EA200970694A1 - ПЭГИЛИРОВАННЫЕ Fab-ФРАГМЕНТЫ АНТИТЕЛ К ПЕПТИДУ Aβ - Google Patents
ПЭГИЛИРОВАННЫЕ Fab-ФРАГМЕНТЫ АНТИТЕЛ К ПЕПТИДУ AβInfo
- Publication number
- EA200970694A1 EA200970694A1 EA200970694A EA200970694A EA200970694A1 EA 200970694 A1 EA200970694 A1 EA 200970694A1 EA 200970694 A EA200970694 A EA 200970694A EA 200970694 A EA200970694 A EA 200970694A EA 200970694 A1 EA200970694 A1 EA 200970694A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- peptide
- pehylated
- antibody fragments
- fab antibody
- fragments
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 title 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 title 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6893—Pre-targeting systems involving an antibody for targeting specific cells clearing therapy or enhanced clearance, i.e. using an antibody clearing agents in addition to T-A and D-M
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Описаны способы профилактики и лечения состояния, связанного с активностью пептида Аβ. В способе используют фрагменты гуманизированного антитела, которые специфично связывают пептид Аβ человека между положениями аминокислот 13 и 28, причем фрагменты антитела ковалентно связаны с молекулой полиэтиленгликоля (ПЭГ).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88543907P | 2007-01-18 | 2007-01-18 | |
PCT/US2008/050554 WO2008088983A1 (en) | 2007-01-18 | 2008-01-09 | PEGYLATED Aβ FAB |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970694A1 true EA200970694A1 (ru) | 2010-02-26 |
EA020979B1 EA020979B1 (ru) | 2015-03-31 |
Family
ID=39332186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970694A EA020979B1 (ru) | 2007-01-18 | 2008-01-09 | ПЭГИЛИРОВАННЫЕ Fab-ФРАГМЕНТЫ АНТИТЕЛ К ПЕПТИДУ Aβ |
Country Status (27)
Country | Link |
---|---|
US (1) | US8066999B2 (ru) |
EP (2) | EP2842967B1 (ru) |
JP (2) | JP5307030B2 (ru) |
KR (2) | KR101414847B1 (ru) |
CN (2) | CN101981053B (ru) |
AR (1) | AR064944A1 (ru) |
AU (1) | AU2008206555B2 (ru) |
BR (1) | BRPI0806715A2 (ru) |
CA (1) | CA2675847C (ru) |
CL (1) | CL2008000121A1 (ru) |
CY (2) | CY1116157T1 (ru) |
DK (1) | DK2121754T3 (ru) |
EA (1) | EA020979B1 (ru) |
ES (2) | ES2615454T3 (ru) |
HK (1) | HK1190623A1 (ru) |
HR (2) | HRP20150237T1 (ru) |
IL (2) | IL199838A (ru) |
LT (1) | LT2842967T (ru) |
MX (1) | MX2009007691A (ru) |
PE (1) | PE20081634A1 (ru) |
PL (1) | PL2121754T3 (ru) |
PT (2) | PT2842967T (ru) |
RS (1) | RS53948B1 (ru) |
SI (2) | SI2842967T1 (ru) |
TW (1) | TW200836763A (ru) |
UA (1) | UA95996C2 (ru) |
WO (1) | WO2008088983A1 (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2310412T (lt) | 2008-06-20 | 2018-07-10 | Novartis Ag | Imunoglobulinai su sumažinta agregacija |
ES2417781T3 (es) | 2008-06-20 | 2013-08-09 | Novartis Ag | Procedimientos para identificar regiones de unión a macromolécula y propensas a la agregación en proteínas y usos de los mismos |
CN106117348A (zh) | 2009-06-04 | 2016-11-16 | 诺华公司 | 识别IgG结合位点的方法 |
SG183369A1 (en) | 2010-03-03 | 2012-09-27 | Boehringer Ingelheim Int | Biparatopic abeta binding polypeptides |
JP6231263B2 (ja) * | 2012-07-17 | 2017-11-15 | 株式会社島津製作所 | アフィニティ支持体及びそれを用いた物質の捕捉方法 |
WO2014022817A2 (en) | 2012-08-03 | 2014-02-06 | Novartis Ag | Methods to identify amino acid residues involved in macromolecular binding and uses therefor |
WO2015036553A1 (en) * | 2013-09-16 | 2015-03-19 | Novo Nordisk Health Care Ag | Thiol functionalized polymers |
KR20150133576A (ko) | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
WO2017079831A1 (en) | 2015-11-09 | 2017-05-18 | The University Of British Columbia | N-terminal epitopes in amyloid beta and conformationally-selective antibodies thereto |
