IL160358A0 - Human antibodies specific for interleukin 15 (il-15) - Google Patents

Human antibodies specific for interleukin 15 (il-15)

Info

Publication number
IL160358A0
IL160358A0 IL16035802A IL16035802A IL160358A0 IL 160358 A0 IL160358 A0 IL 160358A0 IL 16035802 A IL16035802 A IL 16035802A IL 16035802 A IL16035802 A IL 16035802A IL 160358 A0 IL160358 A0 IL 160358A0
Authority
IL
Israel
Prior art keywords
human
human antibodies
antibodies
interleukin
antibodies specific
Prior art date
Application number
IL16035802A
Other languages
English (en)
Original Assignee
Genmab As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genmab As filed Critical Genmab As
Publication of IL160358A0 publication Critical patent/IL160358A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL16035802A 2001-08-23 2002-08-23 Human antibodies specific for interleukin 15 (il-15) IL160358A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31473101P 2001-08-23 2001-08-23
PCT/US2002/026769 WO2003017935A2 (en) 2001-08-23 2002-08-23 Human antibodies specific for interleukin 15 (il-15)

Publications (1)

Publication Number Publication Date
IL160358A0 true IL160358A0 (en) 2004-07-25

Family

ID=23221192

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16035802A IL160358A0 (en) 2001-08-23 2002-08-23 Human antibodies specific for interleukin 15 (il-15)
IL160358A IL160358A (en) 2001-08-23 2004-02-12 Isolated human monoclonal antibodies specific for interleukin 15 (il-15)

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL160358A IL160358A (en) 2001-08-23 2004-02-12 Isolated human monoclonal antibodies specific for interleukin 15 (il-15)

Country Status (24)

Country Link
US (1) US7153507B2 (de)
EP (1) EP1425389B1 (de)
JP (2) JP4359503B2 (de)
KR (1) KR100911951B1 (de)
CN (1) CN100557018C (de)
AT (1) ATE531390T1 (de)
AU (1) AU2002332628B2 (de)
BR (1) BR0212136A (de)
CA (1) CA2456648C (de)
CY (1) CY1112447T1 (de)
DK (1) DK1425389T3 (de)
EA (1) EA014802B1 (de)
ES (1) ES2375271T3 (de)
HU (1) HU229776B1 (de)
IL (2) IL160358A0 (de)
MX (1) MXPA04001486A (de)
NO (1) NO333152B1 (de)
NZ (1) NZ531211A (de)
PL (1) PL217752B1 (de)
PT (1) PT1425389E (de)
RS (1) RS51829B (de)
SI (1) SI1425389T1 (de)
WO (1) WO2003017935A2 (de)
ZA (1) ZA200401144B (de)

Families Citing this family (287)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385745C (en) 2001-06-08 2015-02-17 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
WO2003017935A2 (en) 2001-08-23 2003-03-06 Genmab A/S Human antibodies specific for interleukin 15 (il-15)
US7329405B2 (en) 2001-08-23 2008-02-12 Genmab A/S Human antibodies specific for interleukin 15 (IL-15)
GB0208817D0 (en) * 2002-04-17 2002-05-29 European Molecular Biology Lab Embl Method for producing monoclonal antibodies
JP4892335B2 (ja) * 2003-02-26 2012-03-07 ゲンマブ エー／エス インターロイキン１５（ｉｌ−１５）に特異的なヒト抗体
NZ570709A (en) 2003-06-13 2010-04-30 Univ Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
US20050123542A1 (en) * 2003-11-06 2005-06-09 Genmab A/S Methods for treating disorders involving monocytes
CA2584211C (en) * 2004-10-22 2014-07-08 Amgen Inc. Methods for refolding of recombinant antibodies
MX2007006832A (es) * 2004-12-13 2007-08-07 Cytos Biotechnology Ag Arreglos de antigeno interleucina 15 y usos de los mismos.
