EA201400124A1 - Крупномасштабное производство станнсопорфина высокой чистоты - Google Patents
Крупномасштабное производство станнсопорфина высокой чистотыInfo
- Publication number
- EA201400124A1 EA201400124A1 EA201400124A EA201400124A EA201400124A1 EA 201400124 A1 EA201400124 A1 EA 201400124A1 EA 201400124 A EA201400124 A EA 201400124A EA 201400124 A EA201400124 A EA 201400124A EA 201400124 A1 EA201400124 A1 EA 201400124A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- large scale
- scale manufacture
- purity stannsoporfin
- stannsoporfin
- purity
- Prior art date
Links
- LLDZJTIZVZFNCM-UHFFFAOYSA-J 3-[18-(2-carboxyethyl)-8,13-diethyl-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;dichlorotin(2+) Chemical compound [H+].[H+].[Cl-].[Cl-].[Sn+4].[N-]1C(C=C2C(=C(C)C(=CC=3C(=C(C)C(=C4)N=3)CC)[N-]2)CCC([O-])=O)=C(CCC([O-])=O)C(C)=C1C=C1C(C)=C(CC)C4=N1 LLDZJTIZVZFNCM-UHFFFAOYSA-J 0.000 title abstract 2
- 229950001307 stannsoporfin Drugs 0.000 title abstract 2
- 238000011031 large-scale manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2284—Compounds with one or more Sn-N linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Описаны крупномасштабные (массовые) композиции, содержащие станнсопорфин высокой чистоты, а также способы синтеза таких композиций.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84964106P | 2006-10-04 | 2006-10-04 | |
US90460107P | 2007-02-28 | 2007-02-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201400124A1 true EA201400124A1 (ru) | 2015-01-30 |
EA030262B1 EA030262B1 (ru) | 2018-07-31 |
Family
ID=39144566
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201400124A EA030262B1 (ru) | 2006-10-04 | 2007-10-04 | Способ введения олова в соединение порфирина |
EA200970344A EA019864B1 (ru) | 2006-10-04 | 2007-10-04 | Крупномасштабное производство станнсопорфина высокой чистоты |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970344A EA019864B1 (ru) | 2006-10-04 | 2007-10-04 | Крупномасштабное производство станнсопорфина высокой чистоты |
Country Status (23)
Country | Link |
---|---|
US (9) | US7960371B2 (ru) |
EP (3) | EP2079472B1 (ru) |
JP (2) | JP5524622B2 (ru) |
KR (5) | KR101253541B1 (ru) |
CN (2) | CN101573122B (ru) |
AT (1) | ATE524187T1 (ru) |
AU (1) | AU2007307111B2 (ru) |
BR (1) | BRPI0717775B8 (ru) |
CA (1) | CA2665075C (ru) |
CY (1) | CY1114562T1 (ru) |
DK (1) | DK2079472T3 (ru) |
EA (2) | EA030262B1 (ru) |
ES (1) | ES2556359T3 (ru) |
HK (2) | HK1132191A1 (ru) |
HR (1) | HRP20110746T1 (ru) |
IL (4) | IL197838A (ru) |
MX (2) | MX345035B (ru) |
NO (1) | NO20091575L (ru) |
NZ (4) | NZ703991A (ru) |
PL (1) | PL2079472T3 (ru) |
PT (1) | PT2079472E (ru) |
RS (1) | RS52185B (ru) |
WO (1) | WO2008045377A2 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7375216B2 (en) | 2002-06-04 | 2008-05-20 | Infacare Pharmaceutical Corporation | Preparation of metal mesoporphyrin compounds |
US20060222668A1 (en) * | 2005-04-01 | 2006-10-05 | Wellspring Pharmaceutical Corporation | Stannsoporfin compositions, drug products and methods of manufacture |
RS52185B (en) | 2006-10-04 | 2012-10-31 | Infacare Pharmaceutical Corporation | STANSOPORPHINE PREPARATION WITH HIGH PURITY |
PT2691398T (pt) | 2011-03-30 | 2017-01-02 | Infacare Pharmaceutical Corp | Métodos para sintetizar mesoporfirinas de metal |
JP2015500243A (ja) * | 2011-12-01 | 2015-01-05 | インファケア ファーマスーティカル,コーポレイション | スタンソポルフィンを用いる高ビリルビン血症の治療方法 |
CN103214491B (zh) * | 2013-03-13 | 2016-01-20 | 南京理工大学 | [2,7,12,18-四甲基-3,8-二乙基-13,17-二羧基乙基]-卟啉的制备方法 |
DK3200582T3 (da) | 2014-09-29 | 2024-02-19 | Fred Hutchinson Cancer Center | Sammensætninger, kits og fremgangsmåder til induktion af erhvervet cytoresistens under anvendelse af stressproteininducere |
AU2020229381A1 (en) | 2019-02-28 | 2021-09-16 | Renibus Therapeutics, Inc. | Novel iron compositions and methods of making and using the same |
