SG11201701341UA - Cd73 blockade - Google Patents
Cd73 blockadeInfo
- Publication number
- SG11201701341UA SG11201701341UA SG11201701341UA SG11201701341UA SG11201701341UA SG 11201701341U A SG11201701341U A SG 11201701341UA SG 11201701341U A SG11201701341U A SG 11201701341UA SG 11201701341U A SG11201701341U A SG 11201701341UA SG 11201701341U A SG11201701341U A SG 11201701341UA
- Authority
- SG
- Singapore
- Prior art keywords
- blockade
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462062323P | 2014-10-10 | 2014-10-10 | |
| US201562118549P | 2015-02-20 | 2015-02-20 | |
| US201562133597P | 2015-03-16 | 2015-03-16 | |
| US201562188881P | 2015-07-06 | 2015-07-06 | |
| PCT/EP2015/073370 WO2016055609A1 (en) | 2014-10-10 | 2015-10-09 | Cd73 blockade |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201701341UA true SG11201701341UA (en) | 2017-03-30 |
Family
ID=54291300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201701341UA SG11201701341UA (en) | 2014-10-10 | 2015-10-09 | Cd73 blockade |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10766966B2 (en) |
| EP (2) | EP3204417B1 (en) |
| JP (2) | JP7037359B2 (en) |
| KR (1) | KR102536786B1 (en) |
| CN (1) | CN106852149B (en) |
| AU (2) | AU2015329982B2 (en) |
| BR (1) | BR112017006464A2 (en) |
| CA (1) | CA2957813A1 (en) |
| DK (1) | DK3204417T3 (en) |
| ES (1) | ES2821964T3 (en) |
| IL (1) | IL250579B2 (en) |
| MX (1) | MX2017004691A (en) |
| PT (1) | PT3204417T (en) |
| RU (1) | RU2746804C2 (en) |
| SG (1) | SG11201701341UA (en) |
| WO (1) | WO2016055609A1 (en) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2746804C2 (en) * | 2014-10-10 | 2021-04-21 | Иннейт Фарма | Blockade cd73 |
| ES2877080T3 (en) | 2014-11-10 | 2021-11-16 | Medimmune Ltd | CD73-specific binding molecules and uses thereof |
| EA035766B1 (en) | 2014-11-21 | 2020-08-07 | Бристол-Майерс Сквибб Компани | Antibodies against cd73 and uses thereof |
| SI3221346T1 (en) | 2014-11-21 | 2020-11-30 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| US11130817B2 (en) | 2015-10-12 | 2021-09-28 | Innate Pharma | CD73 blocking agents |
| WO2017118613A1 (en) * | 2016-01-08 | 2017-07-13 | Syddansk Universitet | Bispecific antibodies targeting human cd73 |
| SG11201806861SA (en) * | 2016-03-04 | 2018-09-27 | Bristol Myers Squibb Co | Combination therapy with anti-cd73 antibodies |
| EP3471754A1 (en) | 2016-06-20 | 2019-04-24 | Kymab Limited | Anti-pd-l1 antibodies |
| WO2018013611A1 (en) * | 2016-07-11 | 2018-01-18 | Corvus Pharmaceuticals, Inc. | Anti-cd73 antibodies |
| WO2018110555A1 (en) | 2016-12-13 | 2018-06-21 | アステラス製薬株式会社 | Anti-human cd73 antibody |
| CN112279918A (en) | 2017-01-24 | 2021-01-29 | 天境生物科技(上海)有限公司 | CD73 antibodies and uses thereof |
| MX2019010848A (en) | 2017-03-16 | 2019-10-30 | Innate Pharma | Compositions and methods for treating cancer. |
| EP3606962A4 (en) * | 2017-04-04 | 2020-12-23 | Corvus Pharmaceuticals, Inc. | Methods for treating cd73hi tumors |
| WO2018215535A1 (en) * | 2017-05-23 | 2018-11-29 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Novel cd73 antibody, preparation and uses thereof |
| CA3066774A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| CN111542539B (en) * | 2017-10-06 | 2023-10-20 | 先天制药公司 | Recovery of T cell Activity by CD39/CD73 axis |
| CN111372606B (en) * | 2017-11-15 | 2024-02-20 | 先天制药公司 | Enhancement of ATP release |
| AU2018375738A1 (en) | 2017-11-30 | 2020-06-11 | Novartis Ag | BCMA-targeting chimeric antigen receptor, and uses thereof |