EP3374383A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | BETA-AMYLOID EPITOPES AND ASSOCIATED ANTIBODIES |
WO2017079833A1 (en) | 2015-11-09 | 2017-05-18 | The University Of British Columbia | Epitopes in amyloid beta mid-region and conformationally-selective antibodies thereto |
TWI735600B (zh) | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | 抗-N3pGlu類澱粉β肽抗體及其用途 |
JP6949102B2 (ja) | 2016-08-09 | 2021-10-13 | イーライ リリー アンド カンパニー | 併用療法 |
US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
EP3574020B1 (en) | 2017-07-18 | 2024-05-15 | The University of British Columbia | Antibodies to amyloid beta |
WO2019134039A1 (en) * | 2018-01-04 | 2019-07-11 | Septa Therapeutics, Inc. | Septapeptides associated with neurodegeneracy |
TW202300518A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗N3pGlu類澱粉β抗體及其用途 |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5278049A (en) | 1986-06-03 | 1994-01-11 | Incyte Pharmaceuticals, Inc. | Recombinant molecule encoding human protease nexin |
US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5753624A (en) | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
US5445090A (en) | 1991-07-25 | 1995-08-29 | Mim Industries, Inc. | Interchangeable clamp for use in a sewing machine |
US5837672A (en) | 1992-07-10 | 1998-11-17 | Athena Neurosciences, Inc. | Methods and compositions for the detection of soluble β-amyloid peptide |
US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
CA2115900A1 (en) | 1993-02-22 | 1994-08-23 | Gerald W. Becker | Pharmaceutical screens and antibodies |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5935927A (en) | 1994-02-03 | 1999-08-10 | The Picower Institute For Medical Research | Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts |
US5668651A (en) * | 1994-03-18 | 1997-09-16 | Sharp Kabushiki Kaisha | Polymer-wall LCD having liquid crystal molecules having a plane-symmetrical bend orientation |
US6114133A (en) | 1994-11-14 | 2000-09-05 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41) |
US5688651A (en) | 1994-12-16 | 1997-11-18 | Ramot University Authority For Applied Research And Development Ltd. | Prevention of protein aggregation |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5786180A (en) | 1995-02-14 | 1998-07-28 | Bayer Corporation | Monoclonal antibody 369.2B specific for β A4 peptide |
US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
US20040121415A1 (en) * | 1996-12-10 | 2004-06-24 | King David John | Monovalent antibody fragments |
US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
US6413940B1 (en) | 1997-02-07 | 2002-07-02 | Nymox Corporation | Pharmaceutically active agents that impede the formation of amyloid by impeding the genesis of DMS |
US20020086847A1 (en) | 1997-04-09 | 2002-07-04 | Mindset Biopharmaceuticals (Usa) | Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof |
DK0994728T3 (da) | 1997-04-09 | 2008-12-01 | Intellect Neurosciences Inc | Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf |
US6787319B2 (en) | 1997-04-16 | 2004-09-07 | American Home Products Corp. | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
US6227999B1 (en) | 1997-07-09 | 2001-05-08 | Transmisiones Tsp, S.A. De C.V. | Method and apparatus for operating a clutch in an automated mechanical transmission |
IT1293511B1 (it) | 1997-07-30 | 1999-03-01 | Gentili Ist Spa | Anticorpi monoclonali catalitici ad attivita' proteasica per la lisi selettiva della componente proteica di placche e aggregati correlati |
WO1999007870A1 (en) | 1997-08-11 | 1999-02-18 | Chiron Corporation | Methods for genetically modifying t cells |
US6448369B1 (en) | 1997-11-06 | 2002-09-10 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