JP5757495B2 (ja) 2005-05-16 2015-07-29 アッヴィ バイオテクノロジー リミテッド びらん性多発性関節炎の治療のためのｔｎｆ阻害剤の使用
WO2006138181A2 (en) 2005-06-14 2006-12-28 Amgen Inc. Self-buffering protein formulations
US20070190057A1 (en) 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
US9399061B2 (en) * 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
US9605064B2 (en) 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
US20080131374A1 (en) * 2006-04-19 2008-06-05 Medich John R Uses and compositions for treatment of rheumatoid arthritis
PE20081760A1 (es) 2007-02-09 2009-01-01 Genentech Inc Anticuerpos anti-robo4 y sus usos
EP2171451A4 (de) 2007-06-11 2011-12-07 Abbott Biotech Ltd Verfahren zur behandlung juveniler idiopathischer arthritis
US20110097318A1 (en) * 2007-08-31 2011-04-28 Amgen Inc. Solid-State Protein Formulation
JP5963341B2 (ja) * 2007-09-14 2016-08-10 アムジエン・インコーポレーテツド 均質な抗体集団
EP2205280B1 (de) 2007-09-27 2019-09-04 Amgen Inc. Pharmazeutische formulierungen
EP2219602A1 (de) 2007-11-15 2010-08-25 Amgen, Inc Wässrige formulierung von mit antioxidantien stabilisiertem erythropoese-stimulierendem protein zur parenteralen verabreichung
TWI468417B (zh) 2007-11-30 2015-01-11 Genentech Inc 抗－ｖｅｇｆ抗體
EP2098536A1 (de) 2008-03-05 2009-09-09 4-Antibody AG Isolation und Identifikation antigen- oder ligandenspezifischer Bindungsproteine
JP2011517672A (ja) * 2008-03-24 2011-06-16 アボツト・バイオテクノロジー・リミテツド 骨損失を治療するための方法及び組成物
CU23716A1 (es) 2008-09-30 2011-10-05 Ct Ingenieria Genetica Biotech Péptido antagonista de la actividad de la interleucina-15
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
AR077595A1 (es) 2009-07-27 2011-09-07 Genentech Inc Tratamientos de combinacion
US9321823B2 (en) 2009-09-02 2016-04-26 Genentech, Inc. Mutant smoothened and methods of using the same
CA2778105C (en) 2009-10-23 2019-04-02 Amgen Inc. Vial adapter and system
US8486397B2 (en) 2009-12-11 2013-07-16 Genentech, Inc. Anti-VEGF-C antibodies and methods using same
PL2515941T3 (pl) 2009-12-21 2020-04-30 F. Hoffmann-La Roche Ag Preparat farmaceutyczny zawierający bewacyzumab
CA2800919C (en) 2010-06-07 2019-01-15 Amgen Inc. Drug delivery device
EP2580243B1 (de) 2010-06-09 2019-10-16 Genmab A/S Antikörper gegen menschliches cd38
RS56599B1 (sr) 2010-06-15 2018-02-28 Genmab As Konjugati humanog antitela sa lekom protiv tkivnog faktora
DK2625197T3 (en) 2010-10-05 2016-10-03 Genentech Inc Smoothened MUTANT AND METHODS OF USING THE SAME
WO2012135315A1 (en) 2011-03-31 2012-10-04 Amgen Inc. Vial adapter and system
AU2012245231B2 (en) 2011-04-20 2016-10-13 Amgen Inc. Autoinjector apparatus
CN102250243B (zh) * 2011-07-01 2013-08-28 华绍炳 抗白细胞介素-15抗体
ES2682750T5 (en) * 2011-07-18 2025-02-04 Iba Lifesciences Gmbh Method of reversibly staining a target cell
EA030868B1 (ru) 2011-10-14 2018-10-31 Эмджен Инк. Инжектор и способ его сборки
EP3072548B1 (de) 2012-11-21 2019-03-06 Amgen, Inc Arzneimittelabgabevorrichtung
EP2958941B1 (de) 2013-02-20 2019-04-10 Innate Pharma Verbindung mit spezifischer bindung an kir3dl2 zur verwendung bei der behandlung von peripherem t-zell-lymphom
PT2968467T (pt) 2013-03-13 2020-07-28 Hoffmann La Roche Formulações de oxidação reduzida
RU2707092C2 (ru) 2013-03-13 2019-11-22 Дженентек, Инк. Составы со сниженным окислением
US20140314778A1 (en) 2013-03-13 2014-10-23 Genentech, Inc. Formulations with reduced oxidation
AR095399A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida, método
WO2014160490A1 (en) 2013-03-13 2014-10-02 Genetech, Inc. Antibody formulations
BR112015021993A8 (pt) 2013-03-15 2019-12-03 Genentech Inc polipeptídeo, métodos para sua produção, métodos para cultivo de uma célula, composição farmacêutica, kit, e meio de cultura celular
ES2973257T3 (es) 2013-03-15 2024-06-19 Amgen Inc Casete de fármaco, autoinyector y sistema de autoinyector
CN105142695B (zh) 2013-03-15 2020-06-02 安进公司 身体轮廓可调适的自动注射器装置
EP3593839A1 (de) 2013-03-15 2020-01-15 Amgen Inc. Arzneimittelkassette
CA2897825C (en) 2013-03-22 2022-05-24 Scott R. Gibson Injector and method of assembly
LT3049441T (lt) 2013-09-27 2020-02-10 F. Hoffmann-La Roche Ag Anti-pdl1 antikūnų kompozicija
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
AU2014340174B2 (en) 2013-10-24 2019-09-12 Amgen Inc. Drug delivery system with temperature-sensitive control
MY189089A (en) 2013-12-17 2022-01-25 Genentech Inc Methods of treating cancers using pd-1 axis binding antagonists and taxanes
WO2015095410A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
AU2014364606A1 (en) 2013-12-17 2016-07-07 Genentech, Inc. Combination therapy comprising OX40 binding agonists and PD-1 axis binding antagonists
WO2015120075A2 (en) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened and methods of using the same
US10994112B2 (en) 2014-02-05 2021-05-04 Amgen Inc. Drug delivery system with electromagnetic field generator
MX2016012779A (es) 2014-03-31 2017-04-27 Genentech Inc Terapia de combinacion con agentes antiangiogénesis y agonistas de unión a ox40.
