EA200801571A1 - Композиции, содержащие молекулы ctl4-ig, и способы их получения - Google Patents
Композиции, содержащие молекулы ctl4-ig, и способы их полученияInfo
- Publication number
- EA200801571A1 EA200801571A1 EA200801571A EA200801571A EA200801571A1 EA 200801571 A1 EA200801571 A1 EA 200801571A1 EA 200801571 A EA200801571 A EA 200801571A EA 200801571 A EA200801571 A EA 200801571A EA 200801571 A1 EA200801571 A1 EA 200801571A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- compositions containing
- ctl4
- molecules
- reception
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
Настоящее изобретение раскрывает клетки млекопитающих, способные продуцировать рекомбинантный CTLA4-Ig и его варианты. Также раскрываются композиции, содержащие CTLA4-Ig, и составы. Также раскрываются способы массового получения CTLA4-Ig из клеток млекопитающих, способных продуцировать этот рекомбинантный белок, и способы его очистки.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75226705P | 2005-12-20 | 2005-12-20 | |
US75215005P | 2005-12-20 | 2005-12-20 | |
US84954306P | 2006-10-05 | 2006-10-05 | |
PCT/US2006/049074 WO2007076032A2 (en) | 2005-12-20 | 2006-12-19 | Compositions and methods for producing a composition |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200801571A1 true EA200801571A1 (ru) | 2010-02-26 |
EA017765B1 EA017765B1 (ru) | 2013-03-29 |
Family
ID=38218674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801571A EA017765B1 (ru) | 2005-12-20 | 2006-12-19 | КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ СИАЛИРОВАННЫЕ МОЛЕКУЛЫ CTLA4-Ig, И ЕЕ ПРИМЕНЕНИЕ |
Country Status (25)
Country | Link |
---|---|
US (4) | US10508144B2 (ru) |
EP (2) | EP2253644B1 (ru) |
JP (2) | JP5096369B2 (ru) |
KR (2) | KR101398713B1 (ru) |
CN (1) | CN106589132B (ru) |
AU (2) | AU2006330922B2 (ru) |
BR (2) | BRPI0622251A2 (ru) |
CA (2) | CA2836123C (ru) |
CY (1) | CY1114887T1 (ru) |
DK (2) | DK1969007T3 (ru) |
EA (1) | EA017765B1 (ru) |
ES (2) | ES2439641T3 (ru) |
HK (1) | HK1121173A1 (ru) |
HR (1) | HRP20130975T1 (ru) |
IL (2) | IL192098A (ru) |
MX (1) | MX336807B (ru) |
NO (1) | NO20082716L (ru) |
NZ (1) | NZ597215A (ru) |
PE (1) | PE20080556A1 (ru) |
PL (2) | PL1969007T4 (ru) |
PT (2) | PT2253644E (ru) |
SI (2) | SI1969007T1 (ru) |
TW (2) | TWI398520B (ru) |
WO (1) | WO2007076032A2 (ru) |
ZA (1) | ZA200805301B (ru) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2439641T3 (es) * | 2005-12-20 | 2014-01-24 | Bristol-Myers Squibb Company | Composiciones y procedimientos de producción de una composición |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
EP2450366A1 (en) | 2007-01-30 | 2012-05-09 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
US7915222B2 (en) | 2008-05-05 | 2011-03-29 | Bristol-Myers Squibb Company | Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis |
CN105435211A (zh) | 2008-10-06 | 2016-03-30 | 三维肽胶株式会社 | 组织闭塞剂 |
CN101995476B (zh) * | 2009-08-10 | 2013-07-03 | 中国医学科学院北京协和医院 | 临床化学检验用液体质控血清 |
US9540426B2 (en) * | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
EP2507627A2 (en) | 2009-12-04 | 2012-10-10 | Momenta Pharmaceuticals, Inc. | Antennary fucosylation in glycoproteins from cho cells |
BR112012020254A2 (pt) * | 2010-02-12 | 2016-05-03 | Dsm Ip Assets Bv | método para a purificação de anticorpos a partir de uma mistura de proteína e, unidade operacional única. |
WO2011113019A2 (en) | 2010-03-12 | 2011-09-15 | Abbott Biotherapeutics Corp. | Ctla4 proteins and their uses |
US20120121574A1 (en) * | 2010-11-15 | 2012-05-17 | Luciano Polonelli | Antimicrobial, antiviral, anticancer and immunomodulatory peptides and uses therefore |
