CY1123405T1 - Κυτταρα θηλαστικου που εκφραζουν αντιγονα κυτταρομεγαλοϊου - Google Patents
Κυτταρα θηλαστικου που εκφραζουν αντιγονα κυτταρομεγαλοϊουInfo
- Publication number
- CY1123405T1 CY1123405T1 CY20201100546T CY201100546T CY1123405T1 CY 1123405 T1 CY1123405 T1 CY 1123405T1 CY 20201100546 T CY20201100546 T CY 20201100546T CY 201100546 T CY201100546 T CY 201100546T CY 1123405 T1 CY1123405 T1 CY 1123405T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cells expressing
- mammalian cells
- cytomegalovirus antigen
- expressing cytomegalovirus
- cmv
- Prior art date
Links
- 241000701022 Cytomegalovirus Species 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 210000004962 mammalian cell Anatomy 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16151—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Η εφεύρεση αυτή αφορά σε πρωτεΐνες κυτταρομεγαλοϊού (CMV) κατάλληλες για χρήσεις εμβολίου. Παρέχονται στο παρόν κύτταρα θηλαστικού ξενιστές, συγκεκριμένα CHO κύτταρα, στα οποία οι αλληλουχίες που κωδικοποιούν πρωτεΐνες CMV gH, gL, pUL128, pUL130, pUL131 (ή θραύσμα σχηματισμού συμπλόκου αυτών) είναι σταθερά ενσωματωμένες εντός του γονιδιώματος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14191385.5A EP3015475A1 (en) | 2014-10-31 | 2014-10-31 | Mammalian cells expressing cytomegalovirus antigens |
PCT/IB2015/058349 WO2016067239A1 (en) | 2014-10-31 | 2015-10-29 | Mammalian cells expressing cytomegalovirus antigens |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1123405T1 true CY1123405T1 (el) | 2021-12-31 |
Family
ID=51844603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100546T CY1123405T1 (el) | 2014-10-31 | 2020-06-16 | Κυτταρα θηλαστικου που εκφραζουν αντιγονα κυτταρομεγαλοϊου |
Country Status (19)
Country | Link |
---|---|
US (1) | US10414802B2 (el) |
EP (2) | EP3015475A1 (el) |
JP (1) | JP6688297B2 (el) |
CN (1) | CN107075486B (el) |
AR (1) | AR102464A1 (el) |
BE (3) | BE1023364B1 (el) |
BR (1) | BR112017008827A2 (el) |
CA (1) | CA2964859C (el) |
CY (1) | CY1123405T1 (el) |
DK (1) | DK3212660T3 (el) |
ES (1) | ES2799735T3 (el) |
HR (1) | HRP20200932T1 (el) |
HU (1) | HUE049356T2 (el) |
LT (1) | LT3212660T (el) |
MX (1) | MX2017005661A (el) |
PL (1) | PL3212660T3 (el) |
PT (1) | PT3212660T (el) |
SI (1) | SI3212660T1 (el) |
WO (1) | WO2016067239A1 (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9683022B2 (en) | 2012-07-06 | 2017-06-20 | Glaxosmithkline Biologicals S.A. | Complexes of cytomegalovirus proteins |
EP3052106A4 (en) | 2013-09-30 | 2017-07-19 | ModernaTX, Inc. | Polynucleotides encoding immune modulating polypeptides |
EP4332231A3 (en) * | 2014-04-29 | 2024-05-29 | Novartis AG | Novel vertebrate cells and methods for recombinantly expressing a polypeptide of interest |
EP3048114A1 (en) | 2015-01-22 | 2016-07-27 | Novartis AG | Cytomegalovirus antigens and uses thereof |
MA46316A (fr) | 2015-10-22 | 2021-03-24 | Modernatx Inc | Vaccin contre le cytomégalovirus humain |
JP6980780B2 (ja) | 2016-10-21 | 2021-12-15 | モデルナティーエックス, インコーポレイテッド | ヒトサイトメガロウイルスワクチン |
CN107723276B (zh) * | 2017-11-02 | 2021-08-13 | 上海交通大学 | 一种稳定高表达目标产物的细胞株的构建方法和试剂盒 |
BR112020022393A2 (pt) | 2018-05-04 | 2021-02-02 | SpyBiotech Limited | composição, vacina compreendendo uma composição, método para produzir uma composição, molécula de ácido nucleico, e, vetor, célula hospedeira, kit compreendendo uma composição, e, vacinas para uso na profilaxia e/ou tratamento de infecção por citomegalovírus e por vírus sincicial respiratório. |
JP7179872B2 (ja) * | 2018-12-10 | 2022-11-29 | Kmバイオロジクス株式会社 | サイトメガロウイルスの先天性感染を予防又は治療するためのワクチン |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
AU2021392077A1 (en) * | 2020-12-02 | 2023-07-13 | Seqirus Inc. | Multicistronic rna vaccines and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