JP7498861B2 (ja) * | 2020-10-02 | 2024-06-12 | アジェロ・バイオファーマシューティカルズ・ホールディングス・インコーポレイテッド | ニッケル(ii)エチオポルフィリン-iの製造方法 |
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PT2691398T (pt) | 2011-03-30 | 2017-01-02 | Infacare Pharmaceutical Corp | Métodos para sintetizar mesoporfirinas de metal |
JP2015500243A (ja) | 2011-12-01 | 2015-01-05 | インファケア ファーマスーティカル,コーポレイション | スタンソポルフィンを用いる高ビリルビン血症の治療方法 |
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2007
- 2007-10-04 RS RS20110455A patent/RS52185B/en unknown
- 2007-10-04 KR KR1020097008733A patent/KR101253541B1/ko active IP Right Grant
- 2007-10-04 EA EA201400124A patent/EA030262B1/ru not_active IP Right Cessation
- 2007-10-04 KR KR1020157033361A patent/KR20150138415A/ko not_active Application Discontinuation
- 2007-10-04 MX MX2011007519A patent/MX345035B/es unknown
- 2007-10-04 BR BRPI0717775A patent/BRPI0717775B8/pt not_active IP Right Cessation
- 2007-10-04 KR KR1020147023615A patent/KR101573013B1/ko active Application Filing
- 2007-10-04 NZ NZ703991A patent/NZ703991A/en unknown
- 2007-10-04 PL PL07839341T patent/PL2079472T3/pl unknown
- 2007-10-04 AU AU2007307111A patent/AU2007307111B2/en not_active Ceased
- 2007-10-04 AT AT07839341T patent/ATE524187T1/de active
- 2007-10-04 NZ NZ61567307A patent/NZ615673A/en unknown
- 2007-10-04 CN CN200780043624.XA patent/CN101573122B/zh active Active
- 2007-10-04 CN CN201410188263.XA patent/CN104116745B/zh active Active
- 2007-10-04 EP EP07839341A patent/EP2079472B1/en active Active
- 2007-10-04 EP EP15185138.3A patent/EP2992886A1/en not_active Withdrawn
- 2007-10-04 JP JP2009531482A patent/JP5524622B2/ja not_active Expired - Fee Related
- 2007-10-04 NZ NZ599321A patent/NZ599321A/xx unknown
- 2007-10-04 ES ES11176115.1T patent/ES2556359T3/es active Active
- 2007-10-04 US US11/867,559 patent/US7960371B2/en active Active
- 2007-10-04 EA EA200970344A patent/EA019864B1/ru unknown
- 2007-10-04 KR KR1020147002613A patent/KR20140023447A/ko active Search and Examination
- 2007-10-04 PT PT07839341T patent/PT2079472E/pt unknown
- 2007-10-04 DK DK07839341.0T patent/DK2079472T3/da active
- 2007-10-04 KR KR1020127032529A patent/KR101400714B1/ko active IP Right Grant
- 2007-10-04 EP EP11176115.1A patent/EP2384756B1/en active Active
- 2007-10-04 CA CA2665075A patent/CA2665075C/en active Active
- 2007-10-04 NZ NZ576030A patent/NZ576030A/en unknown
- 2007-10-04 MX MX2009003530A patent/MX2009003530A/es active IP Right Grant
- 2007-10-04 WO PCT/US2007/021485 patent/WO2008045377A2/en active Application Filing
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2009
- 2009-03-26 IL IL197838A patent/IL197838A/en active IP Right Grant
- 2009-04-21 NO NO20091575A patent/NO20091575L/no not_active Application Discontinuation
- 2009-12-22 HK HK09112035.3A patent/HK1132191A1/xx not_active IP Right Cessation
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2010
- 2010-12-15 US US12/968,651 patent/US8530458B2/en active Active
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2011
- 2011-10-07 CY CY20111100961T patent/CY1114562T1/el unknown
- 2011-10-13 HR HR20110746T patent/HRP20110746T1/hr unknown
- 2011-10-27 IL IL215978A patent/IL215978A/en active IP Right Grant
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2012
- 2012-04-11 HK HK12103533.4A patent/HK1162939A1/zh not_active IP Right Cessation
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2013
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2014
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2015
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2016
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2018
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2019
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2020
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