EA200970262A1 - Композиции и способы, относящиеся к антителам к глюкагоновым рецепторам - Google Patents
Композиции и способы, относящиеся к антителам к глюкагоновым рецепторамInfo
- Publication number
- EA200970262A1 EA200970262A1 EA200970262A EA200970262A EA200970262A1 EA 200970262 A1 EA200970262 A1 EA 200970262A1 EA 200970262 A EA200970262 A EA 200970262A EA 200970262 A EA200970262 A EA 200970262A EA 200970262 A1 EA200970262 A1 EA 200970262A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- compositions
- methods
- methods relating
- glucagon receptors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
В настоящем изобретении предложены композиции и способы, относящиеся к антигенсвязывающим белкам, в частности антителам, специфично связывающимся с глюкагоновым рецептором человека. В изобретении также предложены нуклеиновые кислоты, кодирующие указанные антигенсвязывающие белки, а также антитела и способы получения и применения указанных антител, включая способы лечения и предотвращения диабета 2 типа и связанных с ним нарушений, путем введения указанных антител субъекту, нуждающемуся в таком лечении или предотвращении.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84620206P | 2006-09-20 | 2006-09-20 | |
US96897707P | 2007-08-30 | 2007-08-30 | |
PCT/US2007/020349 WO2008036341A2 (en) | 2006-09-20 | 2007-09-19 | Compositions and methods relating to glucagon receptor antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200970262A1 true EA200970262A1 (ru) | 2009-10-30 |
Family
ID=39201088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970262A EA200970262A1 (ru) | 2006-09-20 | 2007-09-19 | Композиции и способы, относящиеся к антителам к глюкагоновым рецепторам |
Country Status (19)
Country | Link |
---|---|
US (2) | US7947809B2 (ru) |
EP (1) | EP2074149B1 (ru) |
JP (1) | JP5513888B2 (ru) |
KR (1) | KR20090059161A (ru) |
CN (1) | CN101589062B (ru) |
AR (1) | AR062895A1 (ru) |
AU (1) | AU2007297652B2 (ru) |
BR (1) | BRPI0715017A8 (ru) |
CA (1) | CA2662613C (ru) |
CL (1) | CL2007002668A1 (ru) |
CR (1) | CR10736A (ru) |
EA (1) | EA200970262A1 (ru) |
ES (1) | ES2444012T3 (ru) |
IL (1) | IL197241A0 (ru) |
MX (2) | MX353319B (ru) |
NO (1) | NO20091534L (ru) |
PE (1) | PE20080846A1 (ru) |
TW (1) | TW200820985A (ru) |
WO (1) | WO2008036341A2 (ru) |
Families Citing this family (45)
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CL2009000586A1 (es) * | 2008-03-27 | 2010-06-04 | Lilly Co Eli | Fragmento fab o anticuerpo monoclonal humanizado que lo comprende que se une a receptor de glucagon humano/glucr, de rata, de raton, y mono cinomolgus; vector que comprende polinuccleotido codificante; celula huesped que lo comprende; composicion farmaceutica; uso para tratar diabetes tipo 1 o 2, o para la perdida de peso |
CN102482350B (zh) * | 2009-09-08 | 2015-08-05 | 株式会社新药 | 作用于胰高血糖素受体的抗体及其应用 |
JO3756B1 (ar) | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
US8771696B2 (en) | 2010-11-23 | 2014-07-08 | Regeneron Pharmaceuticals, Inc. | Method of reducing the severity of stress hyperglycemia with human antibodies to the glucagon receptor |
WO2013059531A1 (en) * | 2011-10-20 | 2013-04-25 | Genentech, Inc. | Anti-gcgr antibodies and uses thereof |
UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
JP6050671B2 (ja) * | 2012-12-07 | 2016-12-21 | ダイキン工業株式会社 | 空気調和装置の配管ユニットの製造方法および空気調和装置の施工方法 |
US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
SG11201508264UA (en) | 2013-05-07 | 2015-11-27 | Rinat Neuroscience Corp | Anti-glucagon receptor antibodies and methods of use thereof |
MX2016002870A (es) | 2013-09-05 | 2017-02-23 | Amgen Inc | Moleculas que contienen fc que presentan perfiles de glicoforma predecibles, consistentes y reproducibles. |
AU2015243246B2 (en) * | 2014-04-10 | 2018-09-06 | Obi Pharma Inc. | Antibodies, pharmaceutical compositions and uses thereof |
MX2016014761A (es) | 2014-05-16 | 2017-05-25 | Amgen Inc | Ensayo para detectar poblaciones celulares linfocitos t colaboradores 1 (th1) y linfocitos t colaboradores (th2). |
