MX2017008817A - Composiciones y metodos para la glicosilacion de proteinas. - Google Patents

Composiciones y metodos para la glicosilacion de proteinas.

Info

Publication number
MX2017008817A
MX2017008817A MX2017008817A MX2017008817A MX2017008817A MX 2017008817 A MX2017008817 A MX 2017008817A MX 2017008817 A MX2017008817 A MX 2017008817A MX 2017008817 A MX2017008817 A MX 2017008817A MX 2017008817 A MX2017008817 A MX 2017008817A
Authority
MX
Mexico
Prior art keywords
methods
compositions
protein glycosylation
oligosaccharyl transferases
oligosaccharyl
Prior art date
Application number
MX2017008817A
Other languages
English (en)
Inventor
Haas Jurgen
Ihssen Julian
Franz Schwede Torsten
THÖNY-MEYER Christiane
Christiane THÖNY-MEYER Linda
Thomas Kowarik Michael
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of MX2017008817A publication Critical patent/MX2017008817A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

En el presente documento se describen oligosacariltransferasas para uso en proteínas N-glicosilantes de interés in vitro y en células huésped. También se proporcionan en el presente documento procedimientos para usar dichos oligosacariltransferasas, ácidos nucleicos que codifican dichas oligosacariltransferasas y células huésped que comprenden dichas oligosacariltransferasas. También se proporcionan en el presente documento glicoconjugados generados usando dichas oligosacariltransferasas.
MX2017008817A 2014-12-30 2015-12-24 Composiciones y metodos para la glicosilacion de proteinas. MX2017008817A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098071P 2014-12-30 2014-12-30
US201462097975P 2014-12-30 2014-12-30
PCT/EP2015/081229 WO2016107818A1 (en) 2014-12-30 2015-12-24 Compositions and methods for protein glycosylation

Publications (1)

Publication Number Publication Date
MX2017008817A true MX2017008817A (es) 2017-10-24

Family

ID=55080101

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008817A MX2017008817A (es) 2014-12-30 2015-12-24 Composiciones y metodos para la glicosilacion de proteinas.

Country Status (17)

