DE69943222D1 - Menschliche ubiqutin ligase e3. verwendung für die modulation von nf-kappa b - Google Patents

Menschliche ubiqutin ligase e3. verwendung für die modulation von nf-kappa b

Info

Publication number
DE69943222D1
DE69943222D1 DE69943222T DE69943222T DE69943222D1 DE 69943222 D1 DE69943222 D1 DE 69943222D1 DE 69943222 T DE69943222 T DE 69943222T DE 69943222 T DE69943222 T DE 69943222T DE 69943222 D1 DE69943222 D1 DE 69943222D1
Authority
DE
Germany
Prior art keywords
human
kappa
modulation
compositions
activation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69943222T
Other languages
English (en)
Inventor
Anthony M Manning
Frank Mercurio
Sharon Amit
Yinon Ben-Neriah
Matti Davis
Ada Hatzubai
Iris Lavon
Avraham Yaron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Signal Pharmaceuticals LLC
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Signal Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem, Signal Pharmaceuticals LLC filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Application granted granted Critical
Publication of DE69943222D1 publication Critical patent/DE69943222D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02019—Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69943222T 1998-12-10 1999-12-09 Menschliche ubiqutin ligase e3. verwendung für die modulation von nf-kappa b Expired - Lifetime DE69943222D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21006098A 1998-12-10 1998-12-10
PCT/US1999/029371 WO2000034447A2 (en) 1998-12-10 1999-12-09 Human ubiquitin ligase e3 for the modulation of nf-kappa b

Publications (1)

Publication Number Publication Date
DE69943222D1 true DE69943222D1 (de) 2011-04-07

Family

ID=22781444

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69943222T Expired - Lifetime DE69943222D1 (de) 1998-12-10 1999-12-09 Menschliche ubiqutin ligase e3. verwendung für die modulation von nf-kappa b

Country Status (12)

Country Link
US (4) US6656713B2 (de)
EP (1) EP1135504B1 (de)
JP (1) JP4633259B2 (de)
KR (2) KR100756689B1 (de)
CN (2) CN102816743A (de)
AT (1) ATE499445T1 (de)
AU (2) AU779893B2 (de)
CA (1) CA2354153C (de)
DE (1) DE69943222D1 (de)
ES (1) ES2361660T3 (de)
IL (3) IL143516A0 (de)
WO (1) WO2000034447A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4695735B2 (ja) * 1996-08-26 2011-06-08 シグナル ファーマシューティカルズ， エルエルシー 刺激誘導性Ｉ（κ）Ｂキナーゼ［ＩＫＫ］シグナルソーム
ATE499445T1 (de) * 1998-12-10 2011-03-15 Signal Pharm Llc Menschliche ubiqutin ligase e3. verwendung für die modulation von nf-kappa b
WO2002011672A2 (en) * 2000-08-07 2002-02-14 Deltagen, Inc. Transgenic mice containing ubiquitin protein ligase e3 gene disruptions
EP1182251A1 (de) * 2000-08-11 2002-02-27 Yissum Research Development Company of the Hebrew University of Jerusalem Verfahren zum Identifizieren von Verbindungen, die die Ubiquitin vermittelte Proteolyse von IkB inhibieren
EP1343816A2 (de) * 2000-12-18 2003-09-17 Hybrigenics Proteine, die mit trcp interagieren
US7037936B2 (en) 2002-06-17 2006-05-02 Signal Pharmaceuticals, Llc. Compounds useful for the treatment of cancer, compositions thereof and methods therewith
US20060256599A1 (en) * 2005-03-22 2006-11-16 Malin Patricia J Database of electronically profiled cells and methods for generating and using same
US20100292306A1 (en) * 2005-05-24 2010-11-18 Carlson C George Compositions And Methods For The Treatment Of Muscular Dystrophy
DE602006014519D1 (de) 2005-12-16 2010-07-08 Nat Cancer Ct Peptide zur transglutaminase-hemmung
WO2007101202A1 (en) * 2006-02-27 2007-09-07 Research Development Foundation Cell-targeted ikb and methods for the use thereof
GB201110938D0 (en) * 2011-06-27 2011-08-10 Iti Scotland Ltd Compounds
US20130210875A1 (en) * 2012-02-10 2013-08-15 Macau University Of Science And Technology Novel binding site of IKK-beta