CA3193070A1 (en) 2014-05-07 2015-11-12 Amgen Inc. Autoinjector with shock reducing elements
JP6817074B2 (ja) 2014-06-03 2021-01-20 アムジエン・インコーポレーテツド 制御可能な薬物送達システム及び使用方法
EP2963057A1 (de) 2014-07-02 2016-01-06 Calypso Biotech SA Antikörper zu IL-15
US20160137727A1 (en) 2014-09-15 2016-05-19 Genentech, Inc. Antibody formulations
JP6766040B2 (ja) 2014-10-14 2020-10-07 アムジエン・インコーポレーテツド 視覚および可聴インジケータを備える薬剤注射装置
EP3209332B1 (de) 2014-10-23 2021-05-26 Amgen Inc. Verringerung der viskosität von pharmazeutischen formulierungen
SG10201807625PA (en) 2014-11-17 2018-10-30 Genentech Inc Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
EP3848072A1 (de) 2014-12-19 2021-07-14 Amgen Inc. Medikamentenabgabevorrichtung mit näherungssensor
JP2017538512A (ja) 2014-12-19 2017-12-28 アムジエン・インコーポレーテツド ライブボタンまたはユーザインタフェースフィールドを含む薬物送達装置
EP3253784B1 (de) 2015-02-04 2020-05-06 Genentech, Inc. Smoothened-mutant und verfahren zur verwendung davon
WO2016133947A1 (en) 2015-02-17 2016-08-25 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
ES2905870T3 (es) 2015-02-27 2022-04-12 Amgen Inc Dispositivo de suministro de fármacos que tiene un mecanismo de protección de aguja con un umbral de resistencia ajustable al movimiento de la protección de aguja
CN116327953A (zh) 2015-06-17 2023-06-27 豪夫迈·罗氏有限公司 使用pd-1轴结合拮抗剂和紫杉烷治疗局部晚期或转移性乳腺癌的方法
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
WO2017027861A1 (en) 2015-08-13 2017-02-16 Amgen Inc. Charged depth filtration of antigen-binding proteins
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
EP3386573B1 (de) 2015-12-09 2019-10-02 Amgen Inc. Autoinjektor mit signalhaube
BR112018010945A2 (pt) 2015-12-30 2018-12-04 Genentech Inc formulações com degradação de polissorbato reduzida
AU2016381694A1 (en) 2015-12-30 2018-07-05 Genentech, Inc. Use of tryptophan derivatives for protein formulations
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
KR20180097615A (ko) 2016-01-08 2018-08-31 에프. 호프만-라 로슈 아게 Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법
EP3411396A1 (de) 2016-02-04 2018-12-12 Curis, Inc. Smoothened-mutant und verfahren zur verwendung davon
US11200298B2 (en) 2016-03-15 2021-12-14 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
WO2017159699A1 (en) 2016-03-15 2017-09-21 Chugai Seiyaku Kabushiki Kaisha Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies
WO2017189089A1 (en) 2016-04-29 2017-11-02 Amgen Inc. Drug delivery device with messaging label
US11389588B2 (en) 2016-05-02 2022-07-19 Amgen Inc. Syringe adapter and guide for filling an on-body injector
EP3455142B1 (de) 2016-05-13 2023-08-09 Amgen Inc. Ampullenhülsenanordnung
US11238150B2 (en) 2016-05-16 2022-02-01 Amgen Inc. Data encryption in medical devices with limited computational capability
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
WO2017209899A1 (en) 2016-06-03 2017-12-07 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
US20180002417A1 (en) * 2016-06-15 2018-01-04 Celimmune Llc Methods and Compositions for the Treatment of Celiac Disease, Non-Celiac Gluten Sensitivity, and Refractory Celiac Disease
WO2018004842A1 (en) 2016-07-01 2018-01-04 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
JP7250674B2 (ja) 2016-08-08 2023-04-03 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト がんの治療及び診断方法
US20190328965A1 (en) 2016-08-17 2019-10-31 Amgen Inc. Drug delivery device with placement detection
US11459401B2 (en) 2016-10-06 2022-10-04 Amgen Inc. Reduced viscosity protein pharmaceutical formulations
US20180110856A1 (en) * 2016-10-21 2018-04-26 Amgen Inc. Pharmaceutical Formulations and Methods of Making the Same
WO2018081234A1 (en) 2016-10-25 2018-05-03 Amgen Inc. On-body injector
AU2017382850B2 (en) * 2016-12-21 2024-11-21 Cephalon Llc Antibodies that specifically bind to human IL-15 and uses thereof
JP7139332B2 (ja) 2016-12-23 2022-09-20 ノバルティス アーゲー 第ｘｉ因子抗体および使用方法
MX2019008432A (es) 2017-01-17 2019-11-18 Amgen Inc Dispositivos de inyeccion y metodos relacionados de uso y ensamblaje.
