HRP20161300T1 - Protutijela protiv aktivina a i njihova upotreba - Google Patents
Protutijela protiv aktivina a i njihova upotreba Download PDFInfo
- Publication number
- HRP20161300T1 HRP20161300T1 HRP20161300TT HRP20161300T HRP20161300T1 HR P20161300 T1 HRP20161300 T1 HR P20161300T1 HR P20161300T T HRP20161300T T HR P20161300TT HR P20161300 T HRP20161300 T HR P20161300T HR P20161300 T1 HRP20161300 T1 HR P20161300T1
- Authority
- HR
- Croatia
- Prior art keywords
- antigen
- binding fragment
- isolated antibody
- reduction
- animal model
- Prior art date
Links
- 239000000488 activin Substances 0.000 title claims 2
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 102000008186 Collagen Human genes 0.000 claims 4
- 108010035532 Collagen Proteins 0.000 claims 4
- 229920001436 collagen Polymers 0.000 claims 4
- 238000011764 rheumatoid arthritis animal model Methods 0.000 claims 4
- 108010023082 activin A Proteins 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 208000016261 weight loss Diseases 0.000 claims 3
- 206010006895 Cachexia Diseases 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000003259 recombinant expression Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 230000004580 weight loss Effects 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 239000004235 Orange GGN Substances 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Claims (11)
1. Izolirano protutijelo, ili njegov antigenski vežući fragment, naznačeno time što se specifično veže na područje cisteinskog čvora u ljudskom aktivinu A, gdje navedeno područje obuhvaća aminokiseline C11-S33 i aminokiseline C81-E111 u slijedu iznijetom u SEQ ID NO:225, te inhibira vezanje ljudskog aktivina A na receptor ljudskog aktivina A.
2. Izolirano protutijelo ili antigenski vežući fragment u skladu s patentnim zahtjevom 1, naznačeni time što navedeni protutijelo ili antigenski vežući fragment imaju najmanje jednu biološku aktivnost in vivo, koja se bira između ublažavanja kaheksije, ublažavanja kaheksije kod miševa s tumorom na debelom crijevu, umanjivanja gubitka tjelesne težine kod miševa s tumorom na debelom crijevu, umanjivanja gubitka tjelesne težine u životinjskom modelu reumatoidnog artritisa izazvanog kolagenom, umanjivanja gubitka mišićne mase u životinjskom modelu reumatoidnog artritisa izazvanog kolagenom, umanjivanja gubitka masne mase u životinjskom modelu reumatoidnog artritisa izazvanog kolagenom, te umanjivanja gubitka tjelesne težine u životinjskom modelu transficiranom AAV-aktivinom A.
3. Izolirano protutijelo ili antigenski vežući fragment u skladu s patentnim zahtjevom 1 ili 2, naznačeni time što su u potpunosti ljudski.
4. Izolirano protutijelo ili antigenski vežući fragment u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačeni time što su namijenjeni upotrebi u terapiji.
5. Izolirani polinukleotid, naznačen time što kodira izolirano protutijelo ili antigenski vežući fragment u skladu s bilo kojim od patentnih zahtjeva 1 do 3.
6. Vektor, naznačen time što sadrži nukleinsku kiselinu koja kodira polinukleotid u skladu s patentnim zahtjevom 5.
7. Vektor u skladu s patentnim zahtjevom 6, naznačen time što se bira iz skupine koju čine plazmid, virusni vektor, neepisomski sisavački vektor, ekspresijski vektor i rekombinantni ekspresijski vektor.
8. Stanica domaćin, naznačena time što je u nju unesen rekombinantni ekspresijski vektor u skladu s patentnim zahtjevom 7.
9. Stanica domaćin u skladu s patentnim zahtjevom 8, naznačena time što je prokariotska ili eukariotska stanica, primjerice stanica sisavca, izborno stanica iz jajnika kineskog hrčka (CHO).
10. Farmaceutski pripravak, naznačen time što sadrži izolirano protutijelo ili antigenski vežući fragment u skladu s bilo kojim od patentnih zahtjeva 1 do 3, uz jednu ili više tvari koje se bira iz skupine koju čine pufer, antioksidant, niskomolekulski polipeptid, protein, aminokiselina, ugljikohidrat, kelirajuće sredstvo, stabilizator, te pomoćno sredstvo.
11. Farmaceutski pripravak, koji sadrži izolirano protutijelo ili antigenski vežući fragment u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što je namijenjen upotrebi u terapiji.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84343006P | 2006-09-08 | 2006-09-08 | |
US95665307P | 2007-08-17 | 2007-08-17 | |
EP12154124.7A EP2559705B1 (en) | 2006-09-08 | 2007-09-07 | Anti-activin a antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20161300T1 true HRP20161300T1 (hr) | 2016-11-18 |
Family
ID=39103486
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20150171TT HRP20150171T1 (hr) | 2006-09-08 | 2015-02-13 | Anti-aktivinska antitijela a i njihove primjene |
HRP20161300TT HRP20161300T1 (hr) | 2006-09-08 | 2016-10-10 | Protutijela protiv aktivina a i njihova upotreba |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20150171TT HRP20150171T1 (hr) | 2006-09-08 | 2015-02-13 | Anti-aktivinska antitijela a i njihove primjene |
Country Status (22)
Country | Link |
---|---|
US (5) | US8309082B2 (hr) |
EP (5) | EP3730517A1 (hr) |
JP (3) | JP5497438B2 (hr) |
AR (1) | AR062703A1 (hr) |
AU (1) | AU2007294580C1 (hr) |
CA (1) | CA2661878C (hr) |
CL (1) | CL2007002567A1 (hr) |
CY (2) | CY1116037T1 (hr) |
DK (2) | DK2559705T3 (hr) |
ES (2) | ES2528798T3 (hr) |
HR (2) | HRP20150171T1 (hr) |
HU (1) | HUE030463T2 (hr) |
LT (1) | LT2559705T (hr) |
ME (1) | ME02539B (hr) |
MX (1) | MX2009002571A (hr) |
PE (1) | PE20080914A1 (hr) |
PL (2) | PL2064239T3 (hr) |
PT (2) | PT2559705T (hr) |
RS (2) | RS53819B1 (hr) |
SI (2) | SI2559705T1 (hr) |
TW (1) | TW200819466A (hr) |
WO (1) | WO2008031061A2 (hr) |
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US7612041B2 (en) | 2005-11-23 | 2009-11-03 | Acceleron Pharma Inc. | Isolated activin-binding ActRIIa polypeptide comprising the SEQ ID NO: 7 and uses for promoting bone growth |
CL2007002567A1 (es) * | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
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