EP1286700A2 - Krebs aktivierte prodrugverbindungen - Google Patents
Krebs aktivierte prodrugverbindungenInfo
- Publication number
- EP1286700A2 EP1286700A2 EP01957808A EP01957808A EP1286700A2 EP 1286700 A2 EP1286700 A2 EP 1286700A2 EP 01957808 A EP01957808 A EP 01957808A EP 01957808 A EP01957808 A EP 01957808A EP 1286700 A2 EP1286700 A2 EP 1286700A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- prodrug
- prodrug according
- biologically active
- peptide
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01957808A EP1286700A2 (de) | 2000-06-01 | 2001-05-29 | Krebs aktivierte prodrugverbindungen |
| PCT/EP2001/006106 WO2001091798A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20899600P | 2000-06-01 | 2000-06-01 | |
| US208996P | 2000-06-01 | ||
| EP00870130 | 2000-06-15 | ||
| EP00870130 | 2000-06-15 | ||
| EP00870306 | 2000-12-18 | ||
| EP00870306 | 2000-12-18 | ||
| EP01957808A EP1286700A2 (de) | 2000-06-01 | 2001-05-29 | Krebs aktivierte prodrugverbindungen |
| PCT/EP2001/006106 WO2001091798A2 (en) | 2000-06-01 | 2001-05-29 | Tumor activated prodrug compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1286700A2 true EP1286700A2 (de) | 2003-03-05 |
Family
ID=27440072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP01957808A Ceased EP1286700A2 (de) | 2000-06-01 | 2001-05-29 | Krebs aktivierte prodrugverbindungen |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP1286700A2 (de) |
| WO (1) | WO2001091798A2 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040120891A1 (en) | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
| US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
| EP1257296A2 (de) * | 2000-02-24 | 2002-11-20 | Genentech, Inc. | Caspase aktvierte prodrug-therapie |
| ATE513563T1 (de) | 2000-10-09 | 2011-07-15 | Isis Innovation | Therapeutische und toleranz-induzierende antikörper |
| JP2005503994A (ja) * | 2000-11-06 | 2005-02-10 | アシロマー ファーマシューティカルズ インコーポレイテッド | 治療成分を神経細胞に細胞内送達するための化合物 |
| WO2002060488A1 (en) * | 2001-01-30 | 2002-08-08 | Universite Catholique De Louvain | Anti-tumor compounds |
| KR100468316B1 (ko) | 2002-01-29 | 2005-01-27 | 주식회사 웰진 | Ｄｎａ의 세포 또는 조직 내 전달 효율을 높이는 펩타이드 |
| PT1537204E (pt) * | 2002-08-23 | 2010-05-05 | Gabriele Multhoff | Granzima b como um indutor da apoptose em células tumorais dependente de hsp70/péptidos hsp70 |
| US20050043215A1 (en) * | 2003-02-19 | 2005-02-24 | Tamara Minko | Complex drug delivery composition and method for treating cancer |
| FR2858936A1 (fr) * | 2003-08-22 | 2005-02-25 | Diatos | Potentialisation de l'activation de prodrogues de haut poids moleculaire |
| EP1765403A4 (de) * | 2004-05-10 | 2011-03-30 | Univ Utah Res Found | Kombiniertes aktives und passives targeting von biologisch aktiven wirkstoffen |
| EP1674113A1 (de) * | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Konjugate von insulinähnlichem Wachstumfaktor-1 und Poly(Ethylenglykol) |
| US7214767B2 (en) * | 2005-05-25 | 2007-05-08 | Hiroshi Kanno | VHL peptide |
| KR101393946B1 (ko) * | 2005-10-21 | 2014-05-12 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 보체 활성화를 억제하는 변형된 프로테아제 |
| JP2009529522A (ja) * | 2006-03-10 | 2009-08-20 | ディアト | 酵素で切断可能なリンカーを介して抗体に複合された抗癌剤 |
| CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| AU2007291501B2 (en) | 2006-08-31 | 2012-07-12 | F. Hoffmann-La Roche Ag | Method for the production of insulin-like growth factor-I |
| CA2696263C (en) | 2007-08-15 | 2017-06-13 | Bing Liu | Monospecific and multispecific antibodies and method of use |
| CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| AU2016213702C1 (en) * | 2007-08-22 | 2018-11-29 | Cytomx Therapeutics, Inc. | Activatable binding polypeptides and methods of identification and use thereof |
| AU2013202755B2 (en) * | 2007-08-22 | 2016-05-12 | Cytomx Therapeutics, Inc. | Activatable binding polypeptides and methods of identification and use thereof |
| EP2385955B1 (de) * | 2009-01-12 | 2020-08-12 | CytomX Therapeutics, Inc. | Modifizierte antikörperzusammensetzungen, verfahren zu ihrer herstellung und verwendung |
| KR20100083632A (ko) * | 2009-01-14 | 2010-07-22 | 울산대학교 산학협력단 | 표적 단백질 분해효소 감응형 항암제 전구체 |