EP3582825A1 (de) 2017-02-17 2019-12-25 Amgen Inc. Wirkstofffreisetzungsvorrichtung mit steriler fluidströmung und zugehöriges verfahren zur montage
CA3052204A1 (en) 2017-02-17 2018-08-23 Amgen Inc. Insertion mechanism for drug delivery device
JP7377596B2 (ja) 2017-02-22 2023-11-10 アムジエン・インコーポレーテツド 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
JP2020508803A (ja) 2017-03-06 2020-03-26 アムジエン・インコーポレーテツド 作動防止特徴部を備える薬物送達デバイス
AU2018230546B2 (en) 2017-03-07 2024-03-21 Amgen Inc. Needle insertion by overpressure
CA3052310A1 (en) 2017-03-09 2018-09-13 Amgen Inc. Insertion mechanism for drug delivery device
KR20240042212A (ko) 2017-03-28 2024-04-01 암겐 인코포레이티드 플런저 로드 및 주사기 조립 시스템 및 방법
AU2018257917B2 (en) 2017-04-24 2023-05-04 University Of Massachusetts Diagnosis and treatment of vitiligo
US12103979B2 (en) 2017-04-28 2024-10-01 Amgen Inc. N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides
AU2018282077B2 (en) 2017-06-08 2023-11-23 Amgen Inc. Torque driven drug delivery device
WO2018226515A1 (en) 2017-06-08 2018-12-13 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
JP7195276B2 (ja) 2017-06-22 2022-12-23 アムジエン・インコーポレーテツド デバイス起動による衝突／衝撃の低減
EP3641861A1 (de) 2017-06-23 2020-04-29 Amgen Inc. Elektronische arzneimittelabgabevorrichtung mit einer durch eine schaltungsanordnung aktivierten kappe
WO2019014014A1 (en) 2017-07-14 2019-01-17 Amgen Inc. NEEDLE INSERTION-RETRACTING SYSTEM HAVING DOUBLE TORSION SPRING SYSTEM
IL271173B2 (en) 2017-07-21 2024-04-01 Amgen Inc Gas permeable sealing member for drug container and methods of assembly
EP4085942A1 (de) 2017-07-25 2022-11-09 Amgen Inc. Arzneimittelabgabevorrichtung mit getriebemodul und verwandtes verfahren zur montage
MA49676A (fr) 2017-07-25 2020-06-03 Amgen Inc Dispositif d'administration de médicament doté d'un système d'accès à un récipient et procédé d'assemblage associé
EP3662287B1 (de) 2017-08-01 2024-02-28 Amgen Inc. Systeme und verfahren zur echtzeit probenvorbereitung von polypetides zur analyse mittels massenspektrometrie
SG11202000785VA (en) 2017-08-01 2020-02-27 Amgen Inc Systems and methods for performing a real-time glycan assay of a sample
WO2019032482A2 (en) 2017-08-09 2019-02-14 Amgen Inc. HYDRAULIC-PNEUMATIC PRESSURE CHAMBER DELIVERY SYSTEM
WO2019036181A1 (en) 2017-08-18 2019-02-21 Amgen Inc. BODY INJECTOR WITH STERILE ADHESIVE PATCH
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
EP3691717B1 (de) 2017-10-04 2023-02-08 Amgen Inc. Durchflussadapter für arzneimittelabgabevorrichtung
EP3691716B1 (de) 2017-10-06 2023-11-29 Amgen Inc. Arzneimittelabgabevorrichtung mit verriegelungsvorrichtung und zugehöriges montageverfahren
EP3694578B1 (de) 2017-10-09 2025-09-24 Amgen Inc. Arzneimittelabgabevorrichtung mit antriebsanordnung sowie zugehöriges verfahren zur montage
EP3703779A1 (de) 2017-11-03 2020-09-09 Amgen Inc. Systeme und ansätze zur sterilisation einer arzneimittelabgabevorrichtung
MA50569A (fr) 2017-11-06 2020-09-16 Amgen Inc Ensembles de remplissage-finition et procédés associés
US20200261648A1 (en) 2017-11-06 2020-08-20 Amgen Inc. Drug delivery device with placement and flow sensing
EP3706826A1 (de) 2017-11-10 2020-09-16 Amgen Inc. Kolben für wirkstofffreisetzungsvorrichtungen
SG11202003004RA (en) 2017-11-16 2020-04-29 Amgen Inc Door latch mechanism for drug delivery device
MA50903A (fr) 2017-11-16 2021-05-12 Amgen Inc Auto-injecteur avec détection de décrochage et de point d'extrémité
WO2019143753A1 (en) 2018-01-17 2019-07-25 Amgen Inc. Drug delivery mechanism
MA52268A (fr) 2018-03-07 2021-01-13 Amgen Inc Seringue à distribution contrôlée
JP7747440B2 (ja) 2018-03-09 2025-10-01 アムジエン・インコーポレーテツド 薬物送達デバイスの逆流防止機構
IL277106B2 (en) 2018-03-13 2024-03-01 Amgen Inc Sequential digestion of polypeptides for mass spectrometric analysis
EP4321870B1 (de) 2018-03-13 2025-07-30 Amgen Inc. Verfahren zur herstellung von trypsinresistenten polypeptiden für massenspektrometrische analyse
SG11202007756XA (en) 2018-03-30 2020-09-29 Amgen Inc Camera-based drug container inspection
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
SG11202012446UA (en) 2018-06-23 2021-01-28 Genentech Inc Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
EP3823611A1 (de) 2018-07-18 2021-05-26 Genentech, Inc. Verfahren zur behandlung von lungenkrebs mit einem pd-1-achsen-bindenden antagonisten, einem antimetabolit und einem platinmittel
WO2020023451A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Delivery devices for administering drugs
