DK1608350T3 - Fremgangsm der til forebyggelse, behandling og diagnosticering af lidelser af proteinaggregation - Google Patents

Fremgangsm der til forebyggelse, behandling og diagnosticering af lidelser af proteinaggregation

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Publication number
DK1608350T3
DK1608350T3 DK04715226T DK04715226T DK1608350T3 DK 1608350 T3 DK1608350 T3 DK 1608350T3 DK 04715226 T DK04715226 T DK 04715226T DK 04715226 T DK04715226 T DK 04715226T DK 1608350 T3 DK1608350 T3 DK 1608350T3
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Prior art keywords
disorders
diagnosis
prevention
procedure
treatment
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DK04715226T
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English (en)
Inventor
Joanne Mclaurin
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Joanne Mclaurin
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Publication of DK1608350T3 publication Critical patent/DK1608350T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0491Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
DK04715226T 2003-02-27 2004-02-27 Fremgangsm der til forebyggelse, behandling og diagnosticering af lidelser af proteinaggregation DK1608350T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US45136303P 2003-02-27 2003-02-27
US52095803P 2003-11-17 2003-11-17
US52353403P 2003-11-19 2003-11-19
US10/787,621 US7521481B2 (en) 2003-02-27 2004-02-26 Methods of preventing, treating and diagnosing disorders of protein aggregation
PCT/CA2004/000272 WO2004075882A1 (en) 2003-02-27 2004-02-27 Methods of preventing, treating and diagnosing disorders of protein aggregation

Publications (1)

Publication Number Publication Date
DK1608350T3 true DK1608350T3 (da) 2009-09-07

Family

ID=32931587

Family Applications (3)

Application Number Title Priority Date Filing Date
DK10010477.7T DK2311445T3 (da) 2003-02-27 2004-02-27 Fremgangsmåder til forebyggelse, behandling og diagnosticering af forstyrrelser med proteinaggregering
DK09005295.2T DK2153829T3 (da) 2003-02-27 2004-02-27 Fremgangsmåder til forebyggelse, behandling og diagnosticering af forstyrrelser med proteinaggregering
DK04715226T DK1608350T3 (da) 2003-02-27 2004-02-27 Fremgangsm der til forebyggelse, behandling og diagnosticering af lidelser af proteinaggregation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK10010477.7T DK2311445T3 (da) 2003-02-27 2004-02-27 Fremgangsmåder til forebyggelse, behandling og diagnosticering af forstyrrelser med proteinaggregering
DK09005295.2T DK2153829T3 (da) 2003-02-27 2004-02-27 Fremgangsmåder til forebyggelse, behandling og diagnosticering af forstyrrelser med proteinaggregering

Country Status (15)

Country Link
US (7) US7521481B2 (da)
EP (4) EP2823813A1 (da)
JP (4) JP4999453B2 (da)
AT (1) ATE432694T1 (da)
AU (2) AU2004216544B2 (da)
BR (1) BRPI0407910A (da)
CA (1) CA2516563C (da)
CY (2) CY1109338T1 (da)
DE (1) DE602004021362D1 (da)
DK (3) DK2311445T3 (da)
ES (3) ES2520047T3 (da)
IL (2) IL170476A (da)
PT (3) PT1608350E (da)
SI (3) SI1608350T1 (da)
WO (1) WO2004075882A1 (da)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003291063A1 (en) * 2002-11-19 2004-06-15 Board Of Trustees Operating Michigan State University Antioxidant and antimicrobial agents and methods of use thereof
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
JP4950659B2 (ja) 2003-06-27 2012-06-13 エチコン、インコーポレイテッド 胎盤組織から由来最多分娩後細胞、及びそれらを作成し使用する方法。
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
US7840270B2 (en) * 2003-07-23 2010-11-23 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US8193250B2 (en) 2004-10-22 2012-06-05 Mount Sinai School Of Medicine Compositions and methods for treating alzheimer's disease and related disorders and promoting a healthy nervous system
EP2186518A1 (en) * 2004-11-17 2010-05-19 McLaurin, Joanne Composition and methods for treatment of disorders of protein aggregation
AU2006202209B2 (en) * 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
US20070111970A1 (en) * 2005-10-13 2007-05-17 Antonio Cruz Inositol compounds and uses of same in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, desposition, accumulation or persistence
AU2006326283B2 (en) 2005-12-12 2012-01-19 Ac Immune S.A. Therapeutic vaccine
WO2007129221A2 (en) * 2006-02-17 2007-11-15 Waratah Parmaceuticals Inc Compositions comprising an epi-inositol compounds and methods for treatment of disorders of protein aggregation
EP1996284A2 (en) * 2006-03-09 2008-12-03 Synapse Biomedical, Inc. Ventilatory assist system and method to improve respiratory function
US20100113613A1 (en) * 2006-03-09 2010-05-06 Waratah Pharmaceuticals cyclohexane polyalcohol formulation for treatment of disorders of protein aggregation
CA2655632A1 (en) * 2006-06-23 2008-01-03 The Feinstein Institute For Medical Research Inhibitors of a.beta. and synuclein aggregation
