MXPA02012157A - Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos. - Google Patents

Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos.

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Publication number
MXPA02012157A
MXPA02012157A MXPA02012157A MXPA02012157A MXPA02012157A MX PA02012157 A MXPA02012157 A MX PA02012157A MX PA02012157 A MXPA02012157 A MX PA02012157A MX PA02012157 A MXPA02012157 A MX PA02012157A MX PA02012157 A MXPA02012157 A MX PA02012157A
Authority
MX
Mexico
Prior art keywords
mediated
blocking
cell
interaction
regulating
Prior art date
Application number
MXPA02012157A
Other languages
English (en)
Inventor
Robert J Peach
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MXPA02012157A publication Critical patent/MXPA02012157A/es

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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Abstract

La invencion proporciona métodos para regular respuestas inmunes mediadas por células, enfermedades del sistema inmune y rechazo de transplantes de aloinjertos al interferir con la interaccion de por lo menos tres moléculas de superficie celular diferentes con sus ligandos naturales. Una primera interaccion celular es mediada por CD28/B7/CTLA4, una segunda interaccion es mediada por CD40/CD154 y una tercera interaccion mediada por la interaccion de LFA-1 con sus ligandos. La regulacion de una respuesta inmune medida por células afecta enfermedades del sistema inmune tales como aquellas asociadas con el transplante de aloinjertos.
MXPA02012157A 2000-06-09 2001-06-08 Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos. MXPA02012157A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21067100P 2000-06-09 2000-06-09
PCT/US2001/018619 WO2001095928A2 (en) 2000-06-09 2001-06-08 Methods for regulating a cell-mediated immune response by blocking lymphocytic signals and by blocking lfa-1 mediated adhesion

Publications (1)

Publication Number Publication Date
MXPA02012157A true MXPA02012157A (es) 2003-06-06

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MXPA02012157A MXPA02012157A (es) 2000-06-09 2001-06-08 Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos.

Country Status (12)

Country Link
US (1) US20020039577A1 (es)
EP (1) EP1294391B1 (es)
JP (1) JP2004503507A (es)
KR (1) KR20030007899A (es)
CN (1) CN1438894A (es)
AU (2) AU7541101A (es)
CA (1) CA2411962A1 (es)
IL (1) IL152316A0 (es)
MX (1) MXPA02012157A (es)
NO (1) NO20025801L (es)
WO (1) WO2001095928A2 (es)
ZA (1) ZA200208897B (es)

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IL152316A0 (en) 2003-05-29
NO20025801D0 (no) 2002-12-03
CA2411962A1 (en) 2001-12-20
EP1294391A2 (en) 2003-03-26
EP1294391B1 (en) 2012-08-15
ZA200208897B (en) 2004-02-09
JP2004503507A (ja) 2004-02-05
US20020039577A1 (en) 2002-04-04
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AU7541101A (en) 2001-12-24
NO20025801L (no) 2002-12-03

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