AU2903899A (en) | 1998-03-12 | 1999-09-27 | Shearwater Polymers Inc. | Poly(ethylene glycol) derivatives with proximal reactive groups |
CA2325600A1 (en) | 1998-05-21 | 1999-11-25 | The University Of Tennessee Research Corporation | Methods for amyloid removal using anti-amyloid antibodies |
CA2376693C (en) | 1999-06-16 | 2013-09-10 | Boston Biomedical Research Institute | Immunological control of .beta.-amyloid levels in vivo |
ES2235926T3 (es) | 1999-08-04 | 2005-07-16 | The University Of Southern California | Ensamblaje globular de proteina beta amiloide y sus usos. |
JP2003509020A (ja) | 1999-09-03 | 2003-03-11 | ラモット・ユニバーシティ・オーソリティ・フォー・アプライド・リサーチ・アンド・インダストリアル・ディベロップメント・リミテッド | プラーク形成疾患の診断、治療、予防に有用な薬剤、組成物、その使用法 |
US6294171B2 (en) | 1999-09-14 | 2001-09-25 | Milkhaus Laboratory, Inc. | Methods for treating disease states comprising administration of low levels of antibodies |
ATE317868T1 (de) | 1999-12-22 | 2006-03-15 | Nektar Therapeutics Al Corp | Sterisch gehinderte derivate von wasserlöslichen polymeren |
US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
EP1257584B2 (en) | 2000-02-24 | 2013-03-06 | Washington University St. Louis | Humanized antibodies that sequester amyloid beta peptide |
US20020009445A1 (en) | 2000-07-12 | 2002-01-24 | Yansheng Du | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
US7067133B2 (en) | 2000-09-06 | 2006-06-27 | Aventis Pharma S.A. | Methods and compositions for diseases associated with amyloidosis |
US6436386B1 (en) | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
JP2005503789A (ja) | 2001-08-17 | 2005-02-10 | イーライ・リリー・アンド・カンパニー | 抗Aβ抗体 |
ES2295401T3 (es) | 2001-08-17 | 2008-04-16 | Washington University | Metodo de ensayo para la enfermedad de alzheimer. |
US20060073149A1 (en) | 2001-08-17 | 2006-04-06 | Bales Kelly R | Rapid improvement of cognition in condition related to abeta |
WO2003016467A2 (en) | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Use of antibodies having high affinity for soluble ass to treat conditions and diseases related to ass |
EP1944040B1 (en) | 2001-08-17 | 2012-08-01 | Washington University | Assay method for Alzheimer's disease |
US7166478B2 (en) | 2002-03-12 | 2007-01-23 | Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses |
CA2483729A1 (en) | 2002-04-25 | 2003-11-06 | Eli Lilly And Company | Method for treating anxiety and mood disorders in older subjects |
DE60329627D1 (de) * | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
DE602004027348D1 (de) * | 2003-02-10 | 2010-07-08 | Applied Molecular Evolution | Abeta-bindende moleküle |
CN1845938B (zh) * | 2003-06-30 | 2010-05-26 | 杜门蒂斯有限公司 | 多肽 |
CA2583017A1 (en) * | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenerative neural diseases such as alzheimer's disease |
EP1838349A1 (en) * | 2004-12-15 | 2007-10-03 | Neuralab, Ltd. | Amyloid beta antibodies for use in improving cognition |
-
2008
- 2008-01-09 UA UAA200907146A patent/UA95996C2/ru unknown
- 2008-01-09 CN CN2008800026216A patent/CN101981053B/zh not_active Expired - Fee Related
- 2008-01-09 CA CA2675847A patent/CA2675847C/en not_active Expired - Fee Related
- 2008-01-09 JP JP2009546461A patent/JP5307030B2/ja not_active Expired - Fee Related
- 2008-01-09 BR BRPI0806715-5A patent/BRPI0806715A2/pt not_active IP Right Cessation
- 2008-01-09 SI SI200831733A patent/SI2842967T1/sl unknown
- 2008-01-09 ES ES14190162.9T patent/ES2615454T3/es active Active
- 2008-01-09 CN CN201310412048.9A patent/CN103479998B/zh not_active Expired - Fee Related
- 2008-01-09 KR KR1020127003094A patent/KR101414847B1/ko not_active IP Right Cessation
- 2008-01-09 US US12/521,309 patent/US8066999B2/en not_active Expired - Fee Related
- 2008-01-09 WO PCT/US2008/050554 patent/WO2008088983A1/en active Application Filing