| AU2010215761B2 (en) | 2009-02-23 | 2017-04-06 | Cytomx Therapeutics, Inc | Proproteins and methods of use thereof |
| JP2015516813A (ja) | 2012-04-27 | 2015-06-18 | シトムクス セラピューティクス，インコーポレイティド | 上皮成長因子受容体を結合する活性化可能抗体及びその使用方法 |
| CN104661677A (zh) | 2012-06-22 | 2015-05-27 | 西托姆克斯治疗公司 | 抗Jagged 1/Jagged 2交叉反应抗体、可活化的抗Jagged抗体及其使用方法 |
| US9856314B2 (en) | 2012-06-22 | 2018-01-02 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and methods of using the same |
| US9487590B2 (en) | 2012-09-25 | 2016-11-08 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind interleukin-6 receptor and methods of use thereof |
| JP6605957B2 (ja) | 2013-01-04 | 2019-11-13 | シトムクス セラピューティクス，インコーポレイティド | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| KR20160018579A (ko) | 2013-06-04 | 2016-02-17 | 싸이톰스 테라퓨틱스, 인크. | 활성화가능 항체를 접합하기 위한 조성물 및 방법 |
| WO2015013671A1 (en) | 2013-07-25 | 2015-01-29 | Cytomx Therapeutics, Inc. | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
| AU2014320332B2 (en) * | 2013-09-12 | 2017-08-03 | Dsm Ip Assets B.V. | Ocular device |
| AU2014324884B2 (en) | 2013-09-25 | 2020-03-26 | Cytomx Therapeutics, Inc | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
| US9540440B2 (en) | 2013-10-30 | 2017-01-10 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| WO2015089283A1 (en) | 2013-12-11 | 2015-06-18 | Cytomx Therapeutics, Inc. | Antibodies that bind activatable antibodies and methods of use thereof |
| WO2015116933A2 (en) | 2014-01-31 | 2015-08-06 | Cytomx Therapeutics, Inc. | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
| BR112017001579A2 (pt) | 2014-07-25 | 2017-11-21 | Cytomx Therapeutics Inc | anticorpos anti-cd3, anticorpos anti-cd3 ativáveis, anticorpos anti-cd3 multiespecíficos, anticorpos anti-cd3 ativáveis multiespecíficos e métodos de uso dos mesmos |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| CA2978942A1 (en) | 2015-03-13 | 2016-09-22 | Cytomx Therapeutics, Inc. | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| WO2016179335A1 (en) | 2015-05-04 | 2016-11-10 | Cytomx Therapeutics, Inc. | Anti-itga3 antibodies, activatable anti-itga3 antibodies, and methods of use thereof |
| BR112017023862A2 (pt) | 2015-05-04 | 2018-07-17 | Cytomx Therapeutics Inc | anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes |
| EA201792414A1 (ru) | 2015-05-04 | 2018-06-29 | Сайтомкс Терапьютикс, Инк. | Антитела против cd166, активируемые антитела против cd166 и способы их применения |
| EP3322732A2 (de) | 2015-07-13 | 2018-05-23 | Cytomx Therapeutics Inc. | Anti-pd-1-antikörper, aktivierbare anti-pd1-antikörper und verfahren zur verwendung davon |
| BR112019008223A2 (pt) | 2016-11-03 | 2019-07-16 | Bristol-Myers Squibb Company | anticorpos anti-ctla-4 ativáveis e usos dos mesmos |
| AU2017371225A1 (en) | 2016-12-09 | 2019-05-16 | Seagen Inc. | Bivalent antibodies masked by coiled coils |
| WO2018222949A1 (en) | 2017-06-01 | 2018-12-06 | Cytomx Therapeutics, Inc. | Activatable anti-pdl1 antibodies, and methods of use thereof |
| US11472889B2 (en) | 2017-10-14 | 2022-10-18 | Cytomx Therapeutics, Inc. | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
| CA3105879A1 (en) | 2018-07-18 | 2020-01-23 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
| IL297225A (en) | 2020-04-10 | 2022-12-01 | Cytomx Therapeutics Inc | Activatable cytokine constructs and related compositions and methods |
| CA3203072A1 (en) | 2020-12-22 | 2022-06-30 | Andrea CASAZZA | Compounds comprising a tetrapeptidic moiety |
| WO2022167664A1 (en) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
| TW202304958A (zh) | 2021-03-16 | 2023-02-01 | 美商Ｃｙｔｏｍｘ生物製藥公司 | 經遮蔽之可活化之細胞介素構築體及相關之組成物及方法 |
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| SI0769967T1 (sl) * | 1994-08-19 | 2008-06-30 | Wallone Region | Konjugati vsebujoäśi protitumorna sredstva in njihova uporaba |
-
2001
- 2001-05-29 WO PCT/EP2001/006106 patent/WO2001091798A2/en active Application Filing
- 2001-05-29 EP EP01957808A patent/EP1286700A2/de not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| See references of WO0191798A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001091798A3 (en) | 2002-12-05 |
| WO2001091798A2 (en) | 2001-12-06 |
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