WO2008061238A3 - Processes for production of 4-biphenylyazetidin-2-ones - Google Patents

Processes for production of 4-biphenylyazetidin-2-ones Download PDF

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Publication number
WO2008061238A3
WO2008061238A3 PCT/US2007/085003 US2007085003W WO2008061238A3 WO 2008061238 A3 WO2008061238 A3 WO 2008061238A3 US 2007085003 W US2007085003 W US 2007085003W WO 2008061238 A3 WO2008061238 A3 WO 2008061238A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
production
biphenylyazetidin
ones
biphenylylazetidin
Prior art date
Application number
PCT/US2007/085003
Other languages
French (fr)
Other versions
WO2008061238A2 (en
Inventor
John J Talley
Timothy C Barden
Original Assignee
Ironwood Pharmaceuticals Inc
John J Talley
Timothy C Barden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc, John J Talley, Timothy C Barden filed Critical Ironwood Pharmaceuticals Inc
Publication of WO2008061238A2 publication Critical patent/WO2008061238A2/en
Publication of WO2008061238A3 publication Critical patent/WO2008061238A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to processes for the production of 4-biphenylylazetidin-2-one derivatives of formula (I).
PCT/US2007/085003 2006-11-16 2007-11-16 Processes for production of 4-biphenylyazetidin-2-ones WO2008061238A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86617406P 2006-11-16 2006-11-16
US60/866,174 2006-11-16

Publications (2)

Publication Number Publication Date
WO2008061238A2 WO2008061238A2 (en) 2008-05-22
WO2008061238A3 true WO2008061238A3 (en) 2008-09-25

Family

ID=39268413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/085003 WO2008061238A2 (en) 2006-11-16 2007-11-16 Processes for production of 4-biphenylyazetidin-2-ones

Country Status (1)

Country Link
WO (1) WO2008061238A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL231215B1 (en) 2011-06-15 2019-02-28 Inst Chemii Organicznej Polskiej Akademii Nauk Process for the preparation of substituted azetidinones and intermediates for the synthesis thereof
CN104744331B (en) * 2013-12-31 2018-05-15 浙江九洲药业股份有限公司 A kind of synthesis technique of Ezetimible intermediate

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004099132A2 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Process for the preparation of trans-isomers of diphenylazetidinone derivatives
WO2006116499A1 (en) * 2005-04-26 2006-11-02 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-one glucuronide derivatives for hypercholesterolemia
WO2006122186A2 (en) * 2005-05-10 2006-11-16 Microbia, Inc. 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia
WO2006122020A2 (en) * 2005-05-06 2006-11-16 Microbia, Inc. Process for production of 4-biphenylyazetidin-2-ones
WO2006124713A2 (en) * 2005-05-13 2006-11-23 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-ones
WO2006127893A2 (en) * 2005-05-25 2006-11-30 Microbia, Inc. Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004099132A2 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Process for the preparation of trans-isomers of diphenylazetidinone derivatives
WO2006116499A1 (en) * 2005-04-26 2006-11-02 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-one glucuronide derivatives for hypercholesterolemia
WO2006122020A2 (en) * 2005-05-06 2006-11-16 Microbia, Inc. Process for production of 4-biphenylyazetidin-2-ones
WO2006122186A2 (en) * 2005-05-10 2006-11-16 Microbia, Inc. 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia
WO2006124713A2 (en) * 2005-05-13 2006-11-23 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-ones
WO2006127893A2 (en) * 2005-05-25 2006-11-30 Microbia, Inc. Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids

Also Published As

Publication number Publication date
WO2008061238A2 (en) 2008-05-22

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