- 2008-01-09 ES ES08713652.9T patent/ES2535641T3/es active Active
- 2008-01-09 PL PL08713652T patent/PL2121754T3/pl unknown
- 2008-01-09 AU AU2008206555A patent/AU2008206555B2/en not_active Ceased
- 2008-01-09 SI SI200831378T patent/SI2121754T1/sl unknown
- 2008-01-09 EP EP14190162.9A patent/EP2842967B1/en active Active
- 2008-01-09 DK DK08713652.9T patent/DK2121754T3/en active
- 2008-01-09 RS RS20150252A patent/RS53948B1/en unknown
- 2008-01-09 PT PT141901629T patent/PT2842967T/pt unknown
- 2008-01-09 PT PT87136529T patent/PT2121754E/pt unknown
- 2008-01-09 EP EP08713652.9A patent/EP2121754B1/en active Active
- 2008-01-09 EA EA200970694A patent/EA020979B1/ru not_active IP Right Cessation
- 2008-01-09 LT LTEP14190162.9T patent/LT2842967T/lt unknown
- 2008-01-09 MX MX2009007691A patent/MX2009007691A/es not_active Application Discontinuation
- 2008-01-09 KR KR1020097015076A patent/KR101160385B1/ko not_active IP Right Cessation
- 2008-01-11 TW TW097101232A patent/TW200836763A/zh unknown
- 2008-01-16 CL CL200800121A patent/CL2008000121A1/es unknown
- 2008-01-17 AR ARP080100214A patent/AR064944A1/es unknown
- 2008-01-17 PE PE2008000153A patent/PE20081634A1/es not_active Application Discontinuation
-
2009
- 2009-07-13 IL IL199838A patent/IL199838A/en not_active IP Right Cessation
-
2013
- 2013-06-26 JP JP2013133551A patent/JP5782479B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-06 IL IL230876A patent/IL230876A/en not_active IP Right Cessation
- 2014-04-22 HK HK14103815.1A patent/HK1190623A1/zh not_active IP Right Cessation
-
2015
- 2015-03-02 HR HRP20150237AT patent/HRP20150237T1/hr unknown
- 2015-03-31 CY CY20151100312T patent/CY1116157T1/el unknown
-
2016
- 2016-12-08 HR HRP20161677TT patent/HRP20161677T1/hr unknown
-
2017
- 2017-01-24 CY CY20171100108T patent/CY1118554T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200970694A1 (ru) | ПЭГИЛИРОВАННЫЕ Fab-ФРАГМЕНТЫ АНТИТЕЛ К ПЕПТИДУ Aβ | |
CY1122458T1 (el) | Αντισωματα αντι-n3pglu αμυλοειδους βητα πεπτιδιου και χρησεις αυτων | |
EA200700136A1 (ru) | Анти-cd154-антитела | |
MX2020001873A (es) | Agentes de union. | |
EA200801842A1 (ru) | Антитела против бета-амилоидного пептида | |
NZ597563A (en) | Muc1 antibodies | |
EA201070812A1 (ru) | Лечение и профилактика амилоидоза | |
EA201490053A1 (ru) | Антитела, которые связываются с ox40, и их применение | |
EA201390146A1 (ru) | Антитела к матриксной металлопротеиназе 9 | |
EA201190132A1 (ru) | Гуманизированные антитела, связывающиеся с cd19, и их применение | |
EA200702053A1 (ru) | Антитела против cd38 для лечения множественной миеломы | |
MX341883B (es) | Composicion farmaceutica para el tratamiento y prevencion de canceres. | |
CY1115871T1 (el) | Μεθοδοι για την αντιμετωπιση ουρικης αρθριτιδας | |
EA201100923A1 (ru) | Антитела человека против тканевого фактора | |
CY1115572T1 (el) | Αντι cxcr4 αντισωματα και χρηση αυτων για τη θεραπεια καρκινου | |
PE20071055A1 (es) | Anticuerpos anti mn | |
EA032189B9 (ru) | Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их | |
RU2010119521A (ru) | Антитела, связывающие il-4 и/или il-13, и их применение | |
JP2016531546A5 (ru) | ||
CY1113630T1 (el) | Αντισωματα αντι-χεπσιδινης και χρησεις εξ αυτωn | |
NZ594682A (en) | Fully human antibodies specific to cadm1 | |
EA201491851A1 (ru) | Композиции и способы для лечения болезни альцгеймера | |
UA113623C2 (uk) | Моноклональне антитіло проти інгібітору шляху тканинного фактора (tfpi) | |
WO2017060322A3 (en) | Ptefb-inhibitor-adc | |
EA201790341A1 (ru) | Анти-ск8 антитела для применения в лечении рака |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ BY KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM KZ RU |