ATE531390T1 - Interleukin-15-(il-15-)spezifische menschliche antikörper - Google Patents

Interleukin-15-(il-15-)spezifische menschliche antikörper

Info

Publication number
ATE531390T1
ATE531390T1 AT02796411T AT02796411T ATE531390T1 AT E531390 T1 ATE531390 T1 AT E531390T1 AT 02796411 T AT02796411 T AT 02796411T AT 02796411 T AT02796411 T AT 02796411T AT E531390 T1 ATE531390 T1 AT E531390T1
Authority
AT
Austria
Prior art keywords
human
antibodies
human antibodies
interleukin
specific human
Prior art date
Application number
AT02796411T
Other languages
English (en)
Inventor
De Winkel Jan Van
Dijk Marcus Van
Janine Schuurman
Arnout Gerritsen
Ole Baadsgaard
Original Assignee
Genmab As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genmab As filed Critical Genmab As
Application granted granted Critical
Publication of ATE531390T1 publication Critical patent/ATE531390T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02796411T 2001-08-23 2002-08-23 Interleukin-15-(il-15-)spezifische menschliche antikörper ATE531390T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31473101P 2001-08-23 2001-08-23
PCT/US2002/026769 WO2003017935A2 (en) 2001-08-23 2002-08-23 Human antibodies specific for interleukin 15 (il-15)

Publications (1)

Publication Number Publication Date
ATE531390T1 true ATE531390T1 (de) 2011-11-15

Family

ID=23221192

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02796411T ATE531390T1 (de) 2001-08-23 2002-08-23 Interleukin-15-(il-15-)spezifische menschliche antikörper

Country Status (24)

Country Link
US (1) US7153507B2 (de)
EP (1) EP1425389B1 (de)
JP (2) JP4359503B2 (de)
KR (1) KR100911951B1 (de)
CN (1) CN100557018C (de)
AT (1) ATE531390T1 (de)
AU (1) AU2002332628B2 (de)
BR (1) BR0212136A (de)
CA (1) CA2456648C (de)
CY (1) CY1112447T1 (de)
DK (1) DK1425389T3 (de)
EA (1) EA014802B1 (de)
ES (1) ES2375271T3 (de)
HU (1) HU229776B1 (de)
IL (2) IL160358A0 (de)
MX (1) MXPA04001486A (de)
NO (1) NO333152B1 (de)
NZ (1) NZ531211A (de)
PL (1) PL217752B1 (de)
PT (1) PT1425389E (de)
RS (1) RS51829B (de)
SI (1) SI1425389T1 (de)
WO (1) WO2003017935A2 (de)
ZA (1) ZA200401144B (de)

