AR071732A1 - Metodos para tratar la enfermedad de alzheimer, reducir la disminucion del volumen cerebral y monitorear una poblacion de pacientes que experimentan tratamiento o profilaxis para una enfermedad, uso de una medida de numero de copia apoe4, forma humanizada de un anticuerpo y acido nucleico aislado. - Google Patents

Metodos para tratar la enfermedad de alzheimer, reducir la disminucion del volumen cerebral y monitorear una poblacion de pacientes que experimentan tratamiento o profilaxis para una enfermedad, uso de una medida de numero de copia apoe4, forma humanizada de un anticuerpo y acido nucleico aislado.

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Publication number
AR071732A1
AR071732A1 ARP080104566A ARP080104566A AR071732A1 AR 071732 A1 AR071732 A1 AR 071732A1 AR P080104566 A ARP080104566 A AR P080104566A AR P080104566 A ARP080104566 A AR P080104566A AR 071732 A1 AR071732 A1 AR 071732A1
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AR
Argentina
Prior art keywords
disease
patient
alzheimer
methods
reduce
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ARP080104566A
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English (en)
Inventor
Ivan Lieberbug
Lars Ekman
Ronald Black
Jim Callaway
Keit Greeg
Jack Steven Jacobsen
Michael Grundman
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Elan Pharma Int Ltd
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Elan Pharma Int Ltd, Wyeth Corp filed Critical Elan Pharma Int Ltd
Publication of AR071732A1 publication Critical patent/AR071732A1/es

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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06QINFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q99/00Subject matter not provided for in other groups of this subclass
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
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  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

Metodos de inmunoterapia de Alzheimer y enfermedades similares en las que el regimen administrado a un paciente depende del genotipo ApoE del paciente. Reivindicacion 1: Un metodo para tratar la enfermedad de Alzheimer, caracterizado por comprender administrar a un paciente que tiene alelos ApoE4 cero ( paciente no portador ApoE4 ) y enfermedad de Alzheimer, un regimen efectivo de un anticuerpo que se une espec¡ficamente a un ep¡topo en el terminal N de Abeta. Reivindicacion 10: Un metodo para reducir disminucion cognitiva en un paciente que tiene alelos ApoE4 cero ( paciente no portador ApoE4 ), que comprende administrar al paciente un anticuerpo que se une espec¡ficamente a un ep¡topo en el terminal N de Abeta en un regimen efectivo para reducir la disminucion cognitiva del paciente con relacion a un paciente de control a quien no se administra el anticuerpo; caracterizado porque: el paciente no portador ApoE4 y el paciente control se han diagnosticado con enfermedad de Alzheimer leve a moderada; y se mide la disminucion cognitiva mediante ADAS-COG, NTB, MMSE o CDR-SB.
ARP080104566A 2007-10-17 2008-10-17 Metodos para tratar la enfermedad de alzheimer, reducir la disminucion del volumen cerebral y monitorear una poblacion de pacientes que experimentan tratamiento o profilaxis para una enfermedad, uso de una medida de numero de copia apoe4, forma humanizada de un anticuerpo y acido nucleico aislado. AR071732A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99942307P 2007-10-17 2007-10-17
US8382708P 2008-07-25 2008-07-25

Publications (1)

Publication Number Publication Date
AR071732A1 true AR071732A1 (es) 2010-07-14

Family

ID=40568093

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080104566A AR071732A1 (es) 2007-10-17 2008-10-17 Metodos para tratar la enfermedad de alzheimer, reducir la disminucion del volumen cerebral y monitorear una poblacion de pacientes que experimentan tratamiento o profilaxis para una enfermedad, uso de una medida de numero de copia apoe4, forma humanizada de un anticuerpo y acido nucleico aislado.

Country Status (32)

Country Link
US (3) US20090155256A1 (es)
EP (2) EP2207565B1 (es)
JP (2) JP5745853B2 (es)
KR (1) KR101197839B1 (es)
CN (2) CN107090032A (es)
AR (1) AR071732A1 (es)
AU (1) AU2008311823A1 (es)
BR (1) BRPI0818000A2 (es)
CA (2) CA2940337A1 (es)
CL (1) CL2008003089A1 (es)
CO (1) CO6331295A2 (es)
CY (1) CY1116552T1 (es)
DK (1) DK2207565T3 (es)
EA (2) EA201590833A1 (es)
ES (1) ES2547230T3 (es)
HK (2) HK1146234A1 (es)
HR (1) HRP20150790T1 (es)
HU (1) HUE025684T2 (es)
IL (1) IL205127A (es)
JO (1) JO3076B1 (es)
MX (1) MX2010004250A (es)
MY (1) MY156454A (es)
PA (1) PA8800801A1 (es)
PE (1) PE20090971A1 (es)
PL (1) PL2207565T3 (es)
PT (1) PT2207565E (es)
RS (1) RS54130B1 (es)
SG (2) SG10201607589XA (es)
SI (1) SI2207565T1 (es)
TW (2) TW201206479A (es)
WO (1) WO2009052439A2 (es)
ZA (1) ZA201002544B (es)

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