HRP20170323T1 - Dopunski aktivin receptor polipeptidi i njihove upotrebe - Google Patents
Dopunski aktivin receptor polipeptidi i njihove upotrebe Download PDFInfo
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- HRP20170323T1 HRP20170323T1 HRP20170323TT HRP20170323T HRP20170323T1 HR P20170323 T1 HRP20170323 T1 HR P20170323T1 HR P20170323T T HRP20170323T T HR P20170323TT HR P20170323 T HRP20170323 T HR P20170323T HR P20170323 T1 HRP20170323 T1 HR P20170323T1
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- 102000018918 Activin Receptors Human genes 0.000 title 1
- 108010052946 Activin Receptors Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 102000004169 proteins and genes Human genes 0.000 claims 19
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 238000006467 substitution reaction Methods 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 206010006895 Cachexia Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 108010059616 Activins Proteins 0.000 claims 3
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 3
- 206010028289 Muscle atrophy Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000000488 activin Substances 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000020763 muscle atrophy Effects 0.000 claims 3
- 201000000585 muscular atrophy Diseases 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 2
- 108010056852 Myostatin Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 208000037157 Azotemia Diseases 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 206010065687 Bone loss Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 claims 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000005486 microgravity Effects 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000009852 uremia Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P19/00—Drugs for skeletal disorders
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12P21/00—Preparation of peptides or proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07K2319/00—Fusion polypeptide
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Organic Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Diabetes (AREA)
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- Wood Science & Technology (AREA)
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- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
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Claims (18)
1. Izolirani protein koji sadrži dopunski aktivin IIB receptor polipeptid (vActRIIB), naznačen time, što je spomenuti polipeptid odabran iz grupe koja se sastoji od:
(a) polipeptida čija je polipeptidna sekvenca navedena u SEQ ID NO:18, izuzev jedne supstitucije aminokiseline na položaju 28, pri čemu je supstitucija odabrana iz bilo kojeg od A, F, Q, V, I, L, M, K, H, W i Y za E;
(b) polipeptida čija je polipeptidna sekvenca navedena u aminokiselinama 19 do 134 od SEQ ID NO:18, izuzev jedne supstitucije aminokiseline na položaju 28, pri čemu je supstitucija odabrana iz bilo kojeg od A, F, Q, V, I, L, M, K, H, W i Y za E;
(c) polipeptida čija je polipeptidna sekvenca navedena u aminokiselinama 23 do 134 od SEQ ID NO:18, izuzev jedne supstitucije aminokiseline na položaju 28, pri čemu je supstitucija odabrana iz bilo kojeg od A, F, Q, V, I, L, M, K, H, W i Y za E;
(d) polipeptida čija je polipeptidna sekvenca navedena u aminokiselinama 25 do 134 od SEQ ID NO:18, izuzev jedne supstitucije aminokiseline na položaju 28, pri čemu je supstitucija odabrana iz bilo kojeg od A, F, Q, V, I, L, M, K, H, W i Y za E;
(e) polipeptida s najmanje 90%-tnim identitetom od (a) do (d), naznačen time, što je supstitucija na položaju 28 odabrana iz bilo kojeg od A, F, Q, V, I, L, M, K, H, W i Y za E, i naznačen time, što polipeptid posjeduje sposobnost vezivanja miostatina, aktivina A ili GDF-11.
2. Izolirani protein prema zahtjevu 1, naznačen time, što
(i) supstitucija na položaju 28 je odabrana iz A, W ili Y za E; ili
(ii) polipeptid prema zahtjevu 1(e) nadalje sadrži supstituciju A za R na položaju 64.
3. Izolirani protein prema zahtjevu 2, naznačen time, što je supstitucija na položaju 28 odabrana iz A, W ili Y za E.
4. Izolirani protein prema zahtjevu 3, naznačen time, što je supstitucija na položaju 28 W za E.
5. Izolirani protein prema bilo kojem zahtjevu od 1 do 3, naznačen time, što polipeptid posjeduje sekvencu odabranu iz grupe koja se sastoji od SEQ ID NO:20, 24, 26, 28, 34, 38, 40, 42 i 87 ili 88.
6. Izolirani protein prema bilo kojem zahtjevu od 1 do 5, naznačen time, što
(i) polipeptid je spojen s najmanje jednim heterolognim polipeptidom;
(ii) polipeptid je spojen s najmanje jednim heterolognim polipeptidom, pri čemu je heterologni polipeptid ljudska Fc domena; ili
(iii) polipeptid je spojen s najmanje jednim heterolognim polipeptidom, pri čemu je heterologni polipeptid ljudska Fc domena i pri čemu protein dodatno sadrži poveznik.
7. Izolirani protein prema zahtjevu 6, naznačen time, što
(a) polipeptid ima najmanje 99%-tni identitet od polipeptida prema zahtjevu 4 i ima supstituciju W za E na položaju 28; i
(b) polipeptid je spojen s najmanje jednim heterolognim polipeptidom, pri čemu je heterologni polipeptid ljudska IgG2 Fc domena čija je polipeptidna sekvenca navedena u SEQ ID NO: 80 i pri čemu protein dodatno sadrži zglobni poveznik čija je polipeptidna sekvenca navedena u SEQ ID NO:79.
8. Izolirani protein prema zahtjevu 6, naznačen time, što protein ima sekvencu odabranu iz grupe koja se sastoji od SEQ ID NO: 60, 62, 64, 87, 88, 91, 93, 95 i 97.