Families Citing this family (287)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
EP1425389B1 (de) 2001-08-23 2011-11-02 Genmab A/S Interleukin-15-(il-15-)spezifische menschliche antikörper
US7329405B2 (en) 2001-08-23 2008-02-12 Genmab A/S Human antibodies specific for interleukin 15 (IL-15)
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
GB0208817D0 (en) * 2002-04-17 2002-05-29 European Molecular Biology Lab Embl Method for producing monoclonal antibodies
ZA200506724B (en) * 2003-02-26 2007-03-28 Genmab As Human antibodies specific for interleukin 15 (IL-15)
NZ570709A (en) 2003-06-13 2010-04-30 Univ Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
US20050123542A1 (en) * 2003-11-06 2005-06-09 Genmab A/S Methods for treating disorders involving monocytes
AU2005299716B2 (en) * 2004-10-22 2012-09-06 Amgen Inc. Methods for refolding of recombinant antibodies
BRPI0519026A2 (pt) * 2004-12-13 2008-12-23 Cytos Biotechnology Ag arranjos de antÍgeno de il-15 e usos dos mesmos
KR20150055116A (ko) 2005-05-16 2015-05-20 애브비 바이오테크놀로지 리미티드 미란성 다발관절염의 치료를 위한 ｔｎｆ 억제제의 용도
JP2008543839A (ja) 2005-06-14 2008-12-04 アムジェン インコーポレーテッド 自己緩衝タンパク質製剤
US20070190057A1 (en) * 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
WO2007120656A2 (en) * 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of rheumatoid arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
MX2009008430A (es) 2007-02-09 2009-10-28 Genentech Inc Anticuerpos anti-robo4 y sus usos.
WO2008154543A2 (en) 2007-06-11 2008-12-18 Abbott Biotechnology Ltd. Methods for treating juvenile idiopathic arthritis
MX2010002249A (es) * 2007-08-31 2010-03-17 Amgen Inc Formulacion de proteina de estado solido.
MX2010002683A (es) * 2007-09-14 2010-03-26 Amgen Inc Poblaciones de anticuerpos homogeneos.
ES2750254T3 (es) 2007-09-27 2020-03-25 Amgen Inc Formulaciones farmacéuticas
EP3381445B1 (de) 2007-11-15 2023-10-25 Amgen Inc. Wässrige antikörperformulierung mit stabilisierung durch antioxidantien zur parenteralen verabreichung
TWI580694B (zh) 2007-11-30 2017-05-01 建南德克公司 抗-ｖｅｇｆ抗體
EP2098536A1 (de) 2008-03-05 2009-09-09 4-Antibody AG Isolation und Identifikation antigen- oder ligandenspezifischer Bindungsproteine
EP2271671A2 (de) * 2008-03-24 2011-01-12 Abbott Biotechnology Ltd. Tnf-alpha-inhibitoren zur behandlung von knochenverlust
CU23716A1 (es) 2008-09-30 2011-10-05 Ct Ingenieria Genetica Biotech Péptido antagonista de la actividad de la interleucina-15
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
AR077595A1 (es) 2009-07-27 2011-09-07 Genentech Inc Tratamientos de combinacion
US9321823B2 (en) 2009-09-02 2016-04-26 Genentech, Inc. Mutant smoothened and methods of using the same
US9662271B2 (en) 2009-10-23 2017-05-30 Amgen Inc. Vial adapter and system
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
CN107095846A (zh) 2009-12-21 2017-08-29 霍夫曼-拉罗奇有限公司 抗体配制剂
CA2800919C (en) 2010-06-07 2019-01-15 Amgen Inc. Drug delivery device
SI2580243T1 (sl) 2010-06-09 2020-02-28 Genmab A/S Protitelesa proti humanemu CD38
SMT201700547T1 (it) 2010-06-15 2018-01-11 Genmab As Coniugati di farmaco anticorpo umano contro il fattore tissutale
US8481680B2 (en) 2010-10-05 2013-07-09 Genentech, Inc. Mutant smoothened and methods of using the same
CA2831100C (en) 2011-03-31 2020-02-18 Mark Dominis Holt Vial adapter and system
CA2833748C (en) 2011-04-20 2019-07-16 Amgen Inc. Autoinjector apparatus
CN102250243B (zh) * 2011-07-01 2013-08-28 华绍炳 抗白细胞介素-15抗体
CN103797028B (zh) * 2011-07-18 2017-08-25 Iba 股份有限公司 使靶细胞可逆染色的方法
LT3045189T (lt) 2011-10-14 2018-06-25 Amgen Inc. Inžektorius ir surinkimo būdas
US12115341B2 (en) 2012-11-21 2024-10-15 Amgen Inc. Drug delivery device
EP2958941B1 (de) * 2013-02-20 2019-04-10 Innate Pharma Verbindung mit spezifischer bindung an kir3dl2 zur verwendung bei der behandlung von peripherem t-zell-lymphom
US10653779B2 (en) 2013-03-13 2020-05-19 Genentech, Inc. Formulations with reduced oxidation
US20140314778A1 (en) 2013-03-13 2014-10-23 Genentech, Inc. Formulations with reduced oxidation
MY174679A (en) 2013-03-13 2020-05-06 Genentech Inc Formulations with reduced oxidation
RS60534B1 (sr) 2013-03-13 2020-08-31 Hoffmann La Roche Formulacije sa smanjenom oksidacijom
NZ711567A (en) 2013-03-13 2020-04-24 Genentech Inc Antibody formulations
AU2014228177B2 (en) 2013-03-15 2018-04-26 Amgen Inc. Body contour adaptable autoinjector device
CA2904661C (en) 2013-03-15 2022-03-15 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
EP2968760B1 (de) 2013-03-15 2024-01-03 Amgen Inc. Medikamentenkassette, autoinjektor und autoinjektorsystem
KR20210037745A (ko) 2013-03-15 2021-04-06 제넨테크, 인크. 항산화제를 함유하는 세포 배양 조성물 및 폴리펩티드 생산 방법
IL292270B2 (en) 2013-03-22 2024-04-01 Amgen Inc Injector and method of assembly
PT3049441T (pt) 2013-09-27 2020-01-21 Hoffmann La Roche Formulações de anticorpos anti-pdl1
SG11201602876WA (en) 2013-10-24 2016-05-30 Amgen Inc Injector and method of assembly
MX2016005315A (es) 2013-10-24 2016-08-11 Amgen Inc Sistema de administracion de farmacos con control sensible a la temperatura.
CA2933881A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
BR112016013963A2 (pt) 2013-12-17 2017-10-10 Genentech Inc terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1
FI3083686T4 (fi) 2013-12-17 2023-05-09 Menetelmiä syöpien hoitamiseksi käyttäen pd-1-akselia sitovia antagonisteja ja taksaaneja
DK3102197T3 (en) 2014-02-04 2018-11-19 Genentech Inc Smoothened mutant and methods for its use
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
JP6588461B2 (ja) 2014-03-31 2019-10-09 ジェネンテック， インコーポレイテッド 抗血管新生剤及びｏｘ４０結合アゴニストを含む併用療法
KR102496507B1 (ko) 2014-05-07 2023-02-03 암겐 인코포레이티드 충격 감소 요소들을 가진 자동 주사기
KR20220143782A (ko) 2014-06-03 2022-10-25 암겐 인코포레이티드 약물 전달 디바이스의 사용자를 보조하기 위한 디바이스들 및 방법들