JP5847418B2 (ja) | 2011-03-30 | 2016-01-20 | 富士フイルム株式会社 | 細胞接着性タンパク質 |
KR101992502B1 (ko) * | 2011-05-12 | 2019-06-24 | 제넨테크, 인크. | 프레임워크 시그너처 펩티드를 사용하여 동물 샘플에서 치료 항체를 검출하기 위한 다중 반응 모니터링 lc-ms/ms 방법 |
WO2013130604A1 (en) * | 2012-02-27 | 2013-09-06 | Biogen Idec Ma Inc. | High-throughput method for sialic acid quantitation |
EP2841952A4 (en) * | 2012-04-22 | 2015-12-02 | Perfinity Biosciences Inc | AUTOMATED PROTEIN DEDUCTION, RECOVERY AND ANALYSIS |
ES2753150T3 (es) * | 2012-06-29 | 2020-04-07 | Bristol Myers Squibb Co | Métodos para reducir la agregación de glucoproteínas |
WO2014008400A2 (en) * | 2012-07-06 | 2014-01-09 | 3-D Matrix, Inc. | Fill-finish process for peptide solutions |
EP2855533A4 (en) * | 2013-03-15 | 2015-11-25 | Momenta Pharmaceuticals Inc | METHODS RELATING TO CTLA4-FC FUSION PROTEINS |
EP2996772B1 (en) | 2013-05-13 | 2018-12-19 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
US20160257754A1 (en) | 2013-10-16 | 2016-09-08 | Momenta Pharmaceuticals Inc. | Sialylated glycoproteins |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
WO2015136370A2 (en) | 2014-03-10 | 2015-09-17 | 3-D Matrix, Ltd. | Sterilization and filtration of peptide compositions |
US10654893B2 (en) | 2014-03-10 | 2020-05-19 | 3-D Matrix, Ltd. | Self-assembling peptide compositions |
BR112016023450A2 (pt) | 2014-04-25 | 2017-10-17 | Bristol Myers Squibb Co | uso de compostos ctla4 para alcançar remissão livre de fármacos em indivíduos com artrite reumatoide precoce |
ES2743903T3 (es) * | 2014-10-15 | 2020-02-21 | Alexion Pharma Inc | Métodos para cambiar el perfil isoeléctrico de un producto proteico y sus usos |
US9512229B2 (en) | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
PT3283508T (pt) | 2015-04-17 | 2021-06-21 | Alpine Immune Sciences Inc | Proteínas imuno modulatórias com afinidades afináveis |
NZ738149A (en) | 2015-06-10 | 2024-02-23 | Univ Texas | Use of exosomes for the treatment of disease |
TWI579030B (zh) * | 2015-12-15 | 2017-04-21 | Cg生物技術有限公司 | 分離細胞之容器、系統及方法 |
WO2017120092A1 (en) | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Combination compositions |
EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
US10613081B2 (en) * | 2016-11-27 | 2020-04-07 | Alireza Palangi | Quality control system and kit for automated ELISA devices |
CN109385401A (zh) * | 2017-08-10 | 2019-02-26 | 北京泰德制药股份有限公司 | 一种表达重组蛋白的cho细胞的培养方法 |
PT3684381T (pt) * | 2017-09-21 | 2023-01-23 | Codiak Biosciences Inc | Produção de vesículas extracelulares em suspensão de células isoladas utilizando meios de cultura celular quimicamente definidos |
EP3694870A1 (en) | 2017-10-10 | 2020-08-19 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
TW201925223A (zh) | 2017-10-18 | 2019-07-01 | 美商艾爾潘免疫科學有限公司 | 變異型icos 配位體免疫調節蛋白及相關組合物及方法 |
JP7102734B2 (ja) * | 2018-01-09 | 2022-07-20 | 東洋製罐グループホールディングス株式会社 | 細胞培養方法及び装置 |
EP4063850A1 (en) * | 2018-04-20 | 2022-09-28 | Janssen Biotech, Inc. | Chromatography column qualification device with transition analysis |
AU2019372675A1 (en) * | 2018-11-02 | 2021-02-04 | Beijing Vdjbio Co., Ltd. | Modified CTLA4 and methods of use thereof |
US11965900B2 (en) * | 2018-11-09 | 2024-04-23 | Wyatt Technology, Llc | Indicating a status of an analytical instrument on a screen of the analytical instrument |
WO2020251862A1 (en) * | 2019-06-14 | 2020-12-17 | Agilent Technologies, Inc. | Methods and kits to improve the fluorescent signal of dmb-labeled sialic acids |
CN114450026A (zh) * | 2019-07-26 | 2022-05-06 | 生命科学股份有限公司 | 用于治疗银屑病用途的唾液酸 |