US12303677B2 (en) 2018-07-24 2025-05-20 Amgen Inc. Hybrid drug delivery devices with optional grip portion and related method of preparation
CA3103681A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Delivery devices for administering drugs
WO2020023336A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with grip portion
JP2021530243A (ja) 2018-07-25 2021-11-11 アスクジーン・ファーマ・インコーポレイテッドAskGene Pharma, Inc. 新規ｉｌ−２１プロドラッグおよびそれを使用する方法
CA3103105A1 (en) 2018-07-31 2020-02-06 Amgen Inc. Fluid path assembly for a drug delivery device
EP3833389A1 (de) 2018-08-08 2021-06-16 Genentech, Inc. Verwendung von tryptophan-derivaten und l-methionin zur proteinformulierung
SG11202013189WA (en) 2018-08-17 2021-01-28 Amgen Inc Activation mechanism for drug delivery device
AU2019342133B8 (en) 2018-09-21 2025-08-07 Genentech, Inc. Diagnostic methods for triple-negative breast cancer
WO2020068623A1 (en) 2018-09-24 2020-04-02 Amgen Inc. Interventional dosing systems and methods
IL281469B2 (en) 2018-09-28 2024-08-01 Amgen Inc Muscle wire escapement activation assembly for a drug delivery device
JP2022503983A (ja) 2018-10-02 2022-01-12 アムジエン・インコーポレーテツド 内力伝達を伴う薬物送達用の注入システム
EP3860686A1 (de) 2018-10-05 2021-08-11 Amgen Inc. Medikamentenabgabevorrichtung mit dosisindikator
KR102848295B1 (ko) 2018-10-15 2025-08-20 암젠 인크 댐핑 메커니즘을 갖는 약물 전달 장치
EA202191038A1 (ru) 2018-10-15 2021-07-06 Эмджен Инк. Способ платформенной сборки для устройства доставки лекарственного средства
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
MA54057A (fr) 2018-11-01 2022-02-09 Amgen Inc Dispositifs d'administration de médicament à rétraction partielle d'élément d'administration de médicament
EP3873566B1 (de) 2018-11-01 2024-11-27 Amgen Inc. Vorrichtung zur verabreichung von medikamenten mit teilweisem rückzug des medikamentenabgabeelements
JP7769544B2 (ja) 2018-12-14 2025-11-13 アムジエン・インコーポレーテツド 勾配によるタンパク質濃度定量を伴う使用のためのシステム適合性方法
US11534547B2 (en) 2019-01-24 2022-12-27 Amgen Inc. Drug delivery systems and methods with pressure sensitive control
EP3914320A1 (de) 2019-01-24 2021-12-01 Amgen Inc. Wirkstoffabgabesysteme und verfahren mit gegendruckerfassung
US20220087901A1 (en) 2019-02-12 2022-03-24 Amgen Inc. Systems and approaches for drug delivery device reconstitution
ES2997201T3 (en) 2019-02-12 2025-02-14 Amgen Inc Take-home drug delivery system
EP3924019A1 (de) 2019-02-12 2021-12-22 Amgen Inc. Kontinuierliche dosiersysteme und ansätze
WO2020167704A1 (en) 2019-02-12 2020-08-20 Amgen Inc. Continuous dosing systems and approaches
US20220072224A1 (en) 2019-02-12 2022-03-10 Amgen Inc. Continuous dosing systems and approaches
US12329720B2 (en) 2019-02-12 2025-06-17 Amgen Inc. Dosing systems and approaches
JP7483731B2 (ja) 2019-02-14 2024-05-15 アムジエン・インコーポレーテツド 試料の調製及びその試料のリアルタイムアッセイの実施のためのシステム及び方法
JP7530376B2 (ja) 2019-02-20 2024-08-07 アムジエン・インコーポレーテツド タンパク質の安定性を決定する方法
MX2021010414A (es) 2019-03-04 2021-09-14 Amgen Inc Reversibilidad in vivo de especies de alto peso molecular.
AU2020245573B2 (en) 2019-03-27 2025-11-20 Amgen Inc. Methods of fingerprinting therapeutic proteins via a two-dimensional (2D) nuclear magnetic resonance technique at natural abundance for formulated biopharmaceutical products
US11464706B2 (en) 2019-04-08 2022-10-11 Amgen Inc. Automated drug delivery device and container
MX2021012233A (es) 2019-04-09 2021-11-03 Amgen Inc Dispositivo de administracion de farmacos con mango inteligente.
MX2021012476A (es) 2019-04-17 2021-11-12 Amgen Inc Cartucho para un autoinyector y metodos relacionados.
MX2021012557A (es) 2019-04-24 2021-11-12 Amgen Inc Conjuntos y metodos de verificacion de esterilizacion de jeringuillas.
EP3958925A1 (de) 2019-04-24 2022-03-02 Amgen Inc. Zubehörteile für injektor
WO2020247790A1 (en) 2019-06-05 2020-12-10 Amgen Inc. Methods of identifying attributes of therapeutic proteins
WO2020252264A1 (en) 2019-06-12 2020-12-17 AskGene Pharma, Inc. Novel il-15 prodrugs and methods of use thereof
CA3137544A1 (en) 2019-06-20 2020-12-24 Amgen Inc. Wireless communication enabled drug delivery device and method
WO2021011716A1 (en) 2019-07-18 2021-01-21 Amgen Inc. Drug delivery device having pressurized vessel
WO2021011717A1 (en) 2019-07-18 2021-01-21 Amgen Inc. Sealing arrangement for drug delivery device
MX2022001112A (es) 2019-08-01 2022-02-16 Amgen Inc Dispositivo de suministro de farmacos con medicion de la temperatura y metodo relacionado.