| PE20211001A1 (en) | 2018-02-27 | 2021-06-01 | Incyte Corp | IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES AS INHIBITORS OF A2A / A2B |
| EA202091710A1 (en) | 2018-03-09 | 2021-02-16 | Агенус Инк. | ANTIBODIES AGAINST CD73 AND METHODS OF THEIR USE |
| EP3762030A4 (en) * | 2018-03-09 | 2022-01-05 | Phanes Therapeutics, Inc. | Anti-cd73 antibodies and uses thereof |
| SG11202009839PA (en) | 2018-04-12 | 2020-11-27 | Bristol Myers Squibb Co | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
| MX2020012376A (en) | 2018-05-18 | 2021-03-09 | Incyte Corp | Fused pyrimidine derivatives as a2a / a2b inhibitors. |
| EP3569618A1 (en) | 2018-05-19 | 2019-11-20 | Boehringer Ingelheim International GmbH | Antagonizing cd73 antibody |
| AR126019A1 (en) | 2018-05-30 | 2023-09-06 | Novartis Ag | ANTIBODIES AGAINST ENTPD2, COMBINATION THERAPIES AND METHODS OF USE OF ANTIBODIES AND COMBINATION THERAPIES |
| KR20210016390A (en) | 2018-06-01 | 2021-02-15 | 노파르티스 아게 | Binding molecules for BCMA and uses thereof |
| SG11202012435UA (en) | 2018-06-18 | 2021-01-28 | Innate Pharma | Compositions and methods for treating cancer |
| AU2019297361B2 (en) | 2018-07-05 | 2024-06-27 | Incyte Corporation | Fused pyrazine derivatives as A2A / A2B inhibitors |
| CN112041348B (en) | 2018-07-25 | 2023-09-22 | 天境生物科技(上海)有限公司 | anti-CD 73 anti-PD-L1 bispecific antibodies |
| CN111499747B (en) * | 2019-01-11 | 2022-03-18 | 康诺亚生物医药科技（成都）有限公司 | anti-CD 73 monoclonal antibody and application thereof |
| US20200345725A1 (en) | 2019-01-11 | 2020-11-05 | Omeros Corporation | Methods and Compositions for Treating Cancer |
| TWI829857B (en) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors |
| SG11202111106WA (en) * | 2019-04-23 | 2021-11-29 | Innate Pharma | Cd73 blocking antibodies |
| JP2022535840A (en) * | 2019-06-06 | 2022-08-10 | ジャコバイオ ファーマスーティカルズ カンパニー リミテッド | CD73-Specific Binding Molecules and Uses of Binding Molecules |
| CN112300279A (en) * | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | Methods and compositions directed to anti-CD 73 antibodies and variants |
| MX2022002682A (en) | 2019-09-06 | 2022-04-07 | Servier Lab | Anti-cd73 antibodies. |
| WO2021053559A1 (en) | 2019-09-18 | 2021-03-25 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| IL292959A (en) | 2019-11-15 | 2022-07-01 | Genzyme Corp | Biparatopic cd73 antibodies |
| JP2023509442A (en) | 2020-01-03 | 2023-03-08 | インサイト・コーポレイション | Combination therapy of CD73 inhibitor and A2A/A2B adenosine receptor inhibitor |
| IL294436A (en) | 2020-01-03 | 2022-09-01 | Incyte Corp | Anti-cd73 antibodies and uses thereof |
| JP2023522365A (en) * | 2020-04-22 | 2023-05-30 | アケソ・バイオファーマ・インコーポレイテッド | Anti-CD73 antibody and its use |
| WO2021247188A1 (en) | 2020-06-05 | 2021-12-09 | Bristol-Myers Squibb Company | Cd73 antagonist potency assay and methods of use thereof |
| EP4169948A1 (en) | 2020-06-22 | 2023-04-26 | Innovent Biologics (Suzhou) Co., Ltd. | Anti-cd73 antibody and use thereof |
| TW202216777A (en) * | 2020-07-10 | 2022-05-01 | 美商生質分子控股有限責任公司 | Tetrahedral antibodies |
| WO2022033978A2 (en) | 2020-08-13 | 2022-02-17 | Innate Pharma | Cancer treatment methods using anti-cd73 antibodies |
| WO2022097060A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
| AU2021401052A1 (en) | 2020-12-18 | 2023-06-22 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| MX2023007850A (en) | 2020-12-29 | 2023-09-11 | Incyte Corp | Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies. |
