HRP20211645T1 - Molekule za vezanje pd-1 i postupci za njihovu uporabu - Google Patents
Molekule za vezanje pd-1 i postupci za njihovu uporabu Download PDFInfo
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- HRP20211645T1 HRP20211645T1 HRP20211645TT HRP20211645T HRP20211645T1 HR P20211645 T1 HRP20211645 T1 HR P20211645T1 HR P20211645T T HRP20211645T T HR P20211645TT HR P20211645 T HRP20211645 T HR P20211645T HR P20211645 T1 HRP20211645 T1 HR P20211645T1
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- cancer
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- human antibody
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- 238000000034 method Methods 0.000 title claims 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 13
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 11
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- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
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Classifications
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Claims (12)
1. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo , naznačeno time, da sadrži varijabilnu domenu teškog lanca i varijabilnu domenu lakog lanca gdje:
navedena varijabilna domena teškog lanca sadrži aminokiselinski slijed SEQ ID NO: 147, i navedena varijabilna domena lakog lanca sadrži aminokiselinski slijed SEQ ID NO: 153.
2. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, prema patentnom zahtjevu 1, naznačeno time, da navedeno protutijelo sadrži Fc regiju, i time da:
(a) navedena Fc regija je izotipa IgG1, IgG2, IgG3 ili IgG4;
(b) spomenuta molekula dodatno sadrži zglobnu domenu; ili
(c) navedena Fc regija jest IgG4 Fc domena i navedeno protutijelo dodatno sadrži zglobnu domenu IgG4 koja sadrži stabilizirajuću mutaciju.
3. Protuljudsko PD-1 protutijelo, prema patentnom zahtjevu 2, naznačeno time, da navedeno protutijelo sadrži: SEQ ID NO: 264 i 266.
4. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, prema patentnom zahtjevu 2, naznačeno time, da navedena Fc regija jest varijanta Fc regije koja sadrži:
(a) jednu ili više aminokiselinskih modifikacija koje smanjuju afinitet varijante Fc regije za FcγR; i/ili
(b) jednu ili više aminokiselinskih modifikacija koje produljuju poluživot varijante Fc regije u serumu.
5. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, prema patentnom zahtjevu 4, naznačeno time, da:
(A) navedene modifikacije koje smanjuju afinitet varijante Fc regije za FcγR, sadrže supstituciju L234A; L235A; ili L234A i L235A, pri čemu je spomenuto numeriranje EU indeksa po Kabatu; i
(B) navedene modifikacije koje povećavaju poluživot varijante Fc regije u serumu, sadrže supstituciju M252Y; M252Y i S254T; M252Y i T256E; M252Y, S254T i T256E; ili K288D i H435K, pri čemu je spomenuto numeriranje EU indeksa po Kabatu.
6. Pripravak, naznačen time, da sadrži PD-1 vezujuće protuljudsko protutijelo, prema bilo kojem od patentnih zahtjeva 1 do 5 i farmaceutski prihvatljiv nosač.
7. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, prema bilo kojem od patentnih zahtjeva 1 do 5, ili pripravak prema patentnom zahtjevu 6, naznačeni time, da su za uporabu u postupku stimulacije imunosnog odgovora posredovanog T stanicom kod pojedinca koji ima rak ili infekciju.
8. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, prema bilo kojem od patentnih zahtjeva 1 do 5, ili pripravak prema patentnom zahtjevu 6, naznačeni time, da su za uporabu u liječenju bolesti ili stanja povezanog s oslabljenim imunosnim sustavom, pri čemu se kod bolesti ili stanja radi o raku ili infekciji.
9. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, prema bilo kojem od patentnih zahtjeva 1 do 5, ili pripravak prema patentnom zahtjevu 6, naznačeni time, da su za uporabu u liječenju raka ili infekcije.
10. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, ili pripravak za uporabu prema bilo kojem od patentnih zahtjeva 7 do 9, naznačeni time, da se navedeni rak bira iz skupine koju čine: tumor nadbubrežne žlijezde, rak povezan s AIDS-om, sarkom mekog dijela alveole, astrocitni tumor, rak mokraćnog mjehura, rak kostiju, rak mozga i kičmenog stuba, metastatski tumor na mozgu, rak dojke, tumori karotidnog tijela, rak grlića maternice, hondrosarkom, hordom, kromofobni karcinom bubrežnih stanica, karcinom svijetlih stanica, rak debelog crijeva, kolorektalni rak, benigni kožni fibrozni histiocitom, dezmoplastični tumor malih okruglih stanica, ependimom, Ewingov tumor, izvankoštani miksoidni hondrosarkom, fibrogenesis imperfecta ossium, fibrozna displazija kosti, rak žučnog mjehura ili žučnih vodova, rak želuca, gestacijska trofoblastična bolest, tumor zametne stanice, rak glave i vrata, hepatocelularni karcinom, tumor stanica otočića, Kaposijev sarkom, rak bubrega, leukemija, lipomski/benigni lipomatozni tumor, liposarkom/maligni lipomatozni tumor, rak jetre, limfom, rak pluća, meduloblastom, melanom, meningiom, multipla endokrina neoplazija, multipli mijelom, mijelodisplastični sindrom, neuroblastom, neuroendokrini tumori, rak jajnika, rak gušterače, papilarni tiroidni karcinom, paratiroidni tumor, pedijatrijski rak, tumor ovojnice perifernih živaca, feokromocitom, tumor hipofize, rak prostate, posteriorni melanom srednje očne ovojnice, rijetki hematološki poremećaj, bubrežni metastatski rak, rabdoidni tumor, rabdomiosarkom, sarkom, rak kože, sarkom mekog tkiva, rak rožnatih stanica, rak abdomena, sinovijalni sarkom, rak testisa, timusni karcinom, timom, tiroidni metastatski rak, i rak tijela maternice.
11. Monospecifično monoklonsko PD-1 vezujuće protuljudsko protutijelo, ili pripravak za uporabu prema bilo kojem od patentnih zahtjeva 7 do 9, naznačeni time, da navedeni rak je kolorektalni rak, hepatocelularni karcinom, gliom, rak bubrega, rak dojke, multipli mijelom, rak mokraćnog mjehura, neuroblastom; sarkom, ne-Hodgkinov limfom, rak ne-malih stanica pluća, rak jajnika, rak gušterače, rak rektuma, akutna mijeloična leukemija (AML), kronična mijeloična leukemija (CML), akutna B limfoblastična leukemija (B-ALL), kronična limfocitna leukemija (CLL), leukemija kosmatih stanica (HCL), neoplazma blastičnih plazmacitoidnih dendritičkih stanica (BPDCN), ne-Hodgkinovi limfomi (NHL), uključujući leukemiju plaštenih stanica (MCL), i limfom malih limfocita (SLL), Hodgkinov limfom, sustavnu mastocitozu, ili Burkittov limfom.
12. Uporaba monospecifičnog monoklonskog PD-1 vezujućeg protuljudskog protutijela, prema bilo kojem od patentnih zahtjeva 1 do 5, ili pripravka prema patentnom zahtjevu 6, naznačena time, da je za in vitro detekciju PD-1, pri čemu se navedeno protutijelo označava tako da se može pronaći.
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EP16831339.3A EP3328419B1 (en) | 2015-07-30 | 2016-07-28 | Pd-1-binding molecules and methods of use thereof |
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