GB2389182B - Method of purifying b-secretase - Google Patents

Method of purifying b-secretase

Info

Publication number
GB2389182B
GB2389182B GB0318113A GB0318113A GB2389182B GB 2389182 B GB2389182 B GB 2389182B GB 0318113 A GB0318113 A GB 0318113A GB 0318113 A GB0318113 A GB 0318113A GB 2389182 B GB2389182 B GB 2389182B
Authority
GB
United Kingdom
Prior art keywords
secretase
purifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0318113A
Other versions
GB2389182A (en
GB0318113D0 (en
Inventor
John P Anderson
Guriqbal Basi
Minh Tam Doane
Normand Frigon
Varghese John
Michael Power
Sukanto Sinha
Gwen Tatsuno
Jay Tung
Shuwen Wang
Lisa Mcconlogue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Elan Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharmaceuticals LLC filed Critical Elan Pharmaceuticals LLC
Priority claimed from GB0121314A external-priority patent/GB2364059B/en
Publication of GB0318113D0 publication Critical patent/GB0318113D0/en
Publication of GB2389182A publication Critical patent/GB2389182A/en
Application granted granted Critical
Publication of GB2389182B publication Critical patent/GB2389182B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
GB0318113A 1999-02-10 2000-02-10 Method of purifying b-secretase Expired - Fee Related GB2389182B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11957199P 1999-02-10 1999-02-10
US13917299P 1999-06-15 1999-06-15
GB0121314A GB2364059B (en) 1999-02-10 2000-02-10 Beta-Secretase enzyme compositions and methods

Publications (3)

Publication Number Publication Date
GB0318113D0 GB0318113D0 (en) 2003-09-03
GB2389182A GB2389182A (en) 2003-12-03
GB2389182B true GB2389182B (en) 2004-02-04

Family

ID=29407316

Family Applications (3)

Application Number Title Priority Date Filing Date
GB0318107A Expired - Fee Related GB2389113B (en) 1999-02-10 2000-02-10 B-secretase inhibitor
GB0318112A Expired - Fee Related GB2389114B (en) 1999-02-10 2000-02-10 Mouse b-secretase enzyme
GB0318113A Expired - Fee Related GB2389182B (en) 1999-02-10 2000-02-10 Method of purifying b-secretase

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB0318107A Expired - Fee Related GB2389113B (en) 1999-02-10 2000-02-10 B-secretase inhibitor
GB0318112A Expired - Fee Related GB2389114B (en) 1999-02-10 2000-02-10 Mouse b-secretase enzyme

Country Status (1)

Country Link
GB (3) GB2389113B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067271B1 (en) 1999-02-10 2006-06-27 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
JP2007509898A (en) 2003-11-03 2007-04-19 プロビオドルグ エージー Useful combinations for the treatment of neurological disorders
EP1713780B1 (en) 2004-02-05 2012-01-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020725A2 (en) * 1995-01-06 1996-07-11 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
WO1998026059A1 (en) * 1996-12-11 1998-06-18 Athena Neurosciences, Inc. Beta-secretase isolated from human 293 cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10155487A (en) * 1996-11-28 1998-06-16 Kagaku Gijutsu Shinko Jigyodan Amino acid sequence and dna sequence of protein combination having the same
GB9701684D0 (en) * 1997-01-28 1997-03-19 Smithkline Beecham Plc Novel compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020725A2 (en) * 1995-01-06 1996-07-11 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
WO1998026059A1 (en) * 1996-12-11 1998-06-18 Athena Neurosciences, Inc. Beta-secretase isolated from human 293 cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Brain Res; Vol 750, pp 11-19 (1997). Chevallier et al. *
J Neurochem; Vol 66, pp 2436-2445 (1996). Brown et al. *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067271B1 (en) 1999-02-10 2006-06-27 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7109017B1 (en) 1999-02-10 2006-09-19 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7252963B2 (en) 1999-02-10 2007-08-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7262043B2 (en) 1999-02-10 2007-08-28 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7276349B2 (en) 1999-02-10 2007-10-02 Elan Pharmaceuticals, Inc. Beta-secretase enzyme compositions and methods
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods

Also Published As

Publication number Publication date
GB2389113B (en) 2004-02-04
GB0318112D0 (en) 2003-09-03
GB2389113A (en) 2003-12-03
GB2389182A (en) 2003-12-03
GB2389114A (en) 2003-12-03
GB2389114B (en) 2004-02-04
GB0318113D0 (en) 2003-09-03
GB0318107D0 (en) 2003-09-03

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