US10626179B2 (en) | 2014-06-08 | 2020-04-21 | Remd Biotherapeutics, Inc. | Methods for treating type 1 diabetes using glucagon receptor antagonistic antibodies |
GB201410826D0 (en) * | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
KR20230153495A (ko) * | 2014-10-01 | 2023-11-06 | 메디뮨 리미티드 | 티카그렐로에 대한 항체 및 이의 사용 방법 |
CN111018987B (zh) * | 2014-12-05 | 2023-11-21 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与人内皮素受体特异性结合的抗体及其应用 |
WO2016102657A1 (en) | 2014-12-23 | 2016-06-30 | Novo Nordisk A/S | Alpha-cell re-generation combined with conversion to beta cells |
CA2973964A1 (en) | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
CN107614695B (zh) | 2015-04-02 | 2022-01-25 | 瑞美德生物医药科技有限公司 | 用胰高血糖素受体拮抗性抗体治疗肥胖症和非酒精性脂肪肝病或非酒精性脂肪性肝炎的方法 |
CA2999747A1 (en) | 2015-09-04 | 2017-03-09 | Remd Biotherapeutics, Inc. | Methods for treating heart failure using glucagon receptor antagonistic antibodies |
WO2017062693A1 (en) * | 2015-10-07 | 2017-04-13 | Remd Biotherapeutics, Inc. | Methods for treating rare genetic disorders using glucagon receptor antagonistic antibodies |
KR101896882B1 (ko) | 2015-11-30 | 2018-09-11 | 앱클론(주) | Vegfr2에 특이적으로 결합하는 항체 |
US20190002577A1 (en) * | 2016-01-04 | 2019-01-03 | Remd Biotherapeutics, Inc. | Methods Of Treating Type 2 Diabetes Mellitus Using Glucagon Receptor Antagonistic Antibodies |
EP3493847A4 (en) * | 2016-08-03 | 2020-04-08 | REMD Biotherapeutics, Inc. | COMBINATION OF GLUCAGON RECEPTOR ANTAGONISTS AND PI3K PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER |
CN109922831A (zh) | 2016-08-30 | 2019-06-21 | 瑞泽恩制药公司 | 通过干扰胰高血糖素受体的信号传导治疗重度胰岛素抵抗的方法 |
EP3529278A1 (en) | 2016-10-20 | 2019-08-28 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
EP3573651A4 (en) * | 2017-01-27 | 2020-10-14 | NGM Biopharmaceuticals, Inc. | GLUCAGON RECEPTOR BINDING PROTEINS AND METHODS OF USE |
JP2020510646A (ja) * | 2017-02-20 | 2020-04-09 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Cd33、nkg2d及びcd16と結合するタンパク質 |
JP2020513813A (ja) | 2017-03-14 | 2020-05-21 | アムジエン・インコーポレーテツド | 細胞培養において産生される抗体の総非フコシル化グリコフォームの調節 |
CN107011414B (zh) * | 2017-05-31 | 2020-04-24 | 浙江省农业科学院 | 具有降血糖功能的三肽spf及其用途 |
US20210130480A1 (en) | 2017-08-22 | 2021-05-06 | Regeneron Pharmaceuticals, Inc. | Methods of treating urea cycle disorders by interfering with glucagon receptor signaling |
SG11202009216YA (en) | 2018-03-26 | 2020-10-29 | Amgen Inc | Total afucosylated glycoforms of antibodies produced in cell culture |
CN110357959B (zh) * | 2018-04-10 | 2023-02-28 | 鸿运华宁(杭州)生物医药有限公司 | Gcgr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
US10961315B2 (en) | 2018-07-27 | 2021-03-30 | Ngm Biopharmaceuticals, Inc. | Method of treating type I diabetes by administering a combination of a glucagon receptor antagonist and an anti-CD3 antibody |
JP2022516439A (ja) | 2018-12-21 | 2022-02-28 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | 二特異性タンパク質 |
US20220235140A1 (en) * | 2019-05-29 | 2022-07-28 | Hedgehog, Inc. | Antibody with enhanced binding affinity for endothelin receptor type a |
AU2020329217A1 (en) * | 2019-08-12 | 2022-07-28 | Aptevo Research And Development Llc | 4-1BB and OX40 binding proteins and related compositions and methods, antibodies against 4-1BB, antibodies against OX40 |
EP4034556A1 (en) | 2019-09-26 | 2022-08-03 | Amgen Inc. | Methods of producing antibody compositions |
US20230273126A1 (en) | 2020-06-04 | 2023-08-31 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
JP2023548767A (ja) | 2020-10-15 | 2023-11-21 | アムジエン・インコーポレーテツド | 抗体製造方法における相対不対グリカン |
AU2021411581A1 (en) * | 2020-12-31 | 2023-07-06 | Novarock Biotherapeutics, Ltd. | Antibodies to tnfr2 and uses thereof |
WO2022182664A1 (en) * | 2021-02-23 | 2022-09-01 | 10X Genomics, Inc. | A method for epitope binning of novel monoclonal antibodies |
AU2022289365A1 (en) | 2021-06-07 | 2023-12-14 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
