EA201171259A1 - Антительные гибридные белки с модифицированными сайтами связывания fcrn - Google Patents
Антительные гибридные белки с модифицированными сайтами связывания fcrnInfo
- Publication number
- EA201171259A1 EA201171259A1 EA201171259A EA201171259A EA201171259A1 EA 201171259 A1 EA201171259 A1 EA 201171259A1 EA 201171259 A EA201171259 A EA 201171259A EA 201171259 A EA201171259 A EA 201171259A EA 201171259 A1 EA201171259 A1 EA 201171259A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- fcrn binding
- constant region
- antibody
- fusion proteins
- antibody hybrid
- Prior art date
Links
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 101150050927 Fcgrt gene Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 4
- 108020001507 fusion proteins Proteins 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 abstract 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Plant Pathology (AREA)
Abstract
Раскрыты антительные гибридные белки с модифицированным сайтом связывания FcRn и нуклеиновокислотные молекулы, кодирующие их. Антительный гибридный белок включает две полипептидные цепи, где первая полипептидная цепь включает биологически, предпочтительно терапевтически, активную молекулу, связанную по меньшей мере с частью константной области иммуноглобулина. Вторая полипептидная цепь включает по меньшей мере часть константной области иммуноглобулина. Одна из полипептидных цепей содержит мутацию в константной области, которая приводит к снижению или потере связывания FcRn, но не вызывает существенного снижения времени полужизни указанного антительного гибридного белка в сыворотке. В предпочтительном воплощении изобретение относится к соответственно построенным молекулам Fc-IFNβ. Также раскрыты способы получения гибридных белков и способы применения гибридных белков для лечения заболеваний и облегчения состояний путем введения гибридных белков.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17165009P | 2009-04-22 | 2009-04-22 | |
PCT/EP2010/002377 WO2010121766A1 (en) | 2009-04-22 | 2010-04-19 | Antibody fusion proteins with modified fcrn binding sites |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201171259A1 true EA201171259A1 (ru) | 2012-05-30 |
Family
ID=42335084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171259A EA201171259A1 (ru) | 2009-04-22 | 2010-04-19 | Антительные гибридные белки с модифицированными сайтами связывания fcrn |
Country Status (13)
Country | Link |
---|---|
US (2) | US8907066B2 (ru) |
EP (1) | EP2421896A1 (ru) |
JP (1) | JP5781501B2 (ru) |
KR (1) | KR20120030383A (ru) |
CN (1) | CN102405230A (ru) |
AU (1) | AU2010238858A1 (ru) |
BR (1) | BRPI1016204A2 (ru) |
CA (1) | CA2759333A1 (ru) |
EA (1) | EA201171259A1 (ru) |
IL (1) | IL215538A0 (ru) |
MX (1) | MX2011011044A (ru) |
SG (1) | SG175233A1 (ru) |
WO (1) | WO2010121766A1 (ru) |
Families Citing this family (17)
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SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US9156917B2 (en) | 2011-02-11 | 2015-10-13 | Research Corporation Technologies, Inc. | CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds |
MY172430A (en) | 2013-04-29 | 2019-11-25 | Hoffmann La Roche | Human fcrn-binding modified antibodies and methods of use |
EP2992010B1 (en) * | 2013-04-29 | 2021-03-24 | F.Hoffmann-La Roche Ag | Fc-receptor binding modified asymmetric antibodies and methods of use |
EP3835318A1 (en) | 2014-01-15 | 2021-06-16 | F. Hoffmann-La Roche AG | Fc-region variants with modified fcrn- and maintained protein a-binding properties |
EP3094649A1 (en) * | 2014-01-15 | 2016-11-23 | F. Hoffmann-La Roche AG | Fc-region variants with modified fcrn-binding properties |
EP3842455A1 (en) * | 2014-01-15 | 2021-06-30 | F. Hoffmann-La Roche AG | Fc-region variants with improved protein a-binding |
CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
KR101838919B1 (ko) * | 2015-03-03 | 2018-03-15 | 에이비온 주식회사 | 인간 인터페론-베타 변이체가 접합된 면역사이토카인 및 이의 제조방법 |
CN104922670A (zh) * | 2015-05-06 | 2015-09-23 | 武汉奥斯梅得生物医药有限公司 | 融合免疫蛋白在制备治疗多发性硬化症药物中的应用 |
MX2019003563A (es) * | 2016-09-29 | 2019-08-12 | Beijing Hanmi Pharmaceutical Co Ltd | Construcciones de inmunoglobulina heterodimericas y metodos de preparacion de las mismas. |
TN2019000161A1 (en) | 2016-11-18 | 2020-10-05 | Beijing Hanmi Pharmaceutical Co Ltd | Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody of heterodimeric form and preparation thereof |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
EP3583120B1 (en) | 2017-02-17 | 2022-10-05 | Denali Therapeutics Inc. | Engineered transferrin receptor binding polypeptides |
WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
CN116162171A (zh) * | 2022-10-13 | 2023-05-26 | 深圳市百士通科技开发有限公司 | 抗体突变方法在治疗性抗体药物中的应用 |
CN117467025B (zh) * | 2023-12-28 | 2024-04-16 | 上海鼎新基因科技有限公司 | 一种抗vegf和补体双功能融合蛋白及其应用 |
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-
2010
- 2010-04-19 MX MX2011011044A patent/MX2011011044A/es not_active Application Discontinuation
- 2010-04-19 CA CA2759333A patent/CA2759333A1/en not_active Abandoned
- 2010-04-19 JP JP2012506384A patent/JP5781501B2/ja not_active Expired - Fee Related
- 2010-04-19 BR BRPI1016204A patent/BRPI1016204A2/pt not_active IP Right Cessation
- 2010-04-19 EP EP10714588A patent/EP2421896A1/en not_active Withdrawn
- 2010-04-19 EA EA201171259A patent/EA201171259A1/ru unknown
- 2010-04-19 WO PCT/EP2010/002377 patent/WO2010121766A1/en active Application Filing
- 2010-04-19 SG SG2011075157A patent/SG175233A1/en unknown
- 2010-04-19 CN CN2010800173922A patent/CN102405230A/zh active Pending
- 2010-04-19 KR KR1020117027872A patent/KR20120030383A/ko not_active Application Discontinuation
- 2010-04-19 AU AU2010238858A patent/AU2010238858A1/en not_active Abandoned
- 2010-04-20 US US12/763,662 patent/US8907066B2/en not_active Expired - Fee Related
-
2011
- 2011-10-04 IL IL215538A patent/IL215538A0/en unknown
-
2014
- 2014-10-28 US US14/525,910 patent/US20150274797A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2010121766A1 (en) | 2010-10-28 |
CA2759333A1 (en) | 2010-10-28 |
CN102405230A (zh) | 2012-04-04 |
MX2011011044A (es) | 2011-11-04 |
EP2421896A1 (en) | 2012-02-29 |
AU2010238858A1 (en) | 2011-12-08 |
US20100272720A1 (en) | 2010-10-28 |
US8907066B2 (en) | 2014-12-09 |
JP2012524528A (ja) | 2012-10-18 |
KR20120030383A (ko) | 2012-03-28 |
BRPI1016204A2 (pt) | 2016-04-19 |
IL215538A0 (en) | 2011-12-29 |
JP5781501B2 (ja) | 2015-09-24 |
US20150274797A1 (en) | 2015-10-01 |
SG175233A1 (en) | 2011-11-28 |
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