EP2963057A1 (de) 2014-07-02 2016-01-06 Calypso Biotech SA Antikörper zu IL-15
EP3193932B1 (de) 2014-09-15 2023-04-26 F. Hoffmann-La Roche AG Antikörperformulierungen
MX2021014323A (es) 2014-10-14 2023-02-02 Amgen Inc Dispositivo de inyección de fármaco con indicadores visuales y audibles.
CN114569716A (zh) 2014-10-23 2022-06-03 美国安进公司 降低药物制剂的粘度
EP3221360A1 (de) 2014-11-17 2017-09-27 F. Hoffmann-La Roche AG Kombinationstherapie mit ox40-bindungsagonisten und pd-1-achsenbindungsantagonisten
EP3848072A1 (de) 2014-12-19 2021-07-14 Amgen Inc. Medikamentenabgabevorrichtung mit näherungssensor
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
CA2975875A1 (en) 2015-02-04 2016-08-11 Genentech, Inc. Mutant smoothened and methods of using the same
CA3069716C (en) 2015-02-17 2021-11-09 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
US11806509B2 (en) 2015-02-27 2023-11-07 Amgen Inc. Drug delivery device having a needle guard mechanism with a turnable threshold of resistance to needle guard movement
IL256080B2 (en) 2015-06-17 2025-06-01 Genentech Inc Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
DK3334747T5 (da) 2015-08-13 2024-10-07 Amgen Inc Ladet dybdefiltrering af antigenbindende proteiner
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
EP3386573B1 (de) 2015-12-09 2019-10-02 Amgen Inc. Autoinjektor mit signalhaube
US20170239355A1 (en) 2015-12-30 2017-08-24 Genentech, Inc. Use of tryptophan derivatives for protein formulations
AU2016380988B2 (en) 2015-12-30 2022-07-21 Genentech, Inc. Formulations with reduced degradation of polysorbate
WO2017120178A1 (en) 2016-01-06 2017-07-13 Amgen Inc. Auto-injector with signaling electronics
ES2837428T3 (es) 2016-01-08 2021-06-30 Hoffmann La Roche Procedimientos de tratamiento de cánceres positivos para CEA usando antagonistas de unión al eje PD-1 y anticuerpos biespecíficos anti-CEA/anti-CD3
JP2019509721A (ja) 2016-02-04 2019-04-11 キュリス，インコーポレイテッド 突然変異体スムースンド及びその使用方法
EP3430054B1 (de) 2016-03-15 2021-12-29 Chugai Seiyaku Kabushiki Kaisha Verfahren zur krebsbehandlung mit pd-1-achsenbindenden antagonisten und anti-gpc3-antikörpern
DK3429663T3 (da) 2016-03-15 2020-09-28 Amgen Inc Reduktion af sandsynligheden for glasbrud i anordninger til indgivelse af lægemidler
US11541168B2 (en) 2016-04-29 2023-01-03 Amgen Inc. Drug delivery device with messaging label
US11389588B2 (en) 2016-05-02 2022-07-19 Amgen Inc. Syringe adapter and guide for filling an on-body injector
WO2017197222A1 (en) 2016-05-13 2017-11-16 Amgen Inc. Vial sleeve assembly
WO2017200989A1 (en) 2016-05-16 2017-11-23 Amgen Inc. Data encryption in medical devices with limited computational capability
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
US11541176B2 (en) 2016-06-03 2023-01-03 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
US20180002417A1 (en) 2016-06-15 2018-01-04 Celimmune Llc Methods and Compositions for the Treatment of Celiac Disease, Non-Celiac Gluten Sensitivity, and Refractory Celiac Disease
WO2018004842A1 (en) 2016-07-01 2018-01-04 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
JP7250674B2 (ja) 2016-08-08 2023-04-03 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト がんの治療及び診断方法
US20190328965A1 (en) 2016-08-17 2019-10-31 Amgen Inc. Drug delivery device with placement detection
US11459401B2 (en) 2016-10-06 2022-10-04 Amgen Inc. Reduced viscosity protein pharmaceutical formulations
WO2018075818A1 (en) 2016-10-21 2018-04-26 Amgen Inc. Pharmaceutical formulations and methods of making the same
EP3532127A1 (de) 2016-10-25 2019-09-04 Amgen Inc. Injektor am körper
PT3558369T (pt) 2016-12-21 2025-05-06 Cephalon Llc Anticorpos que se ligam especificamente à il-15 humana e suas utilizações
IL308980A (en) 2016-12-23 2024-01-01 Novartis Ag Antibodies against factor XI and methods of their use
JP2020503976A (ja) 2017-01-17 2020-02-06 アムジエン・インコーポレーテツド 注入デバイスならびに関連する使用および組立方法
EP3582829A1 (de) 2017-02-17 2019-12-25 Amgen Inc. Einführmechanismus für eine arzneimittelabgabevorrichtung
CA3048520A1 (en) 2017-02-17 2018-08-23 Amgen Inc. Drug delivery device with sterile fluid flowpath and related method of assembly
JP7377596B2 (ja) 2017-02-22 2023-11-10 アムジエン・インコーポレーテツド 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
JP2020508803A (ja) 2017-03-06 2020-03-26 アムジエン・インコーポレーテツド 作動防止特徴部を備える薬物送達デバイス
US11571511B2 (en) 2017-03-07 2023-02-07 Amgen Inc. Insertion mechanism and method of inserting a needle of a drug delivery device
KR102893480B1 (ko) 2017-03-09 2025-11-28 암겐 인코포레이티드 약물 전달 장치용 삽입 메커니즘
HUE063805T2 (hu) 2017-03-28 2024-01-28 Amgen Inc Dugattyúrúd és fecskendõ összeállító rendszer és eljárás
EP3615003A4 (de) 2017-04-24 2021-05-26 University Of Massachusetts Lowell Diagnose und behandlung von vitiligo
US12103979B2 (en) 2017-04-28 2024-10-01 Amgen Inc. N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides
AU2018282077B2 (en) 2017-06-08 2023-11-23 Amgen Inc. Torque driven drug delivery device
CA3061982A1 (en) 2017-06-08 2018-12-13 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
MA49447A (fr) 2017-06-22 2020-04-29 Amgen Inc Réduction des impacts/chocs d'activation d'un dispositif
WO2018237225A1 (en) 2017-06-23 2018-12-27 Amgen Inc. Electronic drug delivery device comprising a cap activated by a switch assembly
MA49562A (fr) 2017-07-14 2020-05-20 Amgen Inc Système d'insertion-rétractation d'aiguille présentant un système à ressort en double torsion
MA49626A (fr) 2017-07-21 2020-05-27 Amgen Inc Élément d'étanchéité perméable aux gaz pour récipient à médicament et procédés d'assemblage
JP2020528296A (ja) 2017-07-25 2020-09-24 アムジエン・インコーポレーテツド ギヤモジュールを有する薬物送達デバイス及び関連する組立方法
WO2019022950A1 (en) 2017-07-25 2019-01-31 Amgen Inc. DRUG DELIVERY DEVICE WITH CONTAINER ACCESS SYSTEM AND ASSEMBLY METHOD THEREOF
