BRPI0412567A - anticorpo humano isolado, método de tratamento de uma condição causada pela expressão aumentada de ngf ou pela sensibilidade aumentada ao ngf em um paciente, composição farmacêutica, método para detectar ngf em uma amostra biológica, molécula de ácido nucleico, célula hospedeira, linhagem celular isolada, agente de ligação especìfica em ngf, anticorpo humano isolado ou fragmento de imunoglobulina imunologicamente funcional ou um ligante de antìgeno do mesmo, polinucleotìdeo, vetor de expressão, medicamento para tratar um distúrbio doloroso ou uma condição associada com a expressão aumentada de ngf ou a sensibilidade aumentada ao ngf, e, uso de uma quantidade farmaceuticamente efetiva de anticorpo - Google Patents

anticorpo humano isolado, método de tratamento de uma condição causada pela expressão aumentada de ngf ou pela sensibilidade aumentada ao ngf em um paciente, composição farmacêutica, método para detectar ngf em uma amostra biológica, molécula de ácido nucleico, célula hospedeira, linhagem celular isolada, agente de ligação especìfica em ngf, anticorpo humano isolado ou fragmento de imunoglobulina imunologicamente funcional ou um ligante de antìgeno do mesmo, polinucleotìdeo, vetor de expressão, medicamento para tratar um distúrbio doloroso ou uma condição associada com a expressão aumentada de ngf ou a sensibilidade aumentada ao ngf, e, uso de uma quantidade farmaceuticamente efetiva de anticorpo

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Publication number
BRPI0412567A
BRPI0412567A BRPI0412567-3A BRPI0412567A BRPI0412567A BR PI0412567 A BRPI0412567 A BR PI0412567A BR PI0412567 A BRPI0412567 A BR PI0412567A BR PI0412567 A BRPI0412567 A BR PI0412567A
Authority
BR
Brazil
Prior art keywords
ngf
increased
expression
treating
human antibody
Prior art date
Application number
BRPI0412567-3A
Other languages
English (en)
Inventor
Kenneth D Wild
James J S Treanor
Heather Inoue
Tie J Zhang
Frank Martin
Haichun Huang
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BRPI0412567A publication Critical patent/BRPI0412567A/pt
Publication of BRPI0412567B1 publication Critical patent/BRPI0412567B1/pt

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Abstract

"ANTICORPO HUMANO ISOLADO, MéTODO DE TRATAMENTO DE UMA CONDIçãO CAUSADA PELA EXPRESSãO AUMENTADA DE NGF OU PELA SENSIBILIDADE AUMENTADA AO NGF EM UM PACIENTE, COMPOSIçãO FARMACêUTICA, MéTODO PARA DETECTAR NGF EM UMA AMOSTRA BIOLóGICA, MOLéCULA DE áCIDO NUCLEICO, CéLULA HOSPEDEIRA, LINHAGEM CELULAR ISOLADA, AGENTE DE LIGAçãO ESPECìFICA EM NGF , ANTICORPO HUMANO ISOLADO OU FRAGMENTO DE IMUNOGLOBULINA IMUNOLOGICAMENTE FUNCIONAL OU UM LIGANTE DE ANTìGENO DO MESMO, POLINUCLEOTìDEO, VETOR DE EXPRESSãO, MEDICAMENTO PARA TRATAR UM DISTúRBIO DOLOROSO OU UMA CONDIçãO ASSOCIADA COM A EXPRESSãO AUMENTADA DE NGF OU A SENSIBILIDADE AUMENTADA AO NGF, E, USO DE UMA QUANTIDADE FARMACEUTICAMENTE EFETIVA DE ANTICORPO". Esta invenção refere-se aos anticorpos que interagem com ou se ligam em fator de crescimento de nervo (NGF) e neutralizam deste modo a função de NGF. A invenção também proporciona composições farmacêuticas de citados anticorpos e métodos para neutralizar a função de NGF, e particularmente para tratar distúrbios relacionados com NGF (por exemplo, dor crónica) por administração de uma quantidade farmaceuticamente efetiva de anticorpos anti-NGF. Métodos de detecção da quantidade de NGF em uma amostra usando anticorpos anti-NGF também são proporcionados.
BRPI0412567A 2003-07-15 2004-07-15 anticorpo isolado, ou fragmento de imunoglobulina imunologicamente funcional ou ligante de antígeno do mesmo, composição farmacêutica, molécula de ácido nucleico, medicamento para tratar um distúrbio doloroso ou uma condição associada com a expressão aumentada de ngf ou a sensibilidade aumentada ao ngf, e, uso de uma quantidade farmaceuticamente efetiva de anticorpo ou fragmento de imunoglobulina imunologicamente funcional ou ligante de antígeno do mesmo BRPI0412567B1 (pt)

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PCT/US2004/022876 WO2005019266A2 (en) 2003-07-15 2004-07-15 Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors

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