HRP20201259T1 - Protutijela protiv ox40 i njihova upotreba - Google Patents
Protutijela protiv ox40 i njihova upotreba Download PDFInfo
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- HRP20201259T1 HRP20201259T1 HRP20201259TT HRP20201259T HRP20201259T1 HR P20201259 T1 HRP20201259 T1 HR P20201259T1 HR P20201259T T HRP20201259T T HR P20201259TT HR P20201259 T HRP20201259 T HR P20201259T HR P20201259 T1 HRP20201259 T1 HR P20201259T1
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- Prior art keywords
- seq
- amino acid
- acid sequence
- antibody against
- cdr
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- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 10
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (13)
1. Protutijelo protiv OX40, naznačeno time što sadrži (i) VH lanac koji ima tri CDR-a; i (ii) VL lanac koji ima tri CDR-a, gdje:
VH CDR br. 1 ima aminokiselinski slijed GFTFSRYGMS (SEQ ID NO:101), VH CDR br. 2 ima aminokiselinski slijed TINSNGGRTYYPDSVKG (SEQ ID NO:102), VH CDR br. 3 ima aminokiselinski slijed EGITTAYAMDY (SEQ ID NO:103), VL CDR br. 1 ima aminokiselinski slijed KASQSVDYDGDSYMH (SEQ ID NO:104), VL CDR br. 2 ima aminokiselinski slijed AASILES (SEQ ID NO:105), a VL CDR br. 3 ima aminokiselinski slijed QQSNEDPRT (SEQ ID NO:106).
2. Protutijelo protiv OX40 u skladu s patentnim zahtjevom 1, naznačeno time što je monoklonsko.
3. Protutijelo protiv OX40 u skladu s patentnim zahtjevom 1, naznačeno time što je humanizirano.
4. Protutijelo protiv OX40 u skladu s patentnim zahtjevom 3, naznačeno time što sadrži VH lanac koji ima aminokiselinski slijed:
EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYGMSWVRQAPGKGLELVATINSNG
GRTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAREGITTAYAMDY
WGQGTTVTVSS (SEQ ID NO:22);
i VL lanac koji ima aminokiselinski slijed:
DIVMTQSPDSLAVSLGERATINCKASQSVDYDGDSYMHWYQQKPGQPPKLLIYAA
SILESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSNEDPRTFGGGTKVEIK
(SEQ ID NO:32).
5. Protutijelo protiv OX40 u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačeno time što je IgG.
6. Protutijelo protiv OX40 u skladu s patentnim zahtjevom 5, naznačeno time što je IgG1.
7. Protutijelo protiv OX40 u skladu s patentnim zahtjevom 4, naznačeno time što sadrži teški lanac koji ima aminokiselinski slijed prem SEQ ID NO: 41 ili 42; i laki lanac koji ima aminokiselinski slijed prem SEQ ID NO: 51.
8. Jedna ili više nukleinskih kiselina, naznačene time što imaju nukleotidne sljedove koji kodiraju protutijelo protiv OX40 u skladu s bilo kojim od patentnih zahtjeva 1 do 7.
9. Jedan ili više vektora, naznačeni time što sadrže jednu ili više nukleinskih kiselina u skladu s patentnim zahtjevom 8.
10. Eukariotska stanica domaćin, naznačena time što je transformirana jednim ili više vektora u skladu s patentnim zahtjevom 9.
11. Eukariotska stanica domaćin, naznačena time što je genetički modificirana za eksprimiranje jedne ili više nukleinskih kiselina u skladu s patentnim zahtjevom 8.
12. Eukariotska stanica domaćin u skladu s patentnim zahtjevom 10 ili 11, naznačena time što je sisavačka stanica domaćin.
