EA201890187A1 - Рекомбинантные вирусоподобные частицы (vlp) с использованием протеина группового антигена (gag) вируса бычьего иммунодефицита - Google Patents
Рекомбинантные вирусоподобные частицы (vlp) с использованием протеина группового антигена (gag) вируса бычьего иммунодефицитаInfo
- Publication number
- EA201890187A1 EA201890187A1 EA201890187A EA201890187A EA201890187A1 EA 201890187 A1 EA201890187 A1 EA 201890187A1 EA 201890187 A EA201890187 A EA 201890187A EA 201890187 A EA201890187 A EA 201890187A EA 201890187 A1 EA201890187 A1 EA 201890187A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vlp
- particles
- recombinant virus
- buck
- immunodeficiency
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/866—Baculoviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/045—Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
Abstract
В заявке описаны рекомбинантные вирусоподобные частицы (VLP) протеина группового антигена вируса бычьего иммунодефицита белка ("Bgag"), содержащие один или несколько различных типов целевых белков-патогенов. Также описаны композиции, содержащие новые VLP Bgag, и способы изготовления и использования новых VLP Bgag.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562188084P | 2015-07-02 | 2015-07-02 | |
PCT/US2016/040838 WO2017004586A1 (en) | 2015-07-02 | 2016-07-01 | Recombinant virus like particles using bovine immunodeficiency virus gag protein |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201890187A1 true EA201890187A1 (ru) | 2018-06-29 |
Family
ID=57609369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201890187A EA201890187A1 (ru) | 2015-07-02 | 2016-07-01 | Рекомбинантные вирусоподобные частицы (vlp) с использованием протеина группового антигена (gag) вируса бычьего иммунодефицита |
Country Status (14)
Country | Link |
---|---|
US (2) | US11576965B2 (ru) |
EP (1) | EP3316906A4 (ru) |
JP (2) | JP6978079B2 (ru) |
KR (1) | KR20180032586A (ru) |
CN (2) | CN115927212A (ru) |
BR (1) | BR112018000037A2 (ru) |
CA (1) | CA2991213A1 (ru) |
EA (1) | EA201890187A1 (ru) |
HK (1) | HK1259067A1 (ru) |
MA (1) | MA42312A (ru) |
MX (1) | MX2018000023A (ru) |
PE (1) | PE20180771A1 (ru) |
RU (2) | RU2757723C2 (ru) |
WO (1) | WO2017004586A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201890187A1 (ru) * | 2015-07-02 | 2018-06-29 | Медиджен, Инк. | Рекомбинантные вирусоподобные частицы (vlp) с использованием протеина группового антигена (gag) вируса бычьего иммунодефицита |
CN112279900A (zh) * | 2020-12-30 | 2021-01-29 | 乾元浩生物股份有限公司 | H9n2亚型禽流感病毒基因工程亚单位疫苗及其制备方法与应用 |
CN113398259A (zh) * | 2021-04-30 | 2021-09-17 | 吉林大学 | 一种h9n2亚型禽流感新型标记疫苗的制备方法及其应用 |
CN113403343A (zh) * | 2021-04-30 | 2021-09-17 | 吉林大学 | 一种h3n2与h9n2亚型禽流感二价嵌合型病毒样颗粒的制备 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6864085B2 (en) * | 1999-12-14 | 2005-03-08 | Novartis Ag | Bovine immunodeficiency virus (BIV) based vectors |
EP1576143B1 (en) | 2002-05-17 | 2010-11-24 | Emory University | Virus-like particles, methods of preparation, and immonogenic compositions |
US20060088909A1 (en) | 2002-05-17 | 2006-04-27 | Compans Richard W | Virus-like particles, methods of preparation, and immunogenic compositions |
US8506967B2 (en) * | 2003-07-11 | 2013-08-13 | Novavax, Inc. | Functional influenza virus like particles (VLPs) |
US20100143406A1 (en) | 2006-06-30 | 2010-06-10 | Gale Smith | Methods of enhancing protein incorporation into virus like particles |
US20100047266A1 (en) * | 2006-07-27 | 2010-02-25 | Ligocyte Pharmaceuticals, Inc. | Chimeric virus-like particles |
CA2678966A1 (en) * | 2007-02-21 | 2008-08-28 | Novavax, Inc. | Chimeric newcastle disease virus vlps |
CN105586358B (zh) * | 2007-05-29 | 2020-08-25 | 克里斯多佛·B·里德 | 专能细胞群的生产和使用方法 |
RU2010105858A (ru) * | 2007-07-19 | 2011-08-27 | Новавакс, Инк. (Us) | Вирусоподобные частицы (vlp) вируса varicella zoster и антигены |
WO2011087839A1 (en) * | 2009-12-22 | 2011-07-21 | Baxter International Inc. | Vaccine to influenza a virus |
KR20130108983A (ko) * | 2010-05-26 | 2013-10-07 | 셀렉타 바이오사이언시즈, 인크. | 커플링되지 않은 애주번트를 갖는 나노담체 조성물 |
US20140004146A1 (en) * | 2011-03-17 | 2014-01-02 | Institut Pasteur Of Shanghai, Chinese Academy Of Sciences | Method for producing virus-like particle by using drosophila cell and applications thereof |
WO2015066715A1 (en) * | 2013-11-04 | 2015-05-07 | Viracell Advanced Products, Llc | Virus-like particles and methods related thereto |