| WO2022235569A1 (en) * | 2021-05-05 | 2022-11-10 | Corvus Pharmaceuticals, Inc. | Anti-cd73 compounds to treat oncovirus-positive cancers |
| WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| WO2023206242A1 (en) * | 2022-04-28 | 2023-11-02 | 江苏中新医药有限公司 | Anti-human cd73 monoclonal antibody without hook effect |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1513554B9 (en) | 2002-05-30 | 2011-11-09 | Macrogenics, Inc. | Cd16a binding proteins and use for the treatment of immune disorders |
| JP4462964B2 (en) * | 2003-03-10 | 2010-05-12 | 第一三共株式会社 | Antibodies targeting cancer-specific antigens |
| KR101339628B1 (en) | 2005-05-09 | 2013-12-09 | 메다렉스, 인코포레이티드 | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| KR101888321B1 (en) | 2005-07-01 | 2018-08-13 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | Human monoclonal antibodies to programmed death ligand 1(pd-l1) |
| EP2975057A1 (en) | 2006-07-10 | 2016-01-20 | Fujita Health University | Novel anti-cd73 antibody |
| US20090028857A1 (en) | 2007-07-23 | 2009-01-29 | Cell Genesys, Inc. | Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof |
| US20090130092A1 (en) * | 2007-10-30 | 2009-05-21 | Pinsky David J | Nucleotide phosphate dissipation as a treatment for vascular disorders |
| CN101970499B (en) | 2008-02-11 | 2014-12-31 | 治疗科技公司 | Monoclonal antibodies for tumor treatment |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Pd-1 binding proteins |
| KR20210060670A (en) | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| WO2011066389A1 (en) | 2009-11-24 | 2011-06-03 | Medimmmune, Limited | Targeted binding agents against b7-h1 |
| EA030792B1 (en) | 2009-11-30 | 2018-09-28 | Янссен Байотек, Инк | ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS |
| AR083847A1 (en) | 2010-11-15 | 2013-03-27 | Novartis Ag | FC VARIANTS (CONSTANT FRAGMENT) SILENCERS OF ANTI-CD40 ANTIBODIES |
| MY162489A (en) | 2010-12-23 | 2017-06-15 | Janssen Biotech Inc | ACTIVE PROTEASE-RESISTANT ANTIBODY Fc MUTANTS |
| WO2012145493A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
| PE20141693A1 (en) | 2011-08-01 | 2014-11-24 | Genentech Inc | METHODS TO TREAT CANCER BY THE USE OF AXIS BINDING ANTAGONISTS PD-1 AND MEK INHIBITORS |
| JP6391564B2 (en) | 2012-04-30 | 2018-09-19 | メディミューン，エルエルシー | Molecules, compositions and their use with reduced effector function and extended half-life |
| US9090697B2 (en) * | 2013-03-15 | 2015-07-28 | Bayer Healthcare Llc | Methods for treating bleeding disorders |
| CN103278634B (en) * | 2013-05-16 | 2015-01-07 | 中国科学院近代物理研究所 | Application of CD73 as stem cell surface marker of renal clear cell carcinoma |
| JP6502959B2 (en) | 2013-12-12 | 2019-04-17 | 上海恒瑞医薬有限公司 | PD-1 antibodies, antigen binding fragments thereof and their medical use |
| US20180030144A1 (en) | 2014-10-10 | 2018-02-01 | Innate Pharma | Cd73 blockade |
| RU2746804C2 (en) * | 2014-10-10 | 2021-04-21 | Иннейт Фарма | Blockade cd73 |
| WO2016131950A1 (en) | 2015-02-20 | 2016-08-25 | Innate Pharma | Cd73 blockade |
| KR102554507B1 (en) | 2015-07-24 | 2023-07-11 | 이나뜨 파르마 에스.에이. | Method for detecting tissue-infiltrating NK cells |
| US11130817B2 (en) | 2015-10-12 | 2021-09-28 | Innate Pharma | CD73 blocking agents |
| WO2017157948A1 (en) | 2016-03-14 | 2017-09-21 | Innate Pharma | Anti-cd39 antibodies |
| US20200023071A1 (en) | 2017-02-06 | 2020-01-23 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
| SG11202111106WA (en) | 2019-04-23 | 2021-11-29 | Innate Pharma | Cd73 blocking antibodies |
-
2015
- 2015-10-09 RU RU2017105119A patent/RU2746804C2/en active