IL271499B2 (en) 2017-08-01 2024-12-01 Amgen Inc Systems and methods for real-time polypeptide sample preparation for mass spectrometry analysis
EA202090380A1 (ru) 2017-08-01 2020-05-21 Эмджен Инк. Системы и способы для выполнения анализа гликанов в образце в режиме реального времени
MA49838A (fr) 2017-08-09 2020-06-17 Amgen Inc Systèm de administration de médicaments avec pression hydraulique-pneumatique de chambre
US11077246B2 (en) 2017-08-18 2021-08-03 Amgen Inc. Wearable injector with sterile adhesive patch
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
ES2939292T3 (es) 2017-10-04 2023-04-20 Amgen Inc Adaptador de flujo para dispositivo de administración de fármacos
EP3691716B1 (de) 2017-10-06 2023-11-29 Amgen Inc. Arzneimittelabgabevorrichtung mit verriegelungsvorrichtung und zugehöriges montageverfahren
US11464903B2 (en) 2017-10-09 2022-10-11 Amgen Inc. Drug delivery device with drive assembly and related method of assembly
WO2019090079A1 (en) 2017-11-03 2019-05-09 Amgen Inc. System and approaches for sterilizing a drug delivery device
JP2021501616A (ja) 2017-11-06 2021-01-21 アムジエン・インコーポレーテツド 配置及び流量検出を備える薬物送達デバイス
US12053618B2 (en) 2017-11-06 2024-08-06 Amgen Inc. Fill-finish assemblies and related methods
MA50557A (fr) 2017-11-10 2020-09-16 Amgen Inc Pistons pour dispositifs d'administration de médicament
WO2019099322A1 (en) 2017-11-16 2019-05-23 Amgen Inc. Autoinjector with stall and end point detection
IL273638B2 (en) 2017-11-16 2024-10-01 Amgen Inc Door latch mechanism for drug delivery device
WO2019143753A1 (en) 2018-01-17 2019-07-25 Amgen Inc. Drug delivery mechanism
ES2993017T3 (en) 2018-03-07 2024-12-20 Amgen Inc Controlled dispense syringe
EP3762067A1 (de) 2018-03-09 2021-01-13 Amgen Inc. Rückflussverhinderungsmechanismus für arzneimittelabgabevorrichtung
US12405275B2 (en) 2018-03-13 2025-09-02 Amgen Inc. Methods for the preparation of trypsin-resistant polypeptides for mass spectrometric analysis
KR102775717B1 (ko) 2018-03-13 2025-03-06 암젠 인크 질량 분광 분석을 위한 폴리펩티드의 순차적 소화
US11499922B2 (en) 2018-03-30 2022-11-15 Amgen Inc. Camera-based drug container inspection
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
AU2019288728A1 (en) 2018-06-23 2021-01-14 Genentech, Inc. Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
TW202011991A (zh) 2018-07-18 2020-04-01 美商建南德克公司 用pd-1軸結合拮抗劑、抗代謝劑及鉑劑治療肺癌之方法
WO2020023336A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with grip portion
MA53379A (fr) 2018-07-24 2021-06-02 Amgen Inc Dispositifs d'administration pour l'administration de médicaments
CA3103682A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Delivery devices for administering drugs
WO2020023220A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with tacky skin attachment portion and related method of preparation
US12459980B2 (en) 2018-07-25 2025-11-04 AskGene Pharma, Inc. IL-21 prodrugs and methods of use thereof
MA53320A (fr) 2018-07-31 2021-11-03 Amgen Inc Ensemble de trajet de fluide pour dispositif d'administration de médicament
JP7542521B2 (ja) 2018-08-08 2024-08-30 ジェネンテック， インコーポレイテッド タンパク質製剤のためのトリプトファン誘導体及びｌ－メチオニンの使用
EP3836988A1 (de) 2018-08-17 2021-06-23 Amgen Inc. Aktivierungsmechanismus für eine wirkstofffreisetzungsvorrichtung
ES2955032T3 (es) 2018-09-21 2023-11-28 Hoffmann La Roche Métodos de diagnóstico para el cáncer de mama triple negativo
AU2019347710B2 (en) 2018-09-24 2025-05-08 Amgen Inc. Interventional dosing systems and methods
IL281469B2 (en) 2018-09-28 2024-08-01 Amgen Inc Muscle wire escapement activation assembly for a drug delivery device
US12156991B2 (en) 2018-10-02 2024-12-03 Amgen Inc. Injection systems for drug delivery with internal force transmission
WO2020072846A1 (en) 2018-10-05 2020-04-09 Amgen Inc. Drug delivery device having dose indicator
US12053617B2 (en) 2018-10-15 2024-08-06 Amgen Inc. Drug delivery device having damping mechanism
WO2020081480A1 (en) 2018-10-15 2020-04-23 Amgen Inc. Platform assembly process for drug delivery device
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
US11213620B2 (en) 2018-11-01 2022-01-04 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
US12485219B2 (en) 2018-11-01 2025-12-02 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
TWI852964B (zh) 2018-12-14 2024-08-21 美商安進公司 與依照斜率的蛋白質濃度確定一起使用之系統適用性方法
US11534547B2 (en) 2019-01-24 2022-12-27 Amgen Inc. Drug delivery systems and methods with pressure sensitive control
EP3914320A1 (de) 2019-01-24 2021-12-01 Amgen Inc. Wirkstoffabgabesysteme und verfahren mit gegendruckerfassung
US20220087901A1 (en) 2019-02-12 2022-03-24 Amgen Inc. Systems and approaches for drug delivery device reconstitution
US20220096747A1 (en) 2019-02-12 2022-03-31 Amgen Inc. Continuous dosing systems and approaches
EP3924018A1 (de) 2019-02-12 2021-12-22 Amgen Inc. Kontinuierliche dosiersysteme und ansätze
EP3924019A1 (de) 2019-02-12 2021-12-22 Amgen Inc. Kontinuierliche dosiersysteme und ansätze
WO2020167702A1 (en) 2019-02-12 2020-08-20 Amgen Inc. Take-home drug delivery system
US12329720B2 (en) 2019-02-12 2025-06-17 Amgen Inc. Dosing systems and approaches
ES2987091T3 (es) 2019-02-14 2024-11-13 Amgen Inc Sistemas y métodos para preparar una muestra y realizar un ensayo en tiempo real de la muestra
JP7530376B2 (ja) 2019-02-20 2024-08-07 アムジエン・インコーポレーテツド タンパク質の安定性を決定する方法
JP7570341B2 (ja) 2019-03-04 2024-10-21 アムジエン・インコーポレーテツド 高分子量種のインビボでの可逆性
EP3948242A1 (de) 2019-03-27 2022-02-09 Amgen Inc. Verfahren zum fingerprinting von therapeutischen proteinen mittels einer zweidimensionalen (2d) kernmagnetischen resonanztechnik in natürlicher menge für formulierte biopharmazeutische produkte
US11464706B2 (en) 2019-04-08 2022-10-11 Amgen Inc. Automated drug delivery device and container