DK0747485T3 (da) | 1989-11-06 | 1999-08-16 | Cell Genesys Inc | Fremstilling af proteiner ved anvendelse af homolog rekombination |
US5589392A (en) | 1991-01-14 | 1996-12-31 | Stratagene | Nucleic acid construct encoding a nuclear transport peptide operatively linked to an inducible promoter |
EP2037959B1 (en) | 2006-06-07 | 2016-01-27 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
TR201903651T4 (tr) * | 2010-10-11 | 2019-04-22 | Glaxosmithkline Biologicals Sa | Antijen uygulama platformları. |
US9683022B2 (en) | 2012-07-06 | 2017-06-20 | Glaxosmithkline Biologicals S.A. | Complexes of cytomegalovirus proteins |
JP6392245B2 (ja) | 2012-12-18 | 2018-09-19 | ノバルティス アーゲー | 遺伝子改変哺乳動物細胞における治療用タンパク質の産生 |
SG11201604218RA (en) | 2013-12-20 | 2016-07-28 | Novartis Ag | Novel eukaryotic cells and methods for recombinantly expressing a product of interest |
JP6708548B2 (ja) | 2013-12-20 | 2020-06-10 | ノバルティス アーゲー | 新規真核細胞および目的の生成物を組換え発現させるための方法 |
WO2015165480A1 (en) * | 2014-04-30 | 2015-11-05 | Institute For Research In Biomedicine | Human cytomegalovirus vaccine compositions and method of producing the same |
EP4332231A3 (en) | 2014-04-29 | 2024-05-29 | Novartis AG | Novel vertebrate cells and methods for recombinantly expressing a polypeptide of interest |
-
2014
- 2014-10-31 EP EP14191385.5A patent/EP3015475A1/en not_active Withdrawn
-
2015
- 2015-10-29 JP JP2017523410A patent/JP6688297B2/ja active Active
- 2015-10-29 BR BR112017008827-4A patent/BR112017008827A2/pt not_active Application Discontinuation
- 2015-10-29 LT LTEP15791768.3T patent/LT3212660T/lt unknown
- 2015-10-29 US US15/522,455 patent/US10414802B2/en active Active
- 2015-10-29 CA CA2964859A patent/CA2964859C/en active Active
- 2015-10-29 SI SI201531242T patent/SI3212660T1/sl unknown
- 2015-10-29 CN CN201580059495.8A patent/CN107075486B/zh active Active
- 2015-10-29 ES ES15791768T patent/ES2799735T3/es active Active
- 2015-10-29 AR ARP150103502A patent/AR102464A1/es unknown
- 2015-10-29 HU HUE15791768A patent/HUE049356T2/hu unknown
- 2015-10-29 MX MX2017005661A patent/MX2017005661A/es unknown
- 2015-10-29 EP EP15791768.3A patent/EP3212660B1/en active Active
- 2015-10-29 PT PT157917683T patent/PT3212660T/pt unknown
- 2015-10-29 BE BE2015/5701A patent/BE1023364B1/fr not_active IP Right Cessation
- 2015-10-29 DK DK15791768.3T patent/DK3212660T3/da active
- 2015-10-29 PL PL15791768T patent/PL3212660T3/pl unknown
- 2015-10-29 WO PCT/IB2015/058349 patent/WO2016067239A1/en active Application Filing
-
2016
- 2016-11-24 BE BE2016/5877A patent/BE1023841B1/fr not_active IP Right Cessation
- 2016-11-24 BE BE2016/5876A patent/BE1023840B1/fr not_active IP Right Cessation
-
2020
- 2020-06-10 HR HRP20200932TT patent/HRP20200932T1/hr unknown
- 2020-06-16 CY CY20201100546T patent/CY1123405T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
BE1023841B1 (fr) | 2017-08-10 |
BR112017008827A2 (pt) | 2018-03-27 |
HRP20200932T1 (hr) | 2020-09-18 |
CN107075486B (zh) | 2021-06-22 |
EP3015475A1 (en) | 2016-05-04 |
BE1023364A1 (fr) | 2017-02-20 |
AR102464A1 (es) | 2017-03-01 |
PL3212660T3 (pl) | 2020-10-05 |
EP3212660A1 (en) | 2017-09-06 |
CA2964859C (en) | 2023-04-04 |
JP6688297B2 (ja) | 2020-04-28 |
US20170362278A1 (en) | 2017-12-21 |
ES2799735T3 (es) | 2020-12-21 |
WO2016067239A1 (en) | 2016-05-06 |
EP3212660B1 (en) | 2020-03-25 |
US10414802B2 (en) | 2019-09-17 |
DK3212660T3 (da) | 2020-06-15 |
LT3212660T (lt) | 2020-07-10 |
CN107075486A (zh) | 2017-08-18 |
CA2964859A1 (en) | 2016-05-06 |
JP2017534283A (ja) | 2017-11-24 |
SI3212660T1 (sl) | 2020-07-31 |
BE1023841A1 (fr) | 2017-08-09 |
BE1023364B1 (fr) | 2017-02-20 |
HUE049356T2 (hu) | 2020-09-28 |
PT3212660T (pt) | 2020-06-23 |
MX2017005661A (es) | 2017-06-26 |
BE1023840B1 (fr) | 2017-08-10 |
BE1023840A1 (fr) | 2017-08-09 |
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