BR112019008223A2 - anticorpos anti-ctla-4 ativáveis e usos dos mesmos - Google Patents

anticorpos anti-ctla-4 ativáveis e usos dos mesmos

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Publication number
BR112019008223A2
BR112019008223A2 BR112019008223A BR112019008223A BR112019008223A2 BR 112019008223 A2 BR112019008223 A2 BR 112019008223A2 BR 112019008223 A BR112019008223 A BR 112019008223A BR 112019008223 A BR112019008223 A BR 112019008223A BR 112019008223 A2 BR112019008223 A2 BR 112019008223A2
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BR
Brazil
Prior art keywords
antibodies
tumor
ctla
human anti
activatable
Prior art date
Application number
BR112019008223A
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English (en)
Inventor
Ann Tipton Kimberly
William West James
Deshpande Shrikant
J. Engelhardt John
Original Assignee
Bristol-Myers Squibb Company
Cytomx Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company, Cytomx Therapeutics, Inc. filed Critical Bristol-Myers Squibb Company
Publication of BR112019008223A2 publication Critical patent/BR112019008223A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Urology & Nephrology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • General Physics & Mathematics (AREA)

Abstract

são fornecidos nesta invenção anticorpos anti-ctla-4 humanos ativáveis compreendendo uma cadeia pesada que compreende um domínio vh e uma cadeia leve que compreende uma porção de mascaramento (mm), uma porção clivável (cm) e um domínio vl. tais anticorpos anti-ctla-4 humanos ativáveis possuem atividade de ligação ao ctla-4 no microambiente tumoral, em que a porção de mascaramento é removido através da clivagem proteolítica da porção clivável por proteases específicas do tumor, mas apresentam ligação grandemente reduzida ao ctla-4 fora do tumor. deste modo, os anticorpos anti-ctla-4 humanos ativáveis da presente invenção retêm a atividade antitumoral enquanto reduz os efeitos colaterais associados com a atividade anti-ctla-4 fora do tumor.
BR112019008223A 2016-11-03 2017-11-02 anticorpos anti-ctla-4 ativáveis e usos dos mesmos BR112019008223A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662417212P 2016-11-03 2016-11-03
PCT/US2017/059740 WO2018085555A1 (en) 2016-11-03 2017-11-02 Activatable anti-ctla-4 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BR112019008223A2 true BR112019008223A2 (pt) 2019-07-16

Family

ID=61132883

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019008223A BR112019008223A2 (pt) 2016-11-03 2017-11-02 anticorpos anti-ctla-4 ativáveis e usos dos mesmos

Country Status (19)

Country Link
US (2) US11117968B2 (pt)
EP (1) EP3535300A1 (pt)
JP (2) JP7039582B2 (pt)
KR (2) KR102584340B1 (pt)
CN (1) CN110072890B (pt)
AR (1) AR110678A1 (pt)
AU (1) AU2017355446A1 (pt)
BR (1) BR112019008223A2 (pt)
CA (1) CA3042679A1 (pt)
CL (1) CL2019001226A1 (pt)
CO (1) CO2019004469A2 (pt)
EA (1) EA201990875A1 (pt)
IL (1) IL265625A (pt)
MX (1) MX2019004775A (pt)
MY (1) MY200695A (pt)
PE (1) PE20191131A1 (pt)
SG (1) SG11201902857SA (pt)
TW (2) TW202334213A (pt)
WO (1) WO2018085555A1 (pt)

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CA3042679A1 (en) 2018-05-11
US20190359714A1 (en) 2019-11-28
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US20220089734A1 (en) 2022-03-24
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