AU2020271035A1 (en) 2019-04-09 2021-09-09 Amgen Inc. Drug delivery device with smart grip
AU2020259327B2 (en) 2019-04-17 2025-07-24 Amgen Inc. Cassette for an autoinjector and related methods
WO2020219672A1 (en) 2019-04-24 2020-10-29 Amgen Inc. Injector accessories
ES3032751T3 (en) 2019-04-24 2025-07-24 Amgen Inc Syringe sterilization verification assemblies and methods
MA56121A (fr) 2019-06-05 2022-04-13 Amgen Inc Procédés d'identification d'attributs de protéines thérapeutiques
AU2020291012B2 (en) * 2019-06-12 2025-09-25 AskGene Pharma, Inc. Novel IL-15 prodrugs and methods of use thereof
MX2021015571A (es) 2019-06-20 2022-01-24 Amgen Inc Dispositivo y metodo de administracion de farmacos habilitados para comunicacion inalambrica.
US12329944B2 (en) 2019-07-18 2025-06-17 Amgen Inc. Drug delivery device having pressurized vessel
US20220249778A1 (en) 2019-07-18 2022-08-11 Amgen Inc. Sealing arrangement for drug delivery device
WO2021021848A1 (en) 2019-08-01 2021-02-04 Amgen Inc. Drug delivery device with temperature measurement and related method
MX2022002149A (es) 2019-08-23 2022-03-17 Amgen Inc Dispositivo de suministro de farmacos con componentes de acoplamiento de capuchon de aguja configurable y metodos relacionados.
WO2021045932A1 (en) 2019-09-03 2021-03-11 Amgen Inc. Activatable injection device for drug delivery
MX2022002355A (es) 2019-09-03 2022-04-06 Amgen Inc Dispositivo de inyeccion para suministro de farmacos y envase para el dispositivo de inyeccion.
WO2021050494A1 (en) 2019-09-12 2021-03-18 Amgen Inc. Backflow prevention mechanism for drug delivery device
CA3150482A1 (en) 2019-09-16 2021-03-25 Amgen Inc. Method for external sterilization of drug delivery device
US20210093792A1 (en) 2019-09-30 2021-04-01 Amgen Inc. Drug delivery device and methods of delivering a drug
AU2020360255A1 (en) 2019-09-30 2022-03-17 Amgen Inc. Drug delivery device
CN114450048B (zh) 2019-09-30 2025-02-18 美国安进公司 药物递送装置
EP4037732A1 (de) 2019-09-30 2022-08-10 Amgen Inc. Arzneimittelabgabevorrichtung
CN114450049A (zh) 2019-09-30 2022-05-06 美国安进公司 药物递送装置
US12440625B2 (en) 2019-09-30 2025-10-14 Amgen Inc. Drug delivery device
US12208943B2 (en) 2019-10-07 2025-01-28 Amgen Inc. Packages for pharmaceutical products and methods of assembly
US11660435B2 (en) 2019-10-07 2023-05-30 Amgen Inc. Light-activated ultrasonic delivery and manipulation of liquid medication from a drug reservoir
US20220355025A1 (en) 2019-10-07 2022-11-10 Amgen Inc. Needle insertion mechanism for drug delivery device
US20220362484A1 (en) 2019-10-07 2022-11-17 Amgen Inc. Drug delivery device
EP4041345B1 (de) 2019-10-08 2025-09-24 Amgen Inc. Arzneimittelabgabevorrichtung
CA3152217A1 (en) 2019-10-08 2021-04-15 Amgen Inc. Temperature indicator for drug delivery device
US20240100247A1 (en) 2019-10-08 2024-03-28 Amgen Inc. Needle insertion mechanism for drug delivery device
MX2022004268A (es) 2019-10-08 2022-05-06 Amgen Inc Cartucho para un autoinyector y metodos relacionados.
EP4045108A1 (de) 2019-10-18 2022-08-24 Amgen Inc. Medikamentenabgabevorrichtung und system
US20240091440A1 (en) 2019-10-18 2024-03-21 Amgen Inc. Drug delivery device and system
MX2022004483A (es) 2019-10-18 2022-05-06 Amgen Inc Sistemas y enfoques para reconstitucion en dispositivo de administracion de farmacos.
JP7714533B2 (ja) 2019-10-18 2025-07-29 アムジエン・インコーポレーテツド 薬物送達デバイス再構成のためのシステム及び手法
WO2021080828A1 (en) 2019-10-21 2021-04-29 Amgen Inc. Drug product container and drug delivery system
WO2021080822A1 (en) 2019-10-24 2021-04-29 Amgen Inc. Systems and methods for drug delivery
US20220387710A1 (en) 2019-10-24 2022-12-08 Amgen Inc. Drug delivery device and system
EP4048344A1 (de) 2019-10-24 2022-08-31 Amgen Inc. Arzneimittelabgabevorrichtung
WO2021081321A1 (en) 2019-10-24 2021-04-29 Amgen Inc. Systems and approaches for drug delivery
WO2021081161A1 (en) 2019-10-24 2021-04-29 Amgen Inc. Systems and components for drug delivery and components for preparation of the same
EP4054673A1 (de) 2019-11-07 2022-09-14 Amgen Inc. Wirkstofffreisetzungssystem und verfahren zur verwendung
EP4069340B1 (de) 2019-12-02 2025-10-15 Amgen Inc. Sperrmechanismus für eine wirkstofffreisetzungsvorrichtung
WO2021113070A1 (en) 2019-12-05 2021-06-10 Amgen Inc, Flow restrictor for drug delivery device
WO2021142471A1 (en) 2020-01-11 2021-07-15 AskGene Pharma, Inc. Novel masked cytokines and methods of use thereof
AU2020422420A1 (en) 2020-01-13 2022-06-09 Amgen Inc. Needle shield removers, drug delivery devices, and related methods
US12240652B2 (en) 2020-02-24 2025-03-04 Amgen Inc. Containers and systems for use during external sterilization of drug delivery devices
JP7654684B2 (ja) 2020-03-16 2025-04-01 アムジエン・インコーポレーテツド 薬物送達部材挿入検知アセンブリ、薬物送達デバイス、及び関連方法
CN115209931B (zh) 2020-03-17 2025-05-13 美国安进公司 受控式分配注射器
WO2021221845A1 (en) 2020-04-28 2021-11-04 Amgen Inc. Packaging label
MX2022014688A (es) 2020-05-22 2022-12-16 Amgen Inc Sistema de almacenamiento y metodo para almacenar y transportar medicamentos.
CA3181820A1 (en) 2020-06-16 2021-12-23 Genentech, Inc. Methods and compositions for treating triple-negative breast cancer
US20230294868A1 (en) 2020-09-02 2023-09-21 Amgen Inc. Easy open apparatus for medicament storage carton
WO2022055779A1 (en) 2020-09-09 2022-03-17 Amgen Inc. Swallowable drug delivery devices
WO2022055761A1 (en) 2020-09-11 2022-03-17 Amgen Inc. Inline uv flow device for sterilizing flow cytometry sheath fluid
AU2021343495A1 (en) 2020-09-18 2023-04-27 Amgen Inc. Methods of processing a sample for peptide mapping analysis
CA3192737A1 (en) 2020-10-12 2022-04-21 Amgen Inc. Long-term medicament storage apparatus and methods
JP2023549083A (ja) 2020-11-04 2023-11-22 アムジエン・インコーポレーテツド 薬物送達デバイスアセンブリ及び薬物送達デバイス用アクセサリ
