ES2175083T3 - Moduladores de la agregacion de amiloides. - Google Patents

Moduladores de la agregacion de amiloides.

Info

Publication number
ES2175083T3
ES2175083T3 ES96908805T ES96908805T ES2175083T3 ES 2175083 T3 ES2175083 T3 ES 2175083T3 ES 96908805 T ES96908805 T ES 96908805T ES 96908805 T ES96908805 T ES 96908805T ES 2175083 T3 ES2175083 T3 ES 2175083T3
Authority
ES
Spain
Prior art keywords
aggregation
natural
compounds
amyloid
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96908805T
Other languages
English (en)
Inventor
Mark A Findeis
Howard Benjamin
Marc B Garnick
Malcolm L Gefter
Arvind Hundal
Laura Kasman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Praecis Pharmaceuticals Inc
Original Assignee
Praecis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27410601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2175083(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/404,831 external-priority patent/US5817626A/en
Priority claimed from US08/475,579 external-priority patent/US5854215A/en
Application filed by Praecis Pharmaceuticals Inc filed Critical Praecis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2175083T3 publication Critical patent/ES2175083T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

SE DESCRIBEN COMPUESTOS QUE MODULAN LA AGREGACION DE PROTEINAS O PEPTIDOS AMILOIDOGENICOS. LOS MODULADORES DE LA INVENCION PUEDEN ESTIMULAR LA AGREGACION DE AMILOIDES, O MAS PREFERIBLEMENTE PUEDEN INHIBIR LA AGREGACION DE AMILOIDES NATURAL. EN UNA REALIZACION PREFERIDA, LOS COMPUESTOS MODULAN LA AGREGACION DE PEPTIDOS AMILOIDES {BE} NATURALES ({BE} IZACION PREFERIDA, LOS COMPUESTOS MODULADORES DE AMILOIDES {BE} DE LA INVENCION ESTAN FORMADOS POR UN DOMINIO NUCLEAR DE AGREGACION A{BE} Y UN GRUPO MODIFICADOR ACOPLADO A ESTE, DE FORMA QUE EL COMPUESTO ALTERA LA AGREGACION O INHIBE LA NEUROTOXICIDAD DE PEPTIDOS AMILOIDES {BE} NATURALES CUANDO SE PONEN EN CONTACTO CON LOS PEPTIDOS. ADEMAS, LOS MODULADORES SON CAPACES DE ALTERAR LA AGREGACION DE {BE} AP SE ENCUENTRAN EN UN EXCESO MOLAR CON RELACION A LOS MODULADORES. TAMBIEN SE DESCRIBEN COMPOSICIONES FARMACEUTICAS QUE INCLUYEN LOS COMPUESTOS DE LA INVENCION Y PROCEDIMIENTOS DE DIAGNOSTICO Y TRATAMIENTO PARA ENFERMEDADES AMILOIDOGENICAS QUE UTILIZAN LOS COMPUESTOS DE LA INVENCION.
ES96908805T 1995-03-14 1996-03-14 Moduladores de la agregacion de amiloides. Expired - Lifetime ES2175083T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/404,831 US5817626A (en) 1995-03-14 1995-03-14 Modulators of beta-amyloid peptide aggregation
US08/475,579 US5854215A (en) 1995-03-14 1995-06-07 Modulators of β-amyloid peptide aggregation
US54899895A 1995-10-27 1995-10-27

Publications (1)

Publication Number Publication Date
ES2175083T3 true ES2175083T3 (es) 2002-11-16

Family

ID=27410601

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96908805T Expired - Lifetime ES2175083T3 (es) 1995-03-14 1996-03-14 Moduladores de la agregacion de amiloides.

Country Status (8)

Country Link
US (5) US6319498B1 (es)
EP (1) EP0815134B1 (es)
JP (1) JPH11514333A (es)
AT (1) ATE218583T1 (es)
CA (1) CA2214247C (es)
DE (1) DE69621607T2 (es)
ES (1) ES2175083T3 (es)
WO (1) WO1996028471A1 (es)

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* Cited by examiner, † Cited by third party
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US6319498B1 (en) 2001-11-20
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CA2214247A1 (en) 1996-09-19
US5854204A (en) 1998-12-29
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EP0815134A1 (en) 1998-01-07
DE69621607D1 (de) 2002-07-11
ATE218583T1 (de) 2002-06-15
US20040005307A1 (en) 2004-01-08
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CA2214247C (en) 2004-02-10
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