CY1124634T1 - Μορια προσδεσης pd-1 και lag-3 και μεθοδοι χρησης αυτων - Google Patents

Μορια προσδεσης pd-1 και lag-3 και μεθοδοι χρησης αυτων

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Publication number
CY1124634T1
CY1124634T1 CY20211100853T CY211100853T CY1124634T1 CY 1124634 T1 CY1124634 T1 CY 1124634T1 CY 20211100853 T CY20211100853 T CY 20211100853T CY 211100853 T CY211100853 T CY 211100853T CY 1124634 T1 CY1124634 T1 CY 1124634T1
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Cyprus
Prior art keywords
mab
binding
antibodies
methods
binding molecules
Prior art date
Application number
CY20211100853T
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English (en)
Inventor
Kalpana SHAH
Douglas H. Smith
Ross La Motte-Mohs
Leslie S. Johnson
Paul A. Moore
Ezio Bonvini
Scott Koenig
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Macrogenics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Macrogenics, Inc. filed Critical Macrogenics, Inc.
Publication of CY1124634T1 publication Critical patent/CY1124634T1/el

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Abstract

Η παρούσα εφεύρεση απευθύνεται σε επιλεγμένα αντι-PD αντισώματα ικανά για πρόσδεση και σε PD-1 πιθήκου κυνομόλογου και σε ανθρώπινο PD-1: PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14, ή PD-1 mAb 15 και σε εξανθρωπισμένες και χιμαιρικές εκδόσεις τέτοιων αντισωμάτων. Η εφεύρεση επιπρόσθετα αναφέρεται σε μόρια πρόσδεσης PD-1 που περιλαμβάνουν θραύσματα πρόσδεσης τέτοιων αντι-PD-1 αντισωμάτων, ανοσοσυζεύγματα και σε διειδικά μόρια, συμπεριλαμβανομένων διασωμάτων, BiTEs, διειδικών αντισωμάτων κλπ., που περιλαμβάνουν (i) τέτοια θραύσματα πρόσδεσης PD-1, και (ii) μία επικράτεια ικανή για πρόσδεση επιτόπου μορίου που εμπλέκεται στην ρύθμιση ανοσολογικού σημείου ελέγχου που υπάρχει στην επιφάνεια ενός ανοσοκυττάρου. Η παρούσα εφεύρεση αναφέρεται επίσης σε μεθόδους χρήσης μορίων πρόσδεσης PD-1 για διέγερση ανοσοαποκρίσεων, καθώς και σε μεθόδους ανίχνευσης PD-1.
CY20211100853T 2015-07-30 2021-09-28 Μορια προσδεσης pd-1 και lag-3 και μεθοδοι χρησης αυτων CY1124634T1 (el)

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Application Number Priority Date Filing Date Title
US201562198867P 2015-07-30 2015-07-30
US201562239559P 2015-10-09 2015-10-09
US201562255140P 2015-11-13 2015-11-13
US201662322974P 2016-04-15 2016-04-15
PCT/US2016/044430 WO2017019846A1 (en) 2015-07-30 2016-07-28 Pd-1-binding molecules and methods use thereof
EP16831339.3A EP3328419B1 (en) 2015-07-30 2016-07-28 Pd-1-binding molecules and methods of use thereof

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CY1124634T1 true CY1124634T1 (el) 2022-07-22

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CY20211100956T CY1124723T1 (el) 2015-07-30 2021-11-05 Μορια προσδεσης pd-1 και μεθοδοι χρησης αυτων

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