 (en) * 2012-05-29 2018-06-26 Regents Of The University Of Minnesota Biosynthetic pathways, recombinant cells, and methods
JP6607567B2 (ja) * 2012-12-20 2019-11-20 ディーエスエム アイピー アセッツ ビー．ブイ． アセチルトランスフェラーゼおよびカロテノイドを産生するためのそれらの使用
US10000537B2 (en) 2013-06-05 2018-06-19 Dsm Ip Assets B.V. Polypeptides with permease activity
KR20140147982A (ko) * 2013-06-20 2014-12-31 경상대학교산학협력단 레티노이드 생산에 관여하는 효소를 코딩하는 유전자를 포함하는 미생물 및 이를 이용한 레티노이드의 생산 방법
WO2016110512A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a yeast host cell
CA2980649A1 (en) 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthase
WO2017066561A2 (en) * 2015-10-16 2017-04-20 President And Fellows Of Harvard College Regulatory t cell pd-1 modulation for regulating t cell effector immune responses
CN111107834A (zh) * 2017-09-25 2020-05-05 帝斯曼知识产权资产管理有限公司 类视黄醇的生物合成
BR112020005744A2 (pt) * 2017-09-25 2020-10-13 Dsm Ip Assets B.V. produção de ésteres retinílicos

Also Published As

Publication number Publication date
JP2022515041A (ja) 2022-02-17
EA202191822A1 (ru) 2021-11-16
US20220064607A1 (en) 2022-03-03
CN113227365A (zh) 2021-08-06
EP3906305A1 (en) 2021-11-10
WO2020141168A1 (en) 2020-07-09

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