PL2079472T3 - Wytwarzanie stannsoporfiny o wysokiej czystości na dużą skalę - Google Patents

Wytwarzanie stannsoporfiny o wysokiej czystości na dużą skalę

Info

Publication number
PL2079472T3
PL2079472T3 PL07839341T PL07839341T PL2079472T3 PL 2079472 T3 PL2079472 T3 PL 2079472T3 PL 07839341 T PL07839341 T PL 07839341T PL 07839341 T PL07839341 T PL 07839341T PL 2079472 T3 PL2079472 T3 PL 2079472T3
Authority
PL
Poland
Prior art keywords
stannsoporfin
scale preparation
purity large
purity
compositions
Prior art date
Application number
PL07839341T
Other languages
English (en)
Inventor
George S Drummond
Robert Caroselli
Keith A Cooke
Daniel Levin
David G Roe
Christopher P Boucher
Original Assignee
Infacare Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infacare Pharmaceutical Corp filed Critical Infacare Pharmaceutical Corp
Publication of PL2079472T3 publication Critical patent/PL2079472T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL07839341T 2006-10-04 2007-10-04 Wytwarzanie stannsoporfiny o wysokiej czystości na dużą skalę PL2079472T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84964106P 2006-10-04 2006-10-04
US90460107P 2007-02-28 2007-02-28
EP07839341A EP2079472B1 (en) 2006-10-04 2007-10-04 High-purity large-scale preparation of stannsoporfin
PCT/US2007/021485 WO2008045377A2 (en) 2006-10-04 2007-10-04 High-purity large-scale preparation of stannsoporfin

Publications (1)

Publication Number Publication Date
PL2079472T3 true PL2079472T3 (pl) 2012-01-31

Family

ID=39144566

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07839341T PL2079472T3 (pl) 2006-10-04 2007-10-04 Wytwarzanie stannsoporfiny o wysokiej czystości na dużą skalę

Country Status (22)

Country Link
US (9) US7960371B2 (pl)
EP (3) EP2992886A1 (pl)
JP (2) JP5524622B2 (pl)
KR (5) KR20150138415A (pl)
CN (2) CN104116745B (pl)
AT (1) ATE524187T1 (pl)
AU (1) AU2007307111B2 (pl)
BR (1) BRPI0717775B8 (pl)
CA (1) CA2665075C (pl)
CY (1) CY1114562T1 (pl)
DK (1) DK2079472T3 (pl)
EA (2) EA030262B1 (pl)
ES (1) ES2556359T3 (pl)
HR (1) HRP20110746T1 (pl)
IL (4) IL197838A (pl)
MX (2) MX2009003530A (pl)
NO (1) NO20091575L (pl)
NZ (4) NZ703991A (pl)
PL (1) PL2079472T3 (pl)
PT (1) PT2079472E (pl)
RS (1) RS52185B (pl)
WO (1) WO2008045377A2 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7375216B2 (en) 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
US20060222668A1 (en) * 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
NZ703991A (en) 2006-10-04 2016-07-29 Infacare Pharmaceutical Corp High-purity large-scale preparation of stannsoporfin
EP2691398B1 (en) * 2011-03-30 2016-09-28 InfaCare Pharmaceutical Corporation Methods for synthesizing metal mesoporphyrins
KR20140107355A (ko) * 2011-12-01 2014-09-04 인파케어 파마슈티칼 코포레이션 스탠소포르핀을 이용한 고빌리루빈혈증의 치료 방법들
CN103214491B (zh) * 2013-03-13 2016-01-20 南京理工大学 [2,7,12,18-四甲基-3,8-二乙基-13,17-二羧基乙基]-卟啉的制备方法
CN107072190B (zh) 2014-09-29 2020-10-09 弗莱德哈钦森癌症研究中心 使用应激蛋白质诱导剂诱导获得性细胞抗性的组合物、试剂盒及方法
CN119488480A (zh) 2019-02-28 2025-02-21 雷尼布斯治疗公司 新型铁组合物及其制造和使用方法
IL301776A (en) * 2020-10-02 2023-05-01 Adgero Biopharmaceuticals Holdings Inc Methods for the production of nickel (ii) etioporphyrin-i
WO2025165353A1 (en) * 2024-01-31 2025-08-07 Renibus Therapeutics, Inc. Novel stannic protoporfin compositions, methods of making, and uses thereof