EP4017560A2 (de) 2019-08-23 2022-06-29 Amgen, Inc Arzneimittelabgabevorrichtung mit konfigurierbaren nadelschutzeingriffskomponenten und zugehörige verfahren
JP2022546082A (ja) 2019-09-03 2022-11-02 アムジエン・インコーポレーテツド 薬物送達のための注入デバイス及び注入デバイスのためのパッケージ
CA3150480A1 (en) 2019-09-03 2021-03-11 Amgen Inc. Activatable injection device for drug delivery
US20220362462A1 (en) 2019-09-12 2022-11-17 Amgen Inc. Backflow Prevention Mechanism for Drug Delivery Device
MX2022002980A (es) 2019-09-16 2022-04-06 Amgen Inc Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos.
MX2022003802A (es) 2019-09-30 2022-04-29 Amgen Inc Dispositivo de administracion de farmacos.
FI4037735T3 (fi) 2019-09-30 2025-11-25 Amgen Inc Lääkeaineen annostelulaite
JP2022549349A (ja) 2019-09-30 2022-11-24 アムジエン・インコーポレーテツド 薬物送達デバイス
US20210093797A1 (en) 2019-09-30 2021-04-01 Amgen Inc. Drug delivery device
EP4037731A1 (de) 2019-09-30 2022-08-10 Amgen Inc. Arzneimittelabgabevorrichtung und verfahren zur abgabe eines arzneimittels
CN114450048B (zh) 2019-09-30 2025-02-18 美国安进公司 药物递送装置
EP4041649A1 (de) * 2019-10-07 2022-08-17 Amgen Inc. Verpackungen für pharmazeutische produkte und verfahren zur montage
WO2021071763A1 (en) 2019-10-07 2021-04-15 Amgen Inc. Needle insertion mechanism for drug delivery device
WO2021071780A1 (en) 2019-10-07 2021-04-15 Amgen Inc. Drug delivery devices having light-activated ultrasonic fluid delivery
ES3049662T3 (en) 2019-10-07 2025-12-17 Amgen Inc Drug delivery device with fingerprint sensor
AU2020362062B2 (en) 2019-10-08 2025-07-10 Amgen Inc. Temperature indicator for drug delivery device
US20240100247A1 (en) 2019-10-08 2024-03-28 Amgen Inc. Needle insertion mechanism for drug delivery device
US20240082502A1 (en) 2019-10-08 2024-03-14 Amgen Inc. Drug delivery device
EP4041352A1 (de) 2019-10-08 2022-08-17 Amgen Inc. Kassette für einen autoinjektor und zugehörige verfahren
EP4044989A1 (de) 2019-10-18 2022-08-24 Amgen Inc. Systeme und ansätze zur rekonstitution von vorrichtungen zur medikamentenabgabe
MX2022004483A (es) 2019-10-18 2022-05-06 Amgen Inc Sistemas y enfoques para reconstitucion en dispositivo de administracion de farmacos.
EP4045108A1 (de) 2019-10-18 2022-08-24 Amgen Inc. Medikamentenabgabevorrichtung und system
WO2021076826A2 (en) 2019-10-18 2021-04-22 Amgen Inc. Drug delivery device and system
US20220401643A1 (en) 2019-10-21 2022-12-22 Amgen Inc. Drug product container and drug delivery system
EP4048344A1 (de) 2019-10-24 2022-08-31 Amgen Inc. Arzneimittelabgabevorrichtung
WO2021080822A1 (en) 2019-10-24 2021-04-29 Amgen Inc. Systems and methods for drug delivery
WO2021081321A1 (en) 2019-10-24 2021-04-29 Amgen Inc. Systems and approaches for drug delivery
WO2021081161A1 (en) 2019-10-24 2021-04-29 Amgen Inc. Systems and components for drug delivery and components for preparation of the same
EP4048345A1 (de) 2019-10-24 2022-08-31 Amgen, Inc Arzneimittelabgabevorrichtung und system
US20220395635A1 (en) 2019-11-07 2022-12-15 Amgen Inc. Drug delivery system and method of use
WO2021113101A1 (en) 2019-12-02 2021-06-10 Amgen Inc. Lockout mechanism for drug delivery device
WO2021113070A1 (en) 2019-12-05 2021-06-10 Amgen Inc, Flow restrictor for drug delivery device
AU2021205981A1 (en) 2020-01-11 2022-07-14 AskGene Pharma, Inc. Novel masked cytokines and methods of use thereof
CN114901330A (zh) 2020-01-13 2022-08-12 美国安进公司 针头护罩移除器、药物递送装置、以及相关方法
AU2021226754A1 (en) 2020-02-24 2022-07-07 Amgen Inc. Containers and systems for use during external sterilization of drug delivery devices
CA3170639A1 (en) 2020-03-16 2021-09-23 Amgen Inc. Drug delivery member insertion sensing assemblies, drug delivery devices, and related methods
CN115209931B (zh) 2020-03-17 2025-05-13 美国安进公司 受控式分配注射器
EP4143811A1 (de) 2020-04-28 2023-03-08 Amgen Inc. Verpackungsetikett
MX2022014688A (es) 2020-05-22 2022-12-16 Amgen Inc Sistema de almacenamiento y metodo para almacenar y transportar medicamentos.