13. Postupak proizvodnje protutijela protiv OX40, naznačen time što se sastoji u: (a) uzgoju stanice domaćina u skladu s patentnim zahtjevom 10 ili patentnim zahtjevom 11; i (b) prikupljanju protutijela protiv OX40.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662434761P | 2016-12-15 | 2016-12-15 | |
| EP17826089.9A EP3504242B1 (en) | 2016-12-15 | 2017-12-15 | Anti-ox40 antibodies and their uses |
| PCT/US2017/066680 WO2018112346A1 (en) | 2016-12-15 | 2017-12-15 | Anti-ox40 antibodies and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201259T1 true HRP20201259T1 (hr) | 2020-11-13 |
Family
ID=60937946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201259TT HRP20201259T1 (hr) | 2016-12-15 | 2020-08-11 | Protutijela protiv ox40 i njihova upotreba |
Country Status (36)
| Country | Link |
|---|---|
| US (7) | US10556962B2 (hr) |
| EP (2) | EP3725809A1 (hr) |
| JP (2) | JP6772385B2 (hr) |
| KR (2) | KR102341926B1 (hr) |
| CN (1) | CN110573527A (hr) |
| AR (1) | AR110526A1 (hr) |
| AU (1) | AU2017377036B2 (hr) |
| BR (2) | BR122020025629B1 (hr) |
| CA (1) | CA3045940A1 (hr) |
| CL (1) | CL2019001646A1 (hr) |
| CO (1) | CO2019007288A2 (hr) |
| CR (1) | CR20190330A (hr) |
| CY (1) | CY1123274T1 (hr) |
| DK (1) | DK3504242T3 (hr) |
| DO (1) | DOP2019000165A (hr) |
| EC (1) | ECSP19050049A (hr) |
| ES (1) | ES2813057T3 (hr) |
| HR (1) | HRP20201259T1 (hr) |
| HU (1) | HUE050399T2 (hr) |
| IL (1) | IL267070A (hr) |
| LT (1) | LT3504242T (hr) |
| MA (1) | MA53184A (hr) |
| MX (1) | MX2019007121A (hr) |
| MY (1) | MY198059A (hr) |
| PE (1) | PE20191403A1 (hr) |
| PH (1) | PH12019501357A1 (hr) |
| PL (1) | PL3504242T3 (hr) |
| PT (1) | PT3504242T (hr) |
| RS (1) | RS60664B1 (hr) |
| RU (1) | RU2753493C2 (hr) |
| SG (1) | SG10201914126RA (hr) |
| SI (1) | SI3504242T1 (hr) |
| TW (1) | TWI734879B (hr) |
| UA (1) | UA125041C2 (hr) |
| UY (1) | UY37523A (hr) |
| WO (1) | WO2018112346A1 (hr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS60664B1 (sr) * | 2016-12-15 | 2020-09-30 | Abbvie Biotherapeutics Inc | Anti-ox40 antitela i njihove upotrebe |
| EP3635011A1 (en) * | 2017-06-09 | 2020-04-15 | GlaxoSmithKline Intellectual Property Development Limited | Combination therapy with icos agonist and ox40 agonist to treat cancer |
| US11242398B2 (en) * | 2017-08-01 | 2022-02-08 | Remd Biotherapeutics, Inc. | Anti-OX40 antibodies and methods of activating OX40 |
| CN110790837A (zh) * | 2018-08-02 | 2020-02-14 | 上海君实生物医药科技股份有限公司 | 抗btla抗体 |
| WO2020119789A1 (en) * | 2018-12-14 | 2020-06-18 | Wuxi Biologics (Shanghai) Co., Ltd. | Fully human antibodies against ox40, method for preparing the same, and use thereof |
| US20220017632A1 (en) * | 2018-12-25 | 2022-01-20 | Hanx Biopharmaceutics, Inc | Anti-ox40 monoclonal antibody and application thereof |
| CN110172090B (zh) * | 2019-06-03 | 2020-04-03 | 中山标佳生物科技有限公司 | Cd134单克隆抗体及其制备方法和癌症治疗中的应用 |
| WO2021098851A1 (en) * | 2019-11-20 | 2021-05-27 | Eucure (Beijing) Biopharma Co., Ltd | Anti-ctla4/ox40 bispecific antibodies and uses thereof |
| MX2022007712A (es) | 2019-12-17 | 2022-09-26 | Amgen Inc | Agonista doble de interleucina-2/receptor de tnf para uso en terapia. |
| CN111303285B (zh) * | 2019-12-27 | 2023-06-02 | 百力司康生物医药(杭州)有限公司 | 靶向ox40的抗体及其制备方法和应用 |
| CN113045654A (zh) * | 2019-12-27 | 2021-06-29 | 南开大学 | 抗ox40抗体及其用途 |
| EP4130039A4 (en) * | 2020-03-23 | 2024-07-31 | Bio Thera Solutions Ltd | DEVELOPMENT AND APPLICATION OF AN IMMUNE CELL ACTIVATOR |
| US20230295324A1 (en) * | 2020-06-30 | 2023-09-21 | Harbour Biomed (Shanghai) Co., Ltd | Ox40-targeted antibody, and preparation method therefor and application thereof |
| CN111704671B (zh) * | 2020-08-19 | 2020-11-24 | 广东赛尔生物科技有限公司 | Ox40抗体及其在治疗癌症中的应用 |
| CN112442121A (zh) * | 2020-08-20 | 2021-03-05 | 山东兴瑞生物科技有限公司 | Ox40抗体、其编码基因、及抗体的制备方法和在增强人体免疫功能中的应用 |
| CN114106173A (zh) * | 2020-08-26 | 2022-03-01 | 上海泰槿生物技术有限公司 | 抗ox40抗体、其药物组合物及应用 |
| CN111763258B (zh) * | 2020-09-01 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | 抗ox40抗体及其用途 |
| WO2022117572A2 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | An ltbr agonist in combination therapy against cancer |
| CN115260312A (zh) * | 2021-04-30 | 2022-11-01 | 保诺科技（北京）有限公司 | 结合ox40的抗体或抗原结合片段 |
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| WO2007084559A2 (en) | 2006-01-13 | 2007-07-26 | Board Of Regents, The University Of Texas System | Methods to treat disease states by influencing the signaling of ox40-receptors and high throughput screening methods for identifying substances therefor |
| PT2242771E (pt) | 2007-12-14 | 2013-08-29 | Bristol Myers Squibb Co | Moléculas de ligação ao recetor humano ox40 |
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