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684637A (en) 1981-07-15 1987-08-04 The Rockefeller University Method of decreasing rate of heme metabolism
JPS58501130A (ja) 1981-07-15 1983-07-14 ザ　ロツクフエラ−　ユニバ−シテイ ヘムの代謝速度の低下方法
US4708964A (en) 1984-02-09 1987-11-24 Chemex Pharmaceuticals Lipoxygenase inhibitors
US4619923A (en) 1985-01-14 1986-10-28 The Rockefeller University Metal protoporphyrins in the control of tryptophan metabolism
AU570143B2 (en) 1985-01-14 1988-03-03 Rockefeller University, The Method of increasing heme excretion from a mammal using tin protoporphyrin
US4657902A (en) 1985-03-25 1987-04-14 The Rockefeller University Therapeutic use of tin mesoporphyrin
US4692440A (en) 1985-03-25 1987-09-08 The Rockefeller University Therapeutic use of tin mesoporphyrin
US4692439A (en) 1986-06-20 1987-09-08 The Rockefeller University Therapeutic use of tin diiododeuteroporphyrin
US4668670A (en) 1986-06-20 1987-05-26 The Rockefeller University Tin diiododeuteroporphyrin and therapeutic use thereof
US4861876A (en) 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
US4782049A (en) 1986-12-08 1988-11-01 The Rockefeller University Tin protoporphyrin and tin mesoporphyrin in the treatment of psoriasis
US5990363A (en) 1987-01-02 1999-11-23 Sun Company, Inc. Method for oxidizing alkanes using novel porphyrins synthesized from dipyrromethanes and aldehydes
US4900871A (en) 1987-01-02 1990-02-13 Sun Refining And Marketing Company Hydrocarbon oxidations catalyzed by iron coordination complexes containing a halogenated ligand
KR890701108A (ko) * 1987-09-08 1989-12-19 원본미기재 종양요법의 독성효과를 반전시키기 위한 메탈로포르피린의 사용
US5081115A (en) 1987-10-15 1992-01-14 The Board Of Trustees Of The Leland Stanford Junior University Method to prevent neonatal jaundice with metalloporphyrin compositions
US4831024A (en) 1987-10-15 1989-05-16 The Board Of Trustees Of The Leland Stanford Junior University Method to prevent neonatal jaundice
DE3827940A1 (de) 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5162313A (en) 1989-03-16 1992-11-10 The Rockefeller University Control of heme and iron concentrations in body tissues
US5223494A (en) 1989-09-25 1993-06-29 The Rockefeller University Orally administered porphyrins to control intestinal iron absorption
US5062775A (en) 1989-09-29 1991-11-05 Rocky Mountain Research, Inc. Roller pump in an extra corporeal support system
US5010073A (en) 1989-10-05 1991-04-23 The Rockefeller University Use of liposomes as carriers for metalloporphyrins
US5192757A (en) 1990-12-20 1993-03-09 Glaxo Inc. Cobalt porphyrins
JPH06509357A (ja) 1991-08-01 1994-10-20 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 除草剤性のキノキサリニルオキシエーテル類
US5817830A (en) 1992-08-14 1998-10-06 Trustees Of The University Of Pennsylvania Pyrrolic compounds
US5371199B1 (en) 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
IL108241A (en) * 1992-12-30 2000-08-13 Biosource Genetics Corp Plant expression system comprising a defective tobamovirus replicon integrated into the plant chromosome and a helper virus
WO1994028906A1 (en) 1993-06-14 1994-12-22 The Rockefeller University Treatment of neonatal hyperbilirubin with metalloporphyrin
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
CA2130853A1 (en) 1994-08-25 1996-02-26 Svetlana Kudrevich Process for the syntheses of monosulphonated phthalocyanines, naphthobenzoporphyrazines and porphyrins via a modified meerwein reaction
US6066333A (en) 1994-09-22 2000-05-23 William Harvey Research Limited Pharmaceutical control of inflammation
US5912341A (en) 1995-03-14 1999-06-15 Hoffman/Barrett, L.L.C. Heteroatom-functionalized porphyrazines and multimetallic complexes and polymers derived therefrom
AU6497996A (en) 1995-08-02 1997-02-26 Warner-Lambert Company Amino acid complexes of cobalt (iii) mesoporphyrin ix and cobalt (iii) protoporphyrin ix
US5883246A (en) 1996-03-07 1999-03-16 Qlt Phototherapeutics, Inc. Synthesis of polypyrrolic macrocycles from meso-substituted tripyrrane compounds