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410516B1 (en) 1986-01-09 2002-06-25 President & Fellows Of Harvard College Nuclear factors associated with transcriptional regulation
US5126324A (en) 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
US5519003A (en) 1994-02-01 1996-05-21 Board Of Trustees Of The Leland Stanford Junior University WD-40-derived peptides and uses thereof
US5597898A (en) 1995-02-15 1997-01-28 Yale University NF-κB activation regulatory protein, IκB-β
JP4695735B2 (ja) * 1996-08-26 2011-06-08 シグナル ファーマシューティカルズ， エルエルシー 刺激誘導性Ｉ（κ）Ｂキナーゼ［ＩＫＫ］シグナルソーム
US5972674A (en) 1996-08-26 1999-10-26 Signal Pharmaceuticals, Inc. Stimulus-inducible protein kinase complex and methods of use therefor
US5932425A (en) * 1997-02-18 1999-08-03 Signal Pharmaceuticals, Inc. Compositions and methods for modulating cellular NF-κB activation
US6235512B1 (en) 1997-07-01 2001-05-22 Tularik Inc. IKK-α proteins, nucleic acids and methods
US5851812A (en) 1997-07-01 1998-12-22 Tularik Inc. IKK-β proteins, nucleic acids and methods
US6242253B1 (en) 1997-10-09 2001-06-05 Regents Of The University Of California IkB kinase, subunits thereof, and methods of using same
US6573094B1 (en) * 1997-10-16 2003-06-03 Baylor College Of Medicine F-box genes and proteins
FR2774378A1 (fr) * 1998-01-30 1999-07-30 Inst Nat Sante Rech Med PROTEINE HUMAINE BETA-TrCP DE CIBLAGE DES PROTEINES VERS LES VOIES DE DEGRADATION PAR LE PROTEASOME
ATE499445T1 (de) * 1998-12-10 2011-03-15 Signal Pharm Llc Menschliche ubiqutin ligase e3. verwendung für die modulation von nf-kappa b
US6280623B1 (en) * 1999-03-23 2001-08-28 Hsien-Chih Ma Differential and continuous separation apparatus with controlled parameters for solids and liquids
US6649654B1 (en) 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors

Also Published As

Publication number Publication date
CA2354153C (en) 2011-04-12
ATE499445T1 (de) 2011-03-15
US20070208167A1 (en) 2007-09-06
JP2002539766A (ja) 2002-11-26
WO2000034447A2 (en) 2000-06-15
IL187254A (en) 2010-12-30
WO2000034447A3 (en) 2000-11-09
AU779893B2 (en) 2005-02-17
US7186503B2 (en) 2007-03-06
WO2000034447A9 (en) 2002-08-29
WO2000034447A8 (en) 2001-07-12
US20040203098A1 (en) 2004-10-14
US20030166587A1 (en) 2003-09-04
KR20020007284A (ko) 2002-01-26
US20090233855A1 (en) 2009-09-17
US8263326B2 (en) 2012-09-11
AU2174000A (en) 2000-06-26
CN1346406A (zh) 2002-04-24
JP4633259B2 (ja) 2011-02-16
CA2354153A1 (en) 2000-06-15
AU2004240212A8 (en) 2005-02-10
AU2004240212B2 (en) 2007-12-06
KR100756689B1 (ko) 2007-09-07
IL143516A (en) 2010-11-30
CN102816743A (zh) 2012-12-12
EP1135504A2 (de) 2001-09-26
US6656713B2 (en) 2003-12-02
KR20070050995A (ko) 2007-05-16
US7414120B2 (en) 2008-08-19
EP1135504B1 (de) 2011-02-23
AU2004240212A1 (en) 2005-02-10
IL143516A0 (en) 2002-04-21
ES2361660T3 (es) 2011-06-21

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