EA201000245A1 - Человеческие нейтрализующие антитела к фактору роста нервов (ngf) в качестве селективных ингибиторов метаболического пути ngf - Google Patents

Человеческие нейтрализующие антитела к фактору роста нервов (ngf) в качестве селективных ингибиторов метаболического пути ngf

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Publication number
EA201000245A1
EA201000245A1 EA201000245A EA201000245A EA201000245A1 EA 201000245 A1 EA201000245 A1 EA 201000245A1 EA 201000245 A EA201000245 A EA 201000245A EA 201000245 A EA201000245 A EA 201000245A EA 201000245 A1 EA201000245 A1 EA 201000245A1
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EA
Eurasian Patent Office
Prior art keywords
ngf
growth factor
nerve growth
neutralizing antibodies
selective
Prior art date
Application number
EA201000245A
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English (en)
Other versions
EA030259B1 (ru
EA030259B8 (ru
Inventor
Кеннет Д. мл. Уайлд
Джеймс Дж. С. Тринор
Хайчунь Хуан
Хизер Иноу
Те Дж. Чжан
Франк Мартин
Original Assignee
Амджен Инк.
Медарекс, Инк.
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Publication date
Application filed by Амджен Инк., Медарекс, Инк. filed Critical Амджен Инк.
Publication of EA201000245A1 publication Critical patent/EA201000245A1/ru
Publication of EA030259B1 publication Critical patent/EA030259B1/ru
Publication of EA030259B8 publication Critical patent/EA030259B8/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract

В данном изобретении предложено антитело, которое связывается с фактором роста нервов (NGF) человека и посредством этого нейтрализует функцию NGF. В изобретении также предложена фармацевтическая композиция указанного антитела и ее применение для производства лекарства для лечения связанных с NGF расстройств. Также предложен способ обнаружения NGF в биологическом образце с использованием указанного антитела.
EA201000245A 2003-07-15 2004-07-15 Человеческие нейтрализующие антитела к фактору роста нервов (ngf) в качестве селективных ингибиторов метаболического пути ngf EA030259B8 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48743103P 2003-07-15 2003-07-15

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