Country Link
US (3) US10150952B2 (es)
EP (2) EP4043561A1 (es)
JP (1) JP6850724B2 (es)
CN (1) CN107614679A (es)
BE (1) BE1022998B1 (es)
BR (1) BR112017014031B1 (es)
CA (1) CA2971653A1 (es)
DK (1) DK3240895T3 (es)
ES (1) ES2907211T3 (es)
HR (1) HRP20220500T1 (es)
HU (1) HUE057726T2 (es)
LT (1) LT3240895T (es)
MX (1) MX2017008817A (es)
PL (1) PL3240895T3 (es)
PT (1) PT3240895T (es)
SI (1) SI3240895T1 (es)
WO (2) WO2016107818A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2718051T3 (es) 2013-01-17 2019-06-27 Arsanis Biosciences Gmbh Antígeno específico de E. coli MDR
CA2940547C (en) 2014-02-24 2021-01-05 Glycovaxyn Ag Novel polysaccharide and uses thereof
BE1022998B1 (fr) 2014-12-30 2016-10-28 Glycovaxyn Ag Compositions et procédés de glycosylation de protéines
US10265391B2 (en) 2015-02-26 2019-04-23 Vaxnewmo Llc Acinetobacter O-oligosaccharyltransferases and uses thereof
TWI715617B (zh) 2015-08-24 2021-01-11 比利時商葛蘭素史密斯克藍生物品公司 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物
AR109621A1 (es) 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
GB201704117D0 (en) * 2017-03-15 2017-04-26 London School Hygiene & Tropical Medicine Oligosaccharyl Transferase polypeptide
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
CA3103474A1 (en) 2018-06-16 2019-12-19 Vaxnewmo Llc Glycosylated comp pilin variants, methods of making and uses thereof
WO2020131236A1 (en) * 2018-12-21 2020-06-25 Vaxnewmo Llc O-linked glycosylation recognition motifs
CA3134045A1 (en) 2019-03-18 2020-09-24 Janssen Pharmaceuticals, Inc. Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof
CA3134216A1 (en) 2019-03-18 2020-09-24 Janssen Pharmaceuticals, Inc. Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof
EP3770269A1 (en) 2019-07-23 2021-01-27 GlaxoSmithKline Biologicals S.A. Quantification of bioconjugate glycosylation
BR112022000969A2 (pt) * 2019-08-09 2022-06-14 Glaxosmithkline Biologicals Sa Enzimas pglb oligossacariltransferase mutadas
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
CN110910960B (zh) * 2019-11-30 2022-07-08 浙江天科高新技术发展有限公司 一种鲍曼不动杆菌分子血清型快速分析方法
AU2021342797B2 (en) 2020-09-17 2024-02-08 Janssen Pharmaceuticals, Inc. Multivalent vaccine compositions and uses thereof
WO2022171679A2 (en) * 2021-02-11 2022-08-18 Glaxosmithkline Biologicals Sa Protein
BR112023019874A2 (pt) 2021-04-01 2023-11-07 Janssen Pharmaceuticals Inc Produção de bioconjugados de e. coli o18
WO2023118033A1 (en) 2021-12-22 2023-06-29 Glaxosmithkline Biologicals Sa Vaccine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101524636B1 (ko) * 2005-05-11 2015-06-03 에테하 취리히 원핵 세포로부터의 재조합 ｎ-글리코실화 단백질
CA2711307C (en) * 2008-01-03 2020-10-27 Cornell Research Foundation, Inc. Glycosylated protein expression in prokaryotes
SI2257307T1 (sl) * 2008-02-20 2018-09-28 Glaxosmithkline Biologicals S.A. Biokonjugati, izdelani iz rekombinantnih N-glikoziliranih proteinov iz prokariontskih celic
PT2501406T (pt) * 2009-11-19 2018-02-21 Glaxosmithkline Biologicals Sa Sistema de biossíntese que produz polissacáridos imunogénicos em células procariotas
ES2844596T3 (es) 2010-05-06 2021-07-22 Glaxosmithkline Biologicals Sa Vacunas de bioconjugados de bacterias grampositivas capsulares
CN112980907A (zh) * 2011-11-04 2021-06-18 康奈尔大学 一种用于糖蛋白合成的基于原核生物的无细胞系统
EP2946010B1 (en) * 2013-01-18 2018-08-29 London School of Hygiene and Tropical Medicine Glycosylation method
BE1022998B1 (fr) 2014-12-30 2016-10-28 Glycovaxyn Ag Compositions et procédés de glycosylation de protéines
GB201704117D0 (en) * 2017-03-15 2017-04-26 London School Hygiene & Tropical Medicine Oligosaccharyl Transferase polypeptide

Also Published As

Publication number Publication date
BE1022998B1 (fr) 2016-10-28
BE1022998A1 (fr) 2016-10-28
WO2016107818A8 (en) 2017-08-31
US10577592B2 (en) 2020-03-03
LT3240895T (lt) 2022-04-11
DK3240895T3 (da) 2022-04-11
EP3240895B1 (en) 2022-01-26
US20200181586A1 (en) 2020-06-11
WO2016107818A1 (en) 2016-07-07
JP2018500912A (ja) 2018-01-18
US11015177B2 (en) 2021-05-25
PT3240895T (pt) 2022-03-02
US20190078064A1 (en) 2019-03-14
WO2016107819A1 (en) 2016-07-07
HUE057726T2 (hu) 2022-06-28
EP3240895A1 (en) 2017-11-08
CN107614679A (zh) 2018-01-19
JP6850724B2 (ja) 2021-03-31
ES2907211T3 (es) 2022-04-22
CA2971653A1 (en) 2016-07-07
SI3240895T1 (sl) 2022-04-29
BR112017014031B1 (pt) 2023-11-07
EP4043561A1 (en) 2022-08-17
US20180002679A1 (en) 2018-01-04
US10150952B2 (en) 2018-12-11
HRP20220500T1 (hr) 2022-06-10
BR112017014031A2 (pt) 2018-01-16
PL3240895T3 (pl) 2022-05-02

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