EA201990285A1 - Гетеродимерные иммуноглобулиновые конструкции и способы их получения - Google Patents

Гетеродимерные иммуноглобулиновые конструкции и способы их получения

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Publication number
EA201990285A1
EA201990285A1 EA201990285A EA201990285A EA201990285A1 EA 201990285 A1 EA201990285 A1 EA 201990285A1 EA 201990285 A EA201990285 A EA 201990285A EA 201990285 A EA201990285 A EA 201990285A EA 201990285 A1 EA201990285 A1 EA 201990285A1
Authority
EA
Eurasian Patent Office
Prior art keywords
producing
methods
heterodimeric immunoglobulin
immunoglobulin structures
retain
Prior art date
Application number
EA201990285A
Other languages
English (en)
Inventor
Цзяван Лю
Нанмэн Сун
Дунгэ Ян
Япин Ян
Мэнсоп Ким
Original Assignee
Бейджин Ханми Фармасьютикал Ко., Лтд.
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Publication date
Application filed by Бейджин Ханми Фармасьютикал Ко., Лтд. filed Critical Бейджин Ханми Фармасьютикал Ко., Лтд.
Publication of EA201990285A1 publication Critical patent/EA201990285A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

Согласно настоящему изобретению предложен способ получения стабильных и высокоспецифичных гетеродимерных иммуноглобулиновых конструкций, например биспецифичных антител, сохраняющих желаемые свойства нативных IgG без нежелательного ошибочного спаривания тяжелых и легких цепей, которые могут одновременно связываться с двумя молекулами-мишенями и обладают более высокой эффективностью в лечении сложных заболеваний.
EA201990285A 2016-09-29 2017-09-28 Гетеродимерные иммуноглобулиновые конструкции и способы их получения EA201990285A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610863814 2016-09-29
PCT/CN2017/104044 WO2018059502A1 (en) 2016-09-29 2017-09-28 Heterodimeric immunoglobulin constructs and preparation methods thereof

Publications (1)

Publication Number Publication Date
EA201990285A1 true EA201990285A1 (ru) 2019-12-30

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Country Status (23)

Country Link
US (1) US11498977B2 (ru)
EP (1) EP3504234A4 (ru)
JP (1) JP7424727B2 (ru)
KR (1) KR102242990B1 (ru)
CN (1) CN109790215B (ru)
AU (1) AU2017336867B2 (ru)
BR (1) BR112019006074A2 (ru)
CA (1) CA3035681A1 (ru)
CL (1) CL2019000836A1 (ru)
CO (1) CO2019003133A2 (ru)
DO (1) DOP2019000079A (ru)
EA (1) EA201990285A1 (ru)
EC (1) ECSP19022190A (ru)
IL (1) IL265605B1 (ru)
MX (1) MX2019003563A (ru)
MY (1) MY194994A (ru)
PE (1) PE20190576A1 (ru)
PH (1) PH12019500655A1 (ru)
SA (1) SA519401441B1 (ru)
SG (2) SG11201901307VA (ru)
TN (1) TN2019000055A1 (ru)
WO (1) WO2018059502A1 (ru)
ZA (1) ZA201901708B (ru)

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JP2019535650A (ja) 2019-12-12
ZA201901708B (en) 2022-11-30
SG11201901307VA (en) 2019-03-28
CN109790215B (zh) 2023-06-30
ECSP19022190A (es) 2019-05-31
PE20190576A1 (es) 2019-04-22
CN109790215A (zh) 2019-05-21
IL265605A (en) 2019-05-30
US20190284299A1 (en) 2019-09-19
CL2019000836A1 (es) 2019-08-02
DOP2019000079A (es) 2019-11-15
KR102242990B1 (ko) 2021-04-22
EP3504234A4 (en) 2020-12-02
AU2017336867B2 (en) 2024-03-14
MX2019003563A (es) 2019-08-12
TN2019000055A1 (en) 2020-07-15
KR20190055813A (ko) 2019-05-23
JP7424727B2 (ja) 2024-01-30
SG10201913263SA (en) 2020-03-30
EP3504234A1 (en) 2019-07-03
CA3035681A1 (en) 2018-04-05
CO2019003133A2 (es) 2019-04-12
WO2018059502A1 (en) 2018-04-05
US11498977B2 (en) 2022-11-15
IL265605B1 (en) 2024-02-01
AU2017336867A1 (en) 2019-02-28
MY194994A (en) 2022-12-30
SA519401441B1 (ar) 2022-12-27
BR112019006074A2 (pt) 2019-06-18
PH12019500655A1 (en) 2019-08-05

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