CN110554107B (zh) * | 2019-08-14 | 2022-06-10 | 上海应用技术大学 | 一种高效液相色谱-质谱联用分析食用油中甘油三酯成分的方法 |
WO2021102437A1 (en) | 2019-11-21 | 2021-05-27 | Bristol-Myers Squibb Company | Label-free n-glycan quantification methods |
CN111398308B (zh) * | 2020-03-27 | 2023-01-17 | 上海健康医学院 | 一种片剂、胶囊铝塑泡罩包装质量自动检测方法及系统 |
JP7415771B2 (ja) | 2020-04-24 | 2024-01-17 | 株式会社島津製作所 | 分析支援装置、分析支援方法および分析支援プログラム |
JP7415783B2 (ja) * | 2020-05-12 | 2024-01-17 | 株式会社島津製作所 | 分析支援装置、分析支援方法および分析支援プログラム |
KR20230045615A (ko) * | 2020-08-14 | 2023-04-04 | 브리스톨-마이어스 스큅 컴퍼니 | 단백질을 제조하는 방법 |
JP2023537760A (ja) * | 2020-08-14 | 2023-09-05 | ブリストル-マイヤーズ スクイブ カンパニー | タンパク質の製造工程 |
CN112198302B (zh) * | 2020-10-25 | 2022-12-16 | 中铁二局第一工程有限公司 | 一种细集料含泥量快速检测方法及测量工具 |
EP4281542A1 (en) * | 2021-01-20 | 2023-11-29 | Regeneron Pharmaceuticals, Inc. | Methods of improving protein titer in cell culture |
CA3113278A1 (en) * | 2021-03-25 | 2022-09-25 | Lumex Instruments Canada (0890278 B.C. Ltd.) | Device for electrophoretic analysis of multicomponent liquid samples |
WO2022208550A1 (en) * | 2021-03-31 | 2022-10-06 | Dr. Reddy's Laboratories Limited | Cell culture process for fusion protein composition |
CN113241192B (zh) * | 2021-05-18 | 2023-06-20 | 武汉大学中南医院 | 一种证据合成方法和计算机设备 |
CA3233419A1 (en) * | 2021-09-28 | 2023-04-06 | Kashiv Biosciences, Llc | An improved process for purification of protein |
AU2022358612A1 (en) * | 2021-09-28 | 2024-04-11 | Kashiv Biosciences, Llc | An improved process of purification of fusion protein |
WO2023115027A2 (en) * | 2021-12-16 | 2023-06-22 | Bristol-Myers Squibb Company | Detergent for viral inactivation |
WO2023112992A1 (ja) * | 2021-12-16 | 2023-06-22 | レグセル株式会社 | 免疫系の異常に関連する疾患、障害または症状を処置するための医薬組成物 |
WO2023178329A1 (en) * | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
CN117044627B (zh) * | 2023-10-11 | 2023-12-15 | 中国科学院昆明植物研究所 | 一种高山植物塔黄的组培快繁及离体保存方法 |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4460694A (en) * | 1981-03-26 | 1984-07-17 | University Of Miami | Bovine glycoproteins and use in diagnosing infectious mononucleosis |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
US5856298A (en) | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
DK0606217T4 (da) | 1991-06-27 | 2009-03-30 | Bristol Myers Squibb Co | CTL4-receptor, fusionsproteiner indeholdende den samt anvendelse deraf |
US5851795A (en) * | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
US6090914A (en) | 1991-06-27 | 2000-07-18 | Bristol-Myers Squibb Company | CTLA4/CD28Ig hybrid fusion proteins and uses thereof |
US5844095A (en) * | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
AU3144193A (en) * | 1991-11-21 | 1993-06-15 | Board Of Trustees Of The Leland Stanford Junior University | Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases |
US5456909A (en) | 1992-08-07 | 1995-10-10 | T Cell Sciences, Inc. | Glycoform fractions of recombinant soluble complement receptor 1 (sCR1) having extended half-lives in vivo |
US5773253A (en) | 1993-01-22 | 1998-06-30 | Bristol-Myers Squibb Company | MYPPPY variants of CTL A4 and uses thereof |
US6084067A (en) | 1993-07-26 | 2000-07-04 | Dana-Farber Cancer Institute | CTLA4/CD28 ligands and uses therefor |
EP0722329A4 (en) * | 1993-09-15 | 1998-02-04 | Alpha Therapeutic Corp | CLEANING PROCESS FROM GLYCOPROTEINS ALPHA 1? ACID AND PRODUCT |
US5451660A (en) * | 1993-12-13 | 1995-09-19 | Genentech, Inc. | Method for purifying polypeptides |
US5429746A (en) * | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