US20080097153A1 (en) * 2006-08-24 2008-04-24 Ignagni Anthony R Method and apparatus for grasping an abdominal wall
US20100173960A1 (en) * 2006-09-21 2010-07-08 Antonio Cruz The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
US20080103116A1 (en) * 2006-11-01 2008-05-01 Jennings-Spring Barbara L Method of treatment and compositions of D-chiro inositol and phosphates thereof
US20090214474A1 (en) * 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
JP2010510254A (ja) * 2006-11-24 2010-04-02 ワラタ ファーマシューティカルズ, インコーポレイテッド アルツハイマー病および関連の神経変性疾患のための併用処置
WO2008098001A2 (en) * 2007-02-05 2008-08-14 Synapse Biomedical, Inc. Removable intramuscular electrode
WO2008099210A2 (en) 2007-02-12 2008-08-21 Merck & Co., Inc. Piperazine derivatives for treatment of ad and related conditions
EP2656839A1 (en) * 2007-04-12 2013-10-30 Waratah Pharmaceuticals, Inc. Use of Cyclohexanehexol Derivatives in the Treatment of Ocular Diseases
US20100331267A1 (en) * 2007-04-12 2010-12-30 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of alpha-synucleinopathies
US20110105626A1 (en) * 2007-04-12 2011-05-05 Mclaurin Joanne Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
US20100144891A1 (en) * 2007-04-12 2010-06-10 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
US9820671B2 (en) * 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
WO2009059033A1 (en) * 2007-10-30 2009-05-07 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US20090131857A1 (en) * 2007-11-20 2009-05-21 Mark Geiger Method and apparatus for introducing a medicinal dose directly into a mammalian patient's cerebrospinal fluid
AT506535B1 (de) 2008-02-22 2010-04-15 Affiris Forschungs & Entwicklungs Gmbh Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden
WO2009117728A2 (en) * 2008-03-21 2009-09-24 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
KR101021078B1 (ko) 2008-07-22 2011-03-14 포항공과대학교 산학협력단 이노시톨 또는 트리할로스 유도체 및 이를 함유하는 퇴행성뇌신경계 질환 치료용 약학 조성물
EP2349233A4 (en) * 2008-10-09 2012-04-18 Waratah Pharmaceuticals Inc USE OF SCYLLO-INOSITOLS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH MACULAR DEGENERATION
GB0821994D0 (en) * 2008-12-02 2009-01-07 Ge Healthcare Ltd In viva imaging method
CA2756600C (en) 2009-03-26 2019-08-20 Advanced Technologies And Regenerative Medicine, Llc Human umbilical cord tissue cells as therapy for alzheimer's disease
WO2010110923A2 (en) * 2009-03-27 2010-09-30 Robert Sabin Prophylactic and therapeutic treatment of alzheimer's disease
US20110201060A1 (en) * 2010-02-15 2011-08-18 Abbott Laboratories Process for the preparation of scyllo-inositol
JP2013543513A (ja) 2010-10-13 2013-12-05 エラン ファーマシューティカルズ,インコーポレイテッド シリトールおよび関連化合物の合成方法
EP2635907A4 (en) 2010-11-05 2014-04-16 Univ Brandeis ALPHA-SYNUCLEINE CLIVED ICE AS A BIOLOGICAL MARKER
CN103906520A (zh) * 2011-06-03 2014-07-02 伊兰制药公司 用于治疗行为和精神病症的鲨肌醇
KR101365711B1 (ko) * 2013-04-30 2014-02-21 재단법인 경북해양바이오산업연구원 효모로부터 분리된 신규한 생물학적 계면활성제
US10377855B2 (en) 2014-06-25 2019-08-13 Rensselaer Polytechnic Institute Oxetane polymers and methods of preparation thereof
WO2016047823A1 (ko) * 2014-09-25 2016-03-31 영남대학교 산학협력단 장구채 추출물 또는 이로부터 분리된 보르네시톨을 유효성분으로 함유하는 세포 노화 억제용 조성물
US11191735B2 (en) 2015-03-13 2021-12-07 Nutrition 21, Llc Arginine silicate for periodontal disease
US20170135969A1 (en) 2015-11-12 2017-05-18 Jds Therapeutics, Llc Topical arginine-silicate-inositol for wound healing
US20170354669A1 (en) * 2016-02-24 2017-12-14 The Trustees Of Columbia University In The City Of New York Disruption of the interaction between amyloid beta peptide and dietary lipids
US11938117B2 (en) 2016-09-01 2024-03-26 Nutrition21, LLC Magnesium biotinate compositions and methods of use
WO2018191415A1 (en) 2017-04-11 2018-10-18 Colorado State University Research Foundation Functionalization of metal-organic frameworks
CA3100235A1 (en) 2018-05-16 2019-11-21 Emory University Styrylbenzothiazole derivatives and uses in imaging
CA3118583C (en) 2018-11-02 2024-05-14 Nutrition 21, Llc Compositions containing inositol-stabilized arginine silicate complexes and inositol for improving cognitive function in video gamers
US11471683B2 (en) 2019-01-29 2022-10-18 Synapse Biomedical, Inc. Systems and methods for treating sleep apnea using neuromodulation
EP3789018A1 (en) * 2019-09-09 2021-03-10 Servicio Andaluz De Salud Composition and methods for enhancing or promoting the secretion of ghrelin to promote a healthy metabolic aging
EP4076413A1 (en) 2019-12-16 2022-10-26 Nutrition 21, LLC Methods of production of arginine-silicate complexes
CN115066237A (zh) * 2020-01-03 2022-09-16 生物探索有限公司 用于治疗认知障碍的组合物
EP4215200A1 (en) * 2020-09-17 2023-07-26 Resonac Corporation Autophagy activator
WO2024054416A1 (en) * 2022-09-07 2024-03-14 Eirgen Pharma, Ltd. Scyllo-inositol in combination with immunotherapeutics for the treatment of alzheimer's disease

Family Cites Families (259)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2088897A (en) * 1935-03-25 1937-08-03 Goss Printing Press Co Ltd Printing press