WO2021257503A1 (en) 2020-06-16 2021-12-23 Genentech, Inc. Methods and compositions for treating triple-negative breast cancer
JP2023540484A (ja) 2020-09-02 2023-09-25 アムジエン・インコーポレーテツド 薬剤保管カートン用の簡易開封装置
EP4210805A1 (de) 2020-09-09 2023-07-19 Amgen Inc. Schluckbare wirkstofffreisetzungsvorrichtungen
WO2022055761A1 (en) 2020-09-11 2022-03-17 Amgen Inc. Inline uv flow device for sterilizing flow cytometry sheath fluid
AU2021343495A1 (en) 2020-09-18 2023-04-27 Amgen Inc. Methods of processing a sample for peptide mapping analysis
CA3192737A1 (en) 2020-10-12 2022-04-21 Amgen Inc. Long-term medicament storage apparatus and methods
CA3196039A1 (en) 2020-11-04 2022-05-12 Amgen Inc. Drug delivery device assembly and accessory for drug delivery device
JP7775312B2 (ja) 2020-11-04 2025-11-25 アムジエン・インコーポレーテツド 薬物送達デバイスアセンブリ及び薬物送達デバイス用アクセサリ
US20230381423A1 (en) 2020-11-04 2023-11-30 Amgen Inc. Drug delivery device assembly and accessory for drug delivery device
US20230381426A1 (en) 2020-11-04 2023-11-30 Amgen Inc. Drug delivery device assembly and accessory for drug delivery device
US20240010672A1 (en) 2020-11-05 2024-01-11 Amgen Inc. Materials and methods for protein processing
US20240115462A1 (en) 2021-02-03 2024-04-11 Amgen Inc. High-throughput automated reconstitution of lyophilized drug product
CN116782993A (zh) 2021-02-03 2023-09-19 美国安进公司 用于药物加工的系统和方法
US20240082110A1 (en) 2021-02-03 2024-03-14 Amgen Inc. Coaxial needle adapter and guide bracket for robotic liquid handling platform
IL305213A (en) 2021-03-08 2023-10-01 Amgen Inc Manufacturing process for a hollow piston rod
US20220288326A1 (en) 2021-03-10 2022-09-15 Amgen Inc. Drug delivery device, subassembly for drug delivery device, syringe holder, and method of assembly
WO2022192311A1 (en) 2021-03-10 2022-09-15 Amgen Inc. Drug delivery device
WO2022192308A1 (en) 2021-03-10 2022-09-15 Amgen Inc. Drug delivery device having removable cap
MX2023011160A (es) 2021-03-25 2023-09-29 Amgen Inc Dispositivo de administracion de farmacos.
WO2022212227A1 (en) 2021-03-31 2022-10-06 Amgen Inc. Sound-detection based injection time measurement system for drug delivery devices
WO2022225736A1 (en) 2021-04-22 2022-10-27 Amgen Inc. Methods and systems for automated syringe quality evaluation
EP4330974A1 (de) 2021-04-28 2024-03-06 Amgen Inc. Systeme zur ambulanten behandlung eines patienten und zugehörige verfahren
WO2022245574A1 (en) 2021-05-17 2022-11-24 Amgen Inc. Feedback system and method for a drug product
BR112023024278A2 (pt) 2021-05-21 2024-01-30 Amgen Inc Método de otimizar uma receita de enchimento para um recipiente de fármacos
EP4348141A1 (de) 2021-06-01 2024-04-10 Amgen Inc. Lyophilisierungssystem
JP2024521571A (ja) 2021-06-08 2024-06-03 アムジエン・インコーポレーテツド 薬物送達デバイス、フィンガーグリップ要素及び関連する方法
EP4355395A1 (de) 2021-06-17 2024-04-24 Amgen Inc. Arzneimittelabgabevorrichtung mit stossdämpfer
CA3224996A1 (en) 2021-06-23 2022-12-29 Amgen Inc. Syringes, assemblies, and methods of manufacture
WO2023278125A1 (en) 2021-06-28 2023-01-05 Amgen Inc. Safety device for drug delivery system
EP4370087A1 (de) 2021-07-16 2024-05-22 Amgen Inc. Systeme und ansätze zur arzneimittelverarbeitung von einweg-hardware
JP2024537009A (ja) 2021-09-29 2024-10-10 アムジエン・インコーポレーテツド 事前充填シリンジにおけるプランジャストッパの深さ測定用の装置、システム及び方法
EP4412682A1 (de) 2021-10-06 2024-08-14 Amgen Inc. Durch stoss aktivierte bremsfunktion für eine arzneimittelabgabevorrichtung
TW202327673A (zh) 2021-10-06 2023-07-16 美商安進公司 用於藥物遞送裝置的撞擊啟動式固位特徵
US20240408308A1 (en) 2021-10-11 2024-12-12 Amgen Inc. Characterization apparatus for drug delivery devices or subcomponents thereof
AU2022382741A1 (en) 2021-11-05 2024-04-04 Amgen Inc. Drug delivery devices, components for use within drug delivery devices
TW202325853A (zh) 2021-11-09 2023-07-01 美商安進公司 治療性蛋白之生產
TW202335693A (zh) 2021-11-29 2023-09-16 美商安進公司 活塞桿移除力方法及設備
US20250009976A1 (en) 2021-12-03 2025-01-09 Amgen Inc. Stopper placement in a syringe
CN118829460A (zh) 2022-03-11 2024-10-22 美国安进公司 可调节深度的自动注入器
