CY1121538T1 - Μονοκλωνικα αντισωματα εναντι του αναστολεα του μονοπατιου ιστικου παραγοντα (tfpi) - Google Patents
Μονοκλωνικα αντισωματα εναντι του αναστολεα του μονοπατιου ιστικου παραγοντα (tfpi)Info
- Publication number
- CY1121538T1 CY1121538T1 CY20191100343T CY191100343T CY1121538T1 CY 1121538 T1 CY1121538 T1 CY 1121538T1 CY 20191100343 T CY20191100343 T CY 20191100343T CY 191100343 T CY191100343 T CY 191100343T CY 1121538 T1 CY1121538 T1 CY 1121538T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tfpi
- antibodies against
- tissue factor
- against tissue
- factor inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Παρέχονται απομονωμένα μονοκλωνικά αντισώματα που δεσμεύονται σε συγκεκριμένους επίτοπους του ανθρώπινου αναστολέα του μονοπατιού ιστικού παράγοντα {tissue factor pathway inhibitor, TFPI) καθώς και τα απομονωμένα μόρια νουκλεϊνικού οξέος που κωδικοποιούν τα ως άνω αντισώματα. Παρέχονται επίσης φαρμακευτικές συνθέσεις που περιέχουν τα μονοκλωνικά αντισώματα αντι-TFPI και μέθοδοι για τη θεραπευτική αντιμετώπιση ελλειμμάτων ή ελαττωμάτων στην πήξη με χορήγηση των αντισωμάτων.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161471101P | 2011-04-01 | 2011-04-01 | |
| PCT/US2012/031538 WO2012135671A2 (en) | 2011-04-01 | 2012-03-30 | Monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121538T1 true CY1121538T1 (el) | 2020-05-29 |
Family
ID=46932389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100343T CY1121538T1 (el) | 2011-04-01 | 2019-03-22 | Μονοκλωνικα αντισωματα εναντι του αναστολεα του μονοπατιου ιστικου παραγοντα (tfpi) |
Country Status (37)
| Country | Link |
|---|---|
| US (5) | US20140294832A1 (el) |
| EP (1) | EP2694544B1 (el) |
| JP (4) | JP6170903B2 (el) |
| KR (2) | KR20190079698A (el) |
| CN (2) | CN103797030B (el) |
| AU (3) | AU2012236296A1 (el) |
| BR (1) | BR112013025376A2 (el) |
| CA (2) | CA3068997A1 (el) |
| CL (1) | CL2013002811A1 (el) |
| CO (1) | CO6890074A2 (el) |
| CR (1) | CR20130499A (el) |
| CU (1) | CU20130128A7 (el) |
| CY (1) | CY1121538T1 (el) |
| DK (1) | DK2694544T3 (el) |
| DO (1) | DOP2013000218A (el) |
| EA (2) | EA201991704A3 (el) |
| EC (1) | ECSP13012913A (el) |
| ES (1) | ES2722824T3 (el) |
| GT (1) | GT201300229A (el) |
| HK (1) | HK1243426A1 (el) |
| HR (1) | HRP20190467T1 (el) |
| HU (1) | HUE042706T2 (el) |
| IL (4) | IL228633B (el) |
| LT (1) | LT2694544T (el) |
| MX (1) | MX2013011218A (el) |
| MY (2) | MY190951A (el) |
| PE (1) | PE20141149A1 (el) |
| PH (4) | PH12013502039B1 (el) |
| PL (1) | PL2694544T3 (el) |
| PT (1) | PT2694544T (el) |
| RS (1) | RS58633B1 (el) |
| SG (2) | SG193594A1 (el) |
| SI (1) | SI2694544T1 (el) |
| TR (1) | TR201905101T4 (el) |
| UA (1) | UA113623C2 (el) |
| WO (1) | WO2012135671A2 (el) |
| ZA (1) | ZA201308169B (el) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR122021014783B1 (pt) | 2008-12-19 | 2023-03-14 | Baxalta GmbH | Peptídeo que se liga a tfpi, uso do peptídeo, composição farmacêutica e método para purificação de tfpi |
| WO2010072691A1 (en) | 2008-12-22 | 2010-07-01 | Novo Nordisk A/S | Antibodies against tissue factor pathway inhibitor |
| CN102939098B (zh) | 2010-03-01 | 2016-08-03 | 拜耳医药保健有限公司 | 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体 |
| AU2011227714B2 (en) | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| WO2012135671A2 (en) * | 2011-04-01 | 2012-10-04 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| KR102263685B1 (ko) | 2012-03-21 | 2021-06-11 | 다케다 야쿠힌 고교 가부시키가이샤 | Tfpi 저해제 및 사용 방법 |
| CN107266574A (zh) * | 2012-03-30 | 2017-10-20 | 拜尔健康护理有限责任公司 | 蛋白酶调节的抗体 |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| JP6454678B2 (ja) | 2013-03-15 | 2019-01-16 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | ｐＨ範囲で結合性が異なる薬物動態改善のための抗ＴＦＰＩ抗体変異体 |
