EP1286700A2 - Tumor activated prodrug compounds - Google Patents
Tumor activated prodrug compoundsInfo
- Publication number
- EP1286700A2 EP1286700A2 EP01957808A EP01957808A EP1286700A2 EP 1286700 A2 EP1286700 A2 EP 1286700A2 EP 01957808 A EP01957808 A EP 01957808A EP 01957808 A EP01957808 A EP 01957808A EP 1286700 A2 EP1286700 A2 EP 1286700A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- prodrug
- prodrug according
- biologically active
- peptide
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2001/006106 WO2001091798A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
EP01957808A EP1286700A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20899600P | 2000-06-01 | 2000-06-01 | |
US208996P | 2000-06-01 | ||
EP00870130 | 2000-06-15 | ||
EP00870130 | 2000-06-15 | ||
EP00870306 | 2000-12-18 | ||
EP00870306 | 2000-12-18 | ||
PCT/EP2001/006106 WO2001091798A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
EP01957808A EP1286700A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1286700A2 true EP1286700A2 (en) | 2003-03-05 |
Family
ID=27440072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01957808A Ceased EP1286700A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1286700A2 (en) |
WO (1) | WO2001091798A2 (en) |
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US20040120891A1 (en) | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
BR0108930A (en) * | 2000-02-24 | 2002-12-10 | Genentech Inc | Method of delivering an active agent to a cell type of interest, pharmaceutical composition, caspase-activated prodrug, kit, method of treating mammals, using a caspase conjugate and using a pro-agent |
WO2002030460A2 (en) | 2000-10-09 | 2002-04-18 | Isis Innovation Ltd. | Therapeutic antibodies |
CA2436830A1 (en) * | 2000-11-06 | 2002-06-20 | Asilomar Pharmaceuticals, Inc. | Intracellular delivery of charged therapeutic moieties to nerve cells by means of targeting proteins |
EP1355675A1 (en) * | 2001-01-30 | 2003-10-29 | Universite Catholique De Louvain | Anti-tumor compounds |
KR100468316B1 (en) | 2002-01-29 | 2005-01-27 | 주식회사 웰진 | Peptides increasing the transfer efficiency of DNA into cell or tissue |
AU2003260452A1 (en) * | 2002-08-23 | 2004-03-11 | Gabriele Multhoff | Use of granzyme b as an hsp70/hsp70 peptide dependent inducer of apoptosis in tumor cells |
US20050043215A1 (en) * | 2003-02-19 | 2005-02-24 | Tamara Minko | Complex drug delivery composition and method for treating cancer |
FR2858936A1 (en) * | 2003-08-22 | 2005-02-25 | Diatos | New active compound precursor, useful as therapeutic or diagnostic agent or tracer, includes cleavable component that increases half-life in the circulation, attached through hydrophilic spacer |
EP1765403A4 (en) * | 2004-05-10 | 2011-03-30 | Univ Utah Res Found | Combined active and passive targeting of biologically active agents |
EP1674113A1 (en) * | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
US7214767B2 (en) * | 2005-05-25 | 2007-05-08 | Hiroshi Kanno | VHL peptide |
AU2006304804B2 (en) * | 2005-10-21 | 2011-06-02 | Vertex Pharmaceuticals Incorporated | Modified proteases that inhibit complement activation |
US20090220529A1 (en) * | 2006-03-10 | 2009-09-03 | Diatos, S.A. | Anticancer Drugs Conjugated to Antibody via an Enzyme Cleavable Linker |
CL2007002502A1 (en) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | VARIANTS OF THE SIMILAR GROWTH FACTOR TO HUMAN INSULIN-1 (IGF-1) PEGILATED IN LISIN; METHOD OF PRODUCTION; FUSION PROTEIN THAT UNDERSTANDS IT; AND ITS USE TO TREAT ALZHEIMER'S DISEASE. |
KR101106795B1 (en) | 2006-08-31 | 2012-01-18 | 에프. 호프만-라 로슈 아게 | Method for the production of insulin-like growth factor-i |
WO2009021754A2 (en) | 2007-08-15 | 2009-02-19 | Bayer Schering Pharma Aktiengesellschaft | Monospecific and multispecific antibodies and method of use |
US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
AU2013202755B2 (en) * | 2007-08-22 | 2016-05-12 | Cytomx Therapeutics, Inc. | Activatable binding polypeptides and methods of identification and use thereof |
AU2016213702C1 (en) * | 2007-08-22 | 2018-11-29 | Cytomx Therapeutics, Inc. | Activatable binding polypeptides and methods of identification and use thereof |
RU2636046C2 (en) * | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Modified antibodies composition, methods of production and application |
KR20100083632A (en) * | 2009-01-14 | 2010-07-22 | 울산대학교 산학협력단 | Anticancer prodrug sensitive to target protease |
BRPI1011384A2 (en) * | 2009-02-23 | 2016-03-15 | Cytomx Therapeutics Inc | proproteins and their methods of use |
WO2013163631A2 (en) | 2012-04-27 | 2013-10-31 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
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US9517276B2 (en) * | 2013-06-04 | 2016-12-13 | Cytomx Therapeutics, Inc. | Compositions and methods for conjugating activatable antibodies |
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PE20191131A1 (en) | 2016-11-03 | 2019-09-02 | Bristol Myers Squibb Co | ACTIVABLE CYTOTOXIC T LYMPHOCYTE 4 ANTI ANTIGEN (CTLA-4) ANTIBODIES AND THEIR USES |
KR20190089034A (en) | 2016-12-09 | 2019-07-29 | 시애틀 지네틱스, 인크. | Antibodies shielded by coiled coils |
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JP7438106B2 (en) | 2017-10-14 | 2024-02-26 | シートムエックス セラピューティクス,インコーポレイテッド | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
WO2020018700A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
MX2022012592A (en) | 2020-04-10 | 2022-12-07 | Cytomx Therapeutics Inc | Activatable cytokine constructs and related compositions and methods. |
CA3203072A1 (en) | 2020-12-22 | 2022-06-30 | Andrea CASAZZA | Compounds comprising a tetrapeptidic moiety |
WO2022167664A1 (en) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
CA3211924A1 (en) | 2021-03-16 | 2022-09-22 | Sayantan Mitra | Masked activatable cytokine constructs and related compositions and methods |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0769967B1 (en) * | 1994-08-19 | 2007-12-12 | La Region Wallonne | Conjugates comprising an antitumour agent and their use |
-
2001
- 2001-05-29 WO PCT/EP2001/006106 patent/WO2001091798A2/en active Application Filing
- 2001-05-29 EP EP01957808A patent/EP1286700A2/en not_active Ceased
Non-Patent Citations (1)
Title |
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See references of WO0191798A2 * |
Also Published As
Publication number | Publication date |
---|---|
WO2001091798A2 (en) | 2001-12-06 |
WO2001091798A3 (en) | 2002-12-05 |
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