US2557381A (en) * 1946-08-09 1951-06-19 William C Huebner Multiple unit printing press
DE2234089C3 (de) * 1972-07-08 1975-01-23 Automatic Druckmaschinenfabrik Dr. W. Hinniger U. Soehne, 1000 Berlin Offset-Rollen-Rotationsdruckmaschine
GB1581233A (en) * 1976-06-02 1980-12-10 Drg Uk Ltd Printing press
US4201706A (en) 1978-09-22 1980-05-06 Burton, Parsons & Company, Inc. Treatment of corneal edema
US4454151A (en) 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4515722A (en) 1982-03-30 1985-05-07 Merck & Co., Inc. Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents
US4474806A (en) 1982-05-10 1984-10-02 Merck & Co., Inc. Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents
IT1164225B (it) 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
DE3405663A1 (de) 1984-02-17 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung von scyllo-inosit
US5407924A (en) 1984-10-23 1995-04-18 Perstorp Ab Method of treating pain using inositol triphosphate
US5545632A (en) 1984-10-23 1996-08-13 Perstorp Ab Method of treating retroviral disease
US5330979A (en) 1984-10-23 1994-07-19 Perstorp Ab Method of treating renal disorders with inositoltriphosphate
US4735902A (en) 1984-10-23 1988-04-05 Matti Siren Stabilized composition containing inositoltriphosphate
SE465305B (sv) 1986-04-16 1991-08-26 Perstorp Ab Anvaendning av inositolfosfat foer framstaellning av ett laekemedel
US5023248A (en) 1984-10-23 1991-06-11 Perstorp Ab Method of treating diabetes with inositol triphosphate
US5128332A (en) 1984-10-23 1992-07-07 Perstorp Ab Method of treating cardiovascular diseases using inositoltrisphosphate
SE465951B (sv) 1984-10-23 1991-11-25 Perstorp Ab Isomer av inositoltrifosfat foeretraedesvis i saltform foer anvaendning som terapeutiskt eller profylaktiskt medel samt kompositioner daerav
IL74497A (en) 1985-03-05 1990-02-09 Proterra Ag Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
DE3610107A1 (de) * 1986-03-26 1987-10-08 Voith Gmbh J M Stellvorrichtung zum verstellen einer walze
US5057507A (en) 1986-04-16 1991-10-15 Perstorp Ab Method of alleviating bone damage with inositoltriphosphate
US5135923A (en) 1986-04-16 1992-08-04 Perstorp Ab Method of treating cardiovascular diseases
US4758420A (en) 1986-07-14 1988-07-19 The Dow Chemical Company Solvent extraction of polychlorinated organic compounds from porous materials
US4952396A (en) 1986-11-19 1990-08-28 Linus Pauling Institute Of Science & Medicine Method of using phytic acid for inhibiting tumor growth
US4847082A (en) * 1987-01-21 1989-07-11 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
US4758430A (en) 1987-01-21 1988-07-19 Robert Sabin Method of treatment of Alzheimer's disease using phytic acid
NL195004C (nl) 1987-03-04 2003-11-04 Novartis Ag Fenylcarbamaat bevattend farmaceutisch preparaat.
JPH067158Y2 (ja) 1987-03-18 1994-02-23 株式会社藤井合金製作所 配管端末の防水構造
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
DE3808142A1 (de) * 1988-03-11 1989-09-21 Goebel Gmbh Maschf Lagereinrichtung
DE3814752C1 (da) * 1988-04-30 1989-08-31 J.M. Voith Gmbh, 7920 Heidenheim, De
US5334618A (en) * 1991-04-04 1994-08-02 The Children's Medical Center Corporation Method of preventing NMDA receptor-mediated neuronal damage
JPH03102492A (ja) 1989-06-12 1991-04-26 Mitsui Eng & Shipbuild Co Ltd 自動販売機のデータ送信システムおよび複合機能型自動販売機
SE8904355D0 (sv) 1989-12-21 1989-12-21 Perstorp Ab Medicament
US5111814A (en) * 1990-07-06 1992-05-12 Thomas Jefferson University Laryngeal pacemaker
US5217959A (en) 1990-09-06 1993-06-08 Robert Sabin Method of treating multiple sclerosis with phytic acid
JP2984043B2 (ja) 1990-09-18 1999-11-29 旭化成工業株式会社 ミオ・イノシトールデヒドロゲナーゼおよびその製造法
US5112814A (en) 1990-10-24 1992-05-12 Robert Sabin Method of treatment of Parkinson's disease using phytic acid
SE9102068L (sv) * 1991-07-03 1993-01-04 Perstorp Ab Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav
JPH05192163A (ja) 1991-09-30 1993-08-03 Suntory Ltd イノシトールデヒドロゲナーゼ遺伝子
AU662588B2 (en) 1991-12-18 1995-09-07 Schering Corporation Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine H3 agonists/antagonists
SE9200547L (sv) 1992-02-25 1993-06-14 Perstorp Ab En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat
JP3251976B2 (ja) 1992-06-23 2002-01-28 旭化成株式会社 ミオ・イノシトールデヒドロゲナーゼを生産する実質上純粋な微生物
US5351616A (en) * 1992-08-13 1994-10-04 Man Roland Druckmaschinen Ag Rotary web printing machine, particularly for printing on thick or carton-type stock webs with replaceable plate cylinders
DE4229494A1 (de) 1992-09-04 1994-03-10 Basotherm Gmbh Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks
DE69332542T2 (de) 1992-10-05 2003-08-14 Virginia Tech Intellectual Properties Inc., Blacksburg Synthesen von d-chiro-3-inosose und (+)-d-chiro-inositol
US5972328A (en) 1993-03-29 1999-10-26 Queen's University At Kingston Method for treating amyloidosis
US5840294A (en) 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