US6004530A (en) 1996-06-04 1999-12-21 Roche Diagnostics Gmbh Use of metallo-porphyrin conjugates for the detection of biological substances
GB9616353D0 (en) 1996-08-03 1996-09-11 Secr Defence Metallo-porphyrins
US6124452A (en) 1997-12-19 2000-09-26 University Of Nebraska-Lincoln Octafluoro-meso-tetraarylporphyrins and methods for making these compounds
DE19706490C1 (de) 1997-02-19 1998-09-17 Deutsches Krebsforsch Verfahren zur Herstellung von Säureamiden und zur Metallierung von Verbindungen und Verwendung der nach den Verfahren hergestellten Verbindungen
US5886173A (en) 1997-07-30 1999-03-23 Pharmacyclics, Inc. Metallation of macrocycles with 2,4-dicarbonyl-metal complexes
US6194566B1 (en) 1997-12-02 2001-02-27 Schering Aktiengesellschaft Process for the production of metalloporphyrin-metal complex conjugates
JP3673888B2 (ja) 1998-03-09 2005-07-20 独立行政法人科学技術振興機構 ポルフィリン類金属錯体の製造方法
DE19831217A1 (de) 1998-07-03 2000-01-05 Schering Ag Neue Porphyrinderivate, diese enthaltende pharmazeutische Mittel und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
US5973141A (en) 1998-11-27 1999-10-26 Miravant Pharmaceuticals, Inc. Method for the demethoxycarbonylation of porphyrinic compounds such as pheophorbides
CA2402645A1 (en) 2000-03-10 2001-09-20 The Rockefeller University Modulation of cardiovascular injury
US6462192B2 (en) 2001-01-23 2002-10-08 Miravant Pharmaceuticals, Inc. Processes for large scale production of tetrapyrroles
US7020531B1 (en) * 2001-05-01 2006-03-28 Intrapace, Inc. Gastric device and suction assisted method for implanting a device on a stomach wall
WO2002096417A1 (en) 2001-05-31 2002-12-05 Miravant Pharmaceuticals, Inc. Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and mri diagnosis
US7375216B2 (en) 2002-06-04 2008-05-20 Infacare Pharmaceutical Corporation Preparation of metal mesoporphyrin compounds
JP4309839B2 (ja) * 2002-06-04 2009-08-05 インファケア・ファーマシューティカル・コーポレイション 金属メソポルフィリンハライド化合物の調製
US7157401B2 (en) * 2002-10-17 2007-01-02 Carnegie Mellon University Catalyst for the treatment of organic compounds
US20040097481A1 (en) 2002-11-20 2004-05-20 Benjamin Levinson Water-soluble mesoporphyrin compounds and methods of preparation
AU2004204720B2 (en) * 2003-01-08 2009-08-06 Novartis Vaccines And Diagnostics, Inc. Stabilized aqueous compositions comprising tissue factor pathway inhibitor (TFPI) or tissue factor pathway inhibitor variant
US20050247320A1 (en) * 2003-10-10 2005-11-10 Stack Richard S Devices and methods for retaining a gastro-esophageal implant
NL1025049C2 (nl) * 2003-12-18 2005-06-21 Photobiochem N V Werkwijze voor de bereiding van porfyrinederivaten.
US20060222668A1 (en) 2005-04-01 2006-10-05 Wellspring Pharmaceutical Corporation Stannsoporfin compositions, drug products and methods of manufacture
KR20080004531A (ko) 2005-04-01 2008-01-09 인파케어 파마슈티칼 코포레이션 스탄소포르핀 조성물 및 투여
ES2369876T3 (es) 2006-10-04 2011-12-07 Infacare Pharmaceutical Corporation Procedimiento para la producción a gran escala de estansoporfina de alta pureza.
AU2012202684B2 (en) 2006-10-04 2014-04-10 Mallinckrodt Hospital Products IP Limited High-purity large-scale preparation of stannsoporfin
BRPI0717774A2 (pt) 2006-10-04 2014-04-29 Infacare Pharmaceutical Corp Tratamento de hiperbilirrubinemia em recém-nascidos que utiliza baixas dosagens de estansoporfina
NZ703991A (en) * 2006-10-04 2016-07-29 Infacare Pharmaceutical Corp High-purity large-scale preparation of stannsoporfin
FR2914302A1 (fr) * 2007-03-30 2008-10-03 Sanofi Pasteur Sa Procede de preparation de derives de porphyrine, telle que la protoporphyrine (ix) et intermediaire de synthese
EP2691398B1 (en) * 2011-03-30 2016-09-28 InfaCare Pharmaceutical Corporation Methods for synthesizing metal mesoporphyrins
KR20140107355A (ko) 2011-12-01 2014-09-04 인파케어 파마슈티칼 코포레이션 스탠소포르핀을 이용한 고빌리루빈혈증의 치료 방법들
US9635905B2 (en) 2012-12-10 2017-05-02 Nike, Inc. Upper having bonded differentially-oriented inner and outer reinforcing strips

