MX2010002249A - Formulacion de proteina de estado solido. - Google Patents

Formulacion de proteina de estado solido.

Info

Publication number
MX2010002249A
MX2010002249A MX2010002249A MX2010002249A MX2010002249A MX 2010002249 A MX2010002249 A MX 2010002249A MX 2010002249 A MX2010002249 A MX 2010002249A MX 2010002249 A MX2010002249 A MX 2010002249A MX 2010002249 A MX2010002249 A MX 2010002249A
Authority
MX
Mexico
Prior art keywords
proteins
solid
protein formulation
methods
delivery vehicles
Prior art date
Application number
MX2010002249A
Other languages
English (en)
Inventor
Himanshu Gadgil
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2010002249A publication Critical patent/MX2010002249A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Peptides Or Proteins (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se proporcionan sistemas que comprenden vehículos de administración para el almacenamiento estable de proteínas inmovilizadas, por ejemplo, proteínas terapéuticas, en una forma tratable para administración, tal como por inyección o infusión, en combinación con un fluido de elusión. También se proporcionan proteínas adsorbidas a medios cromatográficos en una forma compatible con la administración en un paso de la proteína. Los vehículos de administración de ejemplo son jeringas pre-llenas y módulos pre-llenos de infusión; las proteínas de ejemplo son anticuerpos útiles en terapia. También se proporcionan métodos para producir las proteínas inmovilizadas y métodos para usar las proteínas inmovilizadas, por ejemplo, proteínas terapéuticas.
MX2010002249A 2007-08-31 2008-08-29 Formulacion de proteina de estado solido. MX2010002249A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96954407P 2007-08-31 2007-08-31
PCT/US2008/074793 WO2009029795A1 (en) 2007-08-31 2008-08-29 Solid-state protein formulation

Publications (1)

Publication Number Publication Date
MX2010002249A true MX2010002249A (es) 2010-03-17

Family

ID=39941773

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002249A MX2010002249A (es) 2007-08-31 2008-08-29 Formulacion de proteina de estado solido.

Country Status (7)

Country Link
US (1) US20110097318A1 (es)
EP (1) EP2197421A1 (es)
JP (2) JP5570989B2 (es)
AU (1) AU2008293425B2 (es)
CA (1) CA2698103A1 (es)
MX (1) MX2010002249A (es)
WO (1) WO2009029795A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
DK3045189T3 (en) 2011-10-14 2018-06-18 Amgen Inc Injector and mounting method
US20130281355A1 (en) * 2012-04-24 2013-10-24 Genentech, Inc. Cell culture compositions and methods for polypeptide production
ES2780395T3 (es) * 2012-11-21 2020-08-25 Amgen Inc Dispositivo de administración de fármacos
CA2905207C (en) * 2013-03-15 2022-04-12 Brent Buchine Portable drug mixing and delivery system and method
BR112015024282B1 (pt) 2013-03-22 2022-05-17 Amgen Inc Injetor e método de montagem do injetor
CN105873626A (zh) 2013-10-24 2016-08-17 美国安进公司 注射器和组装方法
GB201320660D0 (en) * 2013-11-22 2014-01-08 Qualasept Ltd Method
CN106310457A (zh) * 2015-06-23 2017-01-11 上海振浦医疗设备有限公司 一次性使用精密过滤注射器及其制作方法
SG11202004467PA (en) * 2017-11-17 2020-06-29 Swedish Orphan Biovitrum Ab Publ Syringe assembly with ion-exchange material
US10830760B2 (en) 2017-12-20 2020-11-10 General Electric Company Device for rapid detection of tuberculosis-lipoarabinomannan (TB-LAM) with enhanced sensitivity
US10837962B2 (en) * 2017-12-20 2020-11-17 General Electric Company Method and associated device for rapid detection of target biomolecules with enhanced sensitivity

