MY188871A - Pd-1-binding molecules and methods of use thereof - Google Patents

Pd-1-binding molecules and methods of use thereof

Info

Publication number
MY188871A
MY188871A MYPI2018000111A MYPI2018000111A MY188871A MY 188871 A MY188871 A MY 188871A MY PI2018000111 A MYPI2018000111 A MY PI2018000111A MY PI2018000111 A MYPI2018000111 A MY PI2018000111A MY 188871 A MY188871 A MY 188871A
Authority
MY
Malaysia
Prior art keywords
mab
binding
antibodies
methods
molecules
Prior art date
Application number
MYPI2018000111A
Inventor
Motte-Mohs Ross La
Kalpana Shah
Smith Douglas H
Johnson Leslie S
Moore Paul A
Ezio Bonvini
Scott Koenig
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Priority claimed from PCT/US2016/044430 external-priority patent/WO2017019846A1/en
Publication of MY188871A publication Critical patent/MY188871A/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and to human PD-1 : PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14, or PD-1 mAb 15, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD-1 -binding molecules that comprise PD-1 binding fragments of such anti-PD-1 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such PD-1 -binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of using molecules that bind PD-1 for stimulating immune responses, as well as methods of detecting PD-1.
MYPI2018000111A 2015-07-30 2016-07-28 Pd-1-binding molecules and methods of use thereof MY188871A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562198867P 2015-07-30 2015-07-30
US201562239559P 2015-10-09 2015-10-09
US201562255140P 2015-11-13 2015-11-13
PCT/US2016/044430 WO2017019846A1 (en) 2015-07-30 2016-07-28 Pd-1-binding molecules and methods use thereof

Publications (1)

Publication Number Publication Date
MY188871A true MY188871A (en) 2022-01-11

Family

ID=87569341

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2018000111A MY188871A (en) 2015-07-30 2016-07-28 Pd-1-binding molecules and methods of use thereof

Country Status (1)

Country Link
MY (1) MY188871A (en)

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