9. Farmaceutski pripravak koji sadrži učinkovitu količinu proteina prema bilo kojem zahtjevu od 1 do 8 u mješavini s farmaceutski prihvatljivim nosačem.
10. Izolirana molekula nukleinske kiseline koja sadrži polinukleotidnu sekvencu koja kodira protein prema bilo kojem zahtjevu od 1 do 8.
11. Izolirana molekula nukleinske kiseline prema zahtjevu 10 koja sadrži polinukleotid odabran iz grupe koja se sastoji od:
(a) polinukleotida čija je sekvenca odabrana iz grupe koja se sastoji od SEQ ID NO:19, 23, 25, 27, 33, 37, 39, 41, 59, 61, 63, 92, 94 i 96 ili njegovog komplementa; i
(b) polinukleotida koji kodira polipeptid čija je sekvenca aminokiseline odabrana iz grupe koja se sastoji od SEQ ID:20, 24, 26, 28, 34, 38, 40, 42, 60, 62, 64, 87, 88, 91, 93, 95 i 97.
12. Rekombinantni vektor ekspresije koji sadrži nukleinsku kiselinu prema zahtjevu 10 ili 11.
13. Stanica domaćin koja sadrži rekombinantni vektor prema zahtjevu 12.
14. Način za proizvodnju proteina prema bilo kojem zahtjevu od 1 do 8 koji se sastoji od kultiviranja stanice domaćina prema zahtjevu 13, na koji način se izražava protein.
15. Protein prema bilo kojem zahtjevu od 1 do 8 ili pripravak prema zahtjevu 9 za upotrebu
(i) u inhibiciji aktivnosti miostatina ili povećanju mišićne mase ili povećanju omjera mišićne mase u odnosu na masno tkivo kod subjekta kojem je potrebna takva terapija;
(ii) u liječenju bolesti koja dovodi do atrofije mišića ili metaboličkog poremećaja kod subjekta kojem je potrebna takva terapija; ili
(iii) u liječenju bolesti u kojoj se aktivin prekomjerno izražava kod subjekta kojem je potrebna takva terapija.
16. Protein ili pripravak za upotrebu kako je opisano u zahtjevu 15, naznačen time, što je bolest koja dovodi do atrofije mišića ili metabolički poremećaj odabran iz mišićne distrofije, amiotrofične lateralne skleroze, kongestivne opstruktivne plućne bolesti, kroničnog zatajenja srca, kaheksije uzrokovane rakom, AIDS-a, kaheksije uzrokovane zatajenjem bubrega, uremije, hakeksije uzrokovane reumatoidnim artritisom, staračke sarkopenije, atrofije organa, sindroma karpalnog tunela, deprivacije androgena, kaheksije uzrokovane opeklinama, dijabetičke nefropatije i atrofije mišića zbog dugotrajnog boravka u krevetu, ozljede leđne moždine, moždanog udara, frakture kostiju, starenja, izloženosti mikrogravitaciji, dijabetesa, pretilosti, hiperglikemije i gubitka koštane mase.
17. Protein ili pripravak za upotrebu kako je opisano u zahtjevu 15, naznačen time, što bolest u kojoj se aktivin prekomjerno izražava jeste rak.
18. Protein ili pripravak za upotrebu kako je opisano u zahtjevu 17, naznačen time što rak jeste rak jajnika.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90545907P | 2007-03-06 | 2007-03-06 | |
| US6547408P | 2008-02-11 | 2008-02-11 | |
| EP08742032.9A EP2132314B1 (en) | 2007-03-06 | 2008-03-06 | Variant activin receptor polypeptides and uses thereof |
| PCT/US2008/003119 WO2008109167A2 (en) | 2007-03-06 | 2008-03-06 | Variant activin receptor polypeptides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170323T1 true HRP20170323T1 (hr) | 2017-04-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170323TT HRP20170323T1 (hr) | 2007-03-06 | 2017-02-27 | Dopunski aktivin receptor polipeptidi i njihove upotrebe |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US7947646B2 (hr) |
| EP (2) | EP2132314B1 (hr) |
| JP (1) | JP5496682B2 (hr) |
| KR (5) | KR101428344B1 (hr) |
| CN (2) | CN105924516A (hr) |
| AR (1) | AR065611A1 (hr) |
| AU (1) | AU2008223338C9 (hr) |
| BR (1) | BRPI0808332A2 (hr) |
| CA (1) | CA2679841C (hr) |
| CL (2) | CL2008000664A1 (hr) |
| CR (2) | CR11054A (hr) |
| CY (1) | CY1118857T1 (hr) |
| DK (1) | DK2132314T3 (hr) |
| EA (2) | EA020510B1 (hr) |
| ES (1) | ES2613043T3 (hr) |
| HR (1) | HRP20170323T1 (hr) |
| HU (1) | HUE032260T2 (hr) |
| IL (2) | IL200605A (hr) |
| LT (1) | LT2132314T (hr) |
| MX (2) | MX2009009495A (hr) |
| NZ (1) | NZ579369A (hr) |
| PE (3) | PE20171325A1 (hr) |
| PH (1) | PH12013502308A1 (hr) |
| PL (1) | PL2132314T3 (hr) |
| PT (1) | PT2132314T (hr) |
| RS (1) | RS55726B1 (hr) |
| SI (1) | SI2132314T1 (hr) |
| TW (3) | TWI454479B (hr) |
| WO (1) | WO2008109167A2 (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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