US20230277778A1 (en) 2020-11-04 2023-09-07 Amgen Inc. Drug delivery device assembly and accessory for drug delivery device
AU2021376106A1 (en) 2020-11-04 2023-04-20 Amgen Inc. Drug delivery device assembly and accessory for drug delivery device
US20230381426A1 (en) 2020-11-04 2023-11-30 Amgen Inc. Drug delivery device assembly and accessory for drug delivery device
WO2022098595A1 (en) 2020-11-05 2022-05-12 Amgen Inc. Materials and methods for protein processing
US20240115462A1 (en) 2021-02-03 2024-04-11 Amgen Inc. High-throughput automated reconstitution of lyophilized drug product
EP4288017B1 (de) 2021-02-03 2025-06-25 Amgen Inc. Koaxialer nadeladapter und führungshalterung für eine robotische flüssigkeitshandhabungsplattform
CN116782993A (zh) 2021-02-03 2023-09-19 美国安进公司 用于药物加工的系统和方法
AU2022232292A1 (en) 2021-03-08 2023-08-31 Amgen Inc. Manufacturing process for hollow plunger rod
EP4304680A1 (de) 2021-03-10 2024-01-17 Amgen Inc. Arzneimittelabgabevorrichtung mit abnehmbarer kappe
MX2023010440A (es) 2021-03-10 2023-09-12 Amgen Inc Dispositivo de administracion de farmacos, subconjunto para dispositivo de administracion de farmacos, soporte de jeringa y metodo de ensamblado.
AU2022233152A1 (en) 2021-03-10 2023-08-17 Amgen Inc. Drug delivery device
AU2022241961A1 (en) 2021-03-25 2023-09-14 Amgen Inc. Drug delivery device
IL305701A (en) 2021-03-31 2023-11-01 Amgen Inc A sound-detection-based injection time measurement system for drug delivery devices
JP2024516113A (ja) 2021-04-22 2024-04-12 アムジエン・インコーポレーテツド 自動化シリンジ品質評価のための方法及びシステム
US20240197989A1 (en) 2021-04-28 2024-06-20 Amgen Inc. Systems for out-patient treatment of a patient, and related methods
EP4341945A1 (de) 2021-05-17 2024-03-27 Amgen Inc. Feedbacksystem und verfahren für ein arzneimittelprodukt
KR20240011135A (ko) 2021-05-21 2024-01-25 암젠 인크 약물 용기를 위한 충전 레시피를 최적화하는 방법
WO2022256199A1 (en) 2021-06-01 2022-12-08 Amgen Inc. Lyophilization system
EP4351682A1 (de) 2021-06-08 2024-04-17 Amgen Inc. Arzneimittelabgabevorrichtungen, fingergriffelemente und zugehörige verfahren
CA3224200A1 (en) 2021-06-17 2022-12-22 Amgen Inc. Drug delivery device having shock absorber
CN117545519A (zh) 2021-06-23 2024-02-09 美国安进公司 注射器、组件和制造方法
US20240269380A1 (en) 2021-06-28 2024-08-15 Amgen Inc. Safety device for drug delivery system
US20250017825A1 (en) 2021-07-16 2025-01-16 Amgen Inc. Systems and approaches for drug processing using single-use hardware
IL310308A (en) 2021-09-29 2024-03-01 Amgen Inc Apparatuses, systems and methods for plunger-stopper depth measurement in pre-filled syringes
MX2024004133A (es) 2021-10-06 2024-04-22 Amgen Inc Herramienta de freno activado por impacto para dispositivo de administracion de farmacos.
CA3233406A1 (en) 2021-10-06 2023-04-13 Amgen Inc. Impact activated retention feature for drug delivery device
AU2022366707A1 (en) 2021-10-11 2024-03-14 Amgen Inc. Characterization apparatus for drug delivery devices or subcomponents thereof
EP4427113A1 (de) 2021-11-05 2024-09-11 Amgen Inc. Arzneimittelabgabevorrichtungen, komponenten zur verwendung in arzneimittelabgabevorrichtungen
WO2023086793A1 (en) 2021-11-09 2023-05-19 Amgen Inc. Production of therapeutic proteins
AU2022396290A1 (en) 2021-11-29 2024-04-04 Amgen Inc. Plunger rod removal force method and fixture
CA3236413A1 (en) 2021-12-03 2023-06-08 Amgen Inc. Stopper placement in a syringe
CN118829460A (zh) 2022-03-11 2024-10-22 美国安进公司 可调节深度的自动注入器
WO2023196111A1 (en) 2022-04-06 2023-10-12 Amgen Inc. Packaging for drug delivery device
JP2025525860A (ja) 2022-08-04 2025-08-07 ノバルティス ファーマ アーゲー アトピー性皮膚炎の治療に有用なｉｌ－１５阻害剤
EP4573553A1 (de) 2022-08-15 2025-06-25 ABSCI Corporation Spezifische zellanreicherung mit quantitativer affinitätsaktivität
CA3261341A1 (en) 2022-08-18 2024-02-22 Amgen Inc. SYRINGE NEEDLE PROTECTOR
JP2025527437A (ja) 2022-08-18 2025-08-22 アムジエン・インコーポレーテツド シリンジ用の針シールドアセンブリ
WO2024049793A1 (en) 2022-08-30 2024-03-07 Amgen Inc. System and method of limiting subvisible particles in a syringe
AU2024265254A1 (en) 2023-05-01 2025-11-13 Amgen Inc. Configurable handheld biological analyzers for identification of biological products based on raman spectroscopy using artificial intelligence
CN118894934A (zh) 2023-05-05 2024-11-05 北京智仁美博生物科技有限公司 抗人il-15的抗体及其用途
WO2024259275A1 (en) 2023-06-14 2024-12-19 Bristol-Myers Squibb Company Near real time sialic acid quantitation of glycoproteins
WO2025019224A1 (en) 2023-07-14 2025-01-23 Amgen Inc. Monitoring systems and methods for injection devices
WO2025072072A1 (en) 2023-09-26 2025-04-03 Amgen Inc. Packaging systems for medical devices
WO2025101602A1 (en) 2023-11-07 2025-05-15 Amgen Inc. Methods of analyzing amino acid content of a therapeutic protein
CN117209605B (zh) * 2023-11-09 2024-01-30 北京百普赛斯生物科技股份有限公司 特异性结合il-15的抗体及其应用
US20250171175A1 (en) 2023-11-28 2025-05-29 Amgen Inc. Automated systems and methods for foil packaging components
WO2025136894A1 (en) 2023-12-18 2025-06-26 Amgen Inc. Ampoule adapter and method of use
WO2025136766A1 (en) 2023-12-20 2025-06-26 Amgen Inc. Packaging for drug administration
WO2025144700A1 (en) 2023-12-27 2025-07-03 Absci Corporation Nanobody library screening using bacterial surface display
WO2025184300A1 (en) 2024-02-28 2025-09-04 Amgen Inc. Drug delivery device
WO2025183760A1 (en) 2024-02-29 2025-09-04 Amgen Inc. Sustainable and modular packaging systems for containers for pharmaceutical use
WO2025213011A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Method of assessing stopper movement in a drug delivery device
WO2025222117A1 (en) 2024-04-19 2025-10-23 Amgen Inc. Drug delivery device
WO2025255028A1 (en) 2024-06-03 2025-12-11 Amgen Inc. High-throughput liquid chromatography-mass spectrometry-based peptide mapping