EP0784482A2 (en) | 1994-06-07 | 1997-07-23 | The Regents Of The University Of Minnesota | Methods for inhibiting antigen specific t cell responses |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
US5721121A (en) * | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US6656466B1 (en) * | 1995-06-06 | 2003-12-02 | Genetech, Inc. | Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition |
EP0845997A1 (en) | 1995-07-27 | 1998-06-10 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
KR100554332B1 (ko) | 1996-11-15 | 2006-02-24 | 제넨테크, 인크. | 뉴로트로핀의 정제 |
PT1897890E (pt) | 1996-11-27 | 2010-02-23 | Genentech Inc | Purificação por afinidade de um polipéptido numa matriz de proteína a |
ZA98533B (en) | 1997-01-31 | 1999-07-22 | Bristol Myers Squibb Co | Soluble CTLA4 mutant molecules and uses thereof. |
US20030124614A1 (en) | 1997-08-29 | 2003-07-03 | Brighams And Womens Hospital Inc. | Novel T-cell membrane protein (TIRC7), peptides and antibodies derived therefrom and uses thereof |
DE59813187D1 (de) | 1997-12-03 | 2005-12-15 | Roche Diagnostics Gmbh | Verfahren zur herstellung von polypeptiden mit geeigneter glykosilierung |
US6528286B1 (en) | 1998-05-29 | 2003-03-04 | Genentech, Inc. | Mammalian cell culture process for producing glycoproteins |
EP1084136B1 (en) | 1998-06-01 | 2004-08-25 | Genentech, Inc. | Separation of antibody monomers from its multimers by use of ion-exchange chromatography |
US6800457B2 (en) | 1998-09-22 | 2004-10-05 | Bristol-Myers Squibb Company | Expression vectors containing hot spot for increased recombinant protein expression in transfected cells |
US6521419B1 (en) | 1998-09-22 | 2003-02-18 | Kanakaraju Koduri | Expression vectors containing hot spot for increased recombinant protein expression in transfected cells |
US6358703B1 (en) * | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
CA2368797C (en) | 1999-04-26 | 2010-08-17 | Genentech, Inc. | Cell culture process |
US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
ATE461935T1 (de) * | 2000-03-27 | 2010-04-15 | Genetics Inst Llc | Verfahren zur reinigung von stark anionischen proteinen |
US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
CN1309735C (zh) | 2000-05-26 | 2007-04-11 | 布里斯托尔-迈尔斯斯奎布公司 | 可溶性ctla4突变体分子及其应用 |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
MXPA02012157A (es) | 2000-06-09 | 2003-06-06 | Bristol Myers Squibb Co | Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos. |
JP2004513878A (ja) | 2000-06-23 | 2004-05-13 | マキシジェン, インコーポレイテッド | 新規同時刺激分子 |
US7183376B2 (en) * | 2000-06-23 | 2007-02-27 | Maxygen, Inc. | Variant B7 co-stimulatory molecules |
US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
EP1372696B1 (en) * | 2000-07-03 | 2008-07-23 | Bristol-Myers Squibb Company | Methods for treating rheumatic diseases using a soluble ctla4 molecule |
US6358265B1 (en) | 2000-07-18 | 2002-03-19 | Specialized Health Products, Inc. | Single-step disposable safety lancet apparatus and methods |
EP1368059A1 (en) * | 2001-01-26 | 2003-12-10 | Emory University | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
HU229680B1 (hu) | 2001-05-23 | 2014-04-28 | Bristol Myers Squibb Co | Eljárások allogén sziget átültetés védelmére oldható CTLA4 mutáns molekulák alkalmazásával |
JP4109204B2 (ja) * | 2002-03-26 | 2008-07-02 | レツク・フアーマシユーテイカルズ・デー・デー | 所望エリスロポエチングリコアイソフォームプロフィールの製造方法 |
PL376821A1 (pl) | 2002-03-27 | 2006-01-09 | Immunex Corporation | Sposoby zwiększania produkcji polipeptydów |
AU2003236018A1 (en) * | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kirin Co., Ltd. | METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcGamma RECEPTOR IIIa |