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4517241A (en) * 1982-12-02 1985-05-14 Alpert Andrew J Chromatographic support material
US5085642A (en) * 1989-07-17 1992-02-04 Survival Technology, Inc. Conveniently carried frequent use autoinjector
US5102393A (en) * 1989-07-17 1992-04-07 Survival Technology, Inc. Autoinjector converted from intramuscular to subcutaneous mode of injection
US5139933A (en) * 1989-09-26 1992-08-18 Vicam, L.P. Assay method for detecting listeria
CA2195557C (en) * 1994-08-12 2006-10-17 Shui-On Leung Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
WO1997001755A2 (en) * 1995-06-26 1997-01-16 Perseptive Biosystems, Inc. High speed, automated, continuous flow, multi-dimensional molecular selection and analysis
US6328967B1 (en) * 1998-03-12 2001-12-11 Allergenics, Inc. Delivery system to modulate immune response
EP1080218A1 (en) * 1998-05-27 2001-03-07 University of Florida Method of preparing recombinant adeno-associated virus compositions by using an iodixanol gradient
TWI257394B (en) * 1998-10-23 2006-07-01 Kirin Amgen Inc Thrombopoietic compounds
SE9803662D0 (sv) * 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab Autoinjector
CN101469329B (zh) * 1998-11-27 2012-10-24 达尔文发现有限公司 增加骨矿化的组合物和方法
EP1006184A1 (en) * 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
EP1260518A4 (en) * 2000-03-02 2004-12-08 Kyowa Hakko Kogyo Kk PROTEIN SEPARATION AND PURIFICATION PROCESS
AUPQ599700A0 (en) * 2000-03-03 2000-03-23 Super Internet Site System Pty Ltd On-line geographical directory
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
DZ3494A1 (fr) * 2001-01-05 2002-07-11 Pfizer Anticorps anti-recepteur du facteur de croissance i analogue a l'insuline
RS51708B (sr) * 2001-05-11 2011-10-31 Amgen Inc. Peptidi i njima srodni molekuli koji se vezuju za tall-1
EP1395283B1 (en) * 2001-05-18 2007-03-07 Walter Reed Army Institute of Research Heterologous protection induced by immunization with invaplex vaccine
DE60228960D1 (de) * 2001-06-22 2008-10-30 Pg Res Foundation Inc Kompakte automatisierte vorrichtung zur trennung von radionukliden
RS51829B (sr) * 2001-08-23 2012-02-29 Genmab A/S. Ljudska antitela specifična za interleukin 15 (il-15)
US7247304B2 (en) * 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7241444B2 (en) * 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
US7217796B2 (en) * 2002-05-24 2007-05-15 Schering Corporation Neutralizing human anti-IGFR antibody
US8034904B2 (en) * 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
US7538195B2 (en) * 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
MXPA05002514A (es) * 2002-09-06 2005-05-27 Amgen Inc Anticuerpo monoclonal anti-il-1r1 humano terapeutico.
US6919426B2 (en) * 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
AU2003285874A1 (en) * 2002-10-16 2004-05-04 Amgen Inc. HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS
EP1572271A1 (de) * 2002-11-25 2005-09-14 Tecpharma Licensing AG Autoinjektor mit rückstellbarer auslösesicherung
US7923032B2 (en) * 2002-11-26 2011-04-12 Seacoast Neuroscience, Inc. Buoyant polymer particles for delivery of therapeutic agents to the central nervous system
KR101304718B1 (ko) * 2002-12-20 2013-09-05 암겐 인코포레이티드 미오스타틴을 저해하는 결합제
JP2007528201A (ja) * 2003-03-14 2007-10-11 ファルマシア・コーポレーション 癌治療のためのｉｇｆ−ｉ受容体に対する抗体
WO2004087756A2 (en) * 2003-04-02 2004-10-14 F. Hoffmann-La Roche Ag Antibodies against insulin-like growth factor i receptor and uses thereof
US7220410B2 (en) * 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
US7579157B2 (en) * 2003-07-10 2009-08-25 Hoffmann-La Roche Inc. Antibody selection method against IGF-IR
EA013614B1 (ru) * 2003-07-15 2010-06-30 Амджен Инк. Изолированное антитело к фактору роста нервов (ngf) и способы его применения
TWI476206B (zh) * 2003-07-18 2015-03-11 Amgen Inc 對肝細胞生長因子具專一性之結合劑
US7704454B1 (en) * 2003-10-08 2010-04-27 Caridianbct, Inc. Methods and devices for processing blood
CN1886426A (zh) * 2003-11-07 2006-12-27 伊姆尼斯公司 结合白细胞介素－4受体的抗体
PE20050928A1 (es) * 2003-11-21 2005-11-08 Schering Corp Combinaciones terapeuticas de anticuerpo anti-igfr1
WO2005079888A2 (en) * 2004-02-19 2005-09-01 Aditech Pharma Ab Delivery device for delivering pyy
CA3031270A1 (en) * 2004-03-03 2005-12-22 Revance Therapeutics, Inc. Compositions and methods for topical diagnostic and therapeutic transport
EP1843812A4 (en) * 2005-02-01 2008-12-03 Intelliject Llc DEVICES, SYSTEMS AND METHOD FOR DISPOSING MEDICAMENTS
US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
NO345593B1 (no) * 2005-07-18 2021-05-03 Amgen Inc Humane anti-B7RP1 nøytraliserende antistoffer
PE20071101A1 (es) * 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
US20070244467A1 (en) * 2005-09-28 2007-10-18 Biodel, Inc., State Of Incorporation Delaware Self-Filling Two Chamber Injectable Device
CL2007002567A1 (es) * 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.