Also Published As

Publication number Publication date
US8530458B2 (en) 2013-09-10
EP2079472B1 (en) 2011-09-14
US8835416B2 (en) 2014-09-16
US20110082292A1 (en) 2011-04-07
BRPI0717775B1 (pt) 2020-10-13
US20140005380A1 (en) 2014-01-02
AU2007307111A1 (en) 2008-04-17
WO2008045377A3 (en) 2008-06-05
PT2079472E (pt) 2011-11-24
BRPI0717775B8 (pt) 2021-05-25
WO2008045377A2 (en) 2008-04-17
KR20140114894A (ko) 2014-09-29
KR20150138415A (ko) 2015-12-09
US20200255458A1 (en) 2020-08-13
HRP20110746T1 (hr) 2011-11-30
JP2014193839A (ja) 2014-10-09
ATE524187T1 (de) 2011-09-15
EA200970344A1 (ru) 2009-10-30
KR20090079219A (ko) 2009-07-21
US9517239B2 (en) 2016-12-13
MX345035B (es) 2017-01-16
US9902745B2 (en) 2018-02-27
NZ599321A (en) 2013-09-27
IL215978A0 (en) 2011-12-29
IL265947A (en) 2019-05-30
EP2384756A3 (en) 2012-02-22
EA019864B1 (ru) 2014-06-30
US20170073362A1 (en) 2017-03-16
BRPI0717775A2 (pt) 2014-04-29
US20180134735A1 (en) 2018-05-17
CN101573122A (zh) 2009-11-04
NZ703991A (en) 2016-07-29
JP5524622B2 (ja) 2014-06-18
IL215978A (en) 2017-08-31
CY1114562T1 (el) 2016-10-05
CA2665075A1 (en) 2008-04-17
US10273255B2 (en) 2019-04-30
CA2665075C (en) 2014-03-18
US10662209B2 (en) 2020-05-26
HK1132191A1 (en) 2010-02-19
EP2384756A2 (en) 2011-11-09
RS52185B (sr) 2012-10-31
US20160000802A1 (en) 2016-01-07
CN104116745A (zh) 2014-10-29
KR20130010026A (ko) 2013-01-24
MX2009003530A (es) 2009-06-26
EA030262B1 (ru) 2018-07-31
HK1162939A1 (en) 2012-09-07
CN104116745B (zh) 2018-07-06
NZ576030A (en) 2012-06-29
DK2079472T3 (da) 2011-10-31
EP2384756B1 (en) 2015-09-16
KR101573013B1 (ko) 2015-12-04
US7960371B2 (en) 2011-06-14
IL248539A0 (en) 2016-12-29
AU2007307111B2 (en) 2012-03-08
KR101253541B1 (ko) 2013-04-15
IL197838A (en) 2016-11-30
KR101400714B1 (ko) 2014-05-30
JP6195367B2 (ja) 2017-09-13
US20150051184A1 (en) 2015-02-19
US20190202846A1 (en) 2019-07-04
US20080125585A1 (en) 2008-05-29
IL197838A0 (en) 2009-12-24
ES2556359T3 (es) 2016-01-15
NZ615673A (en) 2015-03-27
EP2992886A1 (en) 2016-03-09
CN101573122B (zh) 2016-08-03
US11078220B2 (en) 2021-08-03
US9107927B2 (en) 2015-08-18
EA201400124A1 (ru) 2015-01-30
JP2010505853A (ja) 2010-02-25
NO20091575L (no) 2009-07-02
EP2079472A2 (en) 2009-07-22
KR20140023447A (ko) 2014-02-26