AU2022361382A1 (en) | 2021-10-05 | 2024-03-28 | Amgen Inc. | Fc-gamma receptor ii binding and glycan content |
WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
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US5776725A (en) * | 1992-08-28 | 1998-07-07 | Zymogenetics, Inc. | Recombinant production of glucagon receptors |
US5639863A (en) * | 1994-06-21 | 1997-06-17 | Dan; Michael D. | Human monoclonal antibodies specific to cell cycle independent glioma surface antigen |
US5889167A (en) * | 1996-05-22 | 1999-03-30 | Merck & Co., Inc. | Synthetic glucagon binding proteins |
JP2001206899A (ja) * | 1999-11-18 | 2001-07-31 | Japan Tobacco Inc | TGF−βII型受容体に対するヒトモノクローナル抗体及びその医薬用途 |
WO2002045494A2 (en) | 2000-12-06 | 2002-06-13 | Deltagen, Inc. | Transgenic mice containing glucagon receptor gene disruptions |
US6864069B2 (en) | 2001-10-05 | 2005-03-08 | Bayer Pharmaceuticals Corporation | Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use |
MXPA05005921A (es) * | 2002-12-02 | 2005-10-19 | Abgenix Inc | Anticuerpos dirigidos a factor de necrosis tumoral y sus usos. |
WO2006005469A2 (en) * | 2004-07-15 | 2006-01-19 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with glucagon receptor (gcgr) |
NZ556029A (en) * | 2004-12-21 | 2010-04-30 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
EP1851245B1 (en) * | 2005-01-26 | 2012-10-10 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
-
2007
- 2007-09-14 CL CL200702668A patent/CL2007002668A1/es unknown
- 2007-09-19 EA EA200970262A patent/EA200970262A1/ru unknown
- 2007-09-19 ES ES07852417.0T patent/ES2444012T3/es active Active
- 2007-09-19 CN CN200780042973.XA patent/CN101589062B/zh active Active
- 2007-09-19 JP JP2009529233A patent/JP5513888B2/ja active Active
- 2007-09-19 CA CA2662613A patent/CA2662613C/en active Active
- 2007-09-19 TW TW096134772A patent/TW200820985A/zh unknown
- 2007-09-19 BR BRPI0715017A patent/BRPI0715017A8/pt not_active Application Discontinuation
- 2007-09-19 MX MX2013003092A patent/MX353319B/es unknown
- 2007-09-19 AR ARP070104134A patent/AR062895A1/es active IP Right Grant
- 2007-09-19 MX MX2009003093A patent/MX2009003093A/es active IP Right Grant
- 2007-09-19 WO PCT/US2007/020349 patent/WO2008036341A2/en active Application Filing
- 2007-09-19 AU AU2007297652A patent/AU2007297652B2/en active Active
- 2007-09-19 KR KR1020097007922A patent/KR20090059161A/ko not_active Application Discontinuation
- 2007-09-19 EP EP07852417.0A patent/EP2074149B1/en active Active
- 2007-09-20 US US11/903,481 patent/US7947809B2/en active Active
- 2007-09-20 PE PE2007001275A patent/PE20080846A1/es not_active Application Discontinuation
-
2009
- 2009-02-25 IL IL197241A patent/IL197241A0/en unknown
- 2009-04-17 CR CR10736A patent/CR10736A/es not_active Application Discontinuation
- 2009-04-17 NO NO20091534A patent/NO20091534L/no not_active Application Discontinuation
-
2011
- 2011-05-23 US US13/113,996 patent/US8158759B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2010504331A (ja) | 2010-02-12 |
JP5513888B2 (ja) | 2014-06-04 |
EP2074149B1 (en) | 2013-11-06 |
KR20090059161A (ko) | 2009-06-10 |
EP2074149A2 (en) | 2009-07-01 |
US20110223160A1 (en) | 2011-09-15 |
CA2662613A1 (en) | 2008-03-27 |
CN101589062B (zh) | 2014-08-20 |
AU2007297652B2 (en) | 2012-02-16 |
MX2009003093A (es) | 2009-06-05 |
CR10736A (es) | 2009-06-30 |
IL197241A0 (en) | 2011-08-01 |
US7947809B2 (en) | 2011-05-24 |
WO2008036341A2 (en) | 2008-03-27 |
WO2008036341A3 (en) | 2009-02-05 |
BRPI0715017A2 (pt) | 2013-05-28 |
CL2007002668A1 (es) | 2008-05-09 |
BRPI0715017A8 (pt) | 2018-04-03 |
PE20080846A1 (es) | 2008-08-23 |
NO20091534L (no) | 2009-04-28 |
TW200820985A (en) | 2008-05-16 |
MX353319B (es) | 2018-01-05 |
US20090041784A1 (en) | 2009-02-12 |
CN101589062A (zh) | 2009-11-25 |
ES2444012T3 (es) | 2014-02-21 |
CA2662613C (en) | 2014-01-28 |
US8158759B2 (en) | 2012-04-17 |
AR062895A1 (es) | 2008-12-10 |
AU2007297652A1 (en) | 2008-03-27 |
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