EA201590833A1 - Антитела для лечения и профилактики болезни альцгеймера и их применение - Google Patents

Антитела для лечения и профилактики болезни альцгеймера и их применение

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Publication number
EA201590833A1
EA201590833A1 EA201590833A EA201590833A EA201590833A1 EA 201590833 A1 EA201590833 A1 EA 201590833A1 EA 201590833 A EA201590833 A EA 201590833A EA 201590833 A EA201590833 A EA 201590833A EA 201590833 A1 EA201590833 A1 EA 201590833A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disease
alzgeimer
antibodies
prevention
treatment
Prior art date
Application number
EA201590833A
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English (en)
Inventor
Рональд Блэк
Ларс Экман
Иван Либербург
Майкл Грандмэн
Джеймс Каллауэй
Кейт М. Грэгг
Джек Стивен Джейкобсен
Дэвиндер Джилл
Людмила Чистякова
Анджела Видом
Original Assignee
Янссен Сайенсиз Айрлэнд Юси
ВАЙЕТ ЭлЭлСи
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Application filed by Янссен Сайенсиз Айрлэнд Юси, ВАЙЕТ ЭлЭлСи filed Critical Янссен Сайенсиз Айрлэнд Юси
Publication of EA201590833A1 publication Critical patent/EA201590833A1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06QINFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q99/00Subject matter not provided for in other groups of this subclass
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Заявляются способы иммунотерапии болезни Альцгеймера и схожих заболеваний, при которых схемы для пациента зависят от генотипа АроЕ пациента.
EA201590833A 2007-10-17 2008-10-17 Антитела для лечения и профилактики болезни альцгеймера и их применение EA201590833A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99942307P 2007-10-17 2007-10-17
US8382708P 2008-07-25 2008-07-25

Publications (1)

Publication Number Publication Date
EA201590833A1 true EA201590833A1 (ru) 2015-08-31

Family

ID=40568093

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201590833A EA201590833A1 (ru) 2007-10-17 2008-10-17 Антитела для лечения и профилактики болезни альцгеймера и их применение
EA201000644A EA022307B1 (ru) 2007-10-17 2008-10-17 Антитела для лечения и профилактики болезни альцгеймера и их применение

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201000644A EA022307B1 (ru) 2007-10-17 2008-10-17 Антитела для лечения и профилактики болезни альцгеймера и их применение

Country Status (32)

Country Link
US (3) US9644025B2 (ru)
EP (2) EP2207565B1 (ru)
JP (2) JP5745853B2 (ru)
KR (1) KR101197839B1 (ru)
CN (2) CN101969988A (ru)
AR (1) AR071732A1 (ru)
AU (1) AU2008311823A1 (ru)
BR (1) BRPI0818000A2 (ru)
CA (2) CA2940337A1 (ru)
CL (1) CL2008003089A1 (ru)
CO (1) CO6331295A2 (ru)
CY (1) CY1116552T1 (ru)
DK (1) DK2207565T3 (ru)
EA (2) EA201590833A1 (ru)
ES (1) ES2547230T3 (ru)
HK (2) HK1146234A1 (ru)
HR (1) HRP20150790T1 (ru)
HU (1) HUE025684T2 (ru)
IL (1) IL205127A (ru)
JO (1) JO3076B1 (ru)
MX (1) MX2010004250A (ru)
MY (1) MY156454A (ru)
PA (1) PA8800801A1 (ru)
PE (1) PE20090971A1 (ru)
PL (1) PL2207565T3 (ru)
PT (1) PT2207565E (ru)
RS (1) RS54130B1 (ru)
SG (2) SG186649A1 (ru)
SI (1) SI2207565T1 (ru)
TW (2) TW201206479A (ru)
WO (1) WO2009052439A2 (ru)
ZA (1) ZA201002544B (ru)

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