ATE504602T1 - Für humane matriptase spezifische bindungsproteine - Google Patents

Für humane matriptase spezifische bindungsproteine

Info

Publication number
ATE504602T1
ATE504602T1 AT05854462T AT05854462T ATE504602T1 AT E504602 T1 ATE504602 T1 AT E504602T1 AT 05854462 T AT05854462 T AT 05854462T AT 05854462 T AT05854462 T AT 05854462T AT E504602 T1 ATE504602 T1 AT E504602T1
Authority
AT
Austria
Prior art keywords
binding proteins
matriptase
proteins specific
disclosed
immunoglobulin molecules
Prior art date
Application number
AT05854462T
Other languages
English (en)
Inventor
Ian Foltz
Chadwick King
Peter Ling
Jaspal Kang
Kathy Manchulenko
Francine Chen
Caroline Scatena
Bruce Keyt
Edwin Madison
Wayne Godfrey
Stanislaw K Morkowski
Jennifer H Richardson
Original Assignee
Amgen Fremont Inc
Dendreon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Fremont Inc, Dendreon Corp filed Critical Amgen Fremont Inc
Application granted granted Critical
Publication of ATE504602T1 publication Critical patent/ATE504602T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
AT05854462T 2004-12-20 2005-12-16 Für humane matriptase spezifische bindungsproteine ATE504602T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63785904P 2004-12-20 2004-12-20
US70646705P 2005-08-08 2005-08-08
PCT/US2005/045755 WO2006068975A2 (en) 2004-12-20 2005-12-16 Binding proteins specific for human matriptase

Publications (1)

Publication Number Publication Date
ATE504602T1 true ATE504602T1 (de) 2011-04-15

Family

ID=36463334

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05854462T ATE504602T1 (de) 2004-12-20 2005-12-16 Für humane matriptase spezifische bindungsproteine

Country Status (8)

Country Link
US (1) US7572444B2 (de)
EP (1) EP1838737B1 (de)
AT (1) ATE504602T1 (de)
AU (1) AU2005319404B2 (de)
CA (1) CA2592249C (de)
DE (1) DE602005027399D1 (de)
TW (1) TW200635946A (de)
WO (1) WO2006068975A2 (de)

Families Citing this family (18)

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US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
ES2611608T3 (es) * 2005-10-21 2017-05-09 Catalyst Biosciences, Inc. Proteasas modificadas que inhiben la activación del complemento
ES2550754T3 (es) * 2007-08-07 2015-11-12 Oxford Biotherapeutics Ltd. Proteína matriptasa y usos de la misma
WO2011063127A1 (en) 2009-11-18 2011-05-26 University Of Medicine And Dentistry Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
CA2761310C (en) 2009-05-07 2017-02-28 Charles S. Craik Antibodies and methods of use thereof
US9849192B2 (en) 2009-11-18 2017-12-26 Rutgers, The State University Of New Jersey Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
ES2676412T3 (es) * 2011-06-02 2018-07-19 Socpra Sciences Santé Et Humaines S.E.C. Inhibidores de matriptasa y usos de los mismos contra infecciones por ortomixovirus
WO2014055663A1 (en) * 2012-10-02 2014-04-10 Rutgers, The State University Of New Jersey Specific delivery of toxins conjugated wtih antibodies to activated matriptase
US9255155B2 (en) 2013-01-31 2016-02-09 The Regents Of The University Of California Antibodies specific for urokinase-type plasminogen activator and methods of treating cancer
TW201605905A (zh) 2013-11-25 2016-02-16 牛津生物治療公司 抗體
WO2015085398A1 (en) * 2013-12-09 2015-06-18 British Columbia Cancer Agency Branch Matriptase variants associated with tumors
BR112016017649B1 (pt) * 2014-01-31 2024-01-30 Cytomx Therapeutics, Inc Polipeptídeo isolado compreendendo substratos de matriptase e de ativador do plasminogênio u e outras porções cliváveis, composição farmacêutica compreendendo o dito polipeptídeo, bem como métodos para produzir e fabricar um polipeptídeo isolado compreendendo uma porção clivável e uso da composição farmacêutica e quantidade terapeuticamente eficaz da dita composição no tratamento de um distúrbio ou doença
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US9139648B1 (en) 2014-07-15 2015-09-22 Kymab Limited Precision medicine by targeting human NAV1.9 variants for treatment of pain
MA41374A (fr) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
IL261757B2 (en) 2016-03-18 2023-09-01 Univ Rutgers Treatment of stem cells with chemotherapeutic agents conjugated to anti-matriptase antibodies using connecting parts that can be broken down in the living body
CN106074473A (zh) * 2016-08-03 2016-11-09 昆明医科大学 双溴丙脒二盐酸盐在制备抑制膀胱癌egfr靶点的药物中的应用
CN120248140A (zh) 2018-12-06 2025-07-04 西托姆克斯治疗公司 基质金属蛋白酶可裂解的和丝氨酸或半胱氨酸蛋白酶可裂解的底物及其使用方法

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Also Published As

Publication number Publication date
DE602005027399D1 (de) 2011-05-19
CA2592249C (en) 2014-07-29
TW200635946A (en) 2006-10-16
CA2592249A1 (en) 2006-06-29
WO2006068975A3 (en) 2006-08-17
AU2005319404A1 (en) 2006-06-29
US7572444B2 (en) 2009-08-11
EP1838737B1 (de) 2011-04-06
AU2005319404B2 (en) 2011-10-20
EP1838737A2 (de) 2007-10-03
US20060171884A1 (en) 2006-08-03
WO2006068975A2 (en) 2006-06-29

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