CY1118994T1 - Πρωτεϊνες συνδεσης αντιγονου il-17 υποδοχεα α - Google Patents
Πρωτεϊνες συνδεσης αντιγονου il-17 υποδοχεα αInfo
- Publication number
- CY1118994T1 CY1118994T1 CY20171100544T CY171100544T CY1118994T1 CY 1118994 T1 CY1118994 T1 CY 1118994T1 CY 20171100544 T CY20171100544 T CY 20171100544T CY 171100544 T CY171100544 T CY 171100544T CY 1118994 T1 CY1118994 T1 CY 1118994T1
- Authority
- CY
- Cyprus
- Prior art keywords
- container
- antibodies
- receptor
- protection connection
- proteins
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε πρωτεΐνες σύνδεσης αντιγόνου υποδοχέα A IL-17 (IL-17RA ή IL-17R), όπως αντισώματα, αλληλουχίες πολυνουκλεοτιδίου που κωδικοποιούν τις εν λόγω πρωτεΐνες σύνδεσης αντιγόνου και συνθέσεις και μεθόδους για διάγνωση και θεραπεία ασθενειών που προκαλούνται από ενεργοποίηση υποδοχέα IL-17 με έναν ή περισσότερους συνδέτες IL-17. Η παρούσα εφεύρεση αφορά στην πιστοποίηση εξουδετερωτικών προσδιοριστών επί υποδοχέα A IL-17 (IL-17RA ή IL-17R) και αντισώματα που συνδέονται προς αυτούς. Απόψεις της εφεύρεσης επίσης περιλαμβάνουν αντισώματα που ανταγωνίζονται για σύνδεση με τα IL-17RA εξουδετερωτικά αντισώματα που περιγράφονται στο παρόν.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82788206P | 2006-10-02 | 2006-10-02 | |
US87307206P | 2006-12-05 | 2006-12-05 | |
US96989507P | 2007-09-04 | 2007-09-04 | |
EP07867194.8A EP2076541B1 (en) | 2006-10-02 | 2007-10-01 | Il-17 receptor a antigen binding proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118994T1 true CY1118994T1 (el) | 2018-01-10 |
Family
ID=39344834
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100442T CY1116291T1 (el) | 2006-10-02 | 2015-05-18 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17 |
CY20171100296T CY1118845T1 (el) | 2006-10-02 | 2017-03-07 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα α il-17 |
CY20171100544T CY1118994T1 (el) | 2006-10-02 | 2017-05-25 | Πρωτεϊνες συνδεσης αντιγονου il-17 υποδοχεα α |
CY2018001C CY2018001I2 (el) | 2006-10-02 | 2018-01-15 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17 |
CY20221100181T CY1125133T1 (el) | 2006-10-02 | 2022-03-02 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100442T CY1116291T1 (el) | 2006-10-02 | 2015-05-18 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17 |
CY20171100296T CY1118845T1 (el) | 2006-10-02 | 2017-03-07 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα α il-17 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2018001C CY2018001I2 (el) | 2006-10-02 | 2018-01-15 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17 |
CY20221100181T CY1125133T1 (el) | 2006-10-02 | 2022-03-02 | Πρωτεϊνες συνδεσης αντιγονου υποδοχεα a il-17 |
Country Status (30)
Country | Link |
---|---|
US (15) | US7833527B2 (el) |
EP (4) | EP2518085B1 (el) |
JP (1) | JP5013383B2 (el) |
KR (2) | KR101240903B1 (el) |
CN (1) | CN103214576B (el) |
AR (1) | AR063090A1 (el) |
AU (2) | AU2007314519C1 (el) |
BR (1) | BRPI0719762B8 (el) |
CA (1) | CA2663537C (el) |
CL (1) | CL2007002800A1 (el) |
CR (1) | CR10760A (el) |
CY (5) | CY1116291T1 (el) |
DK (4) | DK2518085T3 (el) |
EA (1) | EA019397B1 (el) |
ES (4) | ES2624921T3 (el) |
HU (4) | HUE032421T2 (el) |
IL (3) | IL197636B (el) |
LT (4) | LT3165539T (el) |
LU (1) | LUC00056I2 (el) |
MX (1) | MX2009003511A (el) |
MY (1) | MY187263A (el) |
NL (1) | NL300919I2 (el) |
NO (2) | NO344867B1 (el) |
NZ (1) | NZ575631A (el) |
PE (2) | PE20120832A1 (el) |
PL (4) | PL2518085T3 (el) |
PT (4) | PT3165539T (el) |
SI (4) | SI2076541T1 (el) |
TW (1) | TWI396694B (el) |
WO (1) | WO2008054603A2 (el) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1326626B1 (en) * | 2000-10-18 | 2020-04-01 | Immunex Corporation | Methods for treating rheumatoid arthritis using il-17 antagonists |
US7833527B2 (en) * | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
WO2008106131A2 (en) * | 2007-02-28 | 2008-09-04 | Schering Corporation | Combination therapy for treatment of immune disorders |
CA2687720A1 (en) * | 2007-06-13 | 2008-12-24 | Amgen Inc. | Il-17 heteromeric receptor complex |
US20100256600A1 (en) * | 2009-04-04 | 2010-10-07 | Ferrera David A | Neurovascular otw pta balloon catheter and delivery system |
JP2011514335A (ja) * | 2008-02-21 | 2011-05-06 | アムジェン インコーポレイテッド | Il−17ra−il−17rbアンタゴニストおよび該アンタゴニストの使用 |
MX2011003705A (es) * | 2008-10-07 | 2011-06-17 | Novimmune Sa | Metodos de transfeccion en los que la il - v actúa como mediador. |
WO2010062857A1 (en) | 2008-11-26 | 2010-06-03 | Allergan, Inc. | Klk-13 antibody inhibitor for treating dry eye |
WO2010062858A1 (en) * | 2008-11-26 | 2010-06-03 | Allergan, Inc. | Il-17 antibody inhibitor for treating dry eye |
MX2011009362A (es) | 2009-03-05 | 2011-09-26 | Abbott Lab | Proteinas de union a il-17. |
WO2010108154A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Selective and potent peptide inhibitors of kv1.3 |
EP2427203B1 (en) | 2009-05-05 | 2018-10-17 | Novimmune S.A. | Anti-il-17f antibodies and use thereof |
WO2010142551A2 (en) * | 2009-06-12 | 2010-12-16 | Ablynx N.V. | Single variable domain (vhh) antibodies to cytokines of the il-17 receptor family |
EA201270528A1 (ru) * | 2009-10-10 | 2012-12-28 | Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити | Композиции цитокинов семейства il-17 и их применение |
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