Similar Documents

Publication Publication Date Title
IL265947A (en) Preparation of stansoporfin with a high degree of purification on a large scale
MX2008010481A (es) Compuestos que tienen afinado para el receptor f-ht6.
WO2009135646A3 (en) Stable pharmaceutical compositions and their processes for preparation suitable for industrial scale
ZA200708537B (en) Process for preparing nutritional compositions
MX2007013632A (es) Procedimientos para preparar derivados de bencil-benceno sustituidos con glucopiranosilo y sus productos intermedios.
WO2008005877A3 (en) Inhibitors of c-kit and uses thereof
IL222787A0 (en) Process for preparing nebivolol
MX2009005054A (es) Disacaridos de beta 1,6 glucosamina funcionalizados y procedimiento para su preparacion.
PL1891004T3 (pl) Pentafluorosulfanylo-podstawiony związek i jego zastosowanie do wytwarzania środków leczniczych
WO2008140641A3 (en) Pure paliperidone and processes for preparing thereof
MX2010004546A (es) Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina.
WO2008021346A3 (en) Pure paliperidone and processes for preparing thereof
PL2146574T3 (pl) Sposób wytwarzania d-(-)-n,n-dietylo-2-( - naftoksy)propionamidu o wysokiej czystości
UA97965C2 (ru) Замещенные пиразолы, содержащая их композиция, способ их получения и применения
UA99904C2 (ru) Производство станнсопорфина высокой чистоты
MX2010003056A (es) Polimorfos de valomaciclovir.
WO2009152474A3 (en) Process for the preparation of (3s)-3-amino-n-cyclopropyl-2-hydroxyalkanamide derivatives
MX2007013872A (es) Procedimiento para la produccion de 4-bifenililazetidina-2-onas.
MX2009013336A (es) Sintesis de 3-aminopirazoles sustituidos.
WO2011057192A3 (en) Amphiphilic compositions and methods for preparing and using same
MX2011009734A (es) Nuevo procedimiento de preparacion de compuestos de enaminocarbonilio.
SG155231A1 (en) Process for synthesis of dialkoxyorganoboranes
MX2009003196A (es) Proceso para la preparacion de y-butirolactonas.
WO2006082598A3 (en) Novel crystalline forms of rizatriptan benzoate
WO2007034183A3 (en) Process for the preparation of 4-aminopyrazole derivatives