| US9896513B2 (en) | 2013-03-15 | 2018-02-20 | Novo Nordisk A/S | Antibodies capable of specifically binding two epitopes on tissue factor pathway inhibitor |
| CN105473619B (zh) * | 2013-07-19 | 2020-12-15 | 诺和诺德股份有限公司 | 能够引起促凝血活性的识别组织因子途径抑制剂的n-末端部分的抗体 |
| WO2016042093A1 (en) * | 2014-09-17 | 2016-03-24 | Novo Nordisk A/S | Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161) |
| CN112225812A (zh) * | 2015-02-25 | 2021-01-15 | 财团法人牧岩生命科学研究所 | 结合tfpi的新型抗体以及包含所述抗体的组合物 |
| CN114163531A (zh) * | 2015-08-19 | 2022-03-11 | 辉瑞公司 | 组织因子途径抑制剂抗体及其用途 |
| CN112424593A (zh) * | 2018-07-25 | 2021-02-26 | 索尼公司 | 凝血系统分析装置 |
| CN112442127A (zh) * | 2019-08-29 | 2021-03-05 | 苏州康宁杰瑞生物科技有限公司 | 针对tfpi的单克隆抗体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06153985A (ja) * | 1992-11-16 | 1994-06-03 | Teijin Ltd | モノクローナル抗体 |
| UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
| WO2010072691A1 (en) * | 2008-12-22 | 2010-07-01 | Novo Nordisk A/S | Antibodies against tissue factor pathway inhibitor |
| CN102939098B (zh) * | 2010-03-01 | 2016-08-03 | 拜耳医药保健有限公司 | 针对组织因子途径抑制剂(tfpi)的优化的单克隆抗体 |
| WO2012135671A2 (en) * | 2011-04-01 | 2012-10-04 | Bayer Healthcare Llc | Monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
| US9592297B2 (en) * | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| US8613919B1 (en) * | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
-
2012
- 2012-03-30 WO PCT/US2012/031538 patent/WO2012135671A2/en active Application Filing
- 2012-03-30 MY MYPI2017001205A patent/MY190951A/en unknown
- 2012-03-30 PE PE2013002137A patent/PE20141149A1/es active IP Right Grant
- 2012-03-30 AU AU2012236296A patent/AU2012236296A1/en not_active Abandoned
- 2012-03-30 MX MX2013011218A patent/MX2013011218A/es unknown
- 2012-03-30 KR KR1020197018445A patent/KR20190079698A/ko not_active Application Discontinuation
- 2012-03-30 PT PT12762959T patent/PT2694544T/pt unknown
- 2012-03-30 BR BR112013025376A patent/BR112013025376A2/pt active Search and Examination
- 2012-03-30 KR KR1020137028821A patent/KR101995302B1/ko active IP Right Grant
- 2012-03-30 CN CN201280026938.XA patent/CN103797030B/zh not_active Expired - Fee Related
- 2012-03-30 DK DK12762959.0T patent/DK2694544T3/en active
- 2012-03-30 JP JP2014502846A patent/JP6170903B2/ja not_active Expired - Fee Related
- 2012-03-30 RS RS20190338A patent/RS58633B1/sr unknown
- 2012-03-30 TR TR2019/05101T patent/TR201905101T4/tr unknown
- 2012-03-30 PL PL12762959T patent/PL2694544T3/pl unknown
- 2012-03-30 US US14/009,334 patent/US20140294832A1/en not_active Abandoned
- 2012-03-30 SG SG2013071477A patent/SG193594A1/en unknown
- 2012-03-30 LT LTEP12762959.0T patent/LT2694544T/lt unknown
- 2012-03-30 CN CN201710275470.2A patent/CN107090046A/zh active Pending
- 2012-03-30 ES ES12762959T patent/ES2722824T3/es active Active
- 2012-03-30 MY MYPI2013701814A patent/MY165499A/en unknown
- 2012-03-30 SG SG10201602606UA patent/SG10201602606UA/en unknown
- 2012-03-30 SI SI201231558T patent/SI2694544T1/sl unknown
- 2012-03-30 EA EA201991704A patent/EA201991704A3/ru unknown
- 2012-03-30 EP EP12762959.0A patent/EP2694544B1/en active Active
- 2012-03-30 HU HUE12762959A patent/HUE042706T2/hu unknown
- 2012-03-30 UA UAA201312686A patent/UA113623C2/uk unknown
- 2012-03-30 EA EA201301107A patent/EA034214B1/ru not_active IP Right Cessation
- 2012-03-30 CA CA3068997A patent/CA3068997A1/en not_active Abandoned
- 2012-03-30 CA CA2831907A patent/CA2831907C/en not_active Expired - Fee Related
-
2013
- 2013-09-27 GT GT201300229A patent/GT201300229A/es unknown
