BRPI0409562A - tratamento de condições envolvendo placas amilóides - Google Patents

tratamento de condições envolvendo placas amilóides

Info

Publication number
BRPI0409562A
BRPI0409562A BRPI0409562-6A BRPI0409562A BRPI0409562A BR PI0409562 A BRPI0409562 A BR PI0409562A BR PI0409562 A BRPI0409562 A BR PI0409562A BR PI0409562 A BRPI0409562 A BR PI0409562A
Authority
BR
Brazil
Prior art keywords
treatment
conditions involving
amyloid plaques
involving amyloid
administering
Prior art date
Application number
BRPI0409562-6A
Other languages
English (en)
Inventor
Stephen M Strittmatter
Daniel H S Lee
Weiwei Li
Original Assignee
Univ Yale
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Biogen Idec Inc filed Critical Univ Yale
Publication of BRPI0409562A publication Critical patent/BRPI0409562A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"TRATAMENTO DE CONDIçõES ENVOLVENDO PLACAS AMILóIDES". A invenção proporciona métodos para tratar doenças envolvendo deposição aberrante de peptídeo <225>-amilóide (A<225>), inclusive doença de Alzheimer, por meio da administração de antagonistas de receptores Nogo. A invenção também proporciona método para reduzir níveis de peptídeo A<225> em um mamífero por meio da administração de polipeptídeos receptores Nogo solúveis.
BRPI0409562-6A 2003-04-16 2004-04-16 tratamento de condições envolvendo placas amilóides BRPI0409562A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46342403P 2003-04-16 2003-04-16
PCT/US2004/011728 WO2004093893A2 (en) 2003-04-16 2004-04-16 Nogo-receptor antagonists for the treatment of conditions involving amyloid plaques

Publications (1)

Publication Number Publication Date
BRPI0409562A true BRPI0409562A (pt) 2006-04-18

Family

ID=33310776

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409562-6A BRPI0409562A (pt) 2003-04-16 2004-04-16 tratamento de condições envolvendo placas amilóides

Country Status (15)

Country Link
US (1) US20070065429A1 (pt)
EP (1) EP1615654A2 (pt)
JP (1) JP2006523708A (pt)
KR (1) KR20060023959A (pt)
CN (1) CN1832752A (pt)
AU (1) AU2004231742A1 (pt)
BR (1) BRPI0409562A (pt)
CA (1) CA2522649A1 (pt)
EA (1) EA009643B1 (pt)
IS (1) IS8081A (pt)
MX (1) MXPA05011100A (pt)
NO (1) NO20055392L (pt)
RS (1) RS20050774A (pt)
WO (1) WO2004093893A2 (pt)
ZA (1) ZA200509242B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119165B2 (en) * 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
PT1534736E (pt) * 2002-08-10 2010-09-07 Univ Yale Antagonistas do receptor nogo
US20080274112A1 (en) * 2003-08-07 2008-11-06 Lee Daniel H S Nogo Receptor Antagonists
PT1711530E (pt) * 2003-12-22 2009-10-22 Glaxo Group Ltd Imunoglobulinas neutralizantes de nogo-a para o tratamento de doenças neurológicas
US20080045926A1 (en) * 2004-01-30 2008-02-21 Relton Jane K Treatment of Conditions Involving Dopaminergic Neuronal Degeneration Using Nogo Receptor Antagonists
US8581147B2 (en) 2005-03-24 2013-11-12 Lincoln Global, Inc. Three stage power source for electric ARC welding
US9956639B2 (en) 2005-02-07 2018-05-01 Lincoln Global, Inc Modular power source for electric ARC welding and output chopper
US8785816B2 (en) 2004-07-13 2014-07-22 Lincoln Global, Inc. Three stage power source for electric arc welding
US8269141B2 (en) 2004-07-13 2012-09-18 Lincoln Global, Inc. Power source for electric arc welding
US9855620B2 (en) 2005-02-07 2018-01-02 Lincoln Global, Inc. Welding system and method of welding
US9647555B2 (en) 2005-04-08 2017-05-09 Lincoln Global, Inc. Chopper output stage for arc welder power source
BRPI0707276B1 (pt) 2006-01-27 2021-08-31 Biogen Ma Inc Polipeptídeo de fusão antagonista de receptor nogo
JP2010502623A (ja) * 2006-08-31 2010-01-28 バイオジェン・アイデック・エムエイ・インコーポレイテッド Ｎｏｇｏレセプターポリペプチドの末梢投与に関する方法
WO2009114197A2 (en) 2008-03-13 2009-09-17 Yale University Reactivation of axon growth and recovery in chronic spinal cord injury

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US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
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US4510245A (en) * 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
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US4968615A (en) * 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
JPH05244982A (ja) * 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd 擬人化ｂ−ｂ１０
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US7119165B2 (en) * 2000-01-12 2006-10-10 Yale University Nogo receptor-mediated blockade of axonal growth
JP4465148B2 (ja) * 2000-10-06 2010-05-19 イェール ユニバーシティー Ｎｏｇｏレセプターホモログ
EP1423427A2 (en) * 2001-08-27 2004-06-02 Novartis AG Nogo receptor homologues and their use
US20050221420A1 (en) * 2001-10-22 2005-10-06 Carmen Barske Nogo receptor homologues and their use
PT1534736E (pt) * 2002-08-10 2010-09-07 Univ Yale Antagonistas do receptor nogo
US20080274112A1 (en) * 2003-08-07 2008-11-06 Lee Daniel H S Nogo Receptor Antagonists

Also Published As

Publication number Publication date
NO20055392L (no) 2005-11-15
EA200501620A1 (ru) 2006-06-30
JP2006523708A (ja) 2006-10-19
CA2522649A1 (en) 2004-11-04
WO2004093893A3 (en) 2005-03-03
IS8081A (is) 2005-10-21
EP1615654A2 (en) 2006-01-18
MXPA05011100A (es) 2006-04-18
EA009643B1 (ru) 2008-02-28
CN1832752A (zh) 2006-09-13
AU2004231742A1 (en) 2004-11-04
RS20050774A (en) 2007-12-31
AU2004231742A2 (en) 2004-11-04
ZA200509242B (en) 2006-12-27
WO2004093893A2 (en) 2004-11-04
KR20060023959A (ko) 2006-03-15
US20070065429A1 (en) 2007-03-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.