US5643562A (en) 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
DE69333071T2 (de) 1993-04-05 2004-05-06 Aveve N.V. Phytate-Hydrolyse und enzymatische Zusammensetzung für die Hydrolyse von Phytat
CN1072637C (zh) 1993-08-11 2001-10-10 北兴化学工业株式会社 D-手性肌醇的制造方法
US5412080A (en) 1993-08-25 1995-05-02 President And Fellow Of Harvard College Enterobactin compounds
SE502574C2 (sv) 1994-01-25 1995-11-13 Perstorp Ab En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat
DE4408025A1 (de) * 1994-03-10 1995-09-14 Koenig & Bauer Ag Druckwerk für eine Mehrfarbenrollenrotationsdruckmaschine
DE4430693B4 (de) * 1994-08-30 2005-12-22 Man Roland Druckmaschinen Ag Antriebe für eine Rollenrotations-Offsetdruckmaschine
US5550166A (en) 1995-03-17 1996-08-27 Ostlund; Richard E. Pinitol and derivatives thereof for the treatment of metabolic disorders
US5858326A (en) 1995-06-06 1999-01-12 Neurochem, Inc. Methods of increasing amyloid deposition
US6221645B1 (en) 1995-06-07 2001-04-24 Elan Pharmaceuticals, Inc. β-secretase antibody
JP3630344B2 (ja) 1995-11-17 2005-03-16 北興化学工業株式会社 イノシトール立体異性体の製造方法
AU1153097A (en) 1996-06-07 1998-01-05 Eisai Co. Ltd. Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production
TW513409B (en) 1996-06-07 2002-12-11 Eisai Co Ltd Polymorphs of donepezil hydrochloride
US6232486B1 (en) 1996-06-11 2001-05-15 Nutrimed Biotech Molecular probes and modulators for PI-PLC and PI 3-kinase
TW506836B (en) 1996-06-14 2002-10-21 Janssen Pharmaceutica Nv Fast-dissolving galanthamine hydrobromide tablet
US5977078A (en) 1996-09-20 1999-11-02 The Regents Of The Univesity Of California Inositol polyphosphate derivatives and methods of using same
US5880099A (en) 1996-09-20 1999-03-09 The Regents Of The University Of California Inositol polyphosphates and methods of using same
US20030068316A1 (en) 1997-02-05 2003-04-10 Klein William L. Anti-ADDL antibodies and uses thereof
US6218506B1 (en) 1997-02-05 2001-04-17 Northwestern University Amyloid β protein (globular assembly and uses thereof)
AU6682298A (en) 1997-03-10 1998-09-29 Loma Linda University Medical Center Use of r-nsaid's for the prevention of alzheimer's disease
US5998485A (en) 1997-06-16 1999-12-07 Cedars-Sinai Medical Center Method for modulating immune response with inositol
US6153603A (en) 1997-06-27 2000-11-28 Perstorp Ab Method of treating angiogenesis in tumor tissue
GB9801899D0 (en) 1998-01-29 1998-03-25 Univ London Neurotrophic properties of ipgs analogues
DE19805898C2 (de) * 1998-02-13 2003-09-18 Roland Man Druckmasch Druckwerk für eine Rollenrotationsdruckmaschine
US6720190B1 (en) 1998-03-27 2004-04-13 Ole Hindsgaul Methods for screening compound libraries
US5981168A (en) 1998-05-15 1999-11-09 The University Of British Columbia Method and composition for modulating amyloidosis
US6227110B1 (en) * 1998-06-23 2001-05-08 Heidelberger Druckmaschinen Ag Wet printing press with throw-off mechanism
US6310073B1 (en) 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
AUPP589398A0 (en) 1998-09-14 1998-10-08 Walter And Eliza Hall Institute Of Medical Research, The Immunogenic compositions and uses thereof
KR20070013361A (ko) 1998-09-24 2007-01-30 파마시아 앤드 업존 캄파니 엘엘씨 알츠하이머병 세크레타제
AUPP675898A0 (en) 1998-10-27 1998-11-19 Walter And Eliza Hall Institute Of Medical Research, The A method of activating t cells and agents useful for same
US6221856B1 (en) 1999-02-03 2001-04-24 Inologic, Inc. Inositol derivatives for inhibiting superoxide anion production
NZ534876A (en) 1999-02-10 2006-02-24 Elan Pharm Inc Human beta-secretase enzyme, inhibitors and their compositions and uses
GB2389182B (en) 1999-02-10 2004-02-04 Elan Pharm Inc Method of purifying b-secretase
EP1159263A1 (en) 1999-02-26 2001-12-05 Merck & Co., Inc. Novel sulfonamide compounds and uses thereof
US6818430B1 (en) 1999-06-07 2004-11-16 Hokko Chemical Industry Co., Ltd. Process for producing L-epi-2-inosose and novel process for producing epi-inositol
US6864240B1 (en) 1999-06-15 2005-03-08 Elan Pharmaceuticals, Inc. Dipeptide inhibitors of β-secretase
WO2000077030A1 (en) 1999-06-15 2000-12-21 Elan Pharmaceuticals, Inc. Statine-derived tetrapeptide inhibitors of beta-secretase
AU5994900A (en) 1999-07-09 2001-01-30 Isis Innovation Limited Compounds for inhibiting diseases and preparing cells for transplantation
DE19937796B4 (de) * 1999-08-10 2007-03-22 Man Roland Druckmaschinen Ag Druckwerk
DE19937803A1 (de) * 1999-08-10 2001-02-15 Roland Man Druckmasch Druckwerk
DE19937805A1 (de) * 1999-08-10 2001-02-15 Roland Man Druckmasch Druckwerk
US20020052311A1 (en) * 1999-09-03 2002-05-02 Beka Solomon Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
US6329256B1 (en) 1999-09-24 2001-12-11 Advanced Micro Devices, Inc. Self-aligned damascene gate formation with low gate resistance
JP2001163810A (ja) 1999-09-30 2001-06-19 Microbial Chem Res Found 1d−キロ−イノシトールの新規合成方法および中間体
CA2388733C (en) 1999-10-18 2012-09-18 Muscletech Research And Development, Inc. Food supplement for increasing lean mass and strength