EP4504295A1 (de) 2022-04-06 2025-02-12 Amgen Inc. Verpackung für eine arzneimittelabgabevorrichtung
WO2024028448A1 (en) 2022-08-04 2024-02-08 Calypso Biotech Sa Il-15 inhibitors useful for the treatment of atopic dermatitis
WO2024040020A1 (en) 2022-08-15 2024-02-22 Absci Corporation Quantitative affinity activity specific cell enrichment
CN119730894A (zh) 2022-08-18 2025-03-28 美国安进公司 用于注射器的针头护罩组件
IL318145A (en) 2022-08-18 2025-03-01 Amgen Inc Needle shield for syringe
AU2023333370A1 (en) 2022-08-30 2025-01-16 Amgen Inc. System and method of limiting subvisible particles in a syringe
WO2024228970A1 (en) 2023-05-01 2024-11-07 Amgen Inc. Configurable handheld biological analyzers for identification of biological products based on raman spectroscopy using artificial intelligence
CN118894934A (zh) 2023-05-05 2024-11-05 北京智仁美博生物科技有限公司 抗人il-15的抗体及其用途
WO2024259275A1 (en) 2023-06-14 2024-12-19 Bristol-Myers Squibb Company Near real time sialic acid quantitation of glycoproteins
WO2025019224A1 (en) 2023-07-14 2025-01-23 Amgen Inc. Monitoring systems and methods for injection devices
WO2025072072A1 (en) 2023-09-26 2025-04-03 Amgen Inc. Packaging systems for medical devices
WO2025101602A1 (en) 2023-11-07 2025-05-15 Amgen Inc. Methods of analyzing amino acid content of a therapeutic protein
CN117209605B (zh) * 2023-11-09 2024-01-30 北京百普赛斯生物科技股份有限公司 特异性结合il-15的抗体及其应用
US20250171175A1 (en) 2023-11-28 2025-05-29 Amgen Inc. Automated systems and methods for foil packaging components
WO2025136894A1 (en) 2023-12-18 2025-06-26 Amgen Inc. Ampoule adapter and method of use
WO2025136766A1 (en) 2023-12-20 2025-06-26 Amgen Inc. Packaging for drug administration
WO2025144700A1 (en) 2023-12-27 2025-07-03 Absci Corporation Nanobody library screening using bacterial surface display
US20250269119A1 (en) 2024-02-28 2025-08-28 Amgen Inc. Drug delivery device
TW202535330A (zh) 2024-02-29 2025-09-16 美商安進公司 用於製藥用途的容器的可持續和模組化包裝系統
WO2025213011A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Method of assessing stopper movement in a drug delivery device
WO2025222117A1 (en) 2024-04-19 2025-10-23 Amgen Inc. Drug delivery device
WO2025255028A1 (en) 2024-06-03 2025-12-11 Amgen Inc. High-throughput liquid chromatography-mass spectrometry-based peptide mapping

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE139258T1 (de) * 1990-01-12 1996-06-15 Cell Genesys Inc Erzeugung xenogener antikörper
US6255458B1 (en) * 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5574138A (en) 1993-03-08 1996-11-12 Immunex Corporation Epithelium-derived T-cell factor
US5591630A (en) * 1994-05-06 1997-01-07 Immunex Corporation Monoclonal antibodies that bind interleukin-15 receptors
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
DE69622854T2 (de) 1995-04-02 2003-04-10 Chugai Seiyaku K.K., Tokio/Tokyo Arzneimittel zur Heilung von Thrombozytopenie
EP0823941A4 (de) 1995-04-28 2001-09-19 Abgenix Inc Menschliche antikörper aus xenomäusen
US5660824A (en) 1995-05-24 1997-08-26 Grabstein; Kenneth H. Muscle trophic factor
CN1241944C (zh) * 1995-09-11 2006-02-15 协和发酵工业株式会社 抗人白介素－5受体α链的抗体
US6001973A (en) 1996-04-26 1999-12-14 Beth Israel Deaconess Medical Center Antagonists of interleukin-15
WO1998016254A1 (en) 1996-10-17 1998-04-23 Immunomedics, Inc. Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
DE69810091T2 (de) 1997-02-21 2003-10-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw., Zwijnaarde Verwendung von interleukin-15
JP4082740B2 (ja) * 1997-02-28 2008-04-30 キリンファーマ株式会社 内因性遺伝子が破壊されている分化多能性保持細胞
GB9814892D0 (en) 1998-07-10 1998-09-09 Kennedy Rheumatology Inst Treatment of celiac disease
WO2001002003A1 (en) 1999-07-06 2001-01-11 Bulfone Paus Silvia Method of treating psoriasis with il-15 antagonist
WO2003017935A2 (en) 2001-08-23 2003-03-06 Genmab A/S Human antibodies specific for interleukin 15 (il-15)

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AU2002332628B2 (en) 2007-07-26
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