BR112017022205A2 - anticorpo anti-vegfr2 humano para terapia de câncer antiangiogênica e objetivada - Google Patents

anticorpo anti-vegfr2 humano para terapia de câncer antiangiogênica e objetivada

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Publication number
BR112017022205A2
BR112017022205A2 BR112017022205A BR112017022205A BR112017022205A2 BR 112017022205 A2 BR112017022205 A2 BR 112017022205A2 BR 112017022205 A BR112017022205 A BR 112017022205A BR 112017022205 A BR112017022205 A BR 112017022205A BR 112017022205 A2 BR112017022205 A2 BR 112017022205A2
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BR
Brazil
Prior art keywords
vegfr2
domain
antiangiogenic
cancer therapy
human anti
Prior art date
Application number
BR112017022205A
Other languages
English (en)
Inventor
Wu Han-Chung
Lu Ruei-Min
Chiu Chiung-Yi
Liu I-Ju
chang Yu-ling
Original Assignee
Academia Sinica
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Publication date
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Publication of BR112017022205A2 publication Critical patent/BR112017022205A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

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  • Health & Medical Sciences (AREA)
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Abstract

a presente invenção refere-se a um anticorpo isolado ou um fragmento de ligação a antígeno do mesmo tendo uma afinidade de ligação específica a um epí-topo localizado dentro do domínio 1 ou domínio 3 do receptor de fator de crescimen-to endotelial vascular 2 humano (vegfr2; seq id no: 74). o epítopo dentro do domínio 3 do vegfr2 é localizado entre os resíduos de amino ácido 250 e 270 de seq id no: 74. o uso do anticorpo ou fragmento de ligação a antígeno do mesmo na fabricação de um medicamento para inibir o desenvolvimento de tumor, a angio-gênese do tumor, e/ou para induzir a citotoxicidade das células de câncer em um indivíduo em necessidade do mesmo é também descrito. também é descrito um mé-todo de detectar a presença de vegfr2 em uma célula endotelial de tumor vascu-lar ou uma célula de câncer em uma amostra biológica.
BR112017022205A 2015-04-14 2016-04-12 anticorpo anti-vegfr2 humano para terapia de câncer antiangiogênica e objetivada BR112017022205A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562147344P 2015-04-14 2015-04-14
PCT/US2016/027057 WO2016168159A1 (en) 2015-04-14 2016-04-12 Anti-vegfr2 human antibody for anti-angiogenic and targeted cancer therapy

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BR112017022205A2 true BR112017022205A2 (pt) 2018-08-28

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US (1) US10196447B2 (pt)
EP (1) EP3283528B1 (pt)
JP (1) JP6542383B2 (pt)
KR (1) KR20170135904A (pt)
CN (1) CN107531789B (pt)
AU (1) AU2016249991B2 (pt)
BR (1) BR112017022205A2 (pt)
CA (1) CA2981883C (pt)
ES (1) ES2882276T3 (pt)
MX (1) MX2017013177A (pt)
NZ (1) NZ735720A (pt)
PT (1) PT3283528T (pt)
SG (1) SG11201707949XA (pt)
TW (1) TWI621629B (pt)
WO (1) WO2016168159A1 (pt)

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JP6959912B2 (ja) 2015-09-23 2021-11-05 ジェネンテック， インコーポレイテッド 抗ｖｅｇｆ抗体の最適化変異体
CN106674349B (zh) * 2017-03-07 2018-03-13 北京东方百泰生物科技有限公司 一种改进的抗vegfr‑2单克隆抗体
GB201710836D0 (en) * 2017-07-05 2017-08-16 Ucl Business Plc ROR1 Car T-Cells
CN114341170B (zh) * 2019-07-19 2023-09-01 神州细胞工程有限公司 一种人源化抗vegfr2抗体及其应用
KR20230039943A (ko) * 2021-09-15 2023-03-22 주식회사 파멥신 항-vegfr2(kdr) 개량 항체 및 이의 용도

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US6811779B2 (en) * 1994-02-10 2004-11-02 Imclone Systems Incorporated Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
WO2002020008A1 (en) 2000-09-06 2002-03-14 The Scripps Research Institute Inhibitors of nadh:ubiquinone oxidoreductase
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
KR100883430B1 (ko) * 2007-06-13 2009-02-12 한국생명공학연구원 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도
CN102083861B (zh) * 2007-08-13 2016-04-13 瓦斯基因治疗公司 使用结合EphB4的人源化抗体的癌症治疗
KR20140019284A (ko) * 2010-09-03 2014-02-14 아카데미아 시니카 항-C-Met 항체 및 이의 이용 방법들
CN105007939B (zh) 2012-10-05 2018-10-19 卡德门企业有限公司 人抗vegfr-2/kdr抗体

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EP3283528A1 (en) 2018-02-21
AU2016249991B2 (en) 2021-03-25
AU2016249991A1 (en) 2017-10-12
US10196447B2 (en) 2019-02-05
TWI621629B (zh) 2018-04-21
CA2981883A1 (en) 2016-10-20
CN107531789A (zh) 2018-01-02
TW201712033A (zh) 2017-04-01
ES2882276T3 (es) 2021-12-01
EP3283528A4 (en) 2019-03-06
WO2016168159A1 (en) 2016-10-20
CN107531789B (zh) 2021-08-10
MX2017013177A (es) 2018-01-30
JP6542383B2 (ja) 2019-07-10
CA2981883C (en) 2019-10-22
EP3283528B1 (en) 2021-07-21
SG11201707949XA (en) 2017-10-30
US20180127504A1 (en) 2018-05-10
PT3283528T (pt) 2021-08-11
KR20170135904A (ko) 2017-12-08
JP2018512434A (ja) 2018-05-17
NZ735720A (en) 2024-07-05

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