- 2015-10-09 CN CN201580055012.7A patent/CN106852149B/en active Active
- 2015-10-09 WO PCT/EP2015/073370 patent/WO2016055609A1/en active Application Filing
- 2015-10-09 BR BR112017006464-2A patent/BR112017006464A2/en active Search and Examination
- 2015-10-09 EP EP15778310.1A patent/EP3204417B1/en active Active
- 2015-10-09 DK DK15778310.1T patent/DK3204417T3/en active
- 2015-10-09 KR KR1020177011231A patent/KR102536786B1/en active IP Right Grant
- 2015-10-09 ES ES15778310T patent/ES2821964T3/en active Active
- 2015-10-09 CA CA2957813A patent/CA2957813A1/en active Pending
- 2015-10-09 SG SG11201701341UA patent/SG11201701341UA/en unknown
- 2015-10-09 JP JP2017518540A patent/JP7037359B2/en active Active
- 2015-10-09 MX MX2017004691A patent/MX2017004691A/en unknown
- 2015-10-09 PT PT157783101T patent/PT3204417T/en unknown
- 2015-10-09 EP EP20180074.5A patent/EP3736294A3/en active Pending
- 2015-10-09 US US15/517,991 patent/US10766966B2/en active Active
- 2015-10-09 AU AU2015329982A patent/AU2015329982B2/en active Active
-
2017
- 2017-02-13 IL IL250579A patent/IL250579B2/en unknown
-
2020
- 2020-07-16 JP JP2020122032A patent/JP7132981B2/en active Active
- 2020-09-02 US US17/009,817 patent/US11958907B2/en active Active
-
2021
- 2021-08-16 AU AU2021215306A patent/AU2021215306A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3204417A1 (en) | 2017-08-16 |
| WO2016055609A1 (en) | 2016-04-14 |
| AU2015329982A1 (en) | 2017-03-09 |
| BR112017006464A2 (en) | 2018-01-30 |
| DK3204417T3 (en) | 2020-10-12 |
| ES2821964T3 (en) | 2021-04-28 |
| JP2020186244A (en) | 2020-11-19 |
| RU2017105119A (en) | 2018-11-12 |
| KR102536786B1 (en) | 2023-05-26 |
| JP7037359B2 (en) | 2022-03-16 |
| MX2017004691A (en) | 2017-10-02 |
| AU2021215306A1 (en) | 2021-09-16 |
| KR20170070077A (en) | 2017-06-21 |
| RU2746804C2 (en) | 2021-04-21 |
| AU2015329982B2 (en) | 2021-05-20 |
| EP3736294A3 (en) | 2021-02-17 |
| JP7132981B2 (en) | 2022-09-07 |
| US20180237536A1 (en) | 2018-08-23 |
| CN106852149B (en) | 2021-08-27 |
| CN106852149A (en) | 2017-06-13 |
| EP3736294A2 (en) | 2020-11-11 |
| US20200392243A1 (en) | 2020-12-17 |
| US10766966B2 (en) | 2020-09-08 |
| JP2018502051A (en) | 2018-01-25 |
| EP3204417B1 (en) | 2020-07-22 |
| RU2017105119A3 (en) | 2019-04-29 |
| IL250579B2 (en) | 2023-05-01 |
| CA2957813A1 (en) | 2016-04-14 |
| IL250579B1 (en) | 2023-01-01 |
| IL250579A0 (en) | 2017-04-30 |
| US11958907B2 (en) | 2024-04-16 |
| PT3204417T (en) | 2020-10-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL250579A0 (en) | Cd73 blockade | |
| AP2017009836A0 (en) | Aminopyridyloxypyrazole compounds | |
| GB201402431D0 (en) | Compounds | |
| GB201404987D0 (en) | Compounds | |
| GB201406591D0 (en) | Compounds | |
| HK1214967A1 (en) | Composition | |
| SG11201704735WA (en) | Composition | |
| AP2017009778A0 (en) | Azetidinyloxyphenylpyrrolidine compounds | |
| HK1218859A1 (en) | Composition | |
| GB201403017D0 (en) | Composition | |
| HK1244432A1 (en) | Composition | |
| GB201414910D0 (en) | Composition | |
| ZA201704464B (en) | Composition | |
| GB201403561D0 (en) | Composition | |
| GB201414555D0 (en) | Composition | |
| GB201410493D0 (en) | Composition | |
| GB201519442D0 (en) | Composition | |
| ZA201606127B (en) | Composition | |
| GB201420628D0 (en) | Composition | |
| GB201415483D0 (en) | Composition | |
| GB201404390D0 (en) | Composition | |
| GB201405361D0 (en) | Compounds | |
| GB201402648D0 (en) | Composition | |
| IL250781A0 (en) | Composition | |
| GB201503484D0 (en) | Composition |