RS51829B - Ljudska antitela specifična za interleukin 15 (il-15) - Google Patents

Ljudska antitela specifična za interleukin 15 (il-15)

Info

Publication number
RS51829B
RS51829B YU15104A YUP15104A RS51829B RS 51829 B RS51829 B RS 51829B YU 15104 A YU15104 A YU 15104A YU P15104 A YUP15104 A YU P15104A RS 51829 B RS51829 B RS 51829B
Authority
RS
Serbia
Prior art keywords
human
seq
amino acid
cdr2
cdr1
Prior art date
Application number
YU15104A
Other languages
English (en)
Inventor
Jan G. J. Van De Winkel
Marcus Antonius Van Dijk
Janine Schuurman
Arnout F. Gerritsen
Ole Baadsgaard
Original Assignee
Genmab A/S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genmab A/S. filed Critical Genmab A/S.
Publication of YU15104A publication Critical patent/YU15104A/sh
Publication of RS51829B publication Critical patent/RS51829B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

LJUDSKA ANTITELA SPECIFIČNA ZA INTERLEUKIN 15 (IL-15). Izolovano humano monoklonalno antitelo koje se vezuje za humani IL-15,koje sadrži varjabilne region humanog teškog lanca koji obuhvataju CDR1, CDR2i CDR3 sekvence i varjabilne region humanog lakog lanca koji obuhvataju CDR1,CDR2 i CDR3 sekvence, naznačeno time, štoa) CDR3 sekvenca varjabilnog regiona humanog teškog lanca obuhvata CDR3 amino kiselinsku sekevncu prikazanu na slici 2 (SEQ ID NO:2) i sekvenca CDR3 varjabilnog regiona lakog lanca obuhvata CDR3 amino kiselinsku sekvencu prikazanu na slici 3 (SEQ ID NO:4);b) CDR2 sekvenca varjabilnog regiona humanog teškog lanca obuhvata CDR2 amino kiselinsku sekvencu prikazanu na Slici 2 (SEQ ID NO:2) i CDR2 sekvenca varjabilnog regiona humanog lakog lanca obuhvata CDR2 amino kiselinsku sekvencu prikazanu na slici 3 (SEQ ID NO:4) ; ic) CDR1 sekvenca varjabilnog regiona humanog teškog lanca obuhvata CDR1 amino kiselinsku sekvencu prikazanu na slici 2 (SEQ ID NO:2) i CDR1 sekvenca humanog lakog lanca obuhvata CDR1 amino kiselinsku sekvencu prikazanu na slici 3 (SEQ ID NO:4).Prijava sadrži još 59 patentnih zahteva.
YU15104A 2001-08-23 2002-08-23 Ljudska antitela specifična za interleukin 15 (il-15) RS51829B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31473101P 2001-08-23 2001-08-23

Publications (2)

Publication Number Publication Date
YU15104A YU15104A (sh) 2006-08-17
RS51829B true RS51829B (sr) 2012-02-29

Family

ID=23221192

Family Applications (1)

Application Number Title Priority Date Filing Date
YU15104A RS51829B (sr) 2001-08-23 2002-08-23 Ljudska antitela specifična za interleukin 15 (il-15)

Country Status (25)

Country Link
US (1) US7153507B2 (sr)
EP (1) EP1425389B1 (sr)
JP (2) JP4359503B2 (sr)
KR (1) KR100911951B1 (sr)
CN (1) CN100557018C (sr)
AT (1) ATE531390T1 (sr)
AU (1) AU2002332628B2 (sr)
BR (1) BR0212136A (sr)
CA (1) CA2456648C (sr)
CY (1) CY1112447T1 (sr)
DK (1) DK1425389T3 (sr)
EA (1) EA014802B1 (sr)
ES (1) ES2375271T3 (sr)
HK (1) HK1066828A1 (sr)
HU (1) HU229776B1 (sr)
IL (2) IL160358A0 (sr)
MX (1) MXPA04001486A (sr)
NO (1) NO333152B1 (sr)
NZ (1) NZ531211A (sr)
PL (1) PL217752B1 (sr)
PT (1) PT1425389E (sr)
RS (1) RS51829B (sr)
SI (1) SI1425389T1 (sr)
WO (1) WO2003017935A2 (sr)
ZA (1) ZA200401144B (sr)

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HUP0402653A2 (hu) 2005-03-29
NO333152B1 (no) 2013-03-18
CA2456648C (en) 2011-08-16
ES2375271T3 (es) 2012-02-28
MXPA04001486A (es) 2004-10-27
JP2005503151A (ja) 2005-02-03
NZ531211A (en) 2007-04-27
IL160358A (en) 2010-12-30
PL371946A1 (en) 2005-07-11
WO2003017935A2 (en) 2003-03-06
CA2456648A1 (en) 2003-03-06
IL160358A0 (en) 2004-07-25
PT1425389E (pt) 2012-02-07
HK1066828A1 (en) 2005-04-01
KR100911951B1 (ko) 2009-08-13
EA014802B1 (ru) 2011-02-28
PL217752B1 (pl) 2014-08-29
SI1425389T1 (sl) 2012-02-29
EP1425389A2 (en) 2004-06-09
WO2003017935A3 (en) 2003-08-14
EA200400345A1 (ru) 2004-12-30
AU2002332628B2 (en) 2007-07-26
US20030138421A1 (en) 2003-07-24
JP4359503B2 (ja) 2009-11-04
HUP0402653A3 (en) 2010-01-28
YU15104A (sh) 2006-08-17
WO2003017935A9 (en) 2003-04-10
DK1425389T3 (da) 2012-01-30

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