EA200700751A1 - Способы и композиции для улучшения продуцирования рекомбинантного белка - Google Patents
Способы и композиции для улучшения продуцирования рекомбинантного белкаInfo
- Publication number
- EA200700751A1 EA200700751A1 EA200700751A EA200700751A EA200700751A1 EA 200700751 A1 EA200700751 A1 EA 200700751A1 EA 200700751 A EA200700751 A EA 200700751A EA 200700751 A EA200700751 A EA 200700751A EA 200700751 A1 EA200700751 A1 EA 200700751A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- expression
- recombinant protein
- peptide
- compositions
- improving
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
- C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Раскрываются нуклеотидные молекулы, модифицированные с целью повышения экспрессии рекомбинантного белка, например экспрессии антител, связывающих Аβ пептид, и/или для уменьшения или исключения побочных продуктов, образующихся в результате неправильного сплайсинга и/или считывания интронов (IRT). Изобретение также включает способы продуцирования антител, связывающих Аβ пептид, не содержащих побочных продуктов, образующихся в результате неправильного сплайсинга и/или считывания интронов, экспрессией таких нуклеотидных молекул в клеточной культуре в условиях, пригодных для экспрессии антитела, связывающего Аβ пептид.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61647404P | 2004-10-05 | 2004-10-05 | |
PCT/US2005/035854 WO2006041934A2 (en) | 2004-10-05 | 2005-10-05 | Methods and compositions for improving recombinant protein production |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200700751A1 true EA200700751A1 (ru) | 2008-06-30 |
Family
ID=35710394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200700751A EA200700751A1 (ru) | 2004-10-05 | 2005-10-05 | Способы и композиции для улучшения продуцирования рекомбинантного белка |
Country Status (13)
Country | Link |
---|---|
US (3) | US7807804B2 (ru) |
EP (2) | EP1797182A2 (ru) |
JP (2) | JP2008515438A (ru) |
KR (1) | KR20070073885A (ru) |
CN (2) | CN101027391A (ru) |
AU (2) | AU2005294373B2 (ru) |
BR (2) | BRPI0516264A (ru) |
CA (2) | CA2582194A1 (ru) |
EA (1) | EA200700751A1 (ru) |
IL (1) | IL182182A0 (ru) |
MX (2) | MX2007003856A (ru) |
WO (2) | WO2006041934A2 (ru) |
ZA (1) | ZA200703561B (ru) |
Families Citing this family (42)
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US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
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US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
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US20060188512A1 (en) * | 2003-02-01 | 2006-08-24 | Ted Yednock | Active immunization to generate antibodies to solble a-beta |
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AU2006259298B2 (en) | 2005-06-17 | 2012-06-14 | Wyeth Llc | Methods of purifying Fc region containing proteins |
RU2432362C2 (ru) | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
BRPI0619249A2 (pt) | 2005-11-30 | 2011-09-20 | Abbott Lab | anticorpos anti-globulÈmeros-aß, frações que se ligam a antìgeno destes, hibridomas correspondentes, ácidos nucléicos, vetores, células hospedeiras, métodos de produzir os ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos de usar os ditos anticorpos |
PL1994055T3 (pl) * | 2006-03-10 | 2015-02-27 | Wyeth Llc | Przeciwciała anty-5T4 i ich zastosowanie |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
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US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
US20130195881A1 (en) * | 2007-04-27 | 2013-08-01 | Sanjaya Singh | Potent, stable and non-immunosuppressive anti-cd4 antibodies |
JP5512514B2 (ja) | 2007-06-29 | 2014-06-04 | エフ.ホフマン−ラ ロシュ アーゲー | 改善された免疫グロブリンの産生をもたらす重鎖変異体 |
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JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
-
2005
- 2005-10-05 EP EP05803366A patent/EP1797182A2/en not_active Withdrawn
- 2005-10-05 ZA ZA200703561A patent/ZA200703561B/xx unknown
- 2005-10-05 MX MX2007003856A patent/MX2007003856A/es not_active Application Discontinuation
- 2005-10-05 US US11/244,678 patent/US7807804B2/en not_active Expired - Fee Related
- 2005-10-05 AU AU2005294373A patent/AU2005294373B2/en not_active Ceased
- 2005-10-05 CN CNA2005800319406A patent/CN101027391A/zh active Pending
- 2005-10-05 WO PCT/US2005/035854 patent/WO2006041934A2/en active Application Filing
- 2005-10-05 JP JP2007535857A patent/JP2008515438A/ja not_active Ceased
- 2005-10-05 CA CA002582194A patent/CA2582194A1/en not_active Abandoned
- 2005-10-05 US US11/664,865 patent/US20090285806A1/en not_active Abandoned
- 2005-10-05 BR BRPI0516264-5A patent/BRPI0516264A/pt not_active Application Discontinuation
- 2005-10-05 EP EP05812436A patent/EP1828251B1/en active Active
- 2005-10-05 JP JP2007535779A patent/JP4980222B2/ja not_active Expired - Fee Related
- 2005-10-05 WO PCT/US2005/036247 patent/WO2006042158A2/en active Application Filing
- 2005-10-05 BR BRPI0516572-5A patent/BRPI0516572A/pt not_active IP Right Cessation
- 2005-10-05 AU AU2005294131A patent/AU2005294131A1/en not_active Abandoned
- 2005-10-05 CN CN200580034045XA patent/CN101287471B/zh not_active Expired - Fee Related
- 2005-10-05 CA CA002582157A patent/CA2582157A1/en not_active Abandoned
- 2005-10-05 EA EA200700751A patent/EA200700751A1/ru unknown
- 2005-10-05 KR KR1020077010237A patent/KR20070073885A/ko not_active Application Discontinuation
- 2005-10-05 MX MX2007003906A patent/MX2007003906A/es active IP Right Grant
-
2007
- 2007-03-26 IL IL182182A patent/IL182182A0/en unknown
-
2010
- 2010-09-24 US US12/889,623 patent/US20110038863A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2008515430A (ja) | 2008-05-15 |
EP1797182A2 (en) | 2007-06-20 |
CA2582157A1 (en) | 2006-04-20 |
WO2006041934A2 (en) | 2006-04-20 |
CN101027391A (zh) | 2007-08-29 |
US7807804B2 (en) | 2010-10-05 |
EP1828251A2 (en) | 2007-09-05 |
MX2007003856A (es) | 2007-09-19 |
BRPI0516264A (pt) | 2008-08-26 |
WO2006041934A3 (en) | 2008-04-24 |
IL182182A0 (en) | 2007-07-24 |
AU2005294131A1 (en) | 2006-04-20 |
US20090285806A1 (en) | 2009-11-19 |
WO2006042158A2 (en) | 2006-04-20 |
WO2006042158A3 (en) | 2006-06-22 |
BRPI0516572A (pt) | 2008-09-16 |
CA2582194A1 (en) | 2006-04-20 |
ZA200703561B (en) | 2009-09-30 |
JP2008515438A (ja) | 2008-05-15 |
KR20070073885A (ko) | 2007-07-10 |
CN101287471A (zh) | 2008-10-15 |
US20110038863A1 (en) | 2011-02-17 |
AU2005294373B2 (en) | 2011-12-08 |
EP1828251B1 (en) | 2012-09-26 |
CN101287471B (zh) | 2012-10-03 |
EP1828251A4 (en) | 2009-01-21 |
JP4980222B2 (ja) | 2012-07-18 |
US20060099206A1 (en) | 2006-05-11 |
AU2005294373A1 (en) | 2006-04-20 |
MX2007003906A (es) | 2007-05-21 |
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