EA201890187A1 (ru) * | 2015-07-02 | 2018-06-29 | Медиджен, Инк. | Рекомбинантные вирусоподобные частицы (vlp) с использованием протеина группового антигена (gag) вируса бычьего иммунодефицита |
-
2016
- 2016-07-01 EA EA201890187A patent/EA201890187A1/ru unknown
- 2016-07-01 JP JP2018520386A patent/JP6978079B2/ja active Active
- 2016-07-01 CA CA2991213A patent/CA2991213A1/en active Pending
- 2016-07-01 PE PE2018000003A patent/PE20180771A1/es not_active Application Discontinuation
- 2016-07-01 CN CN202210931466.8A patent/CN115927212A/zh active Pending
- 2016-07-01 CN CN201680050161.9A patent/CN108348596B/zh active Active
- 2016-07-01 MA MA042312A patent/MA42312A/fr unknown
- 2016-07-01 RU RU2020125098A patent/RU2757723C2/ru active
- 2016-07-01 KR KR1020187003292A patent/KR20180032586A/ko not_active IP Right Cessation
- 2016-07-01 RU RU2018103757A patent/RU2734118C2/ru active
- 2016-07-01 EP EP16818931.4A patent/EP3316906A4/en active Pending
- 2016-07-01 WO PCT/US2016/040838 patent/WO2017004586A1/en active Application Filing
- 2016-07-01 BR BR112018000037A patent/BR112018000037A2/pt active Search and Examination
- 2016-07-01 US US15/741,443 patent/US11576965B2/en active Active
- 2016-07-01 MX MX2018000023A patent/MX2018000023A/es unknown
-
2019
- 2019-01-29 HK HK19101567.0A patent/HK1259067A1/zh unknown
-
2020
- 2020-09-14 JP JP2020153664A patent/JP2020198893A/ja not_active Withdrawn
-
2023
- 2023-01-12 US US18/153,667 patent/US20230310579A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2018103757A3 (ru) | 2019-12-09 |
KR20180032586A (ko) | 2018-03-30 |
US20180369364A1 (en) | 2018-12-27 |
PE20180771A1 (es) | 2018-05-07 |
CN108348596A (zh) | 2018-07-31 |
RU2020125098A3 (ru) | 2020-12-11 |
JP2020198893A (ja) | 2020-12-17 |
US20230310579A1 (en) | 2023-10-05 |
BR112018000037A2 (pt) | 2018-09-04 |
JP2018525028A (ja) | 2018-09-06 |
MX2018000023A (es) | 2018-08-15 |
RU2020125098A (ru) | 2020-09-04 |
EP3316906A4 (en) | 2019-01-02 |
MA42312A (fr) | 2018-05-09 |
CN115927212A (zh) | 2023-04-07 |
CA2991213A1 (en) | 2017-01-05 |
RU2734118C2 (ru) | 2020-10-13 |
US11576965B2 (en) | 2023-02-14 |
JP6978079B2 (ja) | 2021-12-08 |
EP3316906A1 (en) | 2018-05-09 |
RU2018103757A (ru) | 2019-08-05 |
CN108348596B (zh) | 2022-08-23 |
WO2017004586A1 (en) | 2017-01-05 |
HK1259067A1 (zh) | 2019-11-22 |
RU2757723C2 (ru) | 2021-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202192570A1 (ru) | Иммуногенные композиции и вакцины, содержащие пептиды и белки вируса африканской чумы свиней, и их применение | |
EA202090149A1 (ru) | Антигенсвязывающие белки против вируса папилломы человека (hpv) и способы их применения | |
EA202091898A1 (ru) | Антитела, нейтрализующие вирус иммунодефицита человека | |
PE20171133A1 (es) | Particulas tipo virus modificadas de cmv | |
EA202190906A1 (ru) | Рекомбинантное получение препаратов пептидов коллагена и их применение | |
EA201792573A1 (ru) | Триспецифические связанные белки и способы их применения | |
EA201891420A1 (ru) | Антитела к миостатину, полипептиды, содержащие варианты fc-областей, и способы их применения | |
WO2017066764A3 (en) | Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses | |
EA201991168A1 (ru) | Белок, связывающий простатический специфический мембранный антиген | |
EA201990017A1 (ru) | Антитела к миостатину и способы их применения | |
WO2014134561A3 (en) | Quantification of vaccine compositions | |
EA201891415A1 (ru) | Антигены вируса иммунодефицита человека, векторы, композиции и способы их применения | |
EA201890527A1 (ru) | Терапевтические вакцины против hpv18 | |
EP3266464A3 (en) | Yeast-based therapeutic for chronic hepatitis b infection | |
EA201792466A1 (ru) | АНТИТЕЛА ПРОТИВ FcRn | |
EA201890187A1 (ru) | Рекомбинантные вирусоподобные частицы (vlp) с использованием протеина группового антигена (gag) вируса бычьего иммунодефицита | |
WO2016061504A3 (en) | Recombinant antibodies that recongnize the c-terminal domains of ebola virus nucleoprotein | |
NZ741875A (en) | Canine parvovirus (cpv) virus-like particle (vlp) vaccines and uses thereof | |
MX2017008096A (es) | Pestivirus. | |
EA201892325A1 (ru) | Композиции и способы детектирования белков клетки-хозяина | |
EP3939604A3 (en) | Influenza hemagglutinin protein vaccines | |
WO2015112558A3 (en) | Peptides, devices, and methods for the detection of anaplasma antibodies | |
MY179251A (en) | Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development | |
MX2017003117A (es) | Particula tipo virus de flavivirus. | |
EA202090084A1 (ru) | Новый терапевтический ферментный слитый белок и его применение |