EA032189B9 - Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их - Google Patents

Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их

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Publication number
EA032189B9
EA032189B9 EA201290849A EA201290849A EA032189B9 EA 032189 B9 EA032189 B9 EA 032189B9 EA 201290849 A EA201290849 A EA 201290849A EA 201290849 A EA201290849 A EA 201290849A EA 032189 B9 EA032189 B9 EA 032189B9
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EA
Eurasian Patent Office
Prior art keywords
seq
amino acid
acid sequence
relative
substitution
Prior art date
Application number
EA201290849A
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English (en)
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EA032189B1 (ru
EA201290849A1 (ru
Inventor
Петер Шольц
Зуози Ванг
Юнлианг Пан
Ёанна Грудзинска
Кристиан Фотсмайер
Ян Теббе
Йорг Биркенфельд
Нина Вобст
Зимоне Брюкнер
Зузанне Штайниг
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БАЙЕР ХЕЛЬСКЕР ЛЛСи
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Application filed by БАЙЕР ХЕЛЬСКЕР ЛЛСи filed Critical БАЙЕР ХЕЛЬСКЕР ЛЛСи
Publication of EA201290849A1 publication Critical patent/EA201290849A1/ru
Publication of EA032189B1 publication Critical patent/EA032189B1/ru
Publication of EA032189B9 publication Critical patent/EA032189B9/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Abstract

Изобретение представляет изолированное человеческое моноклональное антитело, которое специфически связывается с человеческим ингибитором пути тканевого фактора (TFPI), где антитело содержит: а) тяжелую цепь антитела человека, содержащую: i) CDR1 участок с аминокислотной последовательностью FTFRSYGMS, содержащей замену R30S или S35D или обе относительно SEQ ID NO: 1; ii) CDR2 участок с аминокислотной последовательностью SIRGSSSSTYYADSVKG, содержащей замену S55R или S56G или обе относительно SEQ ID NO: 1; iii) CDR3 участок с аминокислотной последовательностью KYRYWFDY, содержащей замену K99L относительно SEQ ID NO: 1; и b) легкую цепь антитела человека, содержащую: i) CDR1 участок с аминокислотной последовательностью SGDNLRNYYAH, содержащей замену R28P или N29K относительно SEQ ID NO: 2; ii) CDR2 участок с аминокислотной последовательностью YYDBNRPS, содержащей по меньшей мере одну замену, выбранную из группы, состоящей из Y48F и N51V и их комбинаций относительно SEQ ID NO: 2; iii) CDR3 участок с аминокислотной последовательностью QSWDDGVPV, содержащей по меньшей мере одну замену, выбранную из группы, состоящей из S89A, D91W, D92S, G93S и V94T и их комбинаций относительно SEQ ID NO: 2. Также представлены изолированные человеческие моноклональные антитела, как определено в пп.2, 3. Кроме того, настоящее изобретение предоставляет фармацевтическую композицию для лечения нарушения свертывания крови, содержащую указанные изолированные человеческие моноклональные антитела.
EA201290849A 2010-03-01 2011-03-01 Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их EA032189B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Publications (3)

Publication Number Publication Date
EA201290849A1 EA201290849A1 (ru) 2013-05-30
EA032189B1 EA032189B1 (ru) 2019-04-30
EA032189B9 true EA032189B9 (ru) 2019-09-30

Family

ID=44542552

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201892184A EA201892184A1 (ru) 2010-03-01 2011-03-01 Оптимизированные моноклональные антитела против ингибитора пути тканевого фактора
EA201290849A EA032189B9 (ru) 2010-03-01 2011-03-01 Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201892184A EA201892184A1 (ru) 2010-03-01 2011-03-01 Оптимизированные моноклональные антитела против ингибитора пути тканевого фактора

Country Status (36)

Country Link
US (3) US9309324B2 (ru)
EP (2) EP3345615B1 (ru)
JP (4) JP6025570B2 (ru)
KR (4) KR101903931B1 (ru)
CN (5) CN106188301A (ru)
AU (1) AU2011223710B2 (ru)
BR (1) BR112012022258A2 (ru)
CA (3) CA3101298A1 (ru)
CL (2) CL2012002415A1 (ru)
CO (1) CO6620068A2 (ru)
CR (1) CR20120453A (ru)
CU (1) CU23982B1 (ru)
CY (2) CY1119410T1 (ru)
DK (2) DK2542257T3 (ru)
DO (1) DOP2012000239A (ru)
EA (2) EA201892184A1 (ru)
EC (2) ECSP12012134A (ru)
ES (2) ES2765418T3 (ru)
GT (1) GT201200252A (ru)
HK (2) HK1232232A1 (ru)
HR (2) HRP20171472T1 (ru)
HU (2) HUE047173T2 (ru)
IL (3) IL221551B (ru)
LT (2) LT2542257T (ru)
ME (2) ME03578B (ru)
MX (2) MX2012010198A (ru)
MY (1) MY174760A (ru)
NZ (2) NZ702494A (ru)
PE (1) PE20160538A1 (ru)
PH (3) PH12018500641A1 (ru)
PL (2) PL2542257T3 (ru)
PT (2) PT3345615T (ru)
RS (2) RS59830B1 (ru)
SG (3) SG10201903166PA (ru)
SI (2) SI3345615T1 (ru)
WO (1) WO2011109452A1 (ru)

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UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
RU2562114C2 (ru) * 2008-12-22 2015-09-10 Ново Нордиск А/С Антитела против ингибитора метаболического пути тканевого фактора
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KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
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CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
CN117285632A (zh) * 2022-06-17 2023-12-26 安源医药科技（上海）有限公司 针对tfpi的单克隆抗体及其用途

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