EA201790858A3 - Лечение и профилактика амилоидоза - Google Patents

Лечение и профилактика амилоидоза

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Publication number
EA201790858A3
EA201790858A3 EA201790858A EA201790858A EA201790858A3 EA 201790858 A3 EA201790858 A3 EA 201790858A3 EA 201790858 A EA201790858 A EA 201790858A EA 201790858 A EA201790858 A EA 201790858A EA 201790858 A3 EA201790858 A3 EA 201790858A3
Authority
EA
Eurasian Patent Office
Prior art keywords
amyloidosis
prevention
treatment
amyloid
epitopes
Prior art date
Application number
EA201790858A
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English (en)
Other versions
EA201790858A2 (ru
EA036059B1 (ru
Inventor
Дейл Б. Шенк
Питер А. Сейберт
Джонатан Уолл
Хосе Сальданха
Original Assignee
Протена Байосайенсиз Лимитед
Юниверсити Оф Теннесси Рисерч Фаундейшн
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Application filed by Протена Байосайенсиз Лимитед, Юниверсити Оф Теннесси Рисерч Фаундейшн filed Critical Протена Байосайенсиз Лимитед
Publication of EA201790858A2 publication Critical patent/EA201790858A2/ru
Publication of EA201790858A3 publication Critical patent/EA201790858A3/ru
Publication of EA036059B1 publication Critical patent/EA036059B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

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Abstract

Раскрыты способы, полезные для осуществления профилактики или лечения амилоидоза, включающего амилоидоз AA-типа и амилоидоз AL-типа, путем введения пептидов, содержащих неоэпитопы, такие как фрагменты AA из C-концевой области AA, и антител, специфичных для неоэпитопов агрегированных амилоидных белков, например антител, специфичных для C-концевой области AA-фибрилл. Антитела, ингибирующие образование и/или усиливающие удаление амилоидных депо у пациента, осуществляют таким образом профилактику или лечение амилоидной болезни.
EA201790858A 2007-12-28 2008-12-29 Способ получения антитела или его фрагмента, которое специфически связывается с агрегированным амилоидным белком EA036059B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US754407P 2007-12-28 2007-12-28
US9593208P 2008-09-10 2008-09-10

Publications (3)

Publication Number Publication Date
EA201790858A2 EA201790858A2 (ru) 2017-08-31
EA201790858A3 true EA201790858A3 (ru) 2017-12-29
EA036059B1 EA036059B1 (ru) 2020-09-21

Family

ID=40825109

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EA201070812A EA028356B1 (ru) 2007-12-28 2008-12-29 Лечение и профилактика амилоидоза
EA201790858A EA036059B1 (ru) 2007-12-28 2008-12-29 Способ получения антитела или его фрагмента, которое специфически связывается с агрегированным амилоидным белком

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EA201070812A EA028356B1 (ru) 2007-12-28 2008-12-29 Лечение и профилактика амилоидоза

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US (12) US8791243B2 (ru)
EP (3) EP3693470A1 (ru)
JP (3) JP5730020B2 (ru)
KR (1) KR101603076B1 (ru)
CN (1) CN102016059B (ru)
AU (1) AU2008345022B2 (ru)
BR (1) BRPI0821949B1 (ru)
CA (1) CA2710984C (ru)
CO (1) CO6341486A2 (ru)
DK (1) DK2237803T3 (ru)
EA (2) EA028356B1 (ru)
ES (1) ES2544679T3 (ru)
HK (1) HK1156365A1 (ru)
HU (1) HUE025560T2 (ru)
IL (2) IL206641B (ru)
NO (1) NO20101036L (ru)
NZ (1) NZ586875A (ru)
PL (1) PL2237803T3 (ru)
PT (1) PT2237803E (ru)
SG (2) SG186689A1 (ru)
WO (1) WO2009086539A2 (ru)

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