Also Published As

Publication number Publication date
AU2008293425B2 (en) 2014-09-18
EP2197421A1 (en) 2010-06-23
JP2014198261A (ja) 2014-10-23
AU2008293425A1 (en) 2009-03-05
CA2698103A1 (en) 2009-03-05
JP2011507558A (ja) 2011-03-10
JP5570989B2 (ja) 2014-08-13
US20110097318A1 (en) 2011-04-28
WO2009029795A1 (en) 2009-03-05

Similar Documents

Publication Publication Date Title
MX2010002249A (es) Formulacion de proteina de estado solido.
CA2807942C (en) Erythrocyte-binding therapeutics
MX2011003842A (es) Direccion de celulas que presentan antigeno con inmunonanoterapeuticos.
MX2012010114A (es) Formulaciones concentradas de proteina y usos de las mismas.
WO2008124522A3 (en) Amylin formulations
MX2012012668A (es) Aplicacion de alto cizallamiento en administracion de farmaco.
WO2006055697A3 (en) Cancer immunotherapy incorporating p53
WO2013016363A9 (en) Multi-reservoir infusion pump systems and methods
WO2014047626A3 (en) Power injector device and method of use
WO2008007370A3 (en) Dual chamber injector intergrated with micro-needles
MX341427B (es) Un conjugado de insulina que usa un fragmento de inmunoglobulina.
EP4233981A3 (en) Needleless access connectors and valve elements therefor
WO2007076354A3 (en) Stable protein formulations
WO2012145752A3 (en) Wearable automatic injection device
WO2011064758A3 (en) Fusion proteins of immunoglobulin fc and interferon- alpha
ATE419842T1 (de) Abgabevehikel mit nanoteilchen
WO2006130525A3 (en) Methods for immunotherapy of cancer
WO2012154816A3 (en) Contrast media injection data management system
MX2016000063A (es) Matriz de cromatografia de afinidad.
WO2011051486A3 (en) Pharmaceutical solution of non covalently bound albumin and acylated insulin
TN2009000088A1 (en) Packaging system for pharmaceutical compositions and kit for intravenous administration
WO2007089727A3 (en) Needle-free injection device and priming system
JP2016538840A5 (es)
PH12014501643A1 (en) Interferon and immune globulin fc section fusion protein
TW200727928A (en) Method and apparatus for delivering epinephrine

Legal Events

Date Code Title Description
HH Correction or change in general
FG Grant or registration