PT1529116E - Métodos para o tratamento da demência com base no genótipo da apo e - Google Patents
Métodos para o tratamento da demência com base no genótipo da apo e Download PDFInfo
- Publication number
- PT1529116E PT1529116E PT03747881T PT03747881T PT1529116E PT 1529116 E PT1529116 E PT 1529116E PT 03747881 T PT03747881 T PT 03747881T PT 03747881 T PT03747881 T PT 03747881T PT 1529116 E PT1529116 E PT 1529116E
- Authority
- PT
- Portugal
- Prior art keywords
- apoe
- genotyp
- rivastigmine
- responsiveness
- predicting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/775—Apolipopeptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40169402P | 2002-08-07 | 2002-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1529116E true PT1529116E (pt) | 2009-09-10 |
Family
ID=31715721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT03747881T PT1529116E (pt) | 2002-08-07 | 2003-08-06 | Métodos para o tratamento da demência com base no genótipo da apo e |
Country Status (14)
Country | Link |
---|---|
US (3) | US20060160079A1 (pt) |
EP (1) | EP1529116B1 (pt) |
JP (1) | JP2005534710A (pt) |
CN (1) | CN1681941A (pt) |
AT (1) | ATE435302T1 (pt) |
AU (1) | AU2003266967B2 (pt) |
BR (1) | BR0313588A (pt) |
CA (1) | CA2494585A1 (pt) |
DE (1) | DE60328198D1 (pt) |
DK (1) | DK1529116T3 (pt) |
ES (1) | ES2327914T3 (pt) |
IL (1) | IL166466A0 (pt) |
PT (1) | PT1529116E (pt) |
WO (1) | WO2004015140A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
CA2571856A1 (en) * | 2004-07-20 | 2006-02-09 | Wyeth | Methods of identifying patients at risk of developing encephalitis following immunotherapy for alzheimer's disease |
CA2596523A1 (en) * | 2005-01-31 | 2006-08-10 | Perlegen Sciences, Inc. | Genetic basis of alzheimer's disease and diagnosis and treatment thereof |
US7740593B2 (en) | 2005-12-09 | 2010-06-22 | Senorx, Inc | Guide block for biopsy or surgical devices |
KR101335021B1 (ko) | 2007-07-31 | 2013-12-12 | 액세라인크 | 게놈 테스트의 용도 및 인지 기능 저하 치료용 케톤성 화합물 |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
KR101734152B1 (ko) | 2008-07-03 | 2017-05-11 | 액세라인크 | 신경계 장애의 치료를 위한 아세토아세테이트의 모노글리세리드 및 유도체 |
WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
WO2015020523A1 (en) | 2013-08-07 | 2015-02-12 | Stichting Vu-Vumc | Biomarkers for early diagnosis of alzheimer's disease |
CA3057289A1 (en) | 2017-03-21 | 2018-09-27 | The Jackson Laboratory | A genetically modified mouse expressing human apoe4 and mouse trem2 p.r47h and methods of use thereof |
CN111032038A (zh) * | 2017-05-24 | 2020-04-17 | H.隆德贝克有限公司 | 用于治疗阿尔茨海默氏病的药物组合 |
US20210195879A1 (en) * | 2018-06-21 | 2021-07-01 | The Jackson Laboratory | Genetically modified mouse models of alzheimer's disease |
WO2020176846A2 (en) * | 2019-02-28 | 2020-09-03 | The Rockefeller University | Apoe genotyping in cancer prognostics and treatment |
CN114728875A (zh) | 2019-12-13 | 2022-07-08 | 因思博纳公司 | 金属盐及其用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE262592T1 (de) * | 1992-10-13 | 2004-04-15 | Univ Duke | Verfahren zum nachweis der alzheimer krankheit |
CA2111503A1 (en) * | 1993-12-15 | 1995-06-16 | Mcgill University | Apolipoprotein e polymorphism and alzheimer's disease |
FR2765591B1 (fr) * | 1997-07-01 | 2002-08-09 | Pasteur Institut | Procede de diagnostic de la maladie d'alzheimer |
CO4980891A1 (es) * | 1997-11-14 | 2000-11-27 | Sanofi Sa | Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer |
JP2000069963A (ja) * | 1998-08-31 | 2000-03-07 | Igaku Seibutsugaku Kenkyusho:Kk | アポリポプロテインe4特異モノクローナル抗体 |
ES2237163T3 (es) * | 1998-10-01 | 2005-07-16 | Novartis Ag | Nuevas formulaciones orales de revastigmina de liberacion controlada. |
DE60116313T2 (de) * | 2000-06-30 | 2006-08-31 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen zur behandlung der alzheimerischen krankheit |
-
2003
- 2003-08-06 AT AT03747881T patent/ATE435302T1/de not_active IP Right Cessation
- 2003-08-06 DE DE60328198T patent/DE60328198D1/de not_active Expired - Lifetime
- 2003-08-06 US US10/523,047 patent/US20060160079A1/en not_active Abandoned
- 2003-08-06 CN CNA038212528A patent/CN1681941A/zh active Pending
- 2003-08-06 AU AU2003266967A patent/AU2003266967B2/en not_active Ceased
- 2003-08-06 CA CA002494585A patent/CA2494585A1/en not_active Abandoned
- 2003-08-06 WO PCT/EP2003/008719 patent/WO2004015140A1/en active Application Filing
- 2003-08-06 ES ES03747881T patent/ES2327914T3/es not_active Expired - Lifetime
- 2003-08-06 DK DK03747881T patent/DK1529116T3/da active
- 2003-08-06 PT PT03747881T patent/PT1529116E/pt unknown
- 2003-08-06 JP JP2004526899A patent/JP2005534710A/ja active Pending
- 2003-08-06 BR BR0313588-8A patent/BR0313588A/pt not_active Application Discontinuation
- 2003-08-06 EP EP03747881A patent/EP1529116B1/en not_active Expired - Lifetime
-
2005
- 2005-01-24 IL IL16646605A patent/IL166466A0/xx unknown
-
2007
- 2007-11-16 US US11/941,420 patent/US20080214662A1/en not_active Abandoned
-
2010
- 2010-06-03 US US12/793,436 patent/US20100240744A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20060160079A1 (en) | 2006-07-20 |
DE60328198D1 (de) | 2009-08-13 |
EP1529116A1 (en) | 2005-05-11 |
IL166466A0 (en) | 2006-01-15 |
CN1681941A (zh) | 2005-10-12 |
WO2004015140A1 (en) | 2004-02-19 |
ATE435302T1 (de) | 2009-07-15 |
US20100240744A1 (en) | 2010-09-23 |
AU2003266967A1 (en) | 2004-02-25 |
US20080214662A1 (en) | 2008-09-04 |
ES2327914T3 (es) | 2009-11-05 |
DK1529116T3 (da) | 2009-11-09 |
JP2005534710A (ja) | 2005-11-17 |
EP1529116B1 (en) | 2009-07-01 |
CA2494585A1 (en) | 2004-02-19 |
AU2003266967B2 (en) | 2006-11-16 |
BR0313588A (pt) | 2005-07-12 |
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