EP1496931A4 (en) | 2002-04-19 | 2009-07-01 | Bristol Myers Squibb Co | METHODS OF TREATING AUTOIMMUNE DISEASE USING SOLUBLE CTLA4 MOLECULE AND ARMM OR NSAID |
PT1501369E (pt) | 2002-04-26 | 2015-09-21 | Genentech Inc | Purificação de proteínas com base na não afinidade |
AU2002345524A1 (en) | 2002-06-19 | 2004-01-06 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanyi Ve Ticaret A.S. | A process for the production of substituted phenyl ethers |
ES2285188T3 (es) | 2002-07-15 | 2007-11-16 | Immunex Corporation | Metodo y medios para controlar sialilacion de proteinas producidas por celulas de mamifero. |
US6924124B1 (en) | 2002-08-23 | 2005-08-02 | Immunex Corporation | Feeding strategies for cell culture |
US7541164B2 (en) | 2002-12-23 | 2009-06-02 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
BR0316882A (pt) * | 2002-12-23 | 2005-10-25 | Bristol Myers Squibb Co | Melhora na qualidade de produtos em processos de cultura de células de mamìferos para a produção de proteìnas |
PL2335725T3 (pl) | 2003-04-04 | 2017-04-28 | Genentech, Inc. | Preparaty zawierające wysokoskoncentrowane przeciwciała i białka |
US7118222B2 (en) * | 2003-05-12 | 2006-10-10 | Seiko Epson Corporation | Optical device and protector |
ATE482235T1 (de) | 2003-06-13 | 2010-10-15 | Biogen Idec Inc | Aglycosyl-anti-cd154 (cd40-ligand) antikörper und deren verwendungen |
US7307064B2 (en) | 2003-08-04 | 2007-12-11 | Bristol-Myers Squibb Company | Methods for treating cardiovascular disease using a soluble CTLA4 molecule |
ATE462716T1 (de) * | 2003-10-24 | 2010-04-15 | Amgen Inc | Verfahren zur aufreinigung von proteinen in einer durchflussfraktion aus der chromatographie mit hydrophoben wechselwirkungen |
AU2004309063B2 (en) | 2003-12-31 | 2010-10-28 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
US7253167B2 (en) | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
TW201008595A (en) | 2005-12-20 | 2010-03-01 | Bristol Myers Squibb Co | Stable protein formulations |
ES2439641T3 (es) | 2005-12-20 | 2014-01-24 | Bristol-Myers Squibb Company | Composiciones y procedimientos de producción de una composición |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
EA017733B1 (ru) | 2006-08-28 | 2013-02-28 | Арес Трейдинг С.А. | СПОСОБ ОЧИСТКИ Fc-СЛИТЫХ БЕЛКОВ |
FI2061803T4 (fi) | 2006-08-28 | 2023-03-14 | Process for the purification of fc-containing proteins |
-
2006
- 2006-12-19 ES ES10153282.8T patent/ES2439641T3/es active Active
- 2006-12-19 SI SI200631696T patent/SI1969007T1/sl unknown
- 2006-12-19 PE PE2006001650A patent/PE20080556A1/es not_active Application Discontinuation
- 2006-12-19 AU AU2006330922A patent/AU2006330922B2/en active Active
- 2006-12-19 BR BRPI0622251-0A patent/BRPI0622251A2/pt not_active Application Discontinuation
- 2006-12-19 NZ NZ597215A patent/NZ597215A/xx unknown
- 2006-12-19 JP JP2008547621A patent/JP5096369B2/ja active Active
- 2006-12-19 PL PL06848052T patent/PL1969007T4/pl unknown
- 2006-12-19 PT PT101532828T patent/PT2253644E/pt unknown
- 2006-12-19 BR BRPI0620178-4A patent/BRPI0620178B1/pt active IP Right Grant
- 2006-12-19 DK DK06848052.4T patent/DK1969007T3/da active
- 2006-12-19 PT PT68480524T patent/PT1969007E/pt unknown
- 2006-12-19 KR KR1020087017540A patent/KR101398713B1/ko active IP Right Grant
- 2006-12-19 TW TW095147641A patent/TWI398520B/zh active
- 2006-12-19 TW TW101148477A patent/TWI423986B/zh active
- 2006-12-19 DK DK10153282.8T patent/DK2253644T3/da active
- 2006-12-19 CA CA2836123A patent/CA2836123C/en active Active
- 2006-12-19 US US12/086,786 patent/US10508144B2/en active Active
