MY188871A - Pd-1-binding molecules and methods of use thereof - Google Patents
Pd-1-binding molecules and methods of use thereofInfo
- Publication number
- MY188871A MY188871A MYPI2018000111A MYPI2018000111A MY188871A MY 188871 A MY188871 A MY 188871A MY PI2018000111 A MYPI2018000111 A MY PI2018000111A MY PI2018000111 A MYPI2018000111 A MY PI2018000111A MY 188871 A MY188871 A MY 188871A
- Authority
- MY
- Malaysia
- Prior art keywords
- mab
- binding
- antibodies
- methods
- molecules
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and to human PD-1 : PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14, or PD-1 mAb 15, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD-1 -binding molecules that comprise PD-1 binding fragments of such anti-PD-1 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such PD-1 -binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of using molecules that bind PD-1 for stimulating immune responses, as well as methods of detecting PD-1.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562198867P | 2015-07-30 | 2015-07-30 | |
US201562239559P | 2015-10-09 | 2015-10-09 | |
US201562255140P | 2015-11-13 | 2015-11-13 | |
PCT/US2016/044430 WO2017019846A1 (en) | 2015-07-30 | 2016-07-28 | Pd-1-binding molecules and methods use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MY188871A true MY188871A (en) | 2022-01-11 |
Family
ID=87569341
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI2018000111A MY188871A (en) | 2015-07-30 | 2016-07-28 | Pd-1-binding molecules and methods of use thereof |
Country Status (1)
Country | Link |
---|---|
MY (1) | MY188871A (en) |
-
2016
- 2016-07-28 MY MYPI2018000111A patent/MY188871A/en unknown
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