- 2013-09-30 CU CU2013000128A patent/CU20130128A7/es unknown
- 2013-09-30 PH PH12013502039A patent/PH12013502039B1/en unknown
- 2013-09-30 CR CR20130499A patent/CR20130499A/es unknown
- 2013-09-30 CL CL2013002811A patent/CL2013002811A1/es unknown
- 2013-09-30 DO DO2013000218A patent/DOP2013000218A/es unknown
- 2013-09-30 IL IL228633A patent/IL228633B/en active IP Right Grant
- 2013-10-01 EC ECSP13012913 patent/ECSP13012913A/es unknown
- 2013-10-01 CO CO13233113A patent/CO6890074A2/es unknown
- 2013-10-31 ZA ZA2013/08169A patent/ZA201308169B/en unknown
-
2016
- 2016-07-27 US US15/221,104 patent/US20170107298A1/en not_active Abandoned
-
2017
- 2017-02-17 JP JP2017027825A patent/JP6363747B2/ja not_active Expired - Fee Related
- 2017-05-10 AU AU2017203105A patent/AU2017203105A1/en not_active Abandoned
-
2018
- 2018-01-22 US US15/877,349 patent/US20180194857A1/en not_active Abandoned
- 2018-01-25 IL IL257145A patent/IL257145A/en unknown
- 2018-02-22 HK HK18102557.1A patent/HK1243426A1/zh unknown
- 2018-06-28 JP JP2018122610A patent/JP2018172411A/ja active Pending
- 2018-12-27 US US16/234,239 patent/US20190194353A1/en not_active Abandoned
-
2019
- 2019-02-28 PH PH12019500439A patent/PH12019500439A1/en unknown
- 2019-02-28 PH PH12019500441A patent/PH12019500441A1/en unknown
- 2019-02-28 PH PH12019500440A patent/PH12019500440A1/en unknown
- 2019-03-08 HR HRP20190467TT patent/HRP20190467T1/hr unknown
- 2019-03-15 AU AU2019201814A patent/AU2019201814A1/en not_active Abandoned
- 2019-03-22 CY CY20191100343T patent/CY1121538T1/el unknown
-
2020
- 2020-05-14 IL IL274686A patent/IL274686B/en unknown
- 2020-10-20 JP JP2020176145A patent/JP2021019619A/ja not_active Withdrawn
-
2021
- 2021-03-24 US US17/211,631 patent/US20220041752A1/en not_active Abandoned
- 2021-06-09 IL IL283829A patent/IL283829A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1121538T1 (el) | Μονοκλωνικα αντισωματα εναντι του αναστολεα του μονοπατιου ιστικου παραγοντα (tfpi) | |
| CY1120670T1 (el) | Μονοκλωνικα αντισωματα εναντι του αναστολεα μονοπατιου ιστικου παραγοντα (tfpi) | |
| CY1119410T1 (el) | Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi) | |
| CY1122490T1 (el) | Αντισωματα κατα του ανθρωπινου cd38 | |
| CY1123435T1 (el) | Anti-pd-l1 αντισωματα και χρησεις αυτων | |
| CY1121934T1 (el) | Αντισωματα anti-fcrn | |
| CY1122707T1 (el) | Ετεροκυκλικοι αναστολεις γλουταμινασης | |
| CY1121120T1 (el) | Αρυλ- ή ετεροαρυλ-υποκατεστημενες ενωσεις βενζολιου | |
| CY1123739T1 (el) | Αντισωματα anti-cd38 | |
| CY1122278T1 (el) | Αντι il-36r αντισωματα | |
| CY1120471T1 (el) | Αντισωματα κατα του cd70 | |
| CY1120866T1 (el) | Παρεμποδιστες dna-pk | |
| CY1124000T1 (el) | Υποκατεστημενες 5-φθορο-1η-πυραζολοπυριδινες σε κρυσταλλικη μορφη | |
| CY1119058T1 (el) | Ενωσεις ιμιδαζοπυρρολιδινονης | |
| CY1119445T1 (el) | Αντισωματα εναντι του ανθρωπινου gdf8 | |
| CY1118339T1 (el) | Διειδικα μορια προσδεσης που προσδενονται στον vegf και στην ang2 | |
| CY1121742T1 (el) | Αντισωματα s100a4 και θεραπευτικες χρησεις αυτων | |
| CY1121964T1 (el) | Αντισωματα εναντιον toy csf-1r | |
| EA201591166A1 (ru) | Ингибиторы аутотаксина | |
| EA201400412A1 (ru) | ЗАМЕЩЕННЫЕ БЕНЗИЛИНДАЗОЛЫ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Bub1 КИНАЗЫ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ | |
| EA201491644A1 (ru) | Фармацевтические композиции | |
| EA201492216A1 (ru) | Ингибиторы бромодомена и их применение | |
| UA118332C2 (uk) | Білок, що зв'язує антиген cd27l | |
| EA201401065A1 (ru) | Ang2-связывающие молекулы | |
| CY1116775T1 (el) | Παραγωγα πυριμιδονης ως αναστολεις της ιστικης τρανσγλουταμινασης |