- 2006-12-19 CN CN201610350033.8A patent/CN106589132B/zh active Active
- 2006-12-19 PL PL10153282T patent/PL2253644T3/pl unknown
- 2006-12-19 KR KR1020117029336A patent/KR101391457B1/ko active IP Right Grant
- 2006-12-19 CA CA2634760A patent/CA2634760C/en active Active
- 2006-12-19 WO PCT/US2006/049074 patent/WO2007076032A2/en active Application Filing
- 2006-12-19 EP EP10153282.8A patent/EP2253644B1/en not_active Revoked
- 2006-12-19 EA EA200801571A patent/EA017765B1/ru not_active IP Right Cessation
- 2006-12-19 SI SI200631693T patent/SI2253644T1/sl unknown
- 2006-12-19 ES ES06848052T patent/ES2433092T3/es active Active
- 2006-12-19 EP EP06848052.4A patent/EP1969007B1/en not_active Revoked
-
2008
- 2008-06-12 IL IL192098A patent/IL192098A/en active IP Right Grant
- 2008-06-13 NO NO20082716A patent/NO20082716L/no not_active Application Discontinuation
- 2008-06-18 ZA ZA2008/05301A patent/ZA200805301B/en unknown
- 2008-06-20 MX MX2012006495A patent/MX336807B/es unknown
-
2009
- 2009-02-06 HK HK09101088.2A patent/HK1121173A1/xx unknown
- 2009-12-21 JP JP2009289570A patent/JP5097194B2/ja active Active
-
2010
- 2010-11-08 AU AU2010241289A patent/AU2010241289B2/en active Active
-
2013
- 2013-10-15 HR HRP20130975TT patent/HRP20130975T1/hr unknown
- 2013-12-10 IL IL229904A patent/IL229904A0/en unknown
-
2014
- 2014-01-14 CY CY20141100030T patent/CY1114887T1/el unknown
-
2018
- 2018-07-23 US US16/042,977 patent/US10941189B2/en active Active
- 2018-07-24 US US16/044,217 patent/US10808021B2/en active Active
-
2020
- 2020-11-25 US US17/105,358 patent/US20210246188A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200801571A1 (ru) | Композиции, содержащие молекулы ctl4-ig, и способы их получения | |
PH12015501848A1 (en) | Binding agents | |
ES2353814T3 (es) | Proteinas n-glicosiladas recombinantes de celulas procariotas. | |
EA200800269A1 (ru) | Пищевые изделия со средствами доставки и способы их получения | |
MY174493A (en) | Binding agents | |
NO20084878L (no) | Humanisert C-kit antistoff | |
TW200740844A (en) | Novel MAdCAM antibodies | |
ATE362932T1 (de) | Azaindolverbindungen als kinaseinhibitoren | |
BRPI0506679A (pt) | métodos de tratar osteoartrite com antagonistas de il-6 | |
MY151036A (en) | Synthesis of (r)-n-methylnaltrexone | |
EA201000642A1 (ru) | 2'-фтор-2'-дезокситетрагидроуридины в качестве ингибиторов цитидиндеаминазы | |
WO2006028936A3 (en) | Heteromultimeric molecules | |
MX2007013632A (es) | Procedimientos para preparar derivados de bencil-benceno sustituidos con glucopiranosilo y sus productos intermedios. | |
EA200870116A1 (ru) | Бициклические гетероарильные соединения | |
TW200720256A (en) | IL-12 modulatory compounds | |
DE602006019595D1 (de) | Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors | |
TW200730518A (en) | Crystalline forms of docetaxel and processes for their preparation | |
EA200601608A1 (ru) | Способ производства твёрдой фармацевтической композиции | |
EA200801174A1 (ru) | Антитела-миметики glp-2, полипептиды, композиции, способы и применения | |
EA200801414A1 (ru) | Кальцилитические соединения | |
UA99602C2 (ru) | Антитело, специфически связывающееся с jam-a, способное ингибировать пролиферацию опухолевых клеток | |
EA200800393A1 (ru) | Новые соединения-аналоги камптотецина, способ их получения и фармацевтические композиции, которые их содержат | |
CY1112877T1 (el) | Μεταλλαγματα αυξητικου παραγoντα υψηλης δραστικοτητας | |
CY1114562T1 (el) | Υψηλης καθαροτητας μεγαλης κλιμακας παρασκευη στανσοπορφινης | |
EA200800601A1 (ru) | Связывающие fas антитела |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |