CY1114562T1 - Υψηλης καθαροτητας μεγαλης κλιμακας παρασκευη στανσοπορφινης - Google Patents

Υψηλης καθαροτητας μεγαλης κλιμακας παρασκευη στανσοπορφινης

Info

Publication number
CY1114562T1
CY1114562T1 CY20111100961T CY111100961T CY1114562T1 CY 1114562 T1 CY1114562 T1 CY 1114562T1 CY 20111100961 T CY20111100961 T CY 20111100961T CY 111100961 T CY111100961 T CY 111100961T CY 1114562 T1 CY1114562 T1 CY 1114562T1
Authority
CY
Cyprus
Prior art keywords
stansoporphine
scale preparation
high clean
clean scale
compositions
Prior art date
Application number
CY20111100961T
Other languages
English (en)
Inventor
George S Drummond
Robert Caroselli
Keith A Cooke
Daniel Levin
David G Roe
Christopher P Boucher
Original Assignee
Infacare Pharmaceutical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infacare Pharmaceutical Corporation filed Critical Infacare Pharmaceutical Corporation
Publication of CY1114562T1 publication Critical patent/CY1114562T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Αποκαλύπτονται μεγάλης κλίμακας (μαζικές) συνθέσεις που περιλαμβάνουν υψηλής καθαρότητας στανσοπορφίνη, καθώς επίσης και μέθοδοι σύνθεσης αυτών των συνθέσεων.
CY20111100961T 2006-10-04 2011-10-07 Υψηλης καθαροτητας μεγαλης κλιμακας παρασκευη στανσοπορφινης CY1114562T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84964106P 2006-10-04 2006-10-04
US90460107P 2007-02-28 2007-02-28
EP07839341A EP2079472B1 (en) 2006-10-04 2007-10-04 High-purity large-scale preparation of stannsoporfin

Publications (1)

Publication Number Publication Date
CY1114562T1 true CY1114562T1 (el) 2016-10-05

Family

ID=39144566

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100961T CY1114562T1 (el) 2006-10-04 2011-10-07 Υψηλης καθαροτητας μεγαλης κλιμακας παρασκευη στανσοπορφινης

Country Status (23)

Country Link
US (9) US7960371B2 (el)
EP (3) EP2079472B1 (el)
JP (2) JP5524622B2 (el)
KR (5) KR20140023447A (el)
CN (2) CN104116745B (el)
AT (1) ATE524187T1 (el)
AU (1) AU2007307111B2 (el)
BR (1) BRPI0717775B8 (el)
CA (1) CA2665075C (el)
CY (1) CY1114562T1 (el)
DK (1) DK2079472T3 (el)
EA (2) EA019864B1 (el)
ES (1) ES2556359T3 (el)
HK (2) HK1132191A1 (el)
HR (1) HRP20110746T1 (el)
IL (4) IL197838A (el)
MX (2) MX345035B (el)
NO (1) NO20091575L (el)
NZ (4) NZ703991A (el)
PL (1) PL2079472T3 (el)
PT (1) PT2079472E (el)
RS (1) RS52185B (el)
WO (1) WO2008045377A2 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7375216B2 (en) 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
US20060222668A1 (en) * 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
NZ703991A (en) 2006-10-04 2016-07-29 Infacare Pharmaceutical Corp High-purity large-scale preparation of stannsoporfin
WO2012135686A1 (en) * 2011-03-30 2012-10-04 Infacare Pharmaceutical Corporation Methods for synthesizing metal mesoporphyrins
CN110279699A (zh) * 2011-12-01 2019-09-27 马林克罗特医疗产品知识产权公司 用锡泊芬治疗高胆红素血症的方法
CN103214491B (zh) * 2013-03-13 2016-01-20 南京理工大学 [2,7,12,18-四甲基-3,8-二乙基-13,17-二羧基乙基]-卟啉的制备方法
IL287607B (en) 2014-09-29 2022-07-01 Hutchinson Fred Cancer Res Preparations, kits and methods for inducing acquired cellular resistance using induced stress proteins
SG11202109323UA (en) 2019-02-28 2021-09-29 Renibus Therapeutics Inc Novel iron compositions and methods of making and using the same
EP4221717A1 (en) * 2020-10-02 2023-08-09 Adgero Biopharmaceuticals Holdings, Inc. Methods for the production of nickel (ii) etioporphyrin-i

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58501130A (ja) 1981-07-15 1983-07-14 ザ　ロツクフエラ−　ユニバ−シテイ ヘムの代謝速度の低下方法
US4684637A (en) 1981-07-15 1987-08-04 The Rockefeller University Method of decreasing rate of heme metabolism
US4708964A (en) 1984-02-09 1987-11-24 Chemex Pharmaceuticals Lipoxygenase inhibitors
AU570143B2 (en) 1985-01-14 1988-03-03 Rockefeller University, The Method of increasing heme excretion from a mammal using tin protoporphyrin
US4619923A (en) 1985-01-14 1986-10-28 The Rockefeller University Metal protoporphyrins in the control of tryptophan metabolism
US4692440A (en) 1985-03-25 1987-09-08 The Rockefeller University Therapeutic use of tin mesoporphyrin
US4657902A (en) 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin
US4692439A (en) 1986-06-20 1987-09-08 The Rockefeller University Therapeutic use of tin diiododeuteroporphyrin
US4668670A (en) 1986-06-20 1987-05-26 The Rockefeller University Tin diiododeuteroporphyrin and therapeutic use thereof
US4861876A (en) 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
US4782049A (en) 1986-12-08 1988-11-01 The Rockefeller University Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US5990363A (en) 1987-01-02 1999-11-23 Sun Company, Inc. Method for oxidizing alkanes using novel porphyrins synthesized from dipyrromethanes and aldehydes
US4900871A (en) 1987-01-02 1990-02-13 Sun Refining And Marketing Company Hydrocarbon oxidations catalyzed by iron coordination complexes containing a halogenated ligand
EP0333831B1 (en) * 1987-09-08 1992-07-15 The Rockefeller University Use of metalloporphyrins to reverse the toxic effect of tumor therapy
US4831024A (en) 1987-10-15 1989-05-16 The Board Of Trustees Of The Leland Stanford Junior University Method to prevent neonatal jaundice
US5081115A (en) 1987-10-15 1992-01-14 The Board Of Trustees Of The Leland Stanford Junior University Method to prevent neonatal jaundice with metalloporphyrin compositions
DE3827940A1 (de) 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5162313A (en) 1989-03-16 1992-11-10 The Rockefeller University Control of heme and iron concentrations in body tissues
US5223494A (en) 1989-09-25 1993-06-29 The Rockefeller University Orally administered porphyrins to control intestinal iron absorption
US5062775A (en) 1989-09-29 1991-11-05 Rocky Mountain Research, Inc. Roller pump in an extra corporeal support system
US5010073A (en) 1989-10-05 1991-04-23 The Rockefeller University Use of liposomes as carriers for metalloporphyrins
US5192757A (en) 1990-12-20 1993-03-09 Glaxo Inc. Cobalt porphyrins
AU2401992A (en) 1991-08-01 1993-03-02 E.I. Du Pont De Nemours And Company Herbicidal quinoxalinyloxy ethers
US5817830A (en) 1992-08-14 1998-10-06 Trustees Of The University Of Pennsylvania Pyrrolic compounds
US5371199B1 (en) 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
IL108241A (en) * 1992-12-30 2000-08-13 Biosource Genetics Corp Plant expression system comprising a defective tobamovirus replicon integrated into the plant chromosome and a helper virus
WO1994028906A1 (en) 1993-06-14 1994-12-22 The Rockefeller University Treatment of neonatal hyperbilirubin with metalloporphyrin
US5665869A (en) 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
CA2130853A1 (en) 1994-08-25 1996-02-26 Svetlana Kudrevich Process for the syntheses of monosulphonated phthalocyanines, naphthobenzoporphyrazines and porphyrins via a modified meerwein reaction
US6066333A (en) 1994-09-22 2000-05-23 William Harvey Research Limited Pharmaceutical control of inflammation
US5912341A (en) 1995-03-14 1999-06-15 Hoffman/Barrett, L.L.C. Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom
US5929064A (en) 1995-08-02 1999-07-27 Warner-Lambert Company Amino acid complexes of cobalt (III) mesoporphyrin IX and cobalt (III) protoporphyrin IX
US5883246A (en) 1996-03-07 1999-03-16 Qlt Phototherapeutics, Inc. Synthesis of polypyrrolic macrocycles from meso-substituted tripyrrane compounds
US6004530A (en) 1996-06-04 1999-12-21 Roche Diagnostics Gmbh Use of metallo-porphyrin conjugates for the detection of biological substances
GB9616353D0 (en) 1996-08-03 1996-09-11 Secr Defence Metallo-porphyrins
US6124452A (en) 1997-12-19 2000-09-26 University Of Nebraska-Lincoln Octafluoro-meso-tetraarylporphyrins and methods for making these compounds
DE19706490C1 (de) 1997-02-19 1998-09-17 Deutsches Krebsforsch Verfahren zur Herstellung von Säureamiden und zur Metallierung von Verbindungen und Verwendung der nach den Verfahren hergestellten Verbindungen
US5886173A (en) 1997-07-30 1999-03-23 Pharmacyclics, Inc. Metallation of macrocycles with 2,4-dicarbonyl-metal complexes
US6194566B1 (en) 1997-12-02 2001-02-27 Schering Aktiengesellschaft Process for the production of metalloporphyrin-metal complex conjugates
JP3673888B2 (ja) 1998-03-09 2005-07-20 独立行政法人科学技術振興機構 ポルフィリン類金属錯体の製造方法
DE19831217A1 (de) 1998-07-03 2000-01-05 Schering Ag Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
US5973141A (en) 1998-11-27 1999-10-26 Miravant Pharmaceuticals, Inc. Method for the demethoxycarbonylation of porphyrinic compounds such as pheophorbides
WO2001068099A1 (en) 2000-03-10 2001-09-20 The Rockefeller University Modulation of cardiovascular injury
US6462192B2 (en) * 2001-01-23 2002-10-08 Miravant Pharmaceuticals, Inc. Processes for large scale production of tetrapyrroles
US7020531B1 (en) * 2001-05-01 2006-03-28 Intrapace, Inc. Gastric device and suction assisted method for implanting a device on a stomach wall
CA2448570A1 (en) 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis
US7375216B2 (en) 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
EP1509527B1 (en) * 2002-06-04 2014-05-07 InfaCare Pharmaceutical Corporation Preparation of metal mesoporphyrin halide compounds
US7157401B2 (en) 2002-10-17 2007-01-02 Carnegie Mellon University Catalyst for the treatment of organic compounds
US20040097481A1 (en) * 2002-11-20 2004-05-20 Benjamin Levinson Water-soluble mesoporphyrin compounds and methods of preparation
EA008038B1 (ru) 2003-01-08 2007-02-27 Чирон Корпорейшн Стабилизированные водные композиции, содержащие ингибитор пути метаболизма, тканевого фактора (tfpi) или вариант ингибитора пути метаболизма тканевого фактора
US20050247320A1 (en) * 2003-10-10 2005-11-10 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
NL1025049C2 (nl) 2003-12-18 2005-06-21 Photobiochem N V Werkwijze voor de bereiding van porfyrinederivaten.
AU2006232330A1 (en) 2005-04-01 2006-10-12 Infacare Pharmaceutical Corporation Stannsoporfin compositions and administration
US20060222668A1 (en) 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
WO2008045378A2 (en) 2006-10-04 2008-04-17 Infacare Pharmaceutical Corporation Treatment of infant hyperbilirubinemia using low dosages of stannsoporfin
SI2079472T1 (sl) 2006-10-04 2011-11-30 Infacare Pharmaceutical Corp Priprava velikih količin stansoporfina z visoko čistoto
AU2012202684B2 (en) 2006-10-04 2014-04-10 Mallinckrodt Hospital Products IP Limited High-purity large-scale preparation of stannsoporfin
NZ703991A (en) * 2006-10-04 2016-07-29 Infacare Pharmaceutical Corp High-purity large-scale preparation of stannsoporfin
FR2914302A1 (fr) 2007-03-30 2008-10-03 Sanofi Pasteur Sa Procede de preparation de derives de porphyrine, telle que la protoporphyrine (ix) et intermediaire de synthese
WO2012135686A1 (en) 2011-03-30 2012-10-04 Infacare Pharmaceutical Corporation Methods for synthesizing metal mesoporphyrins
CN110279699A (zh) 2011-12-01 2019-09-27 马林克罗特医疗产品知识产权公司 用锡泊芬治疗高胆红素血症的方法
US9635905B2 (en) 2012-12-10 2017-05-02 Nike, Inc. Upper having bonded differentially-oriented inner and outer reinforcing strips

Also Published As

Publication number Publication date
US11078220B2 (en) 2021-08-03
NO20091575L (no) 2009-07-02
WO2008045377A2 (en) 2008-04-17
CN104116745A (zh) 2014-10-29
KR101573013B1 (ko) 2015-12-04
CN104116745B (zh) 2018-07-06
KR20140023447A (ko) 2014-02-26
JP2010505853A (ja) 2010-02-25
IL197838A (en) 2016-11-30
EP2992886A1 (en) 2016-03-09
HK1132191A1 (en) 2010-02-19
HRP20110746T1 (hr) 2011-11-30
IL265947A (en) 2019-05-30
US9517239B2 (en) 2016-12-13
KR20090079219A (ko) 2009-07-21
US20160000802A1 (en) 2016-01-07
EA019864B1 (ru) 2014-06-30
PT2079472E (pt) 2011-11-24
KR20130010026A (ko) 2013-01-24
DK2079472T3 (da) 2011-10-31
BRPI0717775A2 (pt) 2014-04-29
AU2007307111B2 (en) 2012-03-08
KR20140114894A (ko) 2014-09-29
KR20150138415A (ko) 2015-12-09
NZ703991A (en) 2016-07-29
US20140005380A1 (en) 2014-01-02
CA2665075C (en) 2014-03-18
IL215978A (en) 2017-08-31
NZ599321A (en) 2013-09-27
IL215978A0 (en) 2011-12-29
US20110082292A1 (en) 2011-04-07
US7960371B2 (en) 2011-06-14
CN101573122B (zh) 2016-08-03
NZ615673A (en) 2015-03-27
RS52185B (en) 2012-10-31
EP2079472B1 (en) 2011-09-14
US20180134735A1 (en) 2018-05-17
JP6195367B2 (ja) 2017-09-13
US20080125585A1 (en) 2008-05-29
EA200970344A1 (ru) 2009-10-30
BRPI0717775B8 (pt) 2021-05-25
EP2079472A2 (en) 2009-07-22
US8835416B2 (en) 2014-09-16
NZ576030A (en) 2012-06-29
MX2009003530A (es) 2009-06-26
US20190202846A1 (en) 2019-07-04
PL2079472T3 (pl) 2012-01-31
US9107927B2 (en) 2015-08-18
BRPI0717775B1 (pt) 2020-10-13
MX345035B (es) 2017-01-16
JP5524622B2 (ja) 2014-06-18
US20200255458A1 (en) 2020-08-13
US20150051184A1 (en) 2015-02-19
EA030262B1 (ru) 2018-07-31
CA2665075A1 (en) 2008-04-17
US8530458B2 (en) 2013-09-10
IL197838A0 (en) 2009-12-24
WO2008045377A3 (en) 2008-06-05
ES2556359T3 (es) 2016-01-15
HK1162939A1 (zh) 2012-09-07
US10273255B2 (en) 2019-04-30
JP2014193839A (ja) 2014-10-09
US20170073362A1 (en) 2017-03-16
US10662209B2 (en) 2020-05-26
KR101253541B1 (ko) 2013-04-15
EP2384756A2 (en) 2011-11-09
US9902745B2 (en) 2018-02-27
IL248539A0 (en) 2016-12-29
CN101573122A (zh) 2009-11-04
AU2007307111A1 (en) 2008-04-17
EP2384756B1 (en) 2015-09-16
EP2384756A3 (en) 2012-02-22
KR101400714B1 (ko) 2014-05-30
EA201400124A1 (ru) 2015-01-30
ATE524187T1 (de) 2011-09-15

Similar Documents

Publication Publication Date Title
CY1114562T1 (el) Υψηλης καθαροτητας μεγαλης κλιμακας παρασκευη στανσοπορφινης
DK1858342T3 (da) Fremgangsmåde til fremstilling af ernæringssammensætninger
MX2008008152A (es) Compuestos heterociclicos biciclicos.
MX2008010481A (es) Compuestos que tienen afinado para el receptor f-ht6.
BRPI0908926A2 (pt) Compostos de policarbonato-poliorganosiloxano e/ou poliuretano-poliorganosiloxano
WO2009135646A3 (en) Stable pharmaceutical compositions and their processes for preparation suitable for industrial scale
BRPI0814531A2 (pt) Processo de preparo de composições pulverulentas estáveis
ZA200708581B (en) Novel nutraceutical compositions
MX2009013354A (es) Compuestos de triarilo y composiciones que los contienen.
HK1133642A1 (en) Azaadamantane ester and carbamate derivatives and methods of use thereof
MX2009006750A (es) Derivados de azaadamantano espirociclicos y metodos de uso.
MY155410A (en) Compositions and devices
ITMI20061291A1 (it) Composizioni (per) fluoroelastomeriche
MX2009010176A (es) Derivados de aza-adamantano 4-substituidos y metodos de uso de los mismos.
EA200801549A1 (ru) Новые производные фенантридина в качестве антагонистов брадикинина
EA200702428A1 (ru) Способы получения 4-бифенилилазетидин-2-онов
CY1110944T1 (el) Νεα παραγωγα κυκλοαλκυλιωμενων βενζοθειαδιαζινων, μεθοδος παρασκευης αυτων και οι φαρμακευτικες συνθεσεις που τα περιεχουν
UA99904C2 (ru) Производство станнсопорфина высокой чистоты
EA200870236A1 (ru) Моногидрат римонабанта, способ его получения и фармацевтические композиции на его основе
MX2010003056A (es) Polimorfos de valomaciclovir.
WO2007034183A3 (en) Process for the preparation of 4-aminopyrazole derivatives
WO2011057192A3 (en) Amphiphilic compositions and methods for preparing and using same
WO2009118580A3 (en) Gaba analogs, compositions, and methods for manufacturing thereof
CY1113971T1 (el) Νεα παραγωγα αζαδικυκλο [3.2.0] επτ-3-υλ, μεθοδος παρασκευης αυτων και φαρμακευτικες συνθεσεις που τα περιεχουν
UA84947C2 (en) Use of 2,4(6)-dinitroaniline derivatives as synergists of gramicides