CY1105922T1 - Χρηση υποκατεστημενων παραγωγων αζετιδινονης στη θepαπεια ασθενειας alzheimer - Google Patents
Χρηση υποκατεστημενων παραγωγων αζετιδινονης στη θepαπεια ασθενειας alzheimerInfo
- Publication number
- CY1105922T1 CY1105922T1 CY20071100048T CY071100048T CY1105922T1 CY 1105922 T1 CY1105922 T1 CY 1105922T1 CY 20071100048 T CY20071100048 T CY 20071100048T CY 071100048 T CY071100048 T CY 071100048T CY 1105922 T1 CY1105922 T1 CY 1105922T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alzheimer
- disease
- treatment
- substituted azetidinone
- azetidinone derivatives
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 102000013918 Apolipoproteins E Human genes 0.000 abstract 1
- 108010025628 Apolipoproteins E Proteins 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Παρέχονται μέθοδοι αποτροπής, θεραπείας ή ανακούφισης συμπτωμάτων ασθένειας Alzheimer, ρύθμισης παραγωγής ή επιπέδων πεπτιδίων αμυλοειδούς β (Αβ) ή/και ρύθμισης της ποσότητας της ΑpοΕ ισομορφής 4 στο ρεύμα του αίματος ή/και τον εγκέφαλο, που περιλαμβάνουν το στάδιο χορήγησης σε ένα υποκείμενο που έχει ανάγκη μιας τέτοιας θεραπευτικής αγωγής, μιας αποτελεσματικής ποσότητας μιας σύνθεσης που περιλαμβάνει τουλάχιστον μια ένωση που αντιπροσωπεύεται από τους Τύπους (Ι-Χ) που αποκαλύπτονται εδώ.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29365101P | 2001-05-25 | 2001-05-25 | |
US32391101P | 2001-09-21 | 2001-09-21 | |
PCT/US2002/016306 WO2002096415A2 (en) | 2001-05-25 | 2002-05-22 | Use of azetidinone substituted derivatives in the treatment of alzheimer's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105922T1 true CY1105922T1 (el) | 2011-04-06 |
Family
ID=26968071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100048T CY1105922T1 (el) | 2001-05-25 | 2007-01-15 | Χρηση υποκατεστημενων παραγωγων αζετιδινονης στη θepαπεια ασθενειας alzheimer |
Country Status (14)
Country | Link |
---|---|
US (1) | US20030013699A1 (el) |
EP (1) | EP1392287B8 (el) |
JP (1) | JP2004532868A (el) |
AR (1) | AR038956A1 (el) |
AT (1) | ATE345792T1 (el) |
AU (1) | AU2002308778A1 (el) |
CA (1) | CA2447884A1 (el) |
CY (1) | CY1105922T1 (el) |
DE (1) | DE60216275T2 (el) |
DK (1) | DK1392287T3 (el) |
ES (1) | ES2275007T3 (el) |
MX (1) | MXPA03010843A (el) |
PT (1) | PT1392287E (el) |
WO (1) | WO2002096415A2 (el) |
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US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
JP3144624B2 (ja) * | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
JP2000505063A (ja) * | 1995-12-08 | 2000-04-25 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | アテローム性動脈硬化症の治療のためのアゼチジノン化合物 |
GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
HUP9901359A3 (en) * | 1996-04-26 | 2000-03-28 | Smithkline Beecham Plc | Azetidinone derivatives for the treatment of atherosclerosis, process for their producing and pharmaceutical compositions containing them |
US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
DE69833971T2 (de) * | 1998-01-28 | 2006-11-02 | Warner-Lambert Co. Llc | Verfahren zur behandlung der alzheimerschen krankheit |
-
2002
- 2002-05-22 DE DE60216275T patent/DE60216275T2/de not_active Expired - Fee Related
- 2002-05-22 AU AU2002308778A patent/AU2002308778A1/en not_active Abandoned
- 2002-05-22 CA CA002447884A patent/CA2447884A1/en not_active Abandoned
- 2002-05-22 WO PCT/US2002/016306 patent/WO2002096415A2/en active IP Right Grant
- 2002-05-22 JP JP2002592925A patent/JP2004532868A/ja active Pending
- 2002-05-22 EP EP02774113A patent/EP1392287B8/en not_active Expired - Lifetime
- 2002-05-22 MX MXPA03010843A patent/MXPA03010843A/es active IP Right Grant
- 2002-05-22 AT AT02774113T patent/ATE345792T1/de not_active IP Right Cessation
- 2002-05-22 PT PT02774113T patent/PT1392287E/pt unknown
- 2002-05-22 ES ES02774113T patent/ES2275007T3/es not_active Expired - Lifetime
- 2002-05-22 DK DK02774113T patent/DK1392287T3/da active
- 2002-05-22 US US10/154,106 patent/US20030013699A1/en not_active Abandoned
- 2002-05-22 AR ARP020101893A patent/AR038956A1/es unknown
-
2007
- 2007-01-15 CY CY20071100048T patent/CY1105922T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2447884A1 (en) | 2002-12-05 |
JP2004532868A (ja) | 2004-10-28 |
MXPA03010843A (es) | 2004-02-17 |
WO2002096415A3 (en) | 2003-01-16 |
AR038956A1 (es) | 2005-02-02 |
EP1392287B8 (en) | 2007-01-10 |
US20030013699A1 (en) | 2003-01-16 |
DE60216275D1 (de) | 2007-01-04 |
EP1392287A2 (en) | 2004-03-03 |
EP1392287B1 (en) | 2006-11-22 |
WO2002096415A2 (en) | 2002-12-05 |
ATE345792T1 (de) | 2006-12-15 |
ES2275007T3 (es) | 2007-06-01 |
PT1392287E (pt) | 2007-02-28 |
DE60216275T2 (de) | 2007-06-21 |
AU2002308778A1 (en) | 2002-12-09 |
DK1392287T3 (da) | 2007-03-19 |
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