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1690935A3 (de) * 1990-01-12 2008-07-30 Abgenix, Inc. Bildung von xenogenen Antikörpern
US6255458B1 (en) * 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5574138A (en) 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
US5591630A (en) * 1994-05-06 1997-01-07 Immunex Corporation Monoclonal antibodies that bind interleukin-15 receptors
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
ATE221784T1 (de) 1995-04-02 2002-08-15 Chugai Pharmaceutical Co Ltd Arzneimittel zur heilung von thrombozytopenie
EP0823941A4 (de) 1995-04-28 2001-09-19 Abgenix Inc Menschliche antikörper aus xenomäusen
US5660824A (en) 1995-05-24 1997-08-26 Grabstein; Kenneth H. Muscle trophic factor
JP3946256B2 (ja) * 1995-09-11 2007-07-18 協和醗酵工業株式会社 ヒトインターロイキン５受容体α鎖に対する抗体
ATE298367T1 (de) 1996-04-26 2005-07-15 Beth Israel Hospital Interleukin-15 antagoniste
DE69719529T2 (de) 1996-10-17 2003-12-11 Immunomedics, Inc. Nichtantigenes toxinkonjugat und fusionsprotein eines internalisierendes rezeptorsystems
ATE229342T1 (de) 1997-02-21 2002-12-15 Vlaams Interuniv Inst Biotech Verwendung von interleukin-15
EP0972445B1 (de) * 1997-02-28 2006-07-05 Kirin Beer Kabushiki Kaisha Transgene Mäuse die ein menschliche Antikörper exprimieren
GB9814892D0 (en) * 1998-07-10 1998-09-09 Kennedy Rheumatology Inst Treatment of celiac disease
AU6689700A (en) 1999-07-06 2001-01-22 Silvia Bulfone-Paus Method of treating psoriasis with il-15 antagonist
EP1425389B1 (de) 2001-08-23 2011-11-02 Genmab A/S Interleukin-15-(il-15-)spezifische menschliche antikörper

