CN109476755A - Cd73抗体及其用途 - Google Patents
Cd73抗体及其用途 Download PDFInfo
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- CN109476755A CN109476755A CN201880000859.9A CN201880000859A CN109476755A CN 109476755 A CN109476755 A CN 109476755A CN 201880000859 A CN201880000859 A CN 201880000859A CN 109476755 A CN109476755 A CN 109476755A
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Abstract
Description
Kabat | Chothia | |
CDR-H1 | 31-35 | 26-32 |
CDR-H2 | 50-65 | 52-58 |
CDR-H3 | 95-102 | 95-102 |
CDR-L1 | 24-34 | 26-32 |
CDR-L2 | 50-56 | 50-52 |
CDR-L3 | 89-97 | 91-96 |
名称 | 序列 | SEQ ID NO: |
VH CDR1 | <u>SGY</u>YWN | 1 |
VH CDR2 | YINYG<u>GSN</u>GYNPSLKS | 2 |
VH CDR3 | DYDAYY<u>EA</u>LDD | 3 |
VL CDR1 | RA<u>SS</u>RVNYMH | 4 |
VL CDR2 | ATSNLAS | 5 |
VL CDR3 | <u>QQWSS</u>NPPT | 6 |
样品 | ka(1/Ms) | kd(1/s) | KD(M) |
101-Mu | 8.13E+04 | 3.42E-05 | 4.21E-10 |
mAb1 | 2.08E+05 | 2.73E-05 | 1.31E-10 |
样品 | ka(1/Ms) | kd(1/s) | KD(M) |
Hu101-25 | 7.37E+04 | 5.51E-05 | 7.47E-10 |
Hu101-28 | 5.89E+05 | 3.47E-05 | 5.90E-10 |
101-嵌合体 | EC50=1.35nM |
Hu101-25 | EC50=2.38nM |
Hu101-28 | EC50=1.35nM |
IC50(nM) | 最大抑制率(%) | |
101-嵌合体 | 4.25 | 98% |
Hu101-25 | 4.72 | 99% |
Hu101-28 | 9.35 | 98% |
IC50(nM) | 最大抑制率(%) | |
101-嵌合体 | 1.82 | 100% |
Hu101-25 | 2.98 | 100% |
Hu101-28 | 2.52 | 100% |
名称 | 序列 | SEQ ID NO: |
VH CDR1 | <u>SGY</u>YWN | 1 |
Variant | <u>T</u>GYYWN | 26 |
Variant | <u>C</u>GYYWN | 27 |
Variant | S<u>A</u>YYWN | 28 |
Variant | S<u>P</u>YYWN | 29 |
名称 | 序列 | SEQ ID NO: |
VH CDR2 | YINYG<u>GSN</u>GY NPSLKS | 2 |
Variant | YINYG<u>A</u>SNGY NPSLKS | 30 |
Variant | YINYG<u>P</u>SNGY NPSLKS | 31 |
Variant | YINYGG<u>T</u>NGY NPSLKS | 32 |
Variant | YINYGG<u>C</u>NGY NPSLKS | 33 |
Variant | YINYGGS<u>D</u>GY NPSLKS | 34 |
Variant | YINYGGS<u>E</u>GY NPSLKS | 35 |
Variant | YINYGGS<u>Q</u>GY NPSLKS | 36 |
名称 | 序列 | SEQ ID NO: |
VL CDR1 | RA<u>SS</u>RVNYM H | 4 |
Variant | RA<u>T</u>SRVNYM H | 42 |
Variant | RA<u>C</u>SRVNYM H | 43 |
Variant | RAS<u>T</u>RVNYM H | 44 |
Variant | RAS<u>C</u>RVNYM H | 45 |
名称 | 序列 | SEQ ID NO: |
VL CDR3 | <u>QQWSS</u>NPPT | 6 |
Variant | <u>N</u>QWSSNPPT | 46 |
Variant | <u>D</u>QWSSNPPT | 47 |
Variant | <u>E</u>QWSSNPPT | 48 |
Variant | Q<u>N</u>WSSNPPT | 49 |
Variant | Q<u>D</u>WSSNPPT | 50 |
Variant | Q<u>E</u>WSSNPPT | 51 |
Variant | QQ<u>Y</u>SSNPPT | 52 |
Variant | QQW<u>T</u>SNPPT | 53 |
Variant | QQW<u>C</u>SNPPT | 54 |
Variant | QQWS<u>T</u>NPPT | 55 |
Variant | QQWS<u>C</u>NPPT | 56 |
Claims (50)
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