US7728043B2 (en) 1999-10-22 2010-06-01 Kim Darrick S H L Methods for treatment of beta-amyloid protein-induced ocular disease
EP1235789A2 (en) 1999-11-09 2002-09-04 Eli Lilly And Company $g(b)-AMINOACID COMPOUNDS USEFUL FOR INHIBITING $g(b)-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS
CA2390376A1 (en) 1999-11-09 2001-05-17 William Leonard Scott .beta.-aminoacid compounds useful for inhibiting .beta.-amyloid peptide release and/or its synthesis
DE19963944C1 (de) * 1999-12-31 2001-06-13 Koenig & Bauer Ag Verfahren zum Einstellen einer Walze einer Druckmaschine
EP1254108A1 (en) 2000-01-24 2002-11-06 MERCK SHARP & DOHME LTD. Gamma-secretase inhibitors
DE10008215B4 (de) * 2000-02-23 2013-03-28 Manroland Web Systems Gmbh Druckwerk für eine Rotationsdruckmaschine mit Kreuzschlitten
GB0005251D0 (en) 2000-03-03 2000-04-26 Merck Sharp & Dohme Therapeutic compounds
US20030144255A1 (en) 2000-03-06 2003-07-31 Bain Allen I Compositions for prevention and treatment of dementia
US7365196B2 (en) 2000-03-20 2008-04-29 Merck Sharp & Dohme Ltd. Sulphonamido-substituted bridged bicycloalkyl derivatives
AU2001252958A1 (en) 2000-03-23 2001-10-03 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
GB0008710D0 (en) 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic compounds
CA2406383A1 (en) 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research A.beta.42 lowering agents
US6716826B2 (en) 2000-05-12 2004-04-06 Rodaris Pharmaceuticals Limited Compounds and their uses
US6939857B2 (en) 2000-05-12 2005-09-06 Rodaris Pharmaceuticals Limited Compounds and their uses
EP1283039A4 (en) 2000-05-19 2007-05-30 Takeda Pharmaceutical INHIBITORS OF -SECRETASE
GB0015627D0 (en) 2000-06-26 2000-08-16 Rademacher Group Limited Phosphoglycan messengers and their medical uses
ATE302751T1 (de) 2000-06-30 2005-09-15 Elan Pharm Inc Verbindungen zur behandlung der alzheimerischen krankheit
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
DE10031955A1 (de) 2000-06-30 2002-01-17 Deutsches Krebsforsch Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel
GB0016681D0 (en) 2000-07-06 2000-08-23 Merck Sharp & Dohme Therapeutic compounds
US6559891B1 (en) * 2000-08-15 2003-05-06 Sony Corporation Method and apparatus to generate tri-level HDTV synchronization pulses
US7138400B2 (en) 2000-11-02 2006-11-21 Merck Sharp & Dohme Limited Sulfamides as gamma-secretase inhibitors
CA2465534C (en) 2000-11-02 2009-10-27 Nigel H. Greig Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof
WO2002055715A1 (fr) 2001-01-15 2002-07-18 Hokko Chemical Industry Co., Ltd. Adn codant pour une d-myo-inositol 1-épimérase
EP1357912B9 (en) 2001-02-06 2012-06-13 QLT Inc. Photodynamic therapy of occult choroidal neovascularization linked to age-related macular degeneration
EP1233021A3 (en) 2001-02-20 2002-11-20 Pfizer Products Inc. An inhibitor of Beta amyloid cleavage enzyme
AU2002306848A1 (en) 2001-03-23 2002-10-08 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease with piperidin derivates
ATE270613T1 (de) * 2001-04-09 2004-07-15 Koenig & Bauer Ag Druckwerk einer druckmaschine mit einem linear bewegbaren übertragungszylinder
JP2004534017A (ja) 2001-04-27 2004-11-11 バーテックス ファーマシューティカルズ インコーポレイテッド Baceのインヒビター
EP1395275B1 (en) 2001-05-22 2008-11-12 Merck & Co., Inc. Beta-secretase substrate and uses thereof
JP2004534771A (ja) 2001-05-22 2004-11-18 イーラン ファーマスーティカルズ、インコーポレイテッド アザヒドロキシル化エチルアミン化合物
US7144897B2 (en) 2001-06-01 2006-12-05 Elan Oharmaceuticals, Inc. Hydroxy alkyl amines
US6684775B2 (en) * 2001-06-07 2004-02-03 Heidelberger Druckmaschinen Ag Printing unit with roll-away inkers
WO2002100410A1 (en) 2001-06-08 2002-12-19 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease
WO2002100820A1 (en) 2001-06-11 2002-12-19 Elan Pharmaceuticals, Inc. Substituted aminoalcohols useful in treatment of alzheimer's disease
WO2002100399A1 (en) 2001-06-12 2002-12-19 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
EP1404671B1 (en) 2001-06-12 2006-04-12 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
JP2004532894A (ja) 2001-06-13 2004-10-28 イーラン ファーマスーティカルズ、インコーポレイテッド アルツハイマー病を治療するためのアミンジオール
JP2005500310A (ja) 2001-06-25 2005-01-06 イーラン ファーマスーティカルズ、インコーポレイテッド アルツハイマー病を治療するためのビシクロ化合物の使用
JP3981597B2 (ja) 2001-06-25 2007-09-26 北興化学工業株式会社 シロ−イノソースの製造法及びシロ−イノシトールの製造法
US6982264B2 (en) 2001-06-27 2006-01-03 Elan Pharmaceuticals, Inc. Substituted alcohols useful in treatment of Alzheimer's disease
BR0211121A (pt) 2001-07-10 2004-10-26 Elan Pharm Inc Composto, métodos para o tratamento ou prevenção de doenças e para fabricar um composto, intermediário, e, uso de um composto ou sal
WO2003006021A1 (en) 2001-07-10 2003-01-23 Elan Pharmaceuticals, Inc. Alpha-hydroxyamide statine derivatives for the treatment of alzh eimer's disease
MXPA04000338A (es) 2001-07-10 2004-07-23 Upjohn Co Diamindioles para tratamiento de enfermedad de alzheimer.
