MX2022004501A - Clasificacion de microambientes tumorales. - Google Patents

Clasificacion de microambientes tumorales.

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Publication number
MX2022004501A
MX2022004501A MX2022004501A MX2022004501A MX2022004501A MX 2022004501 A MX2022004501 A MX 2022004501A MX 2022004501 A MX2022004501 A MX 2022004501A MX 2022004501 A MX2022004501 A MX 2022004501A MX 2022004501 A MX2022004501 A MX 2022004501A
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MX
Mexico
Prior art keywords
population
tme
cancer
subject
classifiers
Prior art date
Application number
MX2022004501A
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English (en)
Inventor
Laura E Benjamin
Kristen Strand-Tibbitts
Bronislaw Pytowsky
Matjaz Zganec
Luka Ausec
Rafael Rosengarten
Miha Stajdohar
Original Assignee
Oncxerna Therapeutics Inc
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Publication date
Application filed by Oncxerna Therapeutics Inc filed Critical Oncxerna Therapeutics Inc
Publication of MX2022004501A publication Critical patent/MX2022004501A/es

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Abstract

La descripción proporciona clasificadores basados en la población y no basados en la población para categorizar pacientes y cánceres. Los clasificadores basados en la población descritos integran firmas, es decir, puntuaciones globales relacionadas con la expresión de genes en paneles de genes particulares. Los clasificadores no basados en la población se generan utilizando técnicas de aprendizaje automático (por ejemplo, regresión, bosques aleatorios o ANN). Cada tipo de clasificador estratifica a los pacientes y los cánceres según los microambientes tumorales (TME) como positivos a biomarcador o negativos a biomarcador, y las decisiones de tratamiento se guían por la presencia/ausencia de un TME particular. También se proporcionan métodos para tratar a un sujeto, por ejemplo, un sujeto humano, afectado por cáncer que comprende administrar una terapia particular dependiendo de la clasificación del TME del cáncer según los clasificadores divulgados. También se proporcionan tratamientos personalizados que pueden ser administrados a un sujeto que tiene cáncer clasificado en un TME particular, y a paneles de genes que se pueden usar para identificar a un sujeto humano afectado por un cáncer adecuado para tratamiento con un agente terapéutico particular.
MX2022004501A 2019-11-07 2020-11-04 Clasificacion de microambientes tumorales. MX2022004501A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962932307P 2019-11-07 2019-11-07
US202063008367P 2020-04-10 2020-04-10
US202063060471P 2020-08-03 2020-08-03
US202063070131P 2020-08-25 2020-08-25
PCT/US2020/058956 WO2021092071A1 (en) 2019-11-07 2020-11-04 Classification of tumor microenvironments

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MX2022004501A true MX2022004501A (es) 2022-05-06

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MX2022004501A MX2022004501A (es) 2019-11-07 2020-11-04 Clasificacion de microambientes tumorales.

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US (1) US20210174908A1 (es)
EP (1) EP4055609A1 (es)
JP (1) JP2023500054A (es)
KR (1) KR20220094193A (es)
CN (1) CN114556480A (es)
AU (1) AU2020378280A1 (es)
CA (1) CA3151629A1 (es)
IL (1) IL291748A (es)
MX (1) MX2022004501A (es)
TW (1) TW202132573A (es)
WO (1) WO2021092071A1 (es)

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WO2022266434A1 (en) * 2021-06-18 2022-12-22 Memorial Sloan-Kettering Cancer Center Methods for predicting immune checkpoint blockade efficacy across multiple cancer types
CN113838532B (zh) * 2021-07-26 2022-11-18 南通大学 基于双重自适应邻域半径的多粒度乳腺癌基因分类方法
CN113764032B (zh) * 2021-10-21 2022-02-25 北京安智因生物技术有限公司 一种荧光定量pcr平台基因智能识别和报告自动化系统
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