Also Published As

Publication number Publication date
HUP0402653A2 (hu) 2005-03-29
RS51829B (sr) 2012-02-29
ZA200401144B (en) 2005-05-12
PL217752B1 (pl) 2014-08-29
PT1425389E (pt) 2012-02-07
HUP0402653A3 (en) 2010-01-28
HK1066828A1 (en) 2005-04-01
CA2456648C (en) 2011-08-16
EP1425389A2 (de) 2004-06-09
BR0212136A (pt) 2004-12-07
IL160358A (en) 2010-12-30
KR100911951B1 (ko) 2009-08-13
EP1425389B1 (de) 2011-11-02
CN1571836A (zh) 2005-01-26
PL371946A1 (en) 2005-07-11
MXPA04001486A (es) 2004-10-27
IL160358A0 (en) 2004-07-25
HU229776B1 (hu) 2014-07-28
JP4359503B2 (ja) 2009-11-04
JP2005503151A (ja) 2005-02-03
CY1112447T1 (el) 2015-12-09
EA200400345A1 (ru) 2004-12-30
US7153507B2 (en) 2006-12-26
DK1425389T3 (da) 2012-01-30
KR20040047796A (ko) 2004-06-05
YU15104A (sh) 2006-08-17
ES2375271T3 (es) 2012-02-28
WO2003017935A3 (en) 2003-08-14
CA2456648A1 (en) 2003-03-06
EA014802B1 (ru) 2011-02-28
JP2009256354A (ja) 2009-11-05
SI1425389T1 (sl) 2012-02-29
US20030138421A1 (en) 2003-07-24
AU2002332628B2 (en) 2007-07-26
CN100557018C (zh) 2009-11-04
NO20040752L (no) 2004-04-24
WO2003017935A9 (en) 2003-04-10
EP1425389A4 (de) 2007-08-01
NZ531211A (en) 2007-04-27
NO333152B1 (no) 2013-03-18
WO2003017935A2 (en) 2003-03-06

Similar Documents

Publication Publication Date Title
ATE531390T1 (de) Interleukin-15-(il-15-)spezifische menschliche antikörper
LTC3284753I2 (de)
TW200500378A (en) Human antibodies specific for interleukin 15 (IL-15)
AU2003303237A8 (en) Human monoclonal antibodies to epidermal growth factor receptor (egfr)
EP1590364A4 (de) Humane monoklonale antikörper gegen interleukin 8 (il-8)
DE60037896D1 (de) Menschliche antikörper gegen her2/neu
DK1210374T3 (da) Humane, monoklonale antistoffer over for prostataspecifikt membranantigen
EA200500835A1 (ru) Человеческие моноклональные антитела против cd25
WO2003064606A3 (en) Human monoclonal antibodies to prostate specific membrane antigen (psma)

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1425389

Country of ref document: EP