SG11202009839PA - Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody - Google Patents
Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibodyInfo
- Publication number
- SG11202009839PA SG11202009839PA SG11202009839PA SG11202009839PA SG11202009839PA SG 11202009839P A SG11202009839P A SG 11202009839PA SG 11202009839P A SG11202009839P A SG 11202009839PA SG 11202009839P A SG11202009839P A SG 11202009839PA SG 11202009839P A SG11202009839P A SG 11202009839PA
- Authority
- SG
- Singapore
- Prior art keywords
- antagonist antibody
- combination therapy
- axis
- anticancer combination
- anticancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862656892P | 2018-04-12 | 2018-04-12 | |
US201862680255P | 2018-06-04 | 2018-06-04 | |
PCT/US2019/027219 WO2019200256A1 (en) | 2018-04-12 | 2019-04-12 | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202009839PA true SG11202009839PA (en) | 2020-11-27 |
Family
ID=66323956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202009839PA SG11202009839PA (en) | 2018-04-12 | 2019-04-12 | Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody |
Country Status (12)
Country | Link |
---|---|
US (1) | US20210147570A1 (en) |
EP (1) | EP3773714A1 (en) |
JP (1) | JP2021521182A (en) |
KR (1) | KR20200142542A (en) |
CN (1) | CN112218657A (en) |
AU (1) | AU2019252795A1 (en) |
BR (1) | BR112020020826A2 (en) |
CA (1) | CA3096674A1 (en) |
IL (1) | IL277886A (en) |
MX (1) | MX2020010604A (en) |
SG (1) | SG11202009839PA (en) |
WO (1) | WO2019200256A1 (en) |
Families Citing this family (11)
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CA2968382A1 (en) | 2014-11-21 | 2016-05-26 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
UY36404A (en) | 2014-11-21 | 2016-06-01 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | MONOCLONAL ANTIBODIES (Ab) AS DETECTORS OF CD73 AND INHIBITORS OF THEIR ENZYMATIC ACTIVITY, AND COMPOSITIONS CONTAINING THEM |
TW202400599A (en) | 2018-02-27 | 2024-01-01 | 美商英塞特公司 | Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors |
CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
TWI829857B (en) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors |
BR112022020256A2 (en) * | 2020-04-09 | 2023-01-03 | Aprilbio Co Ltd | MONOCLONAL ANTIBODY OR AN ANTIGEN-BINDING FRAGMENT THEREOF, NUCLEIC ACID, EXPRESSION VECTOR, CELL, COMPOSITION, USE OF THE COMPOSITION AND USE OF THE MONOCLONAL ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF |
MX2022013311A (en) * | 2020-04-22 | 2022-11-14 | Akeso Biopharma Inc | Anti-cd73-anti-pd-1 bispecific antibody and use thereof. |
EP4169948A1 (en) * | 2020-06-22 | 2023-04-26 | Innovent Biologics (Suzhou) Co., Ltd. | Anti-cd73 antibody and use thereof |
CA3207066A1 (en) * | 2020-12-29 | 2022-07-07 | Incyte Corporation | Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies |
CN117337300A (en) * | 2021-05-21 | 2024-01-02 | 百奥泰生物制药股份有限公司 | Use of anti-PD-1 antibodies |
WO2023227110A1 (en) * | 2022-05-26 | 2023-11-30 | I-Mab Biopharma Co., Ltd. | Biomarkers and methods for treating nsclc |
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-
2019
- 2019-04-12 US US17/044,753 patent/US20210147570A1/en active Pending
- 2019-04-12 KR KR1020207032257A patent/KR20200142542A/en unknown
- 2019-04-12 AU AU2019252795A patent/AU2019252795A1/en active Pending
- 2019-04-12 EP EP19720276.5A patent/EP3773714A1/en active Pending
- 2019-04-12 WO PCT/US2019/027219 patent/WO2019200256A1/en unknown
- 2019-04-12 CA CA3096674A patent/CA3096674A1/en active Pending
- 2019-04-12 JP JP2020555523A patent/JP2021521182A/en active Pending
- 2019-04-12 SG SG11202009839PA patent/SG11202009839PA/en unknown
- 2019-04-12 CN CN201980037531.9A patent/CN112218657A/en active Pending
- 2019-04-12 MX MX2020010604A patent/MX2020010604A/en unknown
- 2019-04-12 BR BR112020020826-4A patent/BR112020020826A2/en not_active Application Discontinuation
-
2020
- 2020-10-08 IL IL277886A patent/IL277886A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3096674A1 (en) | 2019-10-17 |
EP3773714A1 (en) | 2021-02-17 |
IL277886A (en) | 2020-11-30 |
KR20200142542A (en) | 2020-12-22 |
AU2019252795A1 (en) | 2020-10-29 |
MX2020010604A (en) | 2020-10-20 |
US20210147570A1 (en) | 2021-05-20 |
WO2019200256A1 (en) | 2019-10-17 |
BR112020020826A2 (en) | 2021-01-19 |
CN112218657A (en) | 2021-01-12 |
JP2021521182A (en) | 2021-08-26 |
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