US20030181531A1 (en) 2003-02-11 2003-09-25 David Sherris Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
US6599891B2 (en) 2001-07-20 2003-07-29 Qlt Inc. Treatment of macular edema
CA2455861A1 (en) 2001-08-03 2003-02-20 Schering Corporation Sulfonamide derivatives as gamma secretase inhibitors
CN1304390C (zh) 2001-08-03 2007-03-14 先灵公司 新颖的γ—分泌酶抑制剂
US20040266871A1 (en) 2001-08-28 2004-12-30 Schostarez Heinrich Josef Methods for treating alzheimer's disease using quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
DE10145322A1 (de) * 2001-09-14 2003-04-03 Ina Schaeffler Kg Lageranordnung für Zylinder, Walzen oder Trommeln
CA2461603A1 (en) 2001-09-24 2003-04-03 Elan Pharmaceuticals, Inc. Substituted amines for the treatment of neurological disorders
WO2003029169A2 (en) 2001-10-04 2003-04-10 Elan Pharmaceuticals, Inc. Hydroxypropylamines
CA2462875A1 (en) 2001-10-05 2003-04-17 Elan Pharmaceuticals, Inc. Allylamides useful in the treatment of alzheimer's disease
CA2464736A1 (en) 2001-10-23 2003-05-15 Oklahoma Medical Research Foundation Beta-secretase inhibitors and methods of use
MXPA04004079A (es) 2001-10-29 2005-07-05 Pharmacia & Upjohn Co Llc Amidas hidroxi sustituidas para tratamiento de enfermedad de alzheimer.
MXPA04004428A (es) 2001-11-08 2004-09-10 Elan Pharm Inc Derivados de 2,3-diamino-2-hidroxipropano n,n`-sustituidos.
AU2002360403A1 (en) 2001-11-19 2003-06-10 Elan Pharmaceuticals, Inc. (4-phenyl) piperidin-3-yl-phenylcarboxylate derivatives and related compounds as beta-secretase inhibitors for the treatment of Alzheimer's disease
DE60211746D1 (de) 2001-11-21 2006-06-29 Elan Pharm Inc Aminosäurederivate zur behandlung der alzheimer-krankheit
JP2005514380A (ja) 2001-12-04 2005-05-19 イーラン ファーマスーティカルズ、インコーポレイテッド アルツハイマー病の治療に有用な複素環を含むペプチドアイソスター
AU2002360508A1 (en) 2001-12-06 2003-06-23 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamines
CH698246B1 (de) 2001-12-20 2009-06-30 Hoffmann La Roche Test zur Identifizierung von Inhibitoren von Beta-Sekretasen.
AU2003206397B2 (en) 2002-01-04 2008-07-17 The Rockefeller University Compositions and methods for prevention and treatment of amyloid-beta peptide-related disorders
CA2472617A1 (en) 2002-01-04 2003-07-17 Elan Pharmaceuticals, Inc. Substituted amino carboxamides for the treatment of alzheimer's disease
AU2003205630A1 (en) 2002-01-18 2003-07-30 The Genetics Company Inc. Beta-secretase inhibitors
US7053220B2 (en) 2002-02-01 2006-05-30 Elan Pharmaceuticals, Inc. Hydroxyalkanoyl aminopyrazoles and related compounds
US7256186B2 (en) 2002-02-06 2007-08-14 Schering Corporation Gamma secretase inhibitors
TW200302717A (en) 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
US20040171614A1 (en) 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
CN1319987C (zh) 2002-04-24 2007-06-06 森启 γ-分泌酶抑制剂
US20040058313A1 (en) 2002-04-24 2004-03-25 Abreu Marcio Marc Compositions, targets, methods and devices for the therapy of ocular and periocular disorders
AU2003229932B2 (en) 2002-05-01 2008-12-11 Merck Sharp & Dohme Limited Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
WO2003094854A2 (en) 2002-05-07 2003-11-20 Elan Pharmaceuticals, Inc. Succinoyl aminopyrazoles and related compounds
DE10223666B4 (de) * 2002-05-28 2006-06-14 Windmöller & Hölscher Kg Farbwerksaufbau bei Flexodruckmaschinen
US6723755B2 (en) 2002-06-12 2004-04-20 Piotr Chomczynski Method of treating rosacea
US20060089355A1 (en) 2002-06-11 2006-04-27 Michel Maillard Methods of treating alzheimer's disease using aromatically substituted w-amino-alkanoic acid amides and alkanoic acid diamides
WO2003103653A1 (en) 2002-06-11 2003-12-18 Elan Pharmaceuticals, Inc. Methods of treating alzheimer's disease using aryl alkanoic acid amides
WO2004002478A1 (en) 2002-06-27 2004-01-08 Elan Pharmaceuticals, Inc. Methods for treating alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
GB0217909D0 (en) 2002-08-01 2002-09-11 Du Pont Chintzed stretch fabrics
GB0218041D0 (en) 2002-08-02 2002-09-11 Merck Sharp & Dohme Chemical process
US7557137B2 (en) 2002-08-05 2009-07-07 Bristol-Myers Squibb Company Gamma-lactams as beta-secretase inhibitors
CN1732161A (zh) 2002-09-06 2006-02-08 艾伦药物公司 1,3-二氨基-2-羟基丙烷前体药物衍生物
UY27967A1 (es) 2002-09-10 2004-05-31 Pfizer Acetil 2-hindroxi-1,3-diaminoalcanos
MXPA05003220A (es) 2002-09-27 2005-07-05 Elan Pharm Inc Compuestos para tratamiento de enfermedad de alzheimer.
US7243510B2 (en) 2002-09-30 2007-07-17 Bp Corporation North America Inc. Reduced carbon dioxide emission system and method for providing power for refrigerant compression and electrical power for a light hydrocarbon gas liquefaction process
JP2006508072A (ja) 2002-10-01 2006-03-09 ノースウエスタン ユニバーシティ アミロイドベータ由来拡散性リガンド(ADDLs)、ADDL代替物、ADDL結合性分子、およびそれらの使用
GB0223038D0 (en) 2002-10-04 2002-11-13 Merck Sharp & Dohme Therapeutic compounds
GB0223039D0 (en) 2002-10-04 2002-11-13 Merck Sharp & Dohme Therapeutic compounds
DE60230455D1 (de) 2002-10-17 2009-01-29 Jingyu Liang Natürliche verbindung für die behandlung von diabetes, deren herstellung und verwendung
CA2507484A1 (en) 2002-11-27 2004-06-17 Elan Pharmaceuticals, Inc. Substituted ureas and carbamates
CN1726033A (zh) 2002-12-11 2006-01-25 法马西亚和厄普乔恩公司 用α7烟碱乙酰胆碱受体激动剂和其它化合物的联合治疗疾病
FR2848452B1 (fr) 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
ATE402934T1 (de) 2003-02-04 2008-08-15 Hoffmann La Roche Malonamidderivate als gamma-secretaseinhibitoren
EP1603548A4 (en) 2003-02-05 2007-10-10 Myriad Genetics Inc COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
GB0308318D0 (en) 2003-04-10 2003-05-14 Merck Sharp & Dohme Therapeutic agents
WO2004094384A2 (en) 2003-04-21 2004-11-04 Elan Pharmaceuticals, Inc. (hetero) arylamide 2-hydroxy-3-diaminoalkanes for use in the treatment of alzheimer’s disease
JP2006524258A (ja) 2003-04-21 2006-10-26 イーラン ファーマスーティカルズ、インコーポレイテッド フェナシル2−ヒドロキシ−3−ジアミノアルカン
WO2004101562A2 (en) 2003-05-13 2004-11-25 Schering Corporation Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
AU2004238607B2 (en) 2003-05-16 2010-05-27 Merck Sharp & Dohme Limited Cyclohexyl sulphones as gamma-secretase inhibitors
US7060698B2 (en) 2003-05-19 2006-06-13 Hoffmann-La Roche Inc. Benzoxazepinone derivatives
AU2004258841B8 (en) 2003-06-05 2010-01-07 Elan Pharmaceuticals, Inc. Acylated amino acid amidyl pyrazoles and related compounds
JP2007516207A (ja) 2003-06-30 2007-06-21 メルク エンド カムパニー インコーポレーテッド アルツハイマー病の治療のためのN−アルキルフェニルカルボキサミドβ−セクレターゼ阻害剤
CN1909897A (zh) 2003-07-01 2007-02-07 默克公司 用于治疗阿尔茨海默病的苯基羧化物β-分泌酶抑制剂
WO2005008250A1 (en) 2003-07-21 2005-01-27 Angiogenetics Sweden Ab Compounds and methods for promoting angiogenesis by using a gamma-secretase inhibitor or inhibiting the gamma-secretase pathway
GB0318447D0 (en) 2003-08-05 2003-09-10 Merck Sharp & Dohme Therapeutic agents
AU2004265298A1 (en) 2003-08-08 2005-02-24 Pharmacopeia, Inc. Cyclic amine BACE-1 inhibitors having a benzamide substituent
AU2004266605A1 (en) 2003-08-14 2005-03-03 Merck & Co., Inc. Macrocyclic beta-secretase inhibitors for the treatment of Alzheimer's disease
ATE509917T1 (de) 2003-09-24 2011-06-15 Merck Sharp & Dohme Gamma-secretase-inhibitoren
KR100793095B1 (ko) 2003-10-01 2008-01-10 주식회사 프로메디텍 Bace 저해효능을 가진 신규한 술폰 아미드 유도체
DE602004014170D1 (de) 2003-10-03 2008-07-10 Merck & Co Inc Benzylether- und benzylamino-beta-sekretase-hemmer zur behandlung von alzheimer-krankheit
GB0323258D0 (en) 2003-10-04 2003-11-05 Merck Sharp & Dohme Therapeutic compounds
KR100884872B1 (ko) 2003-10-06 2009-02-23 에프. 호프만-라 로슈 아게 감마-세크레타제 저해제로서 유용한 치환된다이벤조-아제핀 및 벤조-다이아제핀 유도체
CA2774930C (en) 2003-10-14 2014-08-05 Hokko Chemical Industry Co., Ltd. Method for producing purified scyllo-inositol utilizing boric acid
US20050171112A1 (en) 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
ES2232302B1 (es) 2003-11-07 2006-08-01 Universitat De Les Illes Balears Myo-inositol hexafosfato para uso topico.
GB0326039D0 (en) 2003-11-07 2003-12-10 Merck Sharp & Dohme Therapeutic agents
ATE383160T1 (de) 2003-11-11 2008-01-15 Hoffmann La Roche Phosphinsäurederivate, inhibitoren von beta- sekretase zur behandlung von alzheimer-krankheit
AU2004293416B2 (en) 2003-11-24 2009-09-24 Merck & Co., Inc. Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease
MXPA06005734A (es) 2003-11-28 2006-08-17 Hoffmann La Roche Acidos tetronico y tetramico como inhibidores de beta-secretasa.
CA2548849A1 (en) 2003-12-19 2005-07-21 Merck & Co., Inc. Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
US20050142612A1 (en) 2003-12-31 2005-06-30 Chi-Bom Chae Inhibitors of amyloid precursor protein processing
EP1718741A2 (en) 2004-01-29 2006-11-08 Cellzome Ag Treatment of neurodegenerative diseases by the use of atp7a
WO2005074980A1 (en) 2004-01-29 2005-08-18 Cellzome Ag Treatment of neurodegenerative diseases by the use of gpr49
WO2005095326A2 (en) 2004-03-25 2005-10-13 Elan Pharmaceuticals, Inc. 2-amino- and 2-thio-substituted 1,3-diaminopropanes
AU2005230878A1 (en) 2004-03-30 2005-10-20 Merck & Co., Inc. 2-aminothiazole compounds useful as aspartyl protease inhibitors
AR049377A1 (es) 2004-04-05 2006-07-26 Schering Corp Inhibidores de secretasa gamma
US7847100B2 (en) 2004-04-20 2010-12-07 Merck, Sharp & Dohme, Inc. 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
AU2005236063A1 (en) 2004-04-20 2005-11-03 Merck & Co., Inc. 2, 4, 6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
CN1964940A (zh) 2004-05-13 2007-05-16 默克公司 可用作β-分泌酶抑制剂用于治疗阿尔茨海默氏病的苯基羧酰胺化合物
US20060004096A1 (en) 2004-05-28 2006-01-05 Joseph Larner Method of Treating Endothelial Dysfunction, Oxidative Stress and Related Diseases
JP4406327B2 (ja) 2004-06-29 2010-01-27 儀昭 新田 タイヤチップ製造装置
US8193250B2 (en) 2004-10-22 2012-06-05 Mount Sinai School Of Medicine Compositions and methods for treating alzheimer's disease and related disorders and promoting a healthy nervous system
EP2186518A1 (en) 2004-11-17 2010-05-19 McLaurin, Joanne Composition and methods for treatment of disorders of protein aggregation
WO2006088705A1 (en) 2005-02-14 2006-08-24 Wyeth Terphenyl guanidines as [beta symbol] -secretase inhibitors
WO2006112000A1 (ja) 2005-03-30 2006-10-26 The Niigata Institute Of Science And Technology 大腸菌変異株による2-デオキシ-シロ-イノソースの合成および精製する方法並びに得られた2-デオキシ-シロ-イノソース
KR20060105233A (ko) 2005-04-02 2006-10-11 삼성전자주식회사 하이브리드 디스크, 그 기록 및/또는 재생 장치 및 방법
US7273882B2 (en) 2005-06-21 2007-09-25 Bristol-Myers Squibb Company Aminoacetamide acyl guanidines as β-secretase inhibitors
WO2007011833A2 (en) 2005-07-18 2007-01-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
WO2007019080A2 (en) 2005-08-03 2007-02-15 Merck & Co., Inc. Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease
US7338974B2 (en) 2005-08-12 2008-03-04 Bristol-Myers Squibb Company Macrocyclic diaminopropanes as beta-secretase inhibitors
US20070111970A1 (en) 2005-10-13 2007-05-17 Antonio Cruz Inositol compounds and uses of same in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, desposition, accumulation or persistence
WO2007050612A1 (en) 2005-10-25 2007-05-03 Janssen Pharmaceutica N.V. 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (bace)
WO2007129221A2 (en) 2006-02-17 2007-11-15 Waratah Parmaceuticals Inc Compositions comprising an epi-inositol compounds and methods for treatment of disorders of protein aggregation
US20070197452A1 (en) 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
CA2579188A1 (en) 2006-02-17 2007-08-17 Joanne Mclaurin Treatment of amyloid-related diseases
US20100113613A1 (en) 2006-03-09 2010-05-06 Waratah Pharmaceuticals cyclohexane polyalcohol formulation for treatment of disorders of protein aggregation
EP2024371A1 (en) 2006-05-18 2009-02-18 Merck Frosst Canada Ltd. Phenanthrene derivatives as mpges-1 inhibitors
US20110028719A1 (en) 2006-05-19 2011-02-03 Jacek Slon-Usakiewicz Screening methods for amyloid beta modulators
EP1884531A1 (en) 2006-07-30 2008-02-06 Lonza Compounds GmbH & Co. KG Sheet molding compounds (smc) comprising thermosetting resins based on renewable resources
EP2061317A4 (en) 2006-08-25 2010-06-30 Allan Basbaum INTRATHECAL ADMINISTRATION OF TRIPTAN COMPOSITIONS TO TREAT NON-MIGRAINE PAIN
EP2063807A4 (en) 2006-09-06 2010-03-31 Aortx Inc PROSTHETIC CARDIAC VALVES, SUPPORT STRUCTURES, AND SYSTEMS AND METHODS FOR IMPLANTATION THEREOF
US20100173960A1 (en) 2006-09-21 2010-07-08 Antonio Cruz The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
JP2010510254A (ja) 2006-11-24 2010-04-02 ワラタ ファーマシューティカルズ, インコーポレイテッド アルツハイマー病および関連の神経変性疾患のための併用処置
US20080200437A1 (en) 2006-12-29 2008-08-21 Jean-Marie Lehn Cyclitols and Their Derivatives and Their Therapeutic Applications
WO2008098371A1 (en) 2007-02-16 2008-08-21 The Royal Institution For The Advancement Of Learning/Mcgill University Compositions and method for reducing amyloid beta in a mammal
EP2656839A1 (en) 2007-04-12 2013-10-30 Waratah Pharmaceuticals, Inc. Use of Cyclohexanehexol Derivatives in the Treatment of Ocular Diseases
US20100144891A1 (en) 2007-04-12 2010-06-10 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
US20100331267A1 (en) 2007-04-12 2010-12-30 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of alpha-synucleinopathies
US20110105626A1 (en) 2007-04-12 2011-05-05 Mclaurin Joanne Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
JP5034916B2 (ja) 2007-12-10 2012-09-26 富士通セミコンダクター株式会社 性能評価モデル生成方法、システム性能評価方法、及び性能評価モデル生成装置
EP2323704B1 (en) 2008-08-06 2018-02-28 Invista Technologies S.à.r.l. Preparation of elastic composite structures useful for components of disposable hygiene products and articles of apparel
TW201016208A (en) 2008-09-15 2010-05-01 Elan Pharm Inc Methods of treatment of hyperuricemia and associated disease states
EP2349233A4 (en) 2008-10-09 2012-04-18 Waratah Pharmaceuticals Inc USE OF SCYLLO-INOSITOLS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH MACULAR DEGENERATION
CN103906520A (zh) 2011-06-03 2014-07-02 伊兰制药公